ATE525469T1 - Nachweis kleiner nukleinsäuren - Google Patents
Nachweis kleiner nukleinsäurenInfo
- Publication number
- ATE525469T1 ATE525469T1 AT03813850T AT03813850T ATE525469T1 AT E525469 T1 ATE525469 T1 AT E525469T1 AT 03813850 T AT03813850 T AT 03813850T AT 03813850 T AT03813850 T AT 03813850T AT E525469 T1 ATE525469 T1 AT E525469T1
- Authority
- AT
- Austria
- Prior art keywords
- detection
- present
- nucleic acids
- methods
- mirnas
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 5
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 4
- 108700011259 MicroRNAs Proteins 0.000 abstract 3
- 108020004459 Small interfering RNA Proteins 0.000 abstract 3
- 230000002452 interceptive effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43451802P | 2002-12-18 | 2002-12-18 | |
| PCT/US2003/041549 WO2004057017A2 (en) | 2002-12-18 | 2003-12-18 | Detection of small nucleic acids |
| US10/740,256 US7851150B2 (en) | 2002-12-18 | 2003-12-18 | Detection of small nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE525469T1 true ATE525469T1 (de) | 2011-10-15 |
Family
ID=32685318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03813850T ATE525469T1 (de) | 2002-12-18 | 2003-12-18 | Nachweis kleiner nukleinsäuren |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1573009B1 (de) |
| JP (1) | JP4230457B2 (de) |
| AT (1) | ATE525469T1 (de) |
| AU (1) | AU2003297541A1 (de) |
| CA (1) | CA2510381C (de) |
| MX (1) | MXPA05006633A (de) |
| NO (1) | NO20053465L (de) |
| WO (1) | WO2004057017A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040219565A1 (en) | 2002-10-21 | 2004-11-04 | Sakari Kauppinen | Oligonucleotides useful for detecting and analyzing nucleic acids of interest |
| JP4939055B2 (ja) | 2002-11-13 | 2012-05-23 | トマス ジェファソン ユニバーシティ | 癌の診断および治療のための組成物および方法 |
| US8206904B2 (en) | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
| EP2530157B1 (de) | 2003-07-31 | 2016-09-28 | Regulus Therapeutics Inc. | Oligomerverbindungen und Zusammensetzungen zur Verwendung bei der Modulation von miRNAs |
| CN1867680A (zh) * | 2003-10-14 | 2006-11-22 | 诺瓦提斯公司 | 寡核苷酸微阵列 |
| US8192937B2 (en) | 2004-04-07 | 2012-06-05 | Exiqon A/S | Methods for quantification of microRNAs and small interfering RNAs |
| WO2005098029A2 (en) * | 2004-04-07 | 2005-10-20 | Exiqon A/S | Methods for quantification of micrornas and small interfering rnas |
| WO2006033020A2 (en) * | 2004-04-26 | 2006-03-30 | Rosetta Genomics Ltd. | Methods and apparatus for the detection and validation of micrornas |
| WO2005111211A2 (en) | 2004-05-14 | 2005-11-24 | Rosetta Genomics Ltd. | Micronas and uses thereof |
| US7795419B2 (en) | 2004-05-26 | 2010-09-14 | Rosetta Genomics Ltd. | Viral and viral associated miRNAs and uses thereof |
| EP2290073A3 (de) | 2004-05-28 | 2011-08-31 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit MicroRNA |
| US7575863B2 (en) | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
| US20060057595A1 (en) * | 2004-09-16 | 2006-03-16 | Applera Corporation | Compositions, methods, and kits for identifying and quantitating small RNA molecules |
| CA2857878A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| JP4905959B2 (ja) * | 2005-01-20 | 2012-03-28 | 学校法人 久留米大学 | 小分子ｒｎａの検出方法および小分子ｒｎａ検出用試薬 |
| JP2006292367A (ja) * | 2005-04-05 | 2006-10-26 | Mitsubishi Rayon Co Ltd | ｍｉＲＮＡ検出用マイクロアレイ |
| CA2611507A1 (en) * | 2005-06-09 | 2006-12-21 | Epoch Biosciences, Inc. | Improved primer-based amplification methods |
| CN105039313B (zh) | 2005-06-23 | 2018-10-23 | 科因股份有限公司 | 用于多态性的高通量鉴定和检测的策略 |
| US10316364B2 (en) | 2005-09-29 | 2019-06-11 | Keygene N.V. | Method for identifying the source of an amplicon |
| CA2910861C (en) | 2005-09-29 | 2018-08-07 | Michael Josephus Theresia Van Eijk | High throughput screening of mutagenized populations |
| JP5452021B2 (ja) | 2005-12-22 | 2014-03-26 | キージーン ナムローゼ フェンノートシャップ | ハイスループットａｆｌｐ系多型検出法 |
| WO2007083766A1 (ja) | 2006-01-20 | 2007-07-26 | Olympus Corporation | 分子内プローブによる核酸配列の検出方法 |
| US20090253581A1 (en) | 2006-04-04 | 2009-10-08 | Keygene N.V. | High Throughput Detection of Molecular Markers Based on AFLP and High Throughput Sequencing |
| EP2029774B1 (de) * | 2006-06-01 | 2015-04-01 | Third Wave Technologies, Inc. | Nachweis von nukleinsäuren |
| AU2007307171B2 (en) | 2006-10-04 | 2012-01-19 | Third Wave Technologies, Inc. | Snap-back primers and detectable hairpin structures |
| EP2198050A1 (de) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| JP5322066B2 (ja) | 2008-07-03 | 2013-10-23 | 国立大学法人神戸大学 | 関節リウマチ関連マイクロｒｎａ |
| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
| GB2520763A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
| JP6688318B2 (ja) * | 2015-05-01 | 2020-04-28 | ジェン−プローブ・インコーポレーテッド | 多重侵入切断アッセイ |
| ES2963242T3 (es) | 2015-09-18 | 2024-03-25 | Vanadis Diagnostics | Conjunto de sondas para analizar una muestra de ADN y método para utilizar el mismo |
| CA3078158A1 (en) | 2017-10-06 | 2019-04-11 | Cartana Ab | Rna templated ligation |
| AU2021309966A1 (en) | 2020-07-15 | 2023-02-09 | Biogen Ma Inc. | Medical system including two access ports |
| US12605537B2 (en) | 2022-02-15 | 2026-04-21 | Biogen Ma Inc. | Implantable medical device for use with or having recording electrode |
| CN119365596A (zh) * | 2022-06-20 | 2025-01-24 | 凸版控股株式会社 | 用于检测荧光的方法 |
| JP2024000312A (ja) * | 2022-06-20 | 2024-01-05 | Ｔｏｐｐａｎホールディングス株式会社 | 蛍光物質及び消光物質で標識された一本鎖オリゴヌクレオチド |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288609A (en) | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US7150982B2 (en) | 1991-09-09 | 2006-12-19 | Third Wave Technologies, Inc. | RNA detection assays |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| WO1997027214A1 (en) | 1996-01-24 | 1997-07-31 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
| US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
| US5614402A (en) | 1992-12-07 | 1997-03-25 | Third Wave Technologies, Inc. | 5' nucleases derived from thermostable DNA polymerase |
| US5541311A (en) | 1992-12-07 | 1996-07-30 | Third Wave Technologies, Inc. | Nucleic acid encoding synthesis-deficient thermostable DNA polymerase |
| US6096880A (en) * | 1993-04-15 | 2000-08-01 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US6068818A (en) | 1993-11-01 | 2000-05-30 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| DE69531542T2 (de) | 1994-02-07 | 2004-06-24 | Beckman Coulter, Inc., Fullerton | Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| WO1995029251A1 (en) | 1994-04-25 | 1995-11-02 | Applied Technology Genetics Corporation | Detection of mutation by resolvase cleavage |
| EP0842294B1 (de) | 1994-12-23 | 2002-10-23 | Dade Behring Inc. | Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung |
| US5882867A (en) | 1995-06-07 | 1999-03-16 | Dade Behring Marburg Gmbh | Detection of nucleic acids by formation of template-dependent product |
| US6143495A (en) | 1995-11-21 | 2000-11-07 | Yale University | Unimolecular segment amplification and sequencing |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| CA2239683A1 (en) | 1995-12-22 | 1997-07-03 | Dade Behring Marburg Gmbh | Homogeneous amplification and detection of nucleic acids |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| ES2375764T3 (es) | 1996-11-29 | 2012-03-06 | Third Wave Technologies, Inc. | Endonucleasas fen-1, mezclas y procedimientos de escisión. |
| US6001311A (en) | 1997-02-05 | 1999-12-14 | Protogene Laboratories, Inc. | Apparatus for diverse chemical synthesis using two-dimensional array |
| US6194149B1 (en) | 1998-03-03 | 2001-02-27 | Third Wave Technologies, Inc. | Target-dependent reactions using structure-bridging oligonucleotides |
| EP0983292A4 (de) | 1997-05-05 | 2005-05-18 | Third Wave Tech Inc | Zielabhängige reaktionen mittels strukturüberbrückender oligonukleotide |
| US5919626A (en) | 1997-06-06 | 1999-07-06 | Orchid Bio Computer, Inc. | Attachment of unmodified nucleic acids to silanized solid phase surfaces |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| CA2319712A1 (en) | 1998-02-04 | 1999-08-12 | Variagenics, Inc. | Mismatch detection techniques |
| US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
| EP1098996A1 (de) | 1998-07-20 | 2001-05-16 | Yale University | Verfahren zum nachweis von nukleinsäuren unter verwendung zielgerichteter ligation von zweiteiligen primern |
| US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| US6221603B1 (en) * | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
| JP2004521606A (ja) * | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Ｒｎａの検出法 |
| WO2001098537A2 (en) | 2000-06-17 | 2001-12-27 | Third Wave Technologies, Inc. | Nucleic acid accessible hybridization sites |
| AU2001297524A1 (en) | 2000-11-15 | 2002-09-19 | Third Wave Technologies, Inc. | Fen endonucleases |
| AU2002312411A1 (en) * | 2001-06-07 | 2002-12-16 | Proligo Llc | Microcalorimetric detection of analytes and binding events |
| US20030148519A1 (en) | 2001-11-14 | 2003-08-07 | Engelke David R. | Intracellular expression and delivery of siRNAs in mammalian cells |
| GB0212995D0 (en) | 2002-06-06 | 2002-07-17 | Unilever Plc | Ligand and complex for catalytically bleaching a substrate |
| JPWO2010084839A1 (ja) | 2009-01-26 | 2012-07-19 | 日本電気株式会社 | 尤度推定装置、コンテンツ配信システム、尤度推定方法および尤度推定プログラム |
-
2003
- 2003-12-18 AT AT03813850T patent/ATE525469T1/de not_active IP Right Cessation
- 2003-12-18 EP EP03813850A patent/EP1573009B1/de not_active Expired - Lifetime
- 2003-12-18 WO PCT/US2003/041549 patent/WO2004057017A2/en not_active Ceased
- 2003-12-18 AU AU2003297541A patent/AU2003297541A1/en not_active Abandoned
- 2003-12-18 JP JP2004561463A patent/JP4230457B2/ja not_active Expired - Lifetime
- 2003-12-18 CA CA2510381A patent/CA2510381C/en not_active Expired - Lifetime
- 2003-12-18 MX MXPA05006633A patent/MXPA05006633A/es active IP Right Grant
- 2003-12-18 EP EP10179311A patent/EP2361991A1/de not_active Withdrawn
-
2005
- 2005-07-15 NO NO20053465A patent/NO20053465L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4230457B2 (ja) | 2009-02-25 |
| HK1083111A1 (en) | 2006-06-23 |
| WO2004057017A2 (en) | 2004-07-08 |
| WO2004057017A3 (en) | 2005-03-10 |
| EP1573009A2 (de) | 2005-09-14 |
| CA2510381A1 (en) | 2004-07-08 |
| MXPA05006633A (es) | 2006-05-25 |
| EP1573009B1 (de) | 2011-09-21 |
| NO20053465D0 (no) | 2005-07-15 |
| JP2006510372A (ja) | 2006-03-30 |
| CA2510381C (en) | 2014-07-08 |
| NO20053465L (no) | 2005-09-13 |
| AU2003297541A1 (en) | 2004-07-14 |
| EP2361991A1 (de) | 2011-08-31 |
| EP1573009A4 (de) | 2006-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1573009A4 (de) | Nachweis kleiner nukleinsäuren | |
| WO2006069584A3 (en) | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs | |
| WO2004007718A3 (en) | Rna-interference by single-stranded rna molecules | |
| WO2004092383A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| WO2005028650A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| WO2005040379A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF RAS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| WO2008011431A3 (en) | Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina) | |
| EA201100812A1 (ru) | Фармацевтическая композиция | |
| MXPA05001355A (es) | Formas nuevas adicionales de moleculas de arn de interferencia. | |
| WO2007084865A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF B7-H1 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| EA200870402A1 (ru) | Фармацевтическая композиция | |
| WO2004065600A3 (en) | Rna interference by palindromic or modified rna molecules | |
| WO2007022369A3 (en) | Chemically modified short interfering nucleic acid molecules that mediate rna interference | |
| WO2006081546A3 (en) | Inhibitor nucleic acids | |
| WO2010080129A3 (en) | Extended dicer substrate agents and methods for the specific inhibition of gene expression | |
| EP3358014A3 (de) | Verfahren zur stabilisierung funktioneller nukleinsäuren | |
| WO2007038788A3 (en) | Small interfering rnas as non-specific drugs | |
| WO2012092569A3 (en) | Compositions comprising immunostimulatory nucleic acids and related methods | |
| WO2005045037A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF 5-ALPHA REDUCTASE AND ANDROGEN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| WO2010111503A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF THE HIGH AFFINITY IGE RECEPTOR ALPHA CHAIN (FCεRLα) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | |
| WO2005007855A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF B7-H1 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| WO2005003350A8 (en) | RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER’S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) | |
| WO2008011467A3 (en) | Rna interference mediated inhibition of sterol regulatory element-binding protein 1 (srebp1) gene expression using short interfering nucleic acid (sina) | |
| WO2005045041A3 (en) | Rna interference mediated inhibition of cholesteryl ester transfer protein (cetp) gene expression using short interfering nucleic acid (sina) | |
| WO2007048628A3 (en) | Structures of active guide rna molecules and method of selection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |