ATE525654T1 - Verfahren zum screenen von verbindungen, welche die gpi biosynthese von malariaparasiten hemmen - Google Patents

Verfahren zum screenen von verbindungen, welche die gpi biosynthese von malariaparasiten hemmen

Info

Publication number
ATE525654T1
ATE525654T1 AT03774152T AT03774152T ATE525654T1 AT E525654 T1 ATE525654 T1 AT E525654T1 AT 03774152 T AT03774152 T AT 03774152T AT 03774152 T AT03774152 T AT 03774152T AT E525654 T1 ATE525654 T1 AT E525654T1
Authority
AT
Austria
Prior art keywords
present
gwt1
protein
gpi biosynthesis
malaria parasite
Prior art date
Application number
AT03774152T
Other languages
English (en)
Inventor
Katsura Hata
Kaoru Ogawa
Itaru Tsukada
Kazutaka Nakamoto
Koji Sagane
Keigo Tanaka
Kappei Tsukahara
Toshihiro Horii
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of ATE525654T1 publication Critical patent/ATE525654T1/de

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445Plasmodium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37Assays involving biological materials from specific organisms or of a specific nature from fungi
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/44Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from protozoa
    • G01N2333/445Plasmodium
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03774152T 2002-11-22 2003-11-21 Verfahren zum screenen von verbindungen, welche die gpi biosynthese von malariaparasiten hemmen ATE525654T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42858902P 2002-11-22 2002-11-22
PCT/JP2003/014920 WO2004048567A2 (en) 2002-11-22 2003-11-21 Methods of screening for compounds that inhibit the biosynthesis of gpi in malaria parasites

Publications (1)

Publication Number Publication Date
ATE525654T1 true ATE525654T1 (de) 2011-10-15

Family

ID=32393427

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03774152T ATE525654T1 (de) 2002-11-22 2003-11-21 Verfahren zum screenen von verbindungen, welche die gpi biosynthese von malariaparasiten hemmen

Country Status (9)

Country Link
US (2) US7928215B2 (de)
EP (1) EP1565749B9 (de)
JP (3) JP4315907B2 (de)
KR (4) KR100825547B1 (de)
CN (3) CN100504392C (de)
AT (1) ATE525654T1 (de)
AU (1) AU2003282393B2 (de)
CA (3) CA2721200A1 (de)
WO (1) WO2004048567A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1249227C (zh) * 2000-07-07 2006-04-05 卫材株式会社 真菌细胞壁合成基因
JP4061309B2 (ja) * 2002-11-22 2008-03-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 Gwt1遺伝子産物の酵素活性を阻害する化合物をスクリーニングする方法
US7932272B2 (en) 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
EP1782811A4 (de) 2004-08-09 2010-09-01 Eisai R&D Man Co Ltd Neues anti-malaria-mittel mit heterozyklischer verbindung
WO2006106711A1 (ja) 2005-03-30 2006-10-12 Eisai R & D Management Co., Ltd. ピリジン誘導体を含有する抗真菌剤
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2008035726A1 (en) 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
JP5354542B2 (ja) * 2007-09-14 2013-11-27 国立大学法人 長崎大学 熱帯熱マラリアワクチン候補分子
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
JP5646457B2 (ja) 2008-04-29 2014-12-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリン及びその使用
JP2011523853A (ja) 2008-06-03 2011-08-25 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリン及びその使用
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
EP3252072A3 (de) 2010-08-03 2018-03-14 AbbVie Inc. Immunglobuline mit zweifacher variabler domäne und verwendungen davon
WO2013192517A2 (en) * 2012-06-21 2013-12-27 Whitehead Institute For Biomedical Research Compounds for treating infectious diseases
KR102063576B1 (ko) * 2012-07-24 2020-01-10 한국전자통신연구원 가상화 기반 은닉형 소프트웨어 실행 환경 제공 방법 및 장치
KR101954733B1 (ko) * 2012-10-26 2019-03-06 삼성전자주식회사 보안 콘텐츠를 처리하는 시스템 온 칩 및 그것을 포함하는 모바일 장치
CN109825514A (zh) * 2019-01-24 2019-05-31 华中农业大学 田鼠巴贝斯虫gpi10基因及其编码的蛋白和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2015722A1 (en) * 1989-05-03 1990-11-03 Mitchell S. Gross Malaria vaccine
DE19640817A1 (de) 1996-10-02 1998-05-14 Hermann Prof Dr Bujard Rekombinantes Herstellungsverfahren für ein vollständiges Malaria-Antigen gp190/MSP 1
WO1999021986A1 (en) * 1997-10-29 1999-05-06 Shanghai Second Medical University Cbfbga09: a human sl15 homolog
AU2392300A (en) 1998-12-31 2000-07-31 Millennium Pharmaceuticals, Inc. Use of essential (saccharomyces) genes and polypeptides
WO2001013923A1 (en) 1999-08-20 2001-03-01 Georgetown University Malaria gpi anchors as vaccines anti-parasitic drugs and for use in diagnostics
CN1249227C (zh) * 2000-07-07 2006-04-05 卫材株式会社 真菌细胞壁合成基因
US20040038239A1 (en) * 2000-07-07 2004-02-26 Kappei Tsukahara Fungal cell wall synthesis gene
AU2002225533A1 (en) 2000-12-22 2002-07-08 Stichting Biomedical Primate Research Centre Efficient expression of plasmodium apical membrane antigen 1 in yeast cells
DE10254397B4 (de) 2002-11-21 2010-09-23 Poloplast Gmbh & Co. Kg Universalschlauchkupplung
JP4061309B2 (ja) * 2002-11-22 2008-03-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 Gwt1遺伝子産物の酵素活性を阻害する化合物をスクリーニングする方法

Also Published As

Publication number Publication date
KR20070065452A (ko) 2007-06-22
JP2006506996A (ja) 2006-03-02
CA2704070A1 (en) 2004-06-10
JP2009183290A (ja) 2009-08-20
EP1565749A2 (de) 2005-08-24
JP2009077715A (ja) 2009-04-16
AU2003282393B2 (en) 2007-07-05
KR20100039428A (ko) 2010-04-15
WO2004048567A2 (en) 2004-06-10
US8252294B2 (en) 2012-08-28
KR100825547B1 (ko) 2008-04-25
CN101092627A (zh) 2007-12-26
CN101092628A (zh) 2007-12-26
KR100933759B1 (ko) 2009-12-23
WO2004048567A3 (en) 2004-10-14
EP1565749B1 (de) 2011-09-21
CN101092628B (zh) 2010-11-03
CN101092627B (zh) 2011-08-17
JP4315907B2 (ja) 2009-08-19
JP4376297B2 (ja) 2009-12-02
CA2505067A1 (en) 2004-06-10
KR20050085105A (ko) 2005-08-29
CA2505067C (en) 2011-08-02
CN1742203A (zh) 2006-03-01
AU2003282393A1 (en) 2004-06-18
EP1565749B9 (de) 2012-04-25
CA2721200A1 (en) 2004-06-10
US7928215B2 (en) 2011-04-19
CN100504392C (zh) 2009-06-24
US20110201816A1 (en) 2011-08-18
US20060172404A1 (en) 2006-08-03
KR20070010088A (ko) 2007-01-19

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