ATE527254T1 - Mit imidazol enthaltenden sekundären aminen substituierte benzopyran-derivate, deren herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents

Mit imidazol enthaltenden sekundären aminen substituierte benzopyran-derivate, deren herstellung und diese enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE527254T1
Authority: AT; Austria
Prior art keywords: preparation; secondary amines; derivatives substituted; benzopyran derivatives; pharmaceutical preparations
Prior art date: 2002-08-09

Application number

AT03784665T

Other languages

English (en)

Inventor

Kyu Yang Yi

Sun Kyung Lee

Sung-Eun Yoo

Jee Hee Suh

Nak Jeong Kim

Sun Kyung Hwang

Byung-Ho Lee

Ho Won Seo

Chong Ock Lee

Sang-Un Choi

Original Assignee

Korea Res Inst Chem Tech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-09

Filing date

2003-07-30

Publication date

2011-10-15

2003-07-30 Application filed by Korea Res Inst Chem Tech filed Critical Korea Res Inst Chem Tech

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE527254T1 publication Critical patent/ATE527254T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 5
KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical group C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000003335 secondary amines Chemical group 0.000 title abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
230000001772 anti-angiogenic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
210000002064 heart cell Anatomy 0.000 abstract 1
208000012947 ischemia reperfusion injury Diseases 0.000 abstract 1
210000002569 neuron Anatomy 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
-1 their preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT03784665T 2002-08-09 2003-07-30 Mit imidazol enthaltenden sekundären aminen substituierte benzopyran-derivate, deren herstellung und diese enthaltende pharmazeutische zubereitungen ATE527254T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR10-2002-0047189A KR100492252B1 (ko)	2002-08-09	2002-08-09	이미다졸을 포함하는 이차아민으로 치환된 벤조피란유도체 및 그의 제조방법
PCT/KR2003/001534 WO2004014898A1 (en)	2002-08-09	2003-07-30	Benzopyran derivatives substituted with secondary amines including imidazole, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
ATE527254T1 true ATE527254T1 (de)	2011-10-15

Family

ID=36165420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03784665T ATE527254T1 (de)	2002-08-09	2003-07-30	Mit imidazol enthaltenden sekundären aminen substituierte benzopyran-derivate, deren herstellung und diese enthaltende pharmazeutische zubereitungen

Country Status (10)

Country	Link
US (1)	US7279497B2 (de)
EP (1)	EP1546136B1 (de)
JP (1)	JP4216806B2 (de)
KR (1)	KR100492252B1 (de)
CN (1)	CN1313463C (de)
AT (1)	ATE527254T1 (de)
AU (1)	AU2003247213B8 (de)
CA (1)	CA2493966C (de)
ES (1)	ES2372486T3 (de)
WO (1)	WO2004014898A1 (de)

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KR100512486B1 (ko) *	2003-05-28	2005-09-06	동부한농화학 주식회사	싸이옥소벤즈옥사졸 유도체로 치환된 벤조피란 유도체또는 약학적으로 허용되는 염, 이의 제조방법 및 이를포함하는 약학적 조성물
RU2427572C2 (ru)	2004-06-18	2011-08-27	Чирон Корпорейшн	N-(1-(1-бензил-4-фенил-1н-имидазол-2-ил)-2,2-диметилпропил)бензамидные производные и родственные соединения в качестве ингибиторов кинезинового белка веретена (ksp) для лечения рака
KR100666207B1 (ko)	2005-03-18	2007-01-09	한국화학연구원	Ｒｔｋ 저해활성을 가지는6-알킬아미노-2,2'-이중치환-벤조피란 유도체
JP2008540441A (ja) *	2005-05-03	2008-11-20	バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト	殺虫性の置換されたアミノアルキル複素環式及びヘテロアリール誘導体
KR100694181B1 (ko) *	2005-11-25	2007-03-12	연세대학교 산학협력단	근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
JP4561685B2 (ja) *	2006-04-27	2010-10-13	株式会社豊田自動織機	予混合圧縮着火機関及び予混合圧縮着火機関の吸気制御方法
KR100769732B1 (ko) *	2006-07-21	2007-10-23	한국화학연구원	신경세포 사멸을 억제하는2,2'-알킬치환-3,4-디하이드로-6-알킬아미노 벤조피란유도체
CA2665255A1 (en) *	2006-10-19	2008-04-24	F. Hoffmann-La Roche Ag	Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
AU2007312390B2 (en)	2006-10-19	2013-03-28	F. Hoffmann-La Roche Ag	Aminomethyl-4-imidazoles
WO2008052907A1 (en)	2006-11-02	2008-05-08	F. Hoffmann-La Roche Ag	Substituted 2-imidazoles as modulators of the trace amine associated receptors
EP2084152A2 (de)	2006-11-16	2009-08-05	F. Hoffmann-Roche AG	Substituierte 4-imidazole
AU2007332641A1 (en)	2006-12-13	2008-06-19	F. Hoffmann-La Roche Ag	Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR)
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
UA98951C2 (ru)	2007-02-02	2012-07-10	Ф. Хоффманн-Ля Рош Аг	2-аминооксазолины и лекарственное средство, которое их содержит
AU2008214774A1 (en)	2007-02-15	2008-08-21	F. Hoffmann-La Roche Ag	2-aminooxazolines as TAAR1 ligands
WO2009003868A2 (en)	2007-07-02	2009-01-08	F. Hoffmann-La Roche Ag	2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
JP2010531836A (ja)	2007-07-03	2010-09-30	エフ．ホフマン−ラロシュアーゲー	４−イミダゾリン及びそれらの抗うつ剤としての使用
CA2694362A1 (en)	2007-07-27	2009-02-05	F. Hoffmann-La Roche Ag	2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
WO2009019149A1 (en)	2007-08-03	2009-02-12	F. Hoffmann-La Roche Ag	Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
US20140018402A1 (en) *	2011-03-30	2014-01-16	Catholic University Industry Academic Cooperation Foundation	Pharmaceutical composition for preventing or treating macular degeneration
JP6434496B2 (ja) *	2013-04-22	2018-12-05	アッヴィ・インコーポレイテッド	チアゾールおよびその使用
KR102484846B1 (ko) *	2015-11-27	2023-01-05	한림제약(주)	벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법
EP3757102A1 (de)	2016-03-17	2020-12-30	F. Hoffmann-La Roche AG	5-ethyl-4-methyl-pyrazole-3-carboxamid-derivat mit wirkung als taar agonist
KR102478553B1 (ko)	2018-02-28	2022-12-16	한림제약(주)	벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제
KR102282535B1 (ko) *	2019-11-21	2021-07-27	한국화학연구원	방사선 조사에 의한 조직 또는 세포 손상의 예방 또는 치료용 약학적 조성물

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2002
- 2002-08-09 KR KR10-2002-0047189A patent/KR100492252B1/ko not_active Expired - Lifetime
2003
- 2003-07-30 AT AT03784665T patent/ATE527254T1/de not_active IP Right Cessation
- 2003-07-30 EP EP03784665A patent/EP1546136B1/de not_active Expired - Lifetime
- 2003-07-30 JP JP2004527422A patent/JP4216806B2/ja not_active Expired - Lifetime
- 2003-07-30 CA CA2493966A patent/CA2493966C/en not_active Expired - Lifetime
- 2003-07-30 ES ES03784665T patent/ES2372486T3/es not_active Expired - Lifetime
- 2003-07-30 AU AU2003247213A patent/AU2003247213B8/en not_active Expired
- 2003-07-30 CN CNB038191954A patent/CN1313463C/zh not_active Expired - Lifetime
- 2003-07-30 US US10/523,015 patent/US7279497B2/en not_active Expired - Lifetime
- 2003-07-30 WO PCT/KR2003/001534 patent/WO2004014898A1/en not_active Ceased

Also Published As

Publication number	Publication date
AU2003247213B8 (en)	2007-05-10
CN1313463C (zh)	2007-05-02
EP1546136A1 (de)	2005-06-29
US20050267188A1 (en)	2005-12-01
US7279497B2 (en)	2007-10-09
CN1675202A (zh)	2005-09-28
KR100492252B1 (ko)	2005-05-30
AU2003247213B2 (en)	2007-04-05
JP2006509725A (ja)	2006-03-23
EP1546136A4 (de)	2007-01-24
CA2493966A1 (en)	2004-02-19
EP1546136B1 (de)	2011-10-05
WO2004014898A1 (en)	2004-02-19
AU2003247213A1 (en)	2004-02-25
CA2493966C (en)	2010-03-16
KR20040014023A (ko)	2004-02-14
JP4216806B2 (ja)	2009-01-28
ES2372486T3 (es)	2012-01-20

Legal Events

Date	Code	Title	Description
2012-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE527254T1 (de)	2011-10-15	Mit imidazol enthaltenden sekundären aminen substituierte benzopyran-derivate, deren herstellung und diese enthaltende pharmazeutische zubereitungen
BRPI0415525A (pt)	2006-12-26	derivados de imidazola e seu uso como agentes farmacêuticos
DE69924500D1 (de)	2005-05-04	Chinazolinderivate
IS2114B (is)	2006-06-15	Kínasólínafleiður til að meðhöndla æxli
TW200510392A (en)	2005-03-16	Chemical compounds
TR199903053T2 (xx)	2000-11-21	Benzimidazol t�revleri.
EP1496076A4 (de)	2006-06-21	Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff
FI951454A0 (fi)	1995-03-27	1-(2-oksoasetyyli)piperidiini-2-karboksyylihappojohdannaiset monille lääkkeille resistenttien syöpäsolujen herkistäjinä
BR0113757A (pt)	2004-03-02	Derivados de quinolinona como inibibores de tirosina quinase
ATE293995T1 (de)	2005-05-15	Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten
FI972086A7 (fi)	1997-05-15	Parannetun monilääkeresistenssiaktiivisuuden omaavat uudet aminohappoj ohdokset
HN2004000232A (es)	2011-01-17	" derivados de pirrolo(3,4-c) pirazol activos como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que los comprenden."
MA27093A1 (fr)	2004-12-20	Derives de sulfonamides, leur preparation et leur application comme medicaments.
TR200000223T2 (tr)	2000-07-21	XA faktörünü engelleyen heterosiklik türevler
DE602004031621D1 (de)	2011-04-14	Tricyclische derivate oder pharmazeutisch unnbedenkliche salze davon, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
KR960700063A (ko)	1996-01-19	사람 종양 세포내에서의 테모졸로마이드의 강화방법(Potentiation of temozolomide in human tumour cells)
SE0302573D0 (sv)	2003-09-26	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ATE231852T1 (de)	2003-02-15	Bicyclische aromatische verbindungen
IS6558A (is)	2002-09-20	Blandaðar sjúkdómsmeðferðir með æðaskaðandi virkni
BRPI0409884A (pt)	2006-05-23	compostos, composições farmacêuticas, método para o tratamento ou porfilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
BR0311866A (pt)	2005-03-15	Composições de saponinas ou sapogeninas para terapia de câncer
CY1108266T1 (el)	2014-02-12	Παραγωγα διβενζο(c) χρωμεν-6-ονης ως αντικαρκινικοι παραγοντες
DE69422712D1 (de)	2000-02-24	Tris-platin-komplexe
SE0302570D0 (sv)	2003-09-26	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
NZ324380A (en)	2000-01-28	Therapeutic benzimidazole compounds and their use in treatment of virus infections