ATE527545T1 - Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon - Google Patents

Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon

Info

Publication number
ATE527545T1
ATE527545T1 AT05814007T AT05814007T ATE527545T1 AT E527545 T1 ATE527545 T1 AT E527545T1 AT 05814007 T AT05814007 T AT 05814007T AT 05814007 T AT05814007 T AT 05814007T AT E527545 T1 ATE527545 T1 AT E527545T1
Authority
AT
Austria
Prior art keywords
proteolytic cleavage
epito
fusion
cleavage site
hcv antigens
Prior art date
Application number
AT05814007T
Other languages
English (en)
Inventor
David Y Chien
Doris Coit
Carlos George-Nascimento
Lin Sansan
Angelica Medina-Selby
Laura Tandeske
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Application granted granted Critical
Publication of ATE527545T1 publication Critical patent/ATE527545T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT05814007T 2004-08-27 2005-08-26 Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon ATE527545T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60485804P 2004-08-27 2004-08-27
US61839004P 2004-10-12 2004-10-12
US62150204P 2004-10-22 2004-10-22
US62179004P 2004-10-25 2004-10-25
PCT/US2005/030324 WO2006033768A2 (en) 2004-08-27 2005-08-26 Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof

Publications (1)

Publication Number Publication Date
ATE527545T1 true ATE527545T1 (de) 2011-10-15

Family

ID=35968332

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05814007T ATE527545T1 (de) 2004-08-27 2005-08-26 Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon
AT05810417T ATE542140T1 (de) 2004-08-27 2005-08-26 Nichtstrukturelle hcv-proteinmutanten und verwendungsmöglichkeiten dafür

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05810417T ATE542140T1 (de) 2004-08-27 2005-08-26 Nichtstrukturelle hcv-proteinmutanten und verwendungsmöglichkeiten dafür

Country Status (6)

Country Link
US (1) US7871625B2 (de)
EP (2) EP1799868B1 (de)
JP (2) JP4836281B2 (de)
AT (2) ATE527545T1 (de)
ES (1) ES2377978T3 (de)
WO (2) WO2006033768A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625724B2 (en) * 2005-08-25 2009-12-01 Board Of Regents, The University Of Texas System MAVS in the prevention and treatment of viral diseases
WO2008024518A2 (en) * 2006-08-25 2008-02-28 Novartis Ag Hcv fusion polypeptides
US7858752B2 (en) * 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
MX362075B (es) * 2013-03-14 2019-01-07 Abbott Lab Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo.
WO2014143342A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
CN105378099B (zh) 2013-03-14 2021-05-11 雅培制药有限公司 Hcv核心脂质结合结构域单克隆抗体
ES2832335T3 (es) * 2015-03-27 2021-06-10 Ortho Clinical Diagnostics Inc Polipéptidos NS4A/NS3 modificado del VHC y usos de los mismos

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5350671A (en) 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
WO1989004669A1 (en) 1987-11-18 1989-06-01 Chiron Corporation Nanbv diagnostics and vaccines
HUT54896A (en) 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv
WO1990014436A1 (en) 1989-05-18 1990-11-29 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
GB2276169A (en) 1990-07-05 1994-09-21 Celltech Ltd Antibodies specific for carcinoembryonic antigen
KR0185426B1 (ko) * 1991-06-24 1999-04-01 로버트 피. 블랙버언 씨형 간염 바이러스 폴리펩티드
UA39944C2 (uk) * 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
JP3217600B2 (ja) 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
US5843752A (en) 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
US5990276A (en) 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
US6514731B1 (en) 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
DK0935662T3 (da) 1996-05-24 2006-03-06 Chiron Corp Fusionsprotein med multiple epitoper
IL143798A0 (en) 1999-01-08 2002-04-21 Bristol Myers Squibb Co Hepatitis c virus ns3 protease
JP2001019699A (ja) * 1999-07-06 2001-01-23 Welfide Corp Ｈｃｖのｎｓ３プロテアーゼ活性の測定
US6815160B1 (en) 1999-07-28 2004-11-09 Chiron Corporation Hepatitis C viral antigen immunoassay detection systems
US6986892B1 (en) 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
US20050074465A1 (en) 1999-11-24 2005-04-07 Michael Houghton HCV fusion proteins with modified NS3 domains
DE60036881T2 (de) * 1999-11-24 2008-07-10 Novartis Vaccines and Diagnostics, Inc., Emeryville Neues nichtstrukturelles hcv-polypeptid
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
BRPI0111731C1 (pt) * 2000-06-15 2021-07-27 Chiron Corp suporte sólido de imunoensaio, métodos de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e de produção de um suporte sólido de imunoensaio, e, kit de teste de imunodiagnóstico
WO2004000547A1 (en) 2002-06-21 2003-12-31 Boler Lewyn B Jr Device and system for coating a surface
PL374349A1 (en) * 2002-07-02 2005-10-17 Chiron Corporation Hcv fusion proteins with modified ns3 domains
ES2312806T3 (es) * 2002-09-09 2009-03-01 Novartis Vaccines And Diagnostics, Inc. Ensayo de vhc.

Also Published As

Publication number Publication date
EP1799868A4 (de) 2009-09-23
ES2377978T3 (es) 2012-04-03
EP1802778B1 (de) 2011-10-05
JP5070055B2 (ja) 2012-11-07
JP2008511326A (ja) 2008-04-17
EP1799868B1 (de) 2012-01-18
EP1802778A2 (de) 2007-07-04
EP1802778A4 (de) 2009-12-30
WO2006033768A2 (en) 2006-03-30
WO2006024020A3 (en) 2009-04-02
US7871625B2 (en) 2011-01-18
JP4836281B2 (ja) 2011-12-14
US20080299544A1 (en) 2008-12-04
WO2006024020A2 (en) 2006-03-02
EP1799868A2 (de) 2007-06-27
ATE542140T1 (de) 2012-02-15
WO2006033768A3 (en) 2009-04-09
JP2008515391A (ja) 2008-05-15

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