ATE529408T1 - Verfahren zur herstellung eines vorläufers von montelukast - Google Patents

Verfahren zur herstellung eines vorläufers von montelukast

Info

Publication number: ATE529408T1
Authority: AT; Austria
Prior art keywords: montelukast; precursor; producing
Prior art date: 2004-04-30

Application number

AT10075051T

Other languages

English (en)

Inventor

Arjanne Overeem

Reinerus Gerardus Gieling

Jie Zhu

Lambertus Thijs

Original Assignee

Synthon Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-30

Filing date

2005-04-14

Publication date

2011-11-15

2005-04-14 Application filed by Synthon Bv filed Critical Synthon Bv

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE529408T1 publication Critical patent/ATE529408T1/de

Links

UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229960005127 montelukast Drugs 0.000 title 1
239000002243 precursor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT10075051T 2004-04-30 2005-04-14 Verfahren zur herstellung eines vorläufers von montelukast ATE529408T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US56660304P	2004-04-30	2004-04-30
US58467504P	2004-07-02	2004-07-02
US11/081,695 US7501517B2 (en)	2004-04-30	2005-03-17	Process for making montelukast and intermediates therefor

Publications (1)

Publication Number	Publication Date
ATE529408T1 true ATE529408T1 (de)	2011-11-15

Family

ID=34972158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT10075051T ATE529408T1 (de)	2004-04-30	2005-04-14	Verfahren zur herstellung eines vorläufers von montelukast

Country Status (5)

Country	Link
US (1)	US7501517B2 (de)
EP (2)	EP1740546A2 (de)
AR (1)	AR048875A1 (de)
AT (1)	ATE529408T1 (de)
WO (1)	WO2005105749A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007508271A (ja) *	2003-10-10	2007-04-05	シントン・ベスローテン・フェンノートシャップ	固体状態のモンテルカスト
US7829716B2 (en) *	2004-04-30	2010-11-09	Synthon Pharmaceuticals, Inc.	Process for making montelukast and intermediates therefor
WO2006008750A2 (en) *	2004-07-19	2006-01-26	Matrix Laboratories Ltd	Methyl 2-[(3s)-[3-[(2e)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates
US7812168B2 (en)	2005-07-05	2010-10-12	Teva Pharmaceutical Industries Ltd.	Purification of montelukast
CN101365683A (zh) *	2005-11-18	2009-02-11	斯索恩有限公司	制备孟鲁司特及其中间体的方法
AR057909A1 (es) *	2005-11-18	2007-12-26	Synthon Bv	Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
EP1976522B2 (de)	2005-12-30	2019-07-03	KRKA, tovarna zdravil, d.d., Novo mesto	Pharmazeutische zusammensetzung mit montelukast
WO2007107297A1 (en) *	2006-03-17	2007-09-27	Synthon B.V.	Montelukast amantadine salt
EP1886998A1 (de)	2006-08-09	2008-02-13	Esteve Quimica, S.A.	Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
CN101889081B (zh)	2007-09-28	2014-06-18	科德克希思公司	酮还原酶多肽及其用途
CN102046602A (zh) *	2008-04-25	2011-05-04	斯索恩有限公司	制备孟鲁司特中间体的方法
US8207343B2 (en)	2008-05-26	2012-06-26	Laurus Labs Private Limited	Process for preparing montelukast and salts thereof
WO2011121091A1 (en)	2010-03-31	2011-10-06	Krka, D.D., Novo Mesto	Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
HUP1000425A2 (en)	2010-08-11	2012-03-28	Richter Gedeon Nyrt	Process for the production of montelukast sodium
US8471030B2 (en)	2010-12-06	2013-06-25	Orochem Technologies Inc.	Purification of montelukast using simulated moving bed
CN103467276B (zh) *	2013-09-13	2015-05-06	天津速研医药科技有限公司	一种孟鲁司特钠侧链关键中间体的合成方法
CN111072475A (zh) *	2019-12-20	2020-04-28	牡丹江恒远药业股份有限公司	1-羟甲基环丙基乙酸的合成方法及应用

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US5565473A (en)	1990-10-12	1996-10-15	Merck Frosst Canada, Inc.	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5856322A (en)	1990-10-12	1999-01-05	Merck Frosst Canada, Inc.	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
HU222344B1 (hu)	1990-10-12	2003-06-28	Merck Frosst Canada & Co.	Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására
US5266568A (en)	1990-10-12	1993-11-30	Merck Frosst Canada, Inc.	Hydroxyalkylquinoline ether acids as leukotriene antagonists
US5270324A (en)	1992-04-10	1993-12-14	Merck Frosst Canada, Inc.	Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
TW448160B (en)	1993-12-28	2001-08-01	Merck & Co Inc	Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
GB9423511D0 (en)	1994-11-22	1995-01-11	Glaxo Wellcome Inc	Compositions
US5585115A (en)	1995-01-09	1996-12-17	Edward H. Mendell Co., Inc.	Pharmaceutical excipient having improved compressability
US5523477A (en)	1995-01-23	1996-06-04	Merck & Co., Inc.	Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5869673A (en)	1997-02-28	1999-02-09	Merck & Co., Inc.	Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
CN1420113A (zh) *	2001-11-16	2003-05-28	北京上地新世纪生物医药研究所	孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh) *	2001-12-26	2004-10-20	北京上地新世纪生物医药研究所	一种孟鲁司特钠的制备方法及其制备中间体
US20040265375A1 (en)	2003-04-16	2004-12-30	Platteeuw Johannes J.	Orally disintegrating tablets
JP2007508271A (ja)	2003-10-10	2007-04-05	シントン・ベスローテン・フェンノートシャップ	固体状態のモンテルカスト
US7829716B2 (en)	2004-04-30	2010-11-09	Synthon Pharmaceuticals, Inc.	Process for making montelukast and intermediates therefor

2005
- 2005-03-17 US US11/081,695 patent/US7501517B2/en not_active Expired - Fee Related
- 2005-04-14 EP EP05759120A patent/EP1740546A2/de not_active Withdrawn
- 2005-04-14 WO PCT/EP2005/004011 patent/WO2005105749A2/en not_active Ceased
- 2005-04-14 AT AT10075051T patent/ATE529408T1/de not_active IP Right Cessation
- 2005-04-14 EP EP10075051A patent/EP2181986B1/de not_active Expired - Lifetime
- 2005-04-25 AR ARP050101619A patent/AR048875A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2005105749A2 (en)	2005-11-10
EP2181986B1 (de)	2011-10-19
US20050245569A1 (en)	2005-11-03
WO2005105749A3 (en)	2006-03-02
EP1740546A2 (de)	2007-01-10
US7501517B2 (en)	2009-03-10
AR048875A1 (es)	2006-06-07
EP2181986A1 (de)	2010-05-05

Legal Events

Date	Code	Title	Description
2012-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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