ATE533747T1 - Verfahren zur herstellung von tetrahydrochinolinderivaten - Google Patents

Verfahren zur herstellung von tetrahydrochinolinderivaten

Info

Publication number
ATE533747T1
ATE533747T1 AT07741046T AT07741046T ATE533747T1 AT E533747 T1 ATE533747 T1 AT E533747T1 AT 07741046 T AT07741046 T AT 07741046T AT 07741046 T AT07741046 T AT 07741046T AT E533747 T1 ATE533747 T1 AT E533747T1
Authority
AT
Austria
Prior art keywords
tetrahydrocinoline
derivatives
producing
tetrahydrocinoline derivatives
producing tetrahydrocinoline
Prior art date
Application number
AT07741046T
Other languages
English (en)
Inventor
Masaki Okamoto
Akira Sakuragi
Yoshikazu Mori
Takeshi Hamada
Hitoshi Kubota
Yoshinori Nakamura
Takanori Higashijima
Norimitsu Hayashi
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Application granted granted Critical
Publication of ATE533747T1 publication Critical patent/ATE533747T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT07741046T 2006-03-30 2007-03-29 Verfahren zur herstellung von tetrahydrochinolinderivaten ATE533747T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006092783 2006-03-30
JP2006322845 2006-11-30
PCT/JP2007/057610 WO2007116922A1 (en) 2006-03-30 2007-03-29 A process for preparing tetrahydroquinoline derivatives

Publications (1)

Publication Number Publication Date
ATE533747T1 true ATE533747T1 (de) 2011-12-15

Family

ID=38123770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07741046T ATE533747T1 (de) 2006-03-30 2007-03-29 Verfahren zur herstellung von tetrahydrochinolinderivaten

Country Status (10)

Country Link
US (1) US8084611B2 (de)
EP (2) EP2007728B1 (de)
JP (1) JP5275971B2 (de)
AR (1) AR060174A1 (de)
AT (1) ATE533747T1 (de)
ES (1) ES2374315T3 (de)
PE (1) PE20071150A1 (de)
TW (1) TW200808731A (de)
UY (1) UY30244A1 (de)
WO (1) WO2007116922A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR069165A1 (es) * 2007-11-05 2010-01-06 Novartis Ag Derivados de 4-bencilamino-1-carboxacilpiperidina como inhibidores de cetp utiles para el tratamiento de hiperlipidemia
PT2404901E (pt) * 2007-12-03 2013-08-29 Novartis Ag Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose
CN102020608B (zh) * 2010-09-17 2012-09-05 清华大学 喹啉化合物的制备方法
MA40378B1 (fr) * 2014-08-12 2022-10-31 Newamsterdam Pharma B V Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de la tétrahydroquinoléine
WO2017023165A1 (en) * 2015-08-04 2017-02-09 Dezima Pharma B.V. Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and an atp citrate lyase inhibitor – ampk activator
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
MX2020004071A (es) 2017-10-02 2020-07-28 Arixa Pharmaceuticals Inc Derivados de aztreonam y usos de los mismos.
EP3590927A1 (de) 2018-07-05 2020-01-08 Bayer Animal Health GmbH Neuartige verbindungen zur bekämpfung von arthropoden
US11180500B2 (en) 2018-10-01 2021-11-23 Arixa Pharmaceuticals, Inc. Derivatives of relebactam and uses thereof
MX2021011026A (es) 2019-03-12 2021-10-13 Arixa Pharmaceuticals Inc Forma cristalina de un derivado de avibactam.
WO2020219258A1 (en) 2019-04-25 2020-10-29 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
TWI825323B (zh) * 2019-06-18 2023-12-11 美商美國禮來大藥廠 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物
CA3200234A1 (en) 2020-11-25 2022-06-02 Daryl C. Drummond Lipid nanoparticles for delivery of nucleic acids, and related methods of use
EP4125911B1 (de) 2021-03-05 2024-04-24 NewAmsterdam Pharma B.V. Obicetrapib zur behandlung von demenz
MX2024001170A (es) 2021-07-26 2024-05-14 Newamsterdam Pharma B V Tratamiento de personas hiporreactivas a his.
IL314031A (en) 2021-12-30 2024-09-01 Newamsterdam Pharma B V Obicetrapib and sglt2 inhibitor combination
CN114516865B (zh) * 2022-03-09 2023-06-23 成都师范学院 一类D-π-A型有机共轭分子及其制备方法和应用
EP4531819A2 (de) 2022-05-25 2025-04-09 Akagera Medicines, Inc. Lipidnanopartikel zur abgabe von nukleinsäuren und verfahren zur verwendung davon
PE20251749A1 (es) 2022-07-05 2025-07-09 Newamsterdam Pharma B V Sales de obicetrapib y procesos para su fabricacion y productos intermedios de estos
TW202416994A (zh) 2022-08-22 2024-05-01 荷蘭商新阿姆斯特丹製藥公司 固定劑量醫藥組合物及其用途
EP4661865A1 (de) 2023-02-07 2025-12-17 NewAmsterdam Pharma B.V. Obicetrapib- und ezetimibkombinationsbehandlung und pharmazeutische zusammensetzungen mit fixer dosis
WO2025059594A1 (en) 2023-09-15 2025-03-20 Newamsterdam Pharma B.V. METHODS FOR TREATING HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HeFH)
WO2025093436A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor
WO2025093129A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor
WO2025146262A1 (en) 2024-01-03 2025-07-10 Newamsterdam Pharma B.V. Obicetrapib for use in the treatment of hemoglobinopathies
WO2025146415A1 (en) 2024-01-03 2025-07-10 Newamsterdam Pharma B.V. Improvement in atherosclerotic plaque characteristics with obicetrapib
WO2026062050A1 (en) 2024-09-17 2026-03-26 Newamsterdam Pharma B.V. Obicetrapib for use in methods for treating a subject having heterozygous familial hypercholesterolemia (hefh) and/or atherosclerotic cardiovascular disease (ascvd)
WO2026063944A1 (en) 2024-09-21 2026-03-26 Newamsterdam Pharma B.V. Obicetrapib for the treatment of dementias
WO2026062049A1 (en) 2024-09-21 2026-03-26 Newamsterdam Pharma B.V., Obicetrapib for the treatment of dementias
WO2026087915A1 (en) 2024-10-25 2026-04-30 Newamsterdam Pharma B.V. Treatment and prevention of sepsis or other dysregulated inflammatory responses using cetp inhibitor obicetrapib

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82094C (fi) 1989-02-16 1997-09-09 Valmet Corp Anvaendning av en legering av ett metallpulver och en karbid eller nitrid innefattande belaeggningskomposition foer en i en pappersmaskin anvaendbar yankeecylinder
ATE147732T1 (de) 1989-03-08 1997-02-15 Merck Sharp & Dohme Tetrahydroquinolin-derivate, verwendbar bei neurodegenerativen krankheiten
DE69016125T2 (de) 1989-08-11 1995-06-01 Zeneca Ltd Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
JPH03161360A (ja) 1989-11-21 1991-07-11 Tdk Corp サーマルヘッド
JPH03216566A (ja) 1990-01-22 1991-09-24 Mitsubishi Electric Corp Ｃｃｄリニアイメージセンサのテスト装置
GB9010394D0 (en) 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
IE914573A1 (en) 1991-01-17 1992-07-29 Ici Plc Boron compounds
JPH05213884A (ja) 1991-06-14 1993-08-24 Upjohn Co:The 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
US5576460A (en) 1994-07-27 1996-11-19 Massachusetts Institute Of Technology Preparation of arylamines
US5929281A (en) 1996-04-19 1999-07-27 Tosoh Corporation Process for producing heterocyclic aromatic amine or arylamine
US6147090A (en) 1998-09-17 2000-11-14 Pfizer Inc. 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
HN2000000203A (es) 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
EP1167521A1 (de) 2000-06-30 2002-01-02 Aventis Animal Nutrition S.A. Beschichtete enzymenthaltende Katalysator
WO2002008869A2 (en) 2000-07-25 2002-01-31 Digeo, Inc. Allowance account for interactive television system
JP2002053557A (ja) * 2000-08-14 2002-02-19 Japan Tobacco Inc アポリポ蛋白ａ−ｉ産生促進薬
ATE497385T1 (de) * 2000-08-18 2011-02-15 Ajinomoto Kk Neue phenylalanin-derivate
SE0101161D0 (sv) * 2001-03-30 2001-03-30 Astrazeneca Ab New compounds
ES2256461T3 (es) 2001-04-30 2006-07-16 Pfizer Products Inc. Compuestos utiles como intermediarios de derivados de 4-aminoquinolina.
EP1318139A3 (de) 2001-12-07 2003-07-30 Solvias AG Verfahren zur Herstellung von 3-Aminokarbonsäuren und deren Estern
US6903233B2 (en) 2002-03-11 2005-06-07 Takasago International Corporation Process for producing optically active 3-halogenocarboxylic acid ester and 3-azidocarboxylic acid ester
ES2277142T3 (es) 2002-08-30 2007-07-01 Japan Tobacco Inc. Compuesto de dibencilamina y su uso medicinal.
PL376156A1 (en) 2002-10-04 2005-12-27 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
JP2004238322A (ja) 2003-02-05 2004-08-26 Sumika Fine Chemicals Co Ltd （ｒ）−３−アミノペンタンニトリルメタンスルホン酸塩の製造方法
WO2004072041A1 (en) 2003-02-12 2004-08-26 Care X S.A. Tetrahydroquinolines as agonists of liver- x receptors
US7601842B2 (en) 2003-02-18 2009-10-13 Takasago International Corporation Method for producing an optically active tetrahydroquinoline
CN1795177A (zh) 2003-03-28 2006-06-28 辉瑞产品公司 作为治疗动脉粥样硬化和肥胖症的cetp抑制剂的 1 , 2 , 4 , －取代的1，2，3，4，－四氢－和1，2二氢－喹啉以及1， 2 , 3 ， 4－四氢－喹喔啉衍生物
US7145030B2 (en) 2003-04-24 2006-12-05 Ajinomoto Co., Inc. Production method for optically active N-aryl-β-amino acid compounds
JP2004339205A (ja) 2003-04-24 2004-12-02 Ajinomoto Co Inc 光学活性Ｎ−アリール−β−アミノ酸化合物の製造方法
US7626034B2 (en) 2003-09-18 2009-12-01 Takasago International Corporation Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives
US20050239832A1 (en) * 2004-03-09 2005-10-27 Varghese John Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors
EA200601785A1 (ru) 2004-03-26 2007-02-27 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии
UA90269C2 (ru) 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
JP2005336083A (ja) 2004-05-26 2005-12-08 Sumitomo Chemical Co Ltd 芳香族アミノ化合物の製造方法
JP2008504266A (ja) 2004-06-24 2008-02-14 イーライ リリー アンド カンパニー 異脂肪血症を治療するための化合物及び方法

Also Published As

Publication number Publication date
US8084611B2 (en) 2011-12-27
US20090292125A1 (en) 2009-11-26
JP2009532345A (ja) 2009-09-10
EP2007728A1 (de) 2008-12-31
EP2007728B1 (de) 2011-11-16
AR060174A1 (es) 2008-05-28
EP2154132A1 (de) 2010-02-17
UY30244A1 (es) 2007-11-30
WO2007116922A1 (en) 2007-10-18
ES2374315T3 (es) 2012-02-15
JP5275971B2 (ja) 2013-08-28
TW200808731A (en) 2008-02-16
PE20071150A1 (es) 2007-12-03

Similar Documents

Publication Publication Date Title
ATE455105T1 (de) Verfahren zur herstellung von difluormethylpyrazolylcarboxylaten
EP2170785A4 (de) Verfahren zur herstellung von hydrofluorolefinen
ATE408604T1 (de) Verfahren zur herstellung von 1-alkyl-3- phenyluracilen
ATE480531T1 (de) Verfahren zur herstellung von benzopyran-2- olderivaten
ATE535568T1 (de) Verfahren zur herstellung von polyethylenzusammensetzungen
ATE516816T1 (de) Verfahren zur herstellung von impfstoffen
ATE529527T1 (de) Verfahren zur herstellung von alkoholen
ATE408609T1 (de) Verfahren zur herstellung von n-phenylpyrazol-1- carboxamiden
ATE430480T1 (de) Verfahren zur herstellung von nährmittelzusammensetzungen
ATE516362T1 (de) Verfahren zur herstellung von biodiesel
DE602007001585D1 (de) Verfahren zur herstellung von kunstlatex
ATE546436T1 (de) Verfahren zur herstellung von 2-amino-5- cyanobenzoesäurederivaten
DE602006015090D1 (de) Verfahren zur herstellung von gezielt durchlässigen laminaten
ATE518847T1 (de) Verfahren zur herstellung von betamimetika
ATE548345T1 (de) Verfahren zur herstellung von agomelatin
ATE523483T1 (de) Verfahren zur herstellung von betainen
ATE489015T1 (de) Verfahren zur herstellung von verschlüssen
DE602008006766D1 (de) Verfahren zur herstellung von würzwürfeln
ATE540585T1 (de) Verfahren zur herstellung von tomatenpaste
ATE554088T1 (de) Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten
DE502006001281D1 (de) Verfahren zur herstellung substituierter biphenyle
ATE399157T1 (de) Verfahren zur herstellung von telmisartan
EP2135979A4 (de) Verfahren zur herstellung von nitrid-einkristall
DE602007000239D1 (de) Verfahren zur Herstellung von hohlen Artikeln
ATE431868T1 (de) Verfahren zur herstellung laufmaschenfester textilien