ATE529424T1 - 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus - Google Patents

1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus

Info

Publication number: ATE529424T1
Authority: AT; Austria
Prior art keywords: substituted; 6alkyl; benzimidazolylümethylü; dihydrobenzimidazol; amino
Prior art date: 2005-06-20

Application number

AT06763808T

Other languages

English (en)

Inventor

Jean-Francois Bonfanti

Philippe Muller

Jerome Fortin

Frederic Doublet

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-20

Filing date

2006-06-20

Publication date

2011-11-15

2006-06-20 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE529424T1 publication Critical patent/ATE529424T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
230000010076 replication Effects 0.000 title abstract 2
241000725643 Respiratory syncytial virus Species 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000000623 heterocyclic group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
-1 cyano, aminocarbonyl Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT06763808T 2005-06-20 2006-06-20 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus ATE529424T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05076438		2005-06-20
PCT/EP2006/063365 WO2006136561A1 (en)	2005-06-20	2006-06-20	1- ( 2-amino-3- (substituted alkyl)-3h-benzimidazoiylmethyl) -3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus

Publications (1)

Publication Number	Publication Date
ATE529424T1 true ATE529424T1 (de)	2011-11-15

Family

ID=35276402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06763808T ATE529424T1 (de)	2005-06-20	2006-06-20	1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus

Country Status (12)

Country	Link
US (1)	US8034835B2 (de)
EP (1)	EP1896473B1 (de)
JP (1)	JP5078887B2 (de)
CN (1)	CN101203517B (de)
AT (1)	ATE529424T1 (de)
AU (1)	AU2006260969B2 (de)
BR (1)	BRPI0612628B8 (de)
CA (1)	CA2612263C (de)
MX (1)	MX2007016537A (de)
RU (1)	RU2434000C2 (de)
WO (1)	WO2006136561A1 (de)
ZA (1)	ZA200711080B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009525269A (ja) *	2006-01-30	2009-07-09	ユーロ−セルティークエス．エイ．	カルシウムチャネルブロッカーとしての環状尿素化合物
KR102066297B1 (ko)	2011-10-14	2020-01-14	암비트 바이오사이언시즈 코포레이션	헤테로사이클릭 화합물 및 이의 유형 3 수용체 티로신 키나아제의 조절인자로서의 용도
CA2921294C (en)	2013-08-21	2023-05-16	Alios Biopharma, Inc.	Antiviral compounds
MA41614A (fr)	2015-02-25	2018-01-02	Alios Biopharma Inc	Composés antiviraux
JO3637B1 (ar) *	2015-04-28	2020-08-27	Janssen Sciences Ireland Uc	مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
CN111386118B (zh)	2017-09-29	2023-05-09	英安塔制药有限公司	作为rsv抑制剂的组合药物剂
TW201932470A (zh)	2017-11-29	2019-08-16	愛爾蘭商健生科學愛爾蘭無限公司	具有抗ｒｓｖ活性之吡唑并嘧啶
CA3087926A1 (en)	2018-01-31	2019-08-08	Janssen Sciences Ireland Unlimited Company	Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
AU2019260109B2 (en)	2018-04-23	2023-07-13	Janssen Sciences Ireland Unlimited Company	Heteroaromatic compounds having activity against RSV

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1418175A1 (de)	1999-06-28	2004-05-12	Janssen Pharmaceutica N.V.	Replikationsinhibitoren des respiratorischen Synzytialvirus
MXPA02000120A (es) *	1999-06-28	2002-07-02	Janssen Pharmaceutica Nv	Inhibidores de la replicacion del virus sincitial respiratorio.
JP2003503403A (ja) *	1999-06-28	2003-01-28	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	呼吸合胞体ウイルス複製阻害剤
US6489338B2 (en) *	2000-06-13	2002-12-03	Bristol-Myers Squibb Company	Imidazopyridine and imidazopyrimidine antiviral agents
US7030150B2 (en) *	2001-05-11	2006-04-18	Trimeris, Inc.	Benzimidazole compounds and antiviral uses thereof
AR046959A1 (es) *	2003-12-18	2006-01-04	Tibotec Pharm Ltd	Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
ATE435222T1 (de)	2003-12-18	2009-07-15	Tibotec Pharm Ltd	Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus

2006
- 2006-06-20 AU AU2006260969A patent/AU2006260969B2/en not_active Ceased
- 2006-06-20 CA CA2612263A patent/CA2612263C/en not_active Expired - Lifetime
- 2006-06-20 MX MX2007016537A patent/MX2007016537A/es active IP Right Grant
- 2006-06-20 BR BRPI0612628A patent/BRPI0612628B8/pt not_active IP Right Cessation
- 2006-06-20 EP EP06763808A patent/EP1896473B1/de not_active Expired - Lifetime
- 2006-06-20 CN CN2006800219722A patent/CN101203517B/zh not_active Expired - Fee Related
- 2006-06-20 JP JP2008517487A patent/JP5078887B2/ja not_active Expired - Fee Related
- 2006-06-20 AT AT06763808T patent/ATE529424T1/de not_active IP Right Cessation
- 2006-06-20 WO PCT/EP2006/063365 patent/WO2006136561A1/en not_active Ceased
- 2006-06-20 US US11/993,109 patent/US8034835B2/en active Active
- 2006-06-20 RU RU2008102057/04A patent/RU2434000C2/ru active
2007
- 2007-12-19 ZA ZA200711080A patent/ZA200711080B/xx unknown

Also Published As

Publication number	Publication date
CN101203517B (zh)	2011-07-06
BRPI0612628A2 (pt)	2012-01-03
JP2008546738A (ja)	2008-12-25
BRPI0612628B8 (pt)	2021-05-25
US20100183552A1 (en)	2010-07-22
CA2612263C (en)	2015-04-14
RU2434000C2 (ru)	2011-11-20
CA2612263A1 (en)	2006-12-28
MX2007016537A (es)	2008-03-06
EP1896473B1 (de)	2011-10-19
JP5078887B2 (ja)	2012-11-21
AU2006260969B2 (en)	2011-11-17
BRPI0612628B1 (pt)	2019-12-03
ZA200711080B (en)	2009-03-25
AU2006260969A1 (en)	2006-12-28
RU2008102057A (ru)	2009-07-27
US8034835B2 (en)	2011-10-11
EP1896473A1 (de)	2008-03-12
CN101203517A (zh)	2008-06-18
WO2006136561A1 (en)	2006-12-28

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Legal Events

Date	Code	Title	Description
2012-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties