ATE529424T1 - 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus - Google Patents

1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus

Info

Publication number
ATE529424T1
ATE529424T1 AT06763808T AT06763808T ATE529424T1 AT E529424 T1 ATE529424 T1 AT E529424T1 AT 06763808 T AT06763808 T AT 06763808T AT 06763808 T AT06763808 T AT 06763808T AT E529424 T1 ATE529424 T1 AT E529424T1
Authority
AT
Austria
Prior art keywords
substituted
6alkyl
benzimidazolylümethylü
dihydrobenzimidazol
amino
Prior art date
Application number
AT06763808T
Other languages
English (en)
Inventor
Jean-Francois Bonfanti
Philippe Muller
Jerome Fortin
Frederic Doublet
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE529424T1 publication Critical patent/ATE529424T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06763808T 2005-06-20 2006-06-20 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus ATE529424T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05076438 2005-06-20
PCT/EP2006/063365 WO2006136561A1 (en) 2005-06-20 2006-06-20 1- ( 2-amino-3- (substituted alkyl)-3h-benzimidazoiylmethyl) -3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus

Publications (1)

Publication Number Publication Date
ATE529424T1 true ATE529424T1 (de) 2011-11-15

Family

ID=35276402

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06763808T ATE529424T1 (de) 2005-06-20 2006-06-20 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus

Country Status (12)

Country Link
US (1) US8034835B2 (de)
EP (1) EP1896473B1 (de)
JP (1) JP5078887B2 (de)
CN (1) CN101203517B (de)
AT (1) ATE529424T1 (de)
AU (1) AU2006260969B2 (de)
BR (1) BRPI0612628B8 (de)
CA (1) CA2612263C (de)
MX (1) MX2007016537A (de)
RU (1) RU2434000C2 (de)
WO (1) WO2006136561A1 (de)
ZA (1) ZA200711080B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525269A (ja) 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
AU2012322095B2 (en) 2011-10-14 2017-06-29 Ambit Biosciences Corporation Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases
AU2014308991B2 (en) 2013-08-21 2019-02-14 Janssen Biopharma, Inc. Antiviral compounds
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
BR112020006334A2 (pt) 2017-09-29 2020-09-24 Enanta Pharmaceuticals, Inc. combinação de agentes farmacêuticos como inibidores de rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
SG11202006141RA (en) 2018-01-31 2020-07-29 Janssen Sciences Ireland Unlimited Co Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
US11708369B2 (en) 2018-04-23 2023-07-25 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against RSV

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL147327A0 (en) 1999-06-28 2002-08-14 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
ES2215670T3 (es) 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
SI1196408T1 (en) 1999-06-28 2005-02-28 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
TWI356055B (en) * 2003-12-18 2012-01-11 Tibotec Pharm Ltd Aminobenzimidazoles and benzimidazoles as inhibito
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio

Also Published As

Publication number Publication date
CA2612263C (en) 2015-04-14
JP2008546738A (ja) 2008-12-25
CA2612263A1 (en) 2006-12-28
US8034835B2 (en) 2011-10-11
ZA200711080B (en) 2009-03-25
WO2006136561A1 (en) 2006-12-28
CN101203517B (zh) 2011-07-06
EP1896473B1 (de) 2011-10-19
BRPI0612628A2 (pt) 2012-01-03
MX2007016537A (es) 2008-03-06
EP1896473A1 (de) 2008-03-12
AU2006260969B2 (en) 2011-11-17
RU2008102057A (ru) 2009-07-27
BRPI0612628B1 (pt) 2019-12-03
JP5078887B2 (ja) 2012-11-21
BRPI0612628B8 (pt) 2021-05-25
AU2006260969A1 (en) 2006-12-28
US20100183552A1 (en) 2010-07-22
RU2434000C2 (ru) 2011-11-20
CN101203517A (zh) 2008-06-18

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