NO20085107L - Spirosykliske nitriler som proteaseinhibitorer - Google Patents

Spirosykliske nitriler som proteaseinhibitorer

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Publication number
NO20085107L
NO20085107L NO20085107A NO20085107A NO20085107L NO 20085107 L NO20085107 L NO 20085107L NO 20085107 A NO20085107 A NO 20085107A NO 20085107 A NO20085107 A NO 20085107A NO 20085107 L NO20085107 L NO 20085107L
Authority
NO
Norway
Prior art keywords
protease inhibitors
spirocyclic
nitriles
spirocyclic nitriles
medicaments
Prior art date
Application number
NO20085107A
Other languages
English (en)
Inventor
Manfred Schudok
Michael Wagner
Armin Bauer
Anna Kohlmann
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20085107L publication Critical patent/NO20085107L/no

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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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Abstract

Foreliggende oppfinnelse angår substituerte heterosykliske spiroforbindelser med formel (I) som inhiberer katepsiner, en fremgangsmåte for fremstilling derav og anvendelse av samme som medikamenter.
NO20085107A 2006-06-01 2008-12-08 Spirosykliske nitriler som proteaseinhibitorer NO20085107L (no)

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DE102006025630 2006-06-01
PCT/EP2007/004550 WO2007137738A1 (de) 2006-06-01 2007-05-23 Spiro-cyclische nitrile als protease-inhibitoren

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CN104250233B (zh) * 2014-08-29 2016-03-16 湖南华腾制药有限公司 一种4-叔丁氧羰基-2-环丙基吗啉的制备方法
UA118610C2 (uk) * 2014-09-12 2019-02-11 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спіроциклічні інгібітори катепсину c
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
MX2017005462A (es) 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
CN108602809B (zh) * 2015-12-04 2022-09-30 戴纳立制药公司 异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂
CN110386932A (zh) 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
AU2020250933A1 (en) 2019-04-05 2021-10-28 Centre Hospitalier Régional Et Universitaire De Brest Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
WO2021147882A1 (zh) * 2020-01-21 2021-07-29 深圳信立泰药业股份有限公司 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途

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IL195519A0 (en) 2009-09-01
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US20140073662A1 (en) 2014-03-13
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