ATE529448T1 - Verringerung von endotoxin in polysialinsäuren - Google Patents

Verringerung von endotoxin in polysialinsäuren

Info

Publication number
ATE529448T1
ATE529448T1 AT08709658T AT08709658T ATE529448T1 AT E529448 T1 ATE529448 T1 AT E529448T1 AT 08709658 T AT08709658 T AT 08709658T AT 08709658 T AT08709658 T AT 08709658T AT E529448 T1 ATE529448 T1 AT E529448T1
Authority
AT
Austria
Prior art keywords
endotoxin
polysaccharide
reduction
psa
gel
Prior art date
Application number
AT08709658T
Other languages
English (en)
Inventor
Sanjay Jain
Peter Laing
Gregory Gregoriadis
Original Assignee
Lipoxen Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipoxen Technologies Ltd filed Critical Lipoxen Technologies Ltd
Application granted granted Critical
Publication of ATE529448T1 publication Critical patent/ATE529448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT08709658T 2007-02-28 2008-02-28 Verringerung von endotoxin in polysialinsäuren ATE529448T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07103275 2007-02-28
PCT/GB2008/050138 WO2008104811A1 (en) 2007-02-28 2008-02-28 Reduction of endotoxin in polysialic acids

Publications (1)

Publication Number Publication Date
ATE529448T1 true ATE529448T1 (de) 2011-11-15

Family

ID=38255362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08709658T ATE529448T1 (de) 2007-02-28 2008-02-28 Verringerung von endotoxin in polysialinsäuren

Country Status (12)

Country Link
US (3) US20110159130A1 (de)
EP (3) EP2115010B1 (de)
JP (2) JP2010520320A (de)
KR (1) KR101523111B1 (de)
CN (1) CN101646693B (de)
AT (1) ATE529448T1 (de)
DK (1) DK2115010T3 (de)
ES (1) ES2375314T3 (de)
PL (1) PL2115010T3 (de)
PT (1) PT2115010E (de)
RU (1) RU2473567C2 (de)
WO (1) WO2008104811A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103361283B (zh) * 2012-04-01 2015-06-03 中国科学院微生物研究所 微生物发酵法生产多聚n-乙酰神经氨酸及其提纯方法
US11360079B2 (en) * 2015-12-16 2022-06-14 Neogap Therapeutics Ab T-cell reactivity platform
DE102016106271B4 (de) 2016-04-06 2018-03-29 Axagarius Gmbh & Co. Kg Aufreinigung von Nukleinsäure aus einer Nukleinsäure und Endotoxin enthaltenden Probe
IL277009B2 (en) * 2018-03-08 2024-06-01 Catalent Uk Swindon Zydis Ltd Process to reduce endotoxin in gelatin
TWI814812B (zh) * 2018-05-02 2023-09-11 美商里珍納龍藥品有限公司 用於評估生化過濾器的適合性的方法
CN109182423B (zh) * 2018-09-26 2020-07-07 武汉中科光谷绿色生物技术有限公司 促进大肠杆菌发酵生产聚唾液酸的方法
CN110423290B (zh) * 2019-08-23 2020-06-09 河北常山凯络尼特生物技术有限公司 一种去除寡聚透明质酸钠中内毒素的方法
CN113005161B (zh) * 2021-02-19 2023-04-28 中国科学院合肥物质科学研究院 一种聚唾液酸的制备方法及聚唾液酸制品
WO2024172098A1 (ja) * 2023-02-16 2024-08-22 国立大学法人鳥取大学 動物組織由来のプロテオグリカンのエンドトキシン低減に用いるための剤およびプロテオグリカンの製造方法
CN116253809B (zh) * 2023-04-19 2024-11-05 广州润虹医药科技股份有限公司 一种去除壳聚糖中内毒素的方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740503A (en) * 1980-08-22 1982-03-06 Seikagaku Kogyo Co Ltd Separation of saccharides
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
JPS6245786A (ja) 1985-08-23 1987-02-27 日本フツカ−株式会社 繊維品の防水処理法
GB2192633A (en) 1986-06-13 1988-01-20 Royal Postgrad Med School Endotoxin removal
US5589591A (en) * 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
US5039610A (en) 1989-06-12 1991-08-13 Merck & Co., Inc. Process for removing bacterial endotoxin from gram-negative polysaccharides
US5169535A (en) 1989-09-22 1992-12-08 Kurita Water Industries Ltd. Method of removing endotoxin
US5846951A (en) * 1991-06-06 1998-12-08 The School Of Pharmacy, University Of London Pharmaceutical compositions
GB9112212D0 (en) 1991-06-06 1991-07-24 Gregoriadis Gregory Pharmaceutical compositions
SK18594A3 (en) * 1991-08-16 1994-08-10 Merck & Co Inc Method of production of capsular polysacharide without lipid and endotoxine
JPH06245786A (ja) * 1993-02-23 1994-09-06 Ngk Insulators Ltd コロミン酸の精製方法
DK0775150T3 (da) 1994-02-07 1999-11-08 Qiagen Gmbh Fremgangsmåde til reduktion eller fjernelse af endotoksiner
AUPM388494A0 (en) 1994-02-16 1994-03-10 Csl Limited Process for removing endotoxins
KR100198176B1 (ko) * 1995-05-25 1999-06-15 추후 보충 엔도톡신 혈증 및 그것에 의해 유발되는 다장기 부전증의 치료약
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
CA2278626C (en) * 1997-01-24 2010-04-27 Schweiz. Serum- & Impfinstitut Bern Novel method for the isolation of polysaccharides
CA2316975C (en) * 1997-12-23 2009-03-24 North American Vaccine, Inc. Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines
GB9907553D0 (en) * 1999-04-01 1999-05-26 Cantab Pharma Res Purification of biological preparations
US6774102B1 (en) * 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
DE10010342A1 (de) 2000-03-06 2001-09-20 Merck Patent Gmbh Verfahren zur Abreicherung von Endotoxinen
EP1335931B1 (de) 2000-05-16 2005-12-21 Lipoxen Technologies Limited Derivatisierung von proteinen in wässrigem lösungsmittel
KR100356738B1 (ko) 2000-09-07 2002-10-18 주식회사 삼양제넥스 염기성 단백질로부터 엔도톡신을 제거하는 방법
JP4996791B2 (ja) 2001-03-14 2012-08-08 Ｊｎｃ株式会社 エンドトキシン吸着体、及びそれを用いたエンドトキシンの除去方法
AU2002258734A1 (en) 2001-04-13 2002-10-28 Wyeth Holdings Corporation Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
CN1158295C (zh) * 2002-04-16 2004-07-21 广州市力拓发展有限公司 一种制备单唾液酸四己糖神经节苷脂制剂的方法
AU2002309259A1 (en) * 2002-05-09 2003-11-11 Massimo Porro Improved polysaccharide and glycoconjugate vaccines_____________
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
EP1638990B1 (de) * 2003-06-24 2009-04-08 N.V. Organon Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht-entzündbaren lösungsmitteln
JP2005036036A (ja) * 2003-07-16 2005-02-10 Tanabe Seiyaku Co Ltd エンドトキシン除去方法
KR101113726B1 (ko) * 2003-08-12 2012-02-27 리폭센 테크놀로지즈 리미티드 단백질 유도 및 컨쥬게이션용 시알산 유도체
KR101094032B1 (ko) * 2003-09-17 2011-12-19 센텔리옹 에스아에스 약학적 등급의 플라스미드 ｄｎａ의 제조 방법
ES2640767T3 (es) * 2004-08-12 2017-11-06 Lipoxen Technologies Limited Fraccionamientodepolisacáridos cargados
JP5100980B2 (ja) * 2005-05-18 2012-12-19 株式会社クラレ 化学物質の精製方法
CN100567500C (zh) * 2006-06-22 2009-12-09 江南大学 一种从产聚唾液酸大肠杆菌发酵液中提取聚唾液酸的方法
SI2049692T1 (sl) 2006-07-13 2016-04-29 Serum Institute Of India Ltd Postopek za pripravo polisialične kisline visoke čistosti
CN101511391B (zh) 2006-07-25 2013-03-13 利普生技术有限公司 N末端聚唾液酸化
CN100383153C (zh) * 2006-09-01 2008-04-23 江南大学 一种聚唾液酸水解液的脱色方法

Also Published As

Publication number Publication date
US9212232B2 (en) 2015-12-15
EP2409995A2 (de) 2012-01-25
US20110159130A1 (en) 2011-06-30
DK2115010T3 (da) 2012-02-06
JP5677512B2 (ja) 2015-02-25
WO2008104811A1 (en) 2008-09-04
RU2473567C2 (ru) 2013-01-27
US20160096905A1 (en) 2016-04-07
US20130172537A1 (en) 2013-07-04
PT2115010E (pt) 2012-03-09
EP2409995A3 (de) 2012-08-15
ES2375314T3 (es) 2012-02-28
CN101646693A (zh) 2010-02-10
RU2009134940A (ru) 2011-04-10
EP2115010A1 (de) 2009-11-11
JP2010520320A (ja) 2010-06-10
EP2409994A2 (de) 2012-01-25
JP2013216900A (ja) 2013-10-24
EP2115010B1 (de) 2011-10-19
KR20090125783A (ko) 2009-12-07
EP2409994A3 (de) 2012-08-15
PL2115010T3 (pl) 2012-07-31
US10301396B2 (en) 2019-05-28
CN101646693B (zh) 2013-03-27
KR101523111B1 (ko) 2015-06-25

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