ATE530639T1 - Mikroorganismen und verfahren zur verbesserten produktion von panthothenat - Google Patents
Mikroorganismen und verfahren zur verbesserten produktion von panthothenatInfo
- Publication number
- ATE530639T1 ATE530639T1 AT02746888T AT02746888T ATE530639T1 AT E530639 T1 ATE530639 T1 AT E530639T1 AT 02746888 T AT02746888 T AT 02746888T AT 02746888 T AT02746888 T AT 02746888T AT E530639 T1 ATE530639 T1 AT E530639T1
- Authority
- AT
- Austria
- Prior art keywords
- microorganisms
- methods
- featured
- panthothenate
- invention features
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract 2
- 230000001851 biosynthetic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- OTOIIPJYVQJATP-BYPYZUCNSA-M (R)-pantoate Chemical compound OCC(C)(C)[C@@H](O)C([O-])=O OTOIIPJYVQJATP-BYPYZUCNSA-M 0.000 abstract 1
- PKVVTUWHANFMQC-UHFFFAOYSA-N 2-dehydropantoic acid Chemical compound OCC(C)(C)C(=O)C(O)=O PKVVTUWHANFMQC-UHFFFAOYSA-N 0.000 abstract 1
- QYNUQALWYRSVHF-ABLWVSNPSA-N 5,10-methylenetetrahydrofolic acid Chemical compound C1N2C=3C(=O)NC(N)=NC=3NCC2CN1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-ABLWVSNPSA-N 0.000 abstract 1
- GFKCZHFKMGKIAQ-ABLWVSNPSA-N N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 Chemical class N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 GFKCZHFKMGKIAQ-ABLWVSNPSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940014662 pantothenate Drugs 0.000 abstract 1
- 235000019161 pantothenic acid Nutrition 0.000 abstract 1
- 239000011713 pantothenic acid Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/021336 WO2004005527A1 (en) | 2002-07-03 | 2002-07-03 | Microorganisms and processes for enhanced production of pantothenate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530639T1 true ATE530639T1 (de) | 2011-11-15 |
Family
ID=30113576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02746888T ATE530639T1 (de) | 2002-07-03 | 2002-07-03 | Mikroorganismen und verfahren zur verbesserten produktion von panthothenat |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060099692A1 (de) |
| EP (1) | EP1520030B1 (de) |
| JP (1) | JP2005531326A (de) |
| CN (1) | CN100455669C (de) |
| AT (1) | ATE530639T1 (de) |
| AU (1) | AU2002316575A1 (de) |
| CA (1) | CA2491137A1 (de) |
| DK (1) | DK1520030T3 (de) |
| HU (1) | HUP0500383A2 (de) |
| MX (1) | MXPA04012807A (de) |
| WO (1) | WO2004005527A1 (de) |
| ZA (1) | ZA200500949B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2491145A1 (en) | 2002-07-03 | 2004-01-15 | Basf Aktiengesellschaft | Microorganisms and processes for enhanced production of pantothenate |
| WO2007131750A1 (en) | 2006-05-16 | 2007-11-22 | Dsm Ip Assets B.V. | Process for the production of panthenol |
| SI2493922T1 (sl) | 2009-10-26 | 2017-06-30 | F. Hoffmann-La Roche Ag | Postopek za proizvodnjo glikoziliranega imunoglobulina |
| WO2012175575A2 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased vitamin b5 production |
| WO2012175574A1 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased pantothenate (vitamin b5) production |
| EP3489248A1 (de) * | 2012-04-27 | 2019-05-29 | Retrophin, Inc. | Verfahren zur herstellung von pantothenatderivate zur behandlung neurologischer erkrankungen |
| CN108456701B (zh) * | 2018-03-23 | 2020-10-16 | 精晶药业股份有限公司 | 一种d-泛解酸内酯的制备方法 |
| CN114058609B (zh) * | 2020-12-01 | 2023-11-28 | 北京化工大学 | 一种h-蛋白及其应用 |
| CN113637618B (zh) * | 2021-06-04 | 2024-02-02 | 浙江工业大学 | 一种d-泛酸生产菌、构建方法及应用 |
| CN115595328B (zh) * | 2022-03-07 | 2026-02-13 | 中国科学院微生物研究所 | 天冬氨酸脱羧酶在发酵生产维生素b5中的应用 |
| CN116590209A (zh) * | 2023-06-13 | 2023-08-15 | 浙江工业大学 | 一种产d-泛酸的基因工程菌、构建方法及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19846499A1 (de) * | 1998-10-09 | 2000-04-20 | Degussa | Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen |
| EP2163629B1 (de) * | 1999-09-21 | 2017-03-08 | Basf Se | Verfahren und Mikroorganismen zur Produktion von Panto-Verbindungen |
| KR20040004496A (ko) * | 2001-01-19 | 2004-01-13 | 바스프 악티엔게젤샤프트 | 판토테네이트 생산의 증가 방법 |
| CN100529068C (zh) * | 2001-01-19 | 2009-08-19 | 巴斯福股份公司 | 用于提高泛酸产量的微生物和方法 |
| WO2003004672A1 (en) * | 2001-07-03 | 2003-01-16 | Degussa Ag | Process for the fermentative preparation of d-pantothenic acid and/or salts thereof |
-
2002
- 2002-07-03 JP JP2004519495A patent/JP2005531326A/ja active Pending
- 2002-07-03 CN CNB028292669A patent/CN100455669C/zh not_active Expired - Fee Related
- 2002-07-03 AT AT02746888T patent/ATE530639T1/de not_active IP Right Cessation
- 2002-07-03 CA CA002491137A patent/CA2491137A1/en not_active Abandoned
- 2002-07-03 US US10/520,210 patent/US20060099692A1/en not_active Abandoned
- 2002-07-03 HU HU0500383A patent/HUP0500383A2/hu unknown
- 2002-07-03 WO PCT/US2002/021336 patent/WO2004005527A1/en not_active Ceased
- 2002-07-03 DK DK02746888.3T patent/DK1520030T3/da active
- 2002-07-03 EP EP02746888A patent/EP1520030B1/de not_active Expired - Lifetime
- 2002-07-03 MX MXPA04012807A patent/MXPA04012807A/es not_active Application Discontinuation
- 2002-07-03 AU AU2002316575A patent/AU2002316575A1/en not_active Abandoned
-
2005
- 2005-02-02 ZA ZA200500949A patent/ZA200500949B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200500949B (en) | 2006-12-27 |
| CN100455669C (zh) | 2009-01-28 |
| MXPA04012807A (es) | 2005-02-24 |
| WO2004005527A1 (en) | 2004-01-15 |
| EP1520030A1 (de) | 2005-04-06 |
| DK1520030T3 (da) | 2012-02-27 |
| CA2491137A1 (en) | 2004-01-15 |
| EP1520030B1 (de) | 2011-10-26 |
| CN1639349A (zh) | 2005-07-13 |
| AU2002316575A1 (en) | 2004-01-23 |
| HUP0500383A2 (hu) | 2005-08-29 |
| JP2005531326A (ja) | 2005-10-20 |
| US20060099692A1 (en) | 2006-05-11 |
| EP1520030A4 (de) | 2010-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60216581D1 (de) | Verfahren und mikroorganismus zur verbesserten produktion von pantothenat | |
| WO2004005525A3 (en) | Microorganisms and processes for enhanced production of pantothenate | |
| WO2002057474A3 (en) | Processes for enhanced production of pantothenate | |
| ATE416258T1 (de) | Säure-pilzprotease bei der fermentation von nichtlöslichen stärkesubstraten | |
| MXPA04000622A (es) | Pirazolilcarboxanilidas como funguicidas. | |
| ATE530639T1 (de) | Mikroorganismen und verfahren zur verbesserten produktion von panthothenat | |
| IN2012DN00801A (de) | ||
| DK1513952T3 (da) | Sammensætninger og fremgangsmåder til frembringelse af nukleinsyre af sputum | |
| TW200714294A (en) | Inhibitors of ribonucleotide reductase subunit 2 and uses thereof | |
| DK1208205T3 (da) | Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH | |
| MX2009005655A (es) | Composiciones y usos de un polipeptido alfa-amilasa del bacilo de la especie 195. | |
| PE20060952A1 (es) | Microorganismos productores de acido l-glutamico y metodo para la produccion de acido l-glutamico | |
| EP0976829A3 (de) | Protein-deamiderendes Enzym, dafür kodierendes Gen, Verfahren zur Herstellung und Verwendung davon | |
| WO2005090394A3 (de) | Cyanidtolerante nitrilhydratasen | |
| WO2008019069A3 (en) | Enzymatic aqueous acylation | |
| WO2005040107A3 (en) | Methods for making simvastatin and intermediates | |
| ATE498732T1 (de) | Verfahren zur erhöhung der refinerproduktionsrate und/oder verringerung der spezifischen energie des aufschliessens von holz | |
| WO2004013294A3 (en) | Method of producing non-recombinant bmp-2 and use thereof | |
| TW200506059A (en) | Method for obtaining mastocyte lines from pig tissues and for producing heparin-type molecules | |
| WO2003064622A3 (en) | Aggrecanase molecules | |
| AU2003206926A8 (en) | Cultivation method for micro-organisms and bioreactor | |
| MX2007003268A (es) | Enzima laccasa novedosa y uso de la misma. | |
| AU2003243381A8 (en) | Variants of antithrombin iii | |
| BR0207757A (pt) | Método para produzir uma composição de pantotenato secável por pulverização isenta de beta-alanina, e, composição de pantotenato secável por pulverização | |
| WO2003064597A3 (en) | Aggrecanase molecules |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |