ATE530656T1 - Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. - Google Patents
Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene.Info
- Publication number
- ATE530656T1 ATE530656T1 AT05723518T AT05723518T ATE530656T1 AT E530656 T1 ATE530656 T1 AT E530656T1 AT 05723518 T AT05723518 T AT 05723518T AT 05723518 T AT05723518 T AT 05723518T AT E530656 T1 ATE530656 T1 AT E530656T1
- Authority
- AT
- Austria
- Prior art keywords
- modification
- cytochrome
- nornicotine
- polypeptides
- plants
- Prior art date
Links
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 title abstract 3
- 230000004048 modification Effects 0.000 title 2
- 238000012986 modification Methods 0.000 title 2
- 229930013930 alkaloid Natural products 0.000 title 1
- 150000003797 alkaloid derivatives Chemical class 0.000 title 1
- 241000196324 Embryophyta Species 0.000 abstract 4
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical compound C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 abstract 3
- MYKUKUCHPMASKF-UHFFFAOYSA-N Nornicotine Natural products C1CCNC1C1=CC=CN=C1 MYKUKUCHPMASKF-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- XKABJYQDMJTNGQ-VIFPVBQESA-N n-nitrosonornicotine Chemical compound O=NN1CCC[C@H]1C1=CC=CN=C1 XKABJYQDMJTNGQ-VIFPVBQESA-N 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 abstract 2
- 230000000711 cancerogenic effect Effects 0.000 abstract 2
- 231100000315 carcinogenic Toxicity 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 230000002503 metabolic effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 235000019505 tobacco product Nutrition 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 102000018832 Cytochromes Human genes 0.000 abstract 1
- 108010052832 Cytochromes Proteins 0.000 abstract 1
- 241000208125 Nicotiana Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 239000000779 smoke Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/12—Leaves
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/82—Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
- A01H6/823—Nicotiana, e.g. tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2005/005665 WO2006091194A1 (en) | 2005-02-23 | 2005-02-23 | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530656T1 true ATE530656T1 (de) | 2011-11-15 |
Family
ID=34960891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05723518T ATE530656T1 (de) | 2005-02-23 | 2005-02-23 | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US7884263B2 (de) |
| EP (2) | EP1851317B1 (de) |
| AT (1) | ATE530656T1 (de) |
| BR (1) | BRPI0519985B1 (de) |
| WO (1) | WO2006091194A1 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700834B2 (en) | 2001-11-13 | 2010-04-20 | U.S. Smokless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| US7812227B2 (en) | 2001-11-13 | 2010-10-12 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| US8592663B2 (en) | 2001-11-13 | 2013-11-26 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
| US7855318B2 (en) | 2001-11-13 | 2010-12-21 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from Nicotiana |
| US7700851B2 (en) | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| US10266836B2 (en) | 2001-11-13 | 2019-04-23 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
| US8637731B2 (en) * | 2003-10-16 | 2014-01-28 | U.S. Smokeless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| CN1926235B (zh) | 2003-10-16 | 2012-07-18 | 美国无烟烟草有限责任公司 | 从烟草克隆细胞色素p450基因 |
| US8586837B2 (en) * | 2004-04-29 | 2013-11-19 | U.S. Smokeless Tobacco Company Llc | Nicotiana nucleic acid molecules and uses thereof |
| US20070199097A1 (en) * | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| US11778965B2 (en) * | 2005-02-23 | 2023-10-10 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes |
| ATE530656T1 (de) | 2005-02-23 | 2011-11-15 | Univ North Carolina State | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
| KR101413122B1 (ko) | 2005-02-28 | 2014-07-18 | 22엔디 센츄리 리미티드, 엘엘씨 | 식물의 니코틴 알칼로이드 수준의 감소 |
| KR20080050584A (ko) * | 2005-08-19 | 2008-06-09 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 아라크노캄파 루시페라아제 |
| WO2007105305A1 (ja) * | 2006-03-14 | 2007-09-20 | Japan Tobacco Inc. | 新規なβ－ガラクトシド－α２，６－シアル酸転移酵素、それをコードする遺伝子およびその製造方法 |
| US9551003B2 (en) | 2006-09-13 | 2017-01-24 | 22Nd Century Limited, Llc | Increasing levels of nicotinic alkaloids in plants |
| WO2007072224A2 (en) | 2006-09-13 | 2007-06-28 | Nara Institute Of Science And Technology | Increasing levels of nicotinic alkaloids |
| BRPI0717355B1 (pt) * | 2006-10-13 | 2018-01-16 | North Carolina State University | Método para obtenção de uma planta transgênica de nicotina, método para obtenção de uma semente; construto de ácido nucléico recombinante; método de redução da conversão de nicotina em nornicotina em uma planta de nicotina |
| US9102948B2 (en) | 2006-11-17 | 2015-08-11 | 22Nd Century Limited, Llc | Regulating alkaloids |
| US8319011B2 (en) | 2006-12-15 | 2012-11-27 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| US11332753B2 (en) | 2006-12-15 | 2022-05-17 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| RU2009128896A (ru) * | 2006-12-29 | 2011-02-10 | Эвоник Дегусса ГмБх (DE) | Метионинсинтазы с пониженной способностью к ингибированию продуктом реакции |
| CN101686731B (zh) | 2007-02-23 | 2013-05-08 | 美国无烟烟草有限责任公司 | 新型烟草组合物及制备方法 |
| JP4927774B2 (ja) * | 2007-10-12 | 2012-05-09 | サントリーホールディングス株式会社 | Ｕｄｐ−グルクロン酸転移酵素およびそれをコードするポリヌクレオチド |
| WO2009055454A2 (en) * | 2007-10-22 | 2009-04-30 | University Of Florida Research Foundation, Inc. | Xylan-utilization regulon for efficient bioprocessing of hemicellulose and uses thereof |
| WO2009064771A2 (en) | 2007-11-12 | 2009-05-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| TW200948964A (en) * | 2008-04-17 | 2009-12-01 | Novozymes As | Laccase variants |
| BR112012012192A2 (pt) | 2009-11-25 | 2017-07-04 | Codexis Inc | b-glicosidades variantes recombinantes thermoascus aurantiacus para produção de açúcares fermentáveis a partir da biomassa celulósica |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| CN103228671B (zh) | 2010-09-03 | 2017-08-15 | 菲利普莫里斯产品有限公司 | 植物中的重金属减少 |
| US9096864B2 (en) | 2011-02-28 | 2015-08-04 | North Carolina State University | Tobacco inbred plants NCBEX1F, NCBEX1MS, and NC EX90 |
| EP2681321A1 (de) | 2011-02-28 | 2014-01-08 | Altria Client Services Inc. | Durch inzucht erzeugte tabakpflanzen albex1f und albex1ms |
| EP2565271A1 (de) | 2011-09-02 | 2013-03-06 | Philip Morris Products S.A. | Threonin-Synthase aus Nicotiana Tabacum und Verfahren und Verwendungen davon |
| EP2565265A1 (de) | 2011-09-02 | 2013-03-06 | Philip Morris Products S.A. | Isopropylmalat-Synthase aus Nicotiana Tabacum und Verfahren und Verwendungen davon |
| CN103930543B (zh) * | 2011-09-06 | 2020-11-27 | 诺维信公司 | 葡糖淀粉酶变体和编码它们的多核苷酸 |
| EP2586792A1 (de) | 2011-10-31 | 2013-05-01 | Philip Morris Products S.A. | Modulierung von Beta-Damascenonen in Pflanzen |
| AU2012331235B2 (en) | 2011-10-31 | 2017-06-15 | Philip Morris Products S.A. | Modulating beta-damascenone in plants |
| AP2015008563A0 (en) | 2012-12-21 | 2015-06-30 | Philip Morris Products Sa | Tobacco specific nitrosamine reduction in plants |
| US9603335B2 (en) | 2013-01-11 | 2017-03-28 | North Carolina State University | Tobacco inbred plants K326 SRC, CMS K326 SRC, K346 SRC, CMS K346 SRC, NC1562-1 SRC, NCTG-61 SRC, CMS NCTG-61 SRC and hybrid NC196 SRC |
| US9560830B2 (en) | 2013-03-05 | 2017-02-07 | North Carolina State University | Tobacco inbred and hybrid plants and uses thereof |
| US10375910B2 (en) * | 2013-03-15 | 2019-08-13 | Altria Client Services Llc | Development of tobacco varieties with no or significantly reduced anatabine content |
| EP3113603A1 (de) | 2014-03-03 | 2017-01-11 | North Carolina State University | Inzucht- und hybridtabakpflanzen und daraus hergestellte tabakprodukte |
| EP3113604A1 (de) | 2014-03-03 | 2017-01-11 | North Carolina State University | Inzucht- und hybridtabakpflanzen und daraus hergestellte tabakprodukte |
| EP3113602A1 (de) | 2014-03-03 | 2017-01-11 | North Carolina State University | Inzucht- und hybridtabakpflanzen und daraus hergestellte tabakprodukte |
| EP3140404A1 (de) * | 2014-05-08 | 2017-03-15 | Philip Morris Products S.A. | Reduktion von nikotin für die nornicotinumwandlung in pflanzen |
| US10113174B2 (en) | 2014-07-02 | 2018-10-30 | Altria Client Services Llc | Tobacco having altered leaf properties and methods of making and using |
| CN113652416A (zh) | 2014-10-06 | 2021-11-16 | 奥驰亚客户服务有限公司 | 烟草植物中腋芽生长的遗传控制 |
| US10405571B2 (en) | 2015-06-26 | 2019-09-10 | Altria Client Services Llc | Compositions and methods for producing tobacco plants and products having altered alkaloid levels |
| EP3407704B1 (de) | 2016-01-29 | 2024-08-14 | Philip Morris Products S.A. | Verringerung der cadmiumanreicherung in freilandkultivierten tabakpflanzen |
| EP3426786A1 (de) | 2016-03-11 | 2019-01-16 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und -produkten mit verringerten oder beseitigten wurzeltrieben |
| US10647989B2 (en) | 2016-10-07 | 2020-05-12 | Altria Client Services Llc | Composition and methods for producing tobacco plants and products having reduced tobacco-specific nitrosamines (TSNAs) |
| KR102606956B1 (ko) | 2016-12-20 | 2023-11-29 | 필립모리스 프로덕츠 에스.에이. | 개화까지의 시간이 단축된 식물 |
| WO2018119124A1 (en) | 2016-12-21 | 2018-06-28 | Altria Client Services Llc | Compositions and methods for producing tobacco plants and products having altered alkaloid levels |
| EP3580342A1 (de) | 2017-02-07 | 2019-12-18 | University of Kentucky Research Foundation | Verfahren |
| CN106636146B (zh) * | 2017-02-16 | 2019-09-13 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e5基因突变体及其应用 |
| CN111108205B (zh) | 2017-09-11 | 2024-05-28 | 奥驰亚客户服务有限公司 | 用于生产烟杈减少或消除的烟草植物和制品的组合物和方法 |
| EP3480314A1 (de) | 2017-11-03 | 2019-05-08 | Philip Morris Products S.A. | Regelung des alkaloidgehalts |
| BR112020011386A2 (pt) | 2017-12-07 | 2020-12-01 | R.J. Reynolds Tobacco Company | fatores de transcrição bzip regulam a conversão de nicotina em nornicotina |
| JP7479286B2 (ja) | 2018-01-12 | 2024-05-08 | アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー | タバコ植物を産生するための組成物および方法、ならびに変化したアルカロイドレベルを有する産物 |
| KR20250109246A (ko) | 2018-03-05 | 2025-07-16 | 알트리아 클라이언트 서비시즈 엘엘씨 | 바람직한 잎 품질과 함께 변경된 알칼로이드 수준을 갖는 담배 식물 및 제품을 생성하기 위한 조성물 및 방법 |
| WO2019185699A1 (en) | 2018-03-28 | 2019-10-03 | Philip Morris Products S.A. | Modulating reducing sugar content in a plant |
| KR20200136921A (ko) | 2018-03-28 | 2020-12-08 | 필립모리스 프로덕츠 에스.에이. | 식물 내 아미노산 함량 조절 |
| US11377665B2 (en) | 2018-04-03 | 2022-07-05 | Altria Client Services Llc | Composition and methods for producing tobacco plants and products having increased phenylalanine and reduced tobacco-specific nitrosamines (TSNAs) |
| KR102851176B1 (ko) | 2018-07-26 | 2025-08-28 | 알트리아 클라이언트 서비시즈 엘엘씨 | 알칼로이드 수준이 변경된 담배 식물 및 제품을 생산하기 위한 pmt 공학에 기초한 조성물 및 방법 |
| WO2020141062A1 (en) | 2018-12-30 | 2020-07-09 | Philip Morris Products S.A. | Modulation of nitrate levels in plants via mutation of nitrate reductase |
| US12077765B2 (en) | 2019-01-24 | 2024-09-03 | Altria Client Services Llc | Tobacco plants comprising reduced nicotine and reduced tobacco specific nitrosamines |
| JP7659547B2 (ja) | 2019-10-01 | 2025-04-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節（ｉｎｖ） |
| CN114514321A (zh) | 2019-10-01 | 2022-05-17 | 菲利普莫里斯生产公司 | 调节植物中的糖和氨基酸含量（sultr3） |
| JP2022552261A (ja) | 2019-10-10 | 2022-12-15 | アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー | 変化したアルカロイドレベルを有するタバコ植物およびタバコ製品を作製するためのｑｐｔ操作に基づく組成物および方法 |
| US12270037B2 (en) | 2019-10-10 | 2025-04-08 | Altria Client Services Llc | Compositions and methods for producing tobacco plants and products having altered alkaloid levels with desirable leaf quality via manipulating leaf quality genes |
| EP4069854A1 (de) | 2019-12-03 | 2022-10-12 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und produkten mit veränderten alkaloidspiegeln |
| WO2021146585A1 (en) | 2020-01-17 | 2021-07-22 | Altria Client Services Llc | Methods and compositions related to improved nitrogen use efficiency |
| US20230105789A1 (en) | 2020-01-27 | 2023-04-06 | Altria Client Services Llc | Compositions and Methods Based on PMT Engineering for Producing Tobacco Plants and Products Having Altered Alkaloid Levels |
| WO2021221752A2 (en) | 2020-02-06 | 2021-11-04 | Trustees Of Boston University | High throughput assay for identifying microbial redox enzymes |
| US11331020B2 (en) | 2020-02-06 | 2022-05-17 | Trustees Of Boston University | Enzyme-based electrochemical nicotine biosensor |
| EP4152966A1 (de) | 2020-05-20 | 2023-03-29 | Altria Client Services LLC | Hybrides luft- und feuerhärtungskombinationsverfahren zur verringerung schädlicher und potenziell schädlicher bestandteile in gehärtetem tabak |
| EP4161255A1 (de) | 2020-06-03 | 2023-04-12 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und produkten mit veränderten alkaloidspiegeln |
| US20250043298A1 (en) | 2021-12-20 | 2025-02-06 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| US20250084427A1 (en) | 2021-12-21 | 2025-03-13 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| JP2025518037A (ja) | 2022-05-23 | 2025-06-12 | アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー | タバコ中のアルカロイドを制御するための方法及び組成物 |
| EP4565601A1 (de) | 2022-08-05 | 2025-06-11 | Altria Client Services LLC | Verfahren und zusammensetzungen zur regulierung von alkaloiden in tabak |
| EP4602060A1 (de) | 2022-10-13 | 2025-08-20 | Philip Morris Products S.A. | Erhöhung der effizienz der biomasse und des stickstoffverbrauchs von blättern durch ntp2-regulierung |
| CN116217685B (zh) * | 2023-01-03 | 2026-02-24 | 云南中烟工业有限责任公司 | 一种敲除烟草NtLNP1基因获得叶形改变且低烟碱含量烟草的方法及应用 |
| KR20250139370A (ko) | 2023-02-02 | 2025-09-23 | 필립모리스 프로덕츠 에스.에이. | 리신 케토글루타레이트 환원효소 코딩 유전자 조절 |
| CN120530195A (zh) | 2023-02-02 | 2025-08-22 | 菲利普莫里斯生产公司 | 糖转运蛋白的调节 |
| WO2025003105A1 (en) | 2023-06-29 | 2025-01-02 | Philip Morris Products S.A. | Modulation of genes coding for glutamate dehydrogenase |
| WO2025147663A2 (en) | 2024-01-05 | 2025-07-10 | Altria Client Services Llc | Methods and compositions for modulating trichome density and flavor molecule secretion |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762785A (en) | 1982-08-12 | 1988-08-09 | Calgene, Inc. | Novel method and compositions for introducting alien DNA in vivo |
| EP0320500B1 (de) | 1983-01-13 | 2004-11-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nichtonkogenisches Ti-Plasmidvektorsystem und für das Einschleusen expressionsfähiger Gene in Pflanzengenomen verwendbare rekombinante DNA-Moleküle |
| US5352605A (en) | 1983-01-17 | 1994-10-04 | Monsanto Company | Chimeric genes for transforming plant cells using viral promoters |
| EP0131624B1 (de) | 1983-01-17 | 1992-09-16 | Monsanto Company | Plasmide zur transformation von pflanzenzellen |
| NL8300699A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; werkwijze voor het produceren van agrobacterium tumefaciens bacterien; stabiele cointegraat plasmiden; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| NL8401048A (nl) | 1984-04-03 | 1985-11-01 | Rijksuniversiteit Leiden En Pr | Werkwijze voor het inbouwen van vreemd dna in het genoom van eenzaadlobbige planten. |
| US4732856A (en) | 1984-04-03 | 1988-03-22 | Carnegie Institution Of Washington | Transposable elements and process for using same |
| US5231019A (en) | 1984-05-11 | 1993-07-27 | Ciba-Geigy Corporation | Transformation of hereditary material of plants |
| NL8401780A (nl) | 1984-06-04 | 1986-01-02 | Rijksuniversiteit Leiden En Pr | Werkwijze voor het inbouwen van vreemd dna in het genoom van planten. |
| US5149645A (en) | 1984-06-04 | 1992-09-22 | Rijksuniversiteit Leiden | Process for introducing foreign DNA into the genome of plants |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5569597A (en) | 1985-05-13 | 1996-10-29 | Ciba Geigy Corp. | Methods of inserting viral DNA into plant material |
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| AU7360087A (en) | 1986-04-30 | 1987-11-24 | Boyce Thompson Institute For Plant Research Inc. | Electric field mediated dna transformation of plant cells and organelles |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| US4801540A (en) | 1986-10-17 | 1989-01-31 | Calgene, Inc. | PG gene and its use in plants |
| EP0267159A3 (de) | 1986-11-07 | 1990-05-02 | Ciba-Geigy Ag | Verfahren zur genetischen Modifikation monokotyler Pflanzen |
| US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
| SE455438B (sv) | 1986-11-24 | 1988-07-11 | Aga Ab | Sett att senka en brennares flamtemperatur samt brennare med munstycken for oxygen resp brensle |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| US5608142A (en) | 1986-12-03 | 1997-03-04 | Agracetus, Inc. | Insecticidal cotton plants |
| ES2074999T3 (es) | 1987-05-20 | 1995-10-01 | Ciba Geigy Ag | Plantas de zea mays y plantas de zea mays transgenicas regeneradas de protoplastos o celulas derivadas de protoplastos. |
| US5350689A (en) | 1987-05-20 | 1994-09-27 | Ciba-Geigy Corporation | Zea mays plants and transgenic Zea mays plants regenerated from protoplasts or protoplast-derived cells |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5013658A (en) | 1988-05-13 | 1991-05-07 | Dna Plant Technology Corporation | Transposon tagging of genes in transformed plants |
| ATE112314T1 (de) | 1988-05-17 | 1994-10-15 | Lubrizol Genetics Inc | Pflanzliches ubiquitinpromotorsystem. |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5034323A (en) | 1989-03-30 | 1991-07-23 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| US5231020A (en) | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| US5879918A (en) | 1989-05-12 | 1999-03-09 | Pioneer Hi-Bred International, Inc. | Pretreatment of microprojectiles prior to using in a particle gun |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5141131A (en) | 1989-06-30 | 1992-08-25 | Dowelanco | Method and apparatus for the acceleration of a propellable matter |
| ES2150900T3 (es) | 1989-10-31 | 2000-12-16 | Monsanto Co | Promotor para plantas transgenicas. |
| ATE225853T1 (de) | 1990-04-12 | 2002-10-15 | Syngenta Participations Ag | Gewebe-spezifische promotoren |
| US5498830A (en) | 1990-06-18 | 1996-03-12 | Monsanto Company | Decreased oil content in plant seeds |
| US5260205A (en) | 1990-11-14 | 1993-11-09 | Philip Morris Incorporated | Method of purifying putrescine N-methyltransferase from tobacco plant extract with a polyamine |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| US5668295A (en) | 1990-11-14 | 1997-09-16 | Philip Morris Incorporated | Protein involved in nicotine synthesis, DNA encoding, and use of sense and antisense DNAs corresponding thereto to affect nicotine content in transgenic tobacco cells and plants |
| ES2260886T3 (es) | 1990-11-23 | 2006-11-01 | Bayer Bioscience N.V. | Procedimiento para transformar plantas monocotiledoneas. |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| US5399680A (en) | 1991-05-22 | 1995-03-21 | The Salk Institute For Biological Studies | Rice chitinase promoter |
| US5604121A (en) | 1991-08-27 | 1997-02-18 | Agricultural Genetics Company Limited | Proteins with insecticidal properties against homopteran insects and their use in plant protection |
| CA2130454C (en) | 1992-02-19 | 2008-04-08 | William G. Dougherty | Production of viral resistant plants via introduction of untranslatable plus sense viral rna |
| JPH07505531A (ja) | 1992-04-15 | 1995-06-22 | プラント・ジェネティック・システムズ・エヌ・ブイ | 単子葉植物細胞の形質転換法 |
| GB9210273D0 (en) | 1992-05-13 | 1992-07-01 | Ici Plc | Dna |
| US5311143A (en) | 1992-07-02 | 1994-05-10 | Motorola, Inc. | RF amplifier bias control method and apparatus |
| JP2952041B2 (ja) | 1992-07-27 | 1999-09-20 | パイオニア ハイ−ブレッド インターナショナル，インコーポレイテッド | 培養ダイズ細胞のａｇｒｏｂａｃｔｅｒｉｕｍ媒介形質転換の改良法 |
| IL108241A (en) | 1992-12-30 | 2000-08-13 | Biosource Genetics Corp | Plant expression system comprising a defective tobamovirus replicon integrated into the plant chromosome and a helper virus |
| US5469976A (en) | 1993-04-30 | 1995-11-28 | Burchell; James R. | Shelf allocation and management system |
| DE69404385T2 (de) | 1993-06-04 | 1998-02-19 | Cavis Srl | Trägheitsschalter zur Ausschaltung der Batterie eines Kraftfahrzeuges |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5789156A (en) | 1993-06-14 | 1998-08-04 | Basf Ag | Tetracycline-regulated transcriptional inhibitors |
| FR2712302B1 (fr) | 1993-11-10 | 1996-01-05 | Rhone Poulenc Agrochimie | Eléments promoteurs de gènes chimères de tubuline alpha. |
| DE733059T1 (de) | 1993-12-09 | 1997-08-28 | Univ Jefferson | Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen |
| US5608144A (en) | 1994-08-12 | 1997-03-04 | Dna Plant Technology Corp. | Plant group 2 promoters and uses thereof |
| US5659026A (en) | 1995-03-24 | 1997-08-19 | Pioneer Hi-Bred International | ALS3 promoter |
| ES2326705T3 (es) | 1995-09-14 | 2009-10-16 | Virginia Tech Intellectual Properties, Inc. | Produccion de enzimas lisosomicas en sistemas de expresion basados en plantas. |
| US5760012A (en) | 1996-05-01 | 1998-06-02 | Thomas Jefferson University | Methods and compounds for curing diseases caused by mutations |
| US5731181A (en) | 1996-06-17 | 1998-03-24 | Thomas Jefferson University | Chimeric mutational vectors having non-natural nucleotides |
| US5713376A (en) | 1996-05-13 | 1998-02-03 | Berger; Carl | Non-addictive tobacco products |
| US6072050A (en) | 1996-06-11 | 2000-06-06 | Pioneer Hi-Bred International, Inc. | Synthetic promoters |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| EP0979311A1 (de) | 1997-04-30 | 2000-02-16 | Of The University Of Minnesota Regents | $i(IN VIVO)VERWENDUNG REKOMBINAGENISCHER OLIGONUKLEOBASEN ZUR KORREKTUR GENETISCHER DEFEKTE IN HEPATOZYTEN |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| US7094606B2 (en) | 1997-08-05 | 2006-08-22 | Arntzen Charles J | Use of mixed duplex oligonucleotides to effect localized genetic changes in plants |
| WO1999025821A1 (en) | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Compositions and methods for genetic modification of plants |
| AR014072A1 (es) | 1998-02-26 | 2001-01-31 | Pioneer Hi Bred Int | Molecula de acido nucleico aislada que tiene una secuencia nucleotidica para un promotor que es capaz de iniciar una transcripcion constitutiva en unacelula de planta, construccion adn, vector, celula huesped, metodo para expresar en forma constitutiva una secuencia nucleotidica heteroloca en una |
| CN101818145A (zh) | 1998-03-20 | 2010-09-01 | 联邦科学和工业研究组织 | 控制基因表达 |
| CN1202246C (zh) | 1998-04-08 | 2005-05-18 | 联邦科学和工业研究组织 | 获得修饰表型的方法和措施 |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| US7238860B2 (en) | 2001-04-18 | 2007-07-03 | Mendel Biotechnology, Inc. | Yield-related polynucleotides and polypeptides in plants |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| WO2000049035A1 (en) | 1999-02-19 | 2000-08-24 | The General Hospital Corporation | Gene silencing |
| EP1033405A3 (de) | 1999-02-25 | 2001-08-01 | Ceres Incorporated | DNS-fragmente mit bestimmter Sequenz und die dadurch kodierte Polypeptide |
| AU4991500A (en) | 1999-05-06 | 2000-11-21 | Michael Timko | Regulation of gene expression in tobacco for manipulation of plant growth and secondary metabolism |
| US7151201B2 (en) | 2000-01-21 | 2006-12-19 | The Scripps Research Institute | Methods and compositions to modulate expression in plants |
| EP1276886B1 (de) | 2000-04-26 | 2012-11-28 | Monsanto Technology LLC | Verfahren zur transformation von pflanzenzellplastiden |
| JP2004512020A (ja) | 2000-06-23 | 2004-04-22 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 組換え構築物ならびにこれを遺伝子発現を減少させる際に用いる方法 |
| US20020048814A1 (en) | 2000-08-15 | 2002-04-25 | Dna Plant Technology Corporation | Methods of gene silencing using poly-dT sequences |
| JP3883816B2 (ja) | 2001-03-02 | 2007-02-21 | 富士通株式会社 | 波長分散及び波長分散スロープを可変出来る装置 |
| US7405057B2 (en) | 2001-03-09 | 2008-07-29 | Board Of Trustees Of The University Of Kentucky | Cytochrome P450s and uses thereof |
| CA2449920A1 (en) | 2001-06-08 | 2002-12-19 | Vector Tobacco Ltd. | Modifying nicotine and nitrosamine levels in tobacco |
| US20060157072A1 (en) | 2001-06-08 | 2006-07-20 | Anthony Albino | Method of reducing the harmful effects of orally or transdermally delivered nicotine |
| US7032601B2 (en) | 2001-09-28 | 2006-04-25 | U.S. Smokeless Tobacco Company | Encapsulated materials |
| US6953040B2 (en) | 2001-09-28 | 2005-10-11 | U.S. Smokeless Tobacco Company | Tobacco mint plant material product |
| US20040117869A1 (en) | 2002-01-11 | 2004-06-17 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from Nicotiana |
| US7700834B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| US8592663B2 (en) | 2001-11-13 | 2013-11-26 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
| US20040103449A1 (en) * | 2001-11-13 | 2004-05-27 | U.S. Smokeless Tobacco Company | Identification and use of cytochrome P450 nucleic acid sequences from tobacco |
| US7812227B2 (en) | 2001-11-13 | 2010-10-12 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| US7700851B2 (en) | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| US7855318B2 (en) | 2001-11-13 | 2010-12-21 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from Nicotiana |
| US20040111759A1 (en) | 2001-11-13 | 2004-06-10 | U.S. Smokeless Tobacco Company | Identification and use of cytochrome P450 nucleic acid sequences from tobacco |
| US20040162420A1 (en) | 2002-10-16 | 2004-08-19 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| CA2477452A1 (en) | 2002-03-12 | 2003-09-25 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| CA2478904A1 (en) | 2002-03-14 | 2003-09-18 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing rna and uses thereof |
| EP2336305A3 (de) * | 2002-10-16 | 2011-10-05 | U.S. Smokeless Tobacco Company LLC | Klonen von Cytochrom P450-Genen aus Nikotiana |
| US8637731B2 (en) | 2003-10-16 | 2014-01-28 | U.S. Smokeless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| PL1675957T3 (pl) | 2003-10-16 | 2012-06-29 | U S Smokeless Tobacco Company Llc | Klonowanie genów cytochromu p450 z Nicotiana |
| EP1694832B1 (de) * | 2003-10-16 | 2012-04-18 | U.S. Smokeless Tobacco Company LLC | Nutzung eines cytochrom-p450-gen aus nicotiana |
| CN1926235B (zh) | 2003-10-16 | 2012-07-18 | 美国无烟烟草有限责任公司 | 从烟草克隆细胞色素p450基因 |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| CN104397869B (zh) | 2003-11-07 | 2016-06-08 | 美国无烟烟草有限责任公司 | 烟草组合物 |
| EP1729602A1 (de) | 2003-12-22 | 2006-12-13 | U.S. Smokeless Tobacco Company | Konditionierungsverfahren für tabak- und/oder schnupftabakzusammensetzung |
| EP2295549B1 (de) * | 2004-04-29 | 2015-02-25 | U.S. Smokeless Tobacco Company LLC | Nikotiananukleinsäuremoleküle und deren Verwendung |
| US8586837B2 (en) | 2004-04-29 | 2013-11-19 | U.S. Smokeless Tobacco Company Llc | Nicotiana nucleic acid molecules and uses thereof |
| US7798153B2 (en) | 2004-08-23 | 2010-09-21 | Us Smokeless Tobacco Co. | Nicotiana Kawakamii smokeless tobacco |
| US20060185686A1 (en) | 2004-08-23 | 2006-08-24 | Lawrence Robert H Jr | Nicotiana diversity |
| US20070199097A1 (en) | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| ATE530656T1 (de) | 2005-02-23 | 2011-11-15 | Univ North Carolina State | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
| EA012674B1 (ru) | 2005-04-29 | 2009-12-30 | Филип Моррис Продактс С.А. | Табачный продукт в пакетиках |
| US7757697B2 (en) | 2005-12-22 | 2010-07-20 | Swisher International, Inc. | Method for reducing nitrosamines in tobacco |
| BRPI0717355B1 (pt) | 2006-10-13 | 2018-01-16 | North Carolina State University | Método para obtenção de uma planta transgênica de nicotina, método para obtenção de uma semente; construto de ácido nucléico recombinante; método de redução da conversão de nicotina em nornicotina em uma planta de nicotina |
| US8319011B2 (en) | 2006-12-15 | 2012-11-27 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| US8186360B2 (en) | 2007-04-04 | 2012-05-29 | R.J. Reynolds Tobacco Company | Cigarette comprising dark air-cured tobacco |
| US7667104B2 (en) | 2007-11-06 | 2010-02-23 | Alliance One International, Inc. | Tobacco cultivar AOB 171 |
| WO2009064771A2 (en) | 2007-11-12 | 2009-05-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| JP5550433B2 (ja) | 2010-04-22 | 2014-07-16 | 任天堂株式会社 | 操作装置および情報処理システム |
| US9096864B2 (en) | 2011-02-28 | 2015-08-04 | North Carolina State University | Tobacco inbred plants NCBEX1F, NCBEX1MS, and NC EX90 |
-
2005
- 2005-02-23 AT AT05723518T patent/ATE530656T1/de not_active IP Right Cessation
- 2005-02-23 EP EP05723518A patent/EP1851317B1/de not_active Expired - Lifetime
- 2005-02-23 EP EP10012136.7A patent/EP2338905B1/de not_active Expired - Lifetime
- 2005-02-23 BR BRPI0519985-9A patent/BRPI0519985B1/pt active IP Right Grant
- 2005-02-23 WO PCT/US2005/005665 patent/WO2006091194A1/en not_active Ceased
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2006
- 2006-10-13 US US11/580,765 patent/US7884263B2/en active Active
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2010
- 2010-12-17 US US12/971,801 patent/US9187759B2/en active Active
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- 2015-10-08 US US14/878,083 patent/US9913451B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2006091194A1 (en) | 2006-08-31 |
| BRPI0519985A2 (pt) | 2009-04-07 |
| BRPI0519985B1 (pt) | 2018-01-30 |
| EP2338905A3 (de) | 2011-08-17 |
| US7884263B2 (en) | 2011-02-08 |
| US10383299B2 (en) | 2019-08-20 |
| EP2338905B1 (de) | 2017-11-29 |
| EP2338905A2 (de) | 2011-06-29 |
| US20110174322A1 (en) | 2011-07-21 |
| US11140843B2 (en) | 2021-10-12 |
| US20180160644A1 (en) | 2018-06-14 |
| US9913451B2 (en) | 2018-03-13 |
| EP1851317B1 (de) | 2011-10-26 |
| US20160057967A1 (en) | 2016-03-03 |
| US9187759B2 (en) | 2015-11-17 |
| EP1851317A1 (de) | 2007-11-07 |
| US20080202541A1 (en) | 2008-08-28 |
| US20200022326A1 (en) | 2020-01-23 |
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