ATE530656T1 - Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. - Google Patents
Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene.Info
- Publication number
- ATE530656T1 ATE530656T1 AT05723518T AT05723518T ATE530656T1 AT E530656 T1 ATE530656 T1 AT E530656T1 AT 05723518 T AT05723518 T AT 05723518T AT 05723518 T AT05723518 T AT 05723518T AT E530656 T1 ATE530656 T1 AT E530656T1
- Authority
- AT
- Austria
- Prior art keywords
- modification
- cytochrome
- nornicotine
- polypeptides
- plants
- Prior art date
Links
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 title abstract 3
- 230000004048 modification Effects 0.000 title 2
- 238000012986 modification Methods 0.000 title 2
- 229930013930 alkaloid Natural products 0.000 title 1
- 150000003797 alkaloid derivatives Chemical class 0.000 title 1
- 241000196324 Embryophyta Species 0.000 abstract 4
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical compound C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 abstract 3
- MYKUKUCHPMASKF-UHFFFAOYSA-N Nornicotine Natural products C1CCNC1C1=CC=CN=C1 MYKUKUCHPMASKF-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- XKABJYQDMJTNGQ-VIFPVBQESA-N n-nitrosonornicotine Chemical compound O=NN1CCC[C@H]1C1=CC=CN=C1 XKABJYQDMJTNGQ-VIFPVBQESA-N 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 abstract 2
- 230000000711 cancerogenic effect Effects 0.000 abstract 2
- 231100000315 carcinogenic Toxicity 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 230000002503 metabolic effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 235000019505 tobacco product Nutrition 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 102000018832 Cytochromes Human genes 0.000 abstract 1
- 108010052832 Cytochromes Proteins 0.000 abstract 1
- 241000208125 Nicotiana Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 239000000779 smoke Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/12—Leaves
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/82—Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
- A01H6/823—Nicotiana, e.g. tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2005/005665 WO2006091194A1 (en) | 2005-02-23 | 2005-02-23 | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530656T1 true ATE530656T1 (de) | 2011-11-15 |
Family
ID=34960891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05723518T ATE530656T1 (de) | 2005-02-23 | 2005-02-23 | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US7884263B2 (de) |
| EP (2) | EP1851317B1 (de) |
| AT (1) | ATE530656T1 (de) |
| BR (1) | BRPI0519985B1 (de) |
| WO (1) | WO2006091194A1 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700851B2 (en) | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| US7855318B2 (en) | 2001-11-13 | 2010-12-21 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from Nicotiana |
| US7700834B2 (en) | 2001-11-13 | 2010-04-20 | U.S. Smokless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| US7812227B2 (en) * | 2001-11-13 | 2010-10-12 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| US10266836B2 (en) | 2001-11-13 | 2019-04-23 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
| US8592663B2 (en) | 2001-11-13 | 2013-11-26 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
| EP2330191A1 (de) | 2003-10-16 | 2011-06-08 | U.S. Smokeless Tobacco Company | Klonen von Cytochrom P450-Genen aus Nikotiana |
| US8637731B2 (en) * | 2003-10-16 | 2014-01-28 | U.S. Smokeless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| US8586837B2 (en) | 2004-04-29 | 2013-11-19 | U.S. Smokeless Tobacco Company Llc | Nicotiana nucleic acid molecules and uses thereof |
| US20070199097A1 (en) * | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| US11778965B2 (en) * | 2005-02-23 | 2023-10-10 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes |
| WO2006091194A1 (en) | 2005-02-23 | 2006-08-31 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| KR101538797B1 (ko) | 2005-02-28 | 2015-07-22 | 22엔디 센츄리 리미티드, 엘엘씨 | 식물의 니코틴 알칼로이드 수준의 감소 |
| US8227572B2 (en) * | 2005-08-19 | 2012-07-24 | Commonwealth Scientific And Industrial Research Organisation | Arachnocampa luciferases |
| WO2007105305A1 (ja) * | 2006-03-14 | 2007-09-20 | Japan Tobacco Inc. | 新規なβ－ガラクトシド－α２，６－シアル酸転移酵素、それをコードする遺伝子およびその製造方法 |
| HUE026819T2 (en) | 2006-09-13 | 2016-07-28 | 22Nd Century Ltd Llc | To increase the level of nicotine alkaloids |
| US9551003B2 (en) | 2006-09-13 | 2017-01-24 | 22Nd Century Limited, Llc | Increasing levels of nicotinic alkaloids in plants |
| EP2087123B1 (de) * | 2006-10-13 | 2011-08-10 | North Carolina State University | Änderung des alkaloid-gehalts von tabak mittels modifizierung spezifischer p450-cytochromgene |
| US9102948B2 (en) | 2006-11-17 | 2015-08-11 | 22Nd Century Limited, Llc | Regulating alkaloids |
| US8319011B2 (en) | 2006-12-15 | 2012-11-27 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| US11332753B2 (en) | 2006-12-15 | 2022-05-17 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| US8252555B2 (en) * | 2006-12-29 | 2012-08-28 | Evonik Degussa Ag | Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide |
| CN101686731B (zh) | 2007-02-23 | 2013-05-08 | 美国无烟烟草有限责任公司 | 新型烟草组合物及制备方法 |
| JP4927774B2 (ja) * | 2007-10-12 | 2012-05-09 | サントリーホールディングス株式会社 | Ｕｄｐ−グルクロン酸転移酵素およびそれをコードするポリヌクレオチド |
| US8119367B2 (en) * | 2007-10-22 | 2012-02-21 | University Of Florida Research Foundation, Inc. | Nucleic acids, compositions and uses thereof |
| US8124851B2 (en) | 2007-11-12 | 2012-02-28 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes |
| TW200948964A (en) * | 2008-04-17 | 2009-12-01 | Novozymes As | Laccase variants |
| EP2504431A4 (de) | 2009-11-25 | 2013-10-16 | Codexis Inc | Rekombinante thermoascus-aurantiacus-beta-glucosidase-varianten zur herstellung von fermentierbaren zuckern aus zellulosischer biomasse |
| CN102858983B (zh) | 2010-01-15 | 2015-08-12 | 北卡罗来纳州立大学 | 最小化烟草中去甲烟碱合成的组合物和方法 |
| TR201815375T4 (tr) | 2010-09-03 | 2018-11-21 | Philip Morris Products Sa | Bitkilerde ağır metal redüksiyonu. |
| WO2012118779A1 (en) | 2011-02-28 | 2012-09-07 | North Carolina State University | Tobacco inbred plants ncbex1f, ncbex1ms, and nc ex90 |
| KR20140034160A (ko) | 2011-02-28 | 2014-03-19 | 알트리아 클라이언트 서비시스 인코포레이티드 | 담배 근친교배 식물체 albex1f 및 albex1ms |
| EP2565271A1 (de) | 2011-09-02 | 2013-03-06 | Philip Morris Products S.A. | Threonin-Synthase aus Nicotiana Tabacum und Verfahren und Verwendungen davon |
| EP2565265A1 (de) | 2011-09-02 | 2013-03-06 | Philip Morris Products S.A. | Isopropylmalat-Synthase aus Nicotiana Tabacum und Verfahren und Verwendungen davon |
| WO2013036526A1 (en) * | 2011-09-06 | 2013-03-14 | Novozymes A/S | Glucoamylase variants and polynucleotides encoding same |
| PH12014500916A1 (en) | 2011-10-31 | 2022-12-02 | Philip Morris Products Sa | Modulating beta-damascenone in plants |
| EP2586792A1 (de) | 2011-10-31 | 2013-05-01 | Philip Morris Products S.A. | Modulierung von Beta-Damascenonen in Pflanzen |
| KR102253223B1 (ko) | 2012-12-21 | 2021-05-21 | 필립모리스 프로덕츠 에스.에이. | 식물 내 담배 특이 니트로사민 감소 |
| EP2943059A1 (de) | 2013-01-11 | 2015-11-18 | North Carolina State University | Tabakinzuchtpflanzen k326 src, cms k326 src, k346 src, cms k346 src, nc1562-1 src, nctg-61 src, cms nctg-61 src und hybrid-nc196 src |
| WO2014137802A1 (en) | 2013-03-05 | 2014-09-12 | North Carolina State University | Tobacco inbred and hybrid plants and uses thereof |
| US10375910B2 (en) * | 2013-03-15 | 2019-08-13 | Altria Client Services Llc | Development of tobacco varieties with no or significantly reduced anatabine content |
| WO2015134423A1 (en) | 2014-03-03 | 2015-09-11 | North Carolina State University | Tobacco inbred and hybrid plants and tobacco products made thereof |
| EP3113604A1 (de) | 2014-03-03 | 2017-01-11 | North Carolina State University | Inzucht- und hybridtabakpflanzen und daraus hergestellte tabakprodukte |
| WO2015134438A1 (en) | 2014-03-03 | 2015-09-11 | North Carolina State University | Tobacco inbred and hybrid plants and tobacco products made thereof |
| JP6871158B2 (ja) * | 2014-05-08 | 2021-05-12 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物体におけるニコチンからノルニコチンへの変換の低減 |
| EP3164496A1 (de) | 2014-07-02 | 2017-05-10 | Altria Client Services LLC | Tabak mit veränderten blatteigenschaften und verfahren zur herstellung und verwendung |
| CN113652416A (zh) | 2014-10-06 | 2021-11-16 | 奥驰亚客户服务有限公司 | 烟草植物中腋芽生长的遗传控制 |
| EP4218404A3 (de) | 2015-06-26 | 2023-09-06 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und produkten mit veränderten alkaloidspiegeln |
| EA201891707A1 (ru) | 2016-01-29 | 2018-12-28 | Филип Моррис Продактс С.А. | Уменьшение накопления кадмия в выращенных в поле растениях табака |
| EP3426786A1 (de) | 2016-03-11 | 2019-01-16 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und -produkten mit verringerten oder beseitigten wurzeltrieben |
| EP3523439A1 (de) | 2016-10-07 | 2019-08-14 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und -produkten mit verringerten tabakspezifischen nitrosaminen (tsnas) |
| WO2018114641A1 (en) | 2016-12-20 | 2018-06-28 | Philip Morris Products S.A. | Plants with shortened time to flowering |
| US20190309317A1 (en) | 2016-12-21 | 2019-10-10 | Altria Client Services Llc | Compositions and methods for producing tobacco plants and products having altered alkaloid levels |
| CA3051868A1 (en) | 2017-02-07 | 2018-08-16 | University Of Kentucky Research Foundation | Method |
| CN106636146B (zh) * | 2017-02-16 | 2019-09-13 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e5基因突变体及其应用 |
| WO2019051232A1 (en) | 2017-09-11 | 2019-03-14 | Altria Client Services Llc | COMPOSITIONS AND METHODS FOR PRODUCING TOBACCO PLANTS AND PRODUCTS HAVING REDUCED OR ELIMINATED GOURMETS |
| EP3480314A1 (de) | 2017-11-03 | 2019-05-08 | Philip Morris Products S.A. | Regelung des alkaloidgehalts |
| BR112020011386A2 (pt) * | 2017-12-07 | 2020-12-01 | R.J. Reynolds Tobacco Company | fatores de transcrição bzip regulam a conversão de nicotina em nornicotina |
| CN111836539A (zh) | 2018-01-12 | 2020-10-27 | 奥驰亚客户服务有限公司 | 用于产生烟草植物和具有经过改变的生物碱水平的产品的组合物和方法 |
| BR112020018187A2 (pt) | 2018-03-05 | 2021-04-27 | Altria Client Services Llc | composições e métodos para a produção de plantas e produtos de tabaco que possuem níveis alterados de alcaloides com qualidade de folha desejável |
| CN111818795A (zh) | 2018-03-28 | 2020-10-23 | 菲利普莫里斯生产公司 | 调节植物中的还原糖含量 |
| CN111801423A (zh) | 2018-03-28 | 2020-10-20 | 菲利普莫里斯生产公司 | 调节植物中的氨基酸含量 |
| EP3773017B1 (de) | 2018-04-03 | 2022-06-08 | Altria Client Services LLC | Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und -produkten mit erhöhtem phenylalanin und verringerten tabakspezifischen nitrosaminen (tsnas) |
| KR20250131268A (ko) | 2018-07-26 | 2025-09-02 | 알트리아 클라이언트 서비시즈 엘엘씨 | 알칼로이드 수준이 변경된 담배 식물 및 제품을 생산하기 위한 pmt 공학에 기초한 조성물 및 방법 |
| JP2022515435A (ja) | 2018-12-30 | 2022-02-18 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 硝酸レダクターゼの突然変異による植物における硝酸塩レベルの調節 |
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-
2018
- 2018-01-30 US US15/883,931 patent/US10383299B2/en not_active Expired - Lifetime
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2019
- 2019-07-15 US US16/511,596 patent/US11140843B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20160057967A1 (en) | 2016-03-03 |
| US9913451B2 (en) | 2018-03-13 |
| US20080202541A1 (en) | 2008-08-28 |
| EP2338905A2 (de) | 2011-06-29 |
| US10383299B2 (en) | 2019-08-20 |
| WO2006091194A1 (en) | 2006-08-31 |
| EP2338905A3 (de) | 2011-08-17 |
| US20180160644A1 (en) | 2018-06-14 |
| US20200022326A1 (en) | 2020-01-23 |
| EP1851317A1 (de) | 2007-11-07 |
| US7884263B2 (en) | 2011-02-08 |
| BRPI0519985A2 (pt) | 2009-04-07 |
| US11140843B2 (en) | 2021-10-12 |
| US9187759B2 (en) | 2015-11-17 |
| EP1851317B1 (de) | 2011-10-26 |
| EP2338905B1 (de) | 2017-11-29 |
| BRPI0519985B1 (pt) | 2018-01-30 |
| US20110174322A1 (en) | 2011-07-21 |
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