ATE530825T1 - Verfahren und systeme zur fluidsteuerung in mikrofluidvorrichtungen - Google Patents

Verfahren und systeme zur fluidsteuerung in mikrofluidvorrichtungen

Info

Publication number
ATE530825T1
ATE530825T1 AT02723636T AT02723636T ATE530825T1 AT E530825 T1 ATE530825 T1 AT E530825T1 AT 02723636 T AT02723636 T AT 02723636T AT 02723636 T AT02723636 T AT 02723636T AT E530825 T1 ATE530825 T1 AT E530825T1
Authority
AT
Austria
Prior art keywords
passage
trs
systems
fluid control
obstructs
Prior art date
Application number
AT02723636T
Other languages
English (en)
Inventor
Gene Parunak
Original Assignee
Handylab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Handylab Inc filed Critical Handylab Inc
Application granted granted Critical
Publication of ATE530825T1 publication Critical patent/ATE530825T1/de

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C3/00—Circuit elements having moving parts
    • F15C3/002—Circuit elements having moving parts using fluid droplets or similar deformable bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/20—Other positive-displacement pumps
    • F04B19/24—Pumping by heat expansion of pumped fluid
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0044—Electric operating means therefor using thermo-electric means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/4456—With liquid valves or liquid trap seals
    • Y10T137/4643—Liquid valves

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Theoretical Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Temperature-Responsive Valves (AREA)
  • Details Of Valves (AREA)
  • Micromachines (AREA)
  • Safety Valves (AREA)
AT02723636T 2001-07-26 2002-03-27 Verfahren und systeme zur fluidsteuerung in mikrofluidvorrichtungen ATE530825T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30763801P 2001-07-26 2001-07-26
US09/953,921 US6575188B2 (en) 2001-07-26 2001-09-18 Methods and systems for fluid control in microfluidic devices
PCT/US2002/009441 WO2003012325A1 (en) 2001-07-26 2002-03-27 Methods and systems for fluid control in microfluidics devices

Publications (1)

Publication Number Publication Date
ATE530825T1 true ATE530825T1 (de) 2011-11-15

Family

ID=26975846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02723636T ATE530825T1 (de) 2001-07-26 2002-03-27 Verfahren und systeme zur fluidsteuerung in mikrofluidvorrichtungen

Country Status (5)

Country Link
US (1) US6575188B2 (de)
EP (1) EP1425528B1 (de)
JP (4) JP4519462B2 (de)
AT (1) ATE530825T1 (de)
WO (1) WO2003012325A1 (de)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) * 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
JP4246629B2 (ja) * 2001-09-11 2009-04-02 アークレイ株式会社 測定用具
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US20030138819A1 (en) * 2001-10-26 2003-07-24 Haiqing Gong Method for detecting disease
US7452509B2 (en) * 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US6935617B2 (en) * 2002-07-26 2005-08-30 Applera Corporation Valve assembly for microfluidic devices, and method for opening and closing the same
US6883326B2 (en) * 2002-08-30 2005-04-26 The Boeing Company One-shot electro-pneumatic actuator
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US7195036B2 (en) * 2002-11-04 2007-03-27 The Regents Of The University Of Michigan Thermal micro-valves for micro-integrated devices
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
FR2856046B1 (fr) * 2003-06-16 2005-07-29 Biomerieux Sa Microvanne fluidique a ouverture par commande electrique
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US20050056799A1 (en) * 2003-09-11 2005-03-17 Malone Steven J. Valves having a thermostatic actuator controlled by a peltier device
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2572382T3 (es) * 2004-05-03 2016-05-31 Handylab Inc Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos
GB2414059B (en) * 2004-05-10 2008-06-11 E2V Tech Uk Ltd Microfluidic device
US8642353B2 (en) 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
US7686040B2 (en) * 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
US20060018795A1 (en) * 2004-07-23 2006-01-26 General Electric Company Fabrication methods and multifunctional substrate materials for chemical and biological analysis in microfluidic systems
US20060070697A1 (en) * 2004-09-23 2006-04-06 Ingersoll Machine Tools, Inc. Method and apparatus for directing resin-impregnated tape
WO2006044841A2 (en) 2004-10-18 2006-04-27 Applera Corporation Fluid processing device including size-changing barrier
EP1827693B1 (de) * 2004-12-09 2010-03-24 Scandinavian Micro Biodevices ApS Mikrofluidvorrichtung und verfahren zur herstellung einer mikrofluidvorrichtung
US8172375B2 (en) * 2004-12-17 2012-05-08 Brother Kogyo Kabushiki Kaisha Valve and actuator employing capillary electrowetting phenomenon
EP1843849A2 (de) * 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH Verfahren zur herstellung einer mikrofluidischen vorrichtung und mikrofluidische vorrichtungen
KR100668335B1 (ko) * 2005-04-02 2007-01-12 삼성전자주식회사 자성 왁스 플러그를 구비한 마이크로 밸브 및 자성 왁스를이용한 유동 제어 방법
JP2006300145A (ja) * 2005-04-18 2006-11-02 Erumu:Kk マイクロバルブ及び該マイクロバルブを有するマイクロチップ
US20060245933A1 (en) * 2005-05-02 2006-11-02 General Electric Company Valve and pump for microfluidic systems and methods for fabrication
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
US20080226502A1 (en) * 2005-07-07 2008-09-18 Jacques Jonsmann Microfluidic Methods and Support Instruments
FR2888912B1 (fr) * 2005-07-25 2007-08-24 Commissariat Energie Atomique Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif
WO2007018117A1 (ja) * 2005-08-05 2007-02-15 Yuzo Mori 電子ビームアシストｅｅｍ法
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
EP1949197B1 (de) * 2005-10-24 2010-03-17 CeQur ApS Strömungssystem und mikrofluidisches system mit einem strömungssystem
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998433B2 (en) * 2006-04-04 2011-08-16 Samsung Electronics Co., Ltd. Valve unit and apparatus having the same
KR100763922B1 (ko) * 2006-04-04 2007-10-05 삼성전자주식회사 밸브 유닛 및 이를 구비한 장치
KR100738113B1 (ko) * 2006-05-10 2007-07-12 삼성전자주식회사 상전이형 밸브 및 그 제작방법
EP1884284A1 (de) * 2006-08-04 2008-02-06 Samsung Electronics Co., Ltd. Absperrventileinheit und Reaktionsvorrichtung mit Absperrventil
US8464760B2 (en) * 2006-08-16 2013-06-18 Samsung Electronic Co., Ltd. Valve unit, reaction apparatus with the same, and method of forming valve in channel
KR100851980B1 (ko) * 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
KR100846501B1 (ko) 2006-11-09 2008-07-17 삼성전자주식회사 밸브 유닛 및 이를 구비한 유체 처리 장치
JP5013823B2 (ja) * 2006-11-10 2012-08-29 キヤノン株式会社 感温型ワンショットバルブ、およびその製造方法
US8709787B2 (en) * 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8931501B2 (en) * 2006-12-20 2015-01-13 Applied Biosystems, Llc Devices and methods for flow control in microfluidic structures
EP2101917A1 (de) * 2007-01-10 2009-09-23 Scandinavian Micro Biodevices A/S Mikrofluidische vorrichtung und mikrofluidisches system und verfahren zur testdurchführung
JP4169115B1 (ja) * 2007-02-27 2008-10-22 コニカミノルタホールディングス株式会社 流路切換システム
EP1977830A1 (de) * 2007-03-30 2008-10-08 Roche Diagnostics GmbH Mikrofluidisches temperaturangetriebenes Ventil
JP5032890B2 (ja) * 2007-05-31 2012-09-26 キヤノン株式会社 ワンショットバルブ、およびその製造方法
US7980272B2 (en) * 2007-06-21 2011-07-19 Samsung Electronics Co., Ltd. Microfluidic valve, method of manufacturing the same, and microfluidic device comprising the microfluidic valve
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20100252124A1 (en) * 2007-11-22 2010-10-07 Koninklijke Philips Electronics N.V. Valve for a microfluidic system
CN101960190B (zh) * 2008-02-26 2013-02-06 株式会社爱发科 开闭阀
US8063236B2 (en) * 2008-05-08 2011-11-22 University Of Florida Research Foundation, Inc. Method for transferring N-atoms from metal complexes to organic and inorganic substrates
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US20100009351A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
EP2307141B1 (de) 2008-07-29 2019-02-20 Scandinavian Micro Biodevices ApS Mikrofluidische vorrichtung
KR101390717B1 (ko) * 2008-09-02 2014-04-30 삼성전자주식회사 미세유동장치 및 미세유동장치에의 시료주입방법
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
EP4512526A3 (de) 2008-09-23 2025-06-04 Bio-Rad Laboratories, Inc. Tropfenbasiertes assaysystem
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
JP5766178B2 (ja) 2009-03-24 2015-08-19 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ ＳｌｉｐＣｈｉｐ装置および方法
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
FR2945097B1 (fr) * 2009-04-30 2011-06-03 Commissariat Energie Atomique Vanne microfluidique a usage unique.
EP2437891B1 (de) 2009-06-03 2013-04-24 Koninklijke Philips Electronics N.V. Ventil mit material mit modifizierbarem penetrierbarkeitsgrad
DE102009035292A1 (de) * 2009-07-30 2011-02-03 Karlsruher Institut für Technologie Vorrichtung zum Steuern des Durchflusses von Fluiden durch mikrofluidische Kanäle, Verfahren zu ihrem Betrieb und ihre Verwendung
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
EP3574990B1 (de) 2010-11-01 2022-04-06 Bio-Rad Laboratories, Inc. System zur formung von emulsionen
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
CN103534360A (zh) 2011-03-18 2014-01-22 伯乐生命医学产品有限公司 借助对信号的组合使用进行的多重数字分析
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
EP3395957B1 (de) 2011-04-25 2020-08-12 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzungen zur nukleinsäureanalyse
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
ES2645966T3 (es) 2011-09-30 2017-12-11 Becton, Dickinson And Company Tira reactiva unificada
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
DE102012005992B3 (de) * 2012-03-23 2013-07-11 Karlsruher Institut für Technologie Bistabiler Aktor, Aktoranordnung, Verfahren zum Aktuieren und Verwendung
EP2647435B1 (de) * 2012-04-05 2020-08-05 ThinXXS Microtechnology AG Anordnung aus einer flusszelle und einem temperierelement
RU2500944C1 (ru) * 2012-05-15 2013-12-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский авиационный институт (национальный исследовательский университет)" (МАИ) Запорная арматура с автономной системой уплотнения
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US9789483B2 (en) 2013-03-11 2017-10-17 Cue Inc. System for portable and easy-to-use detection of analytes with mobile computing device
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
US9617921B2 (en) * 2013-07-31 2017-04-11 General Electric Company Thermal actuator including fluid with high temperature stability
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
DE102014002972B4 (de) * 2014-03-06 2019-06-19 Arianegroup Gmbh Einmalig betätigbare Ventilanordnung für eine Raumfahrtkomponente und Raumfahrtkomponente
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
WO2016083550A1 (en) * 2014-11-26 2016-06-02 Imec Vzw Compact glass-based fluid analysis device and method to fabricate
WO2016083329A1 (en) * 2014-11-26 2016-06-02 Imec Vzw A compact fluid analysis device and method to fabricate
NL2014801B1 (en) * 2015-05-13 2017-01-27 Berkin Bv Fluid flow device, comprising a valve unit, as well as method of manufacturing the same.
CA2992596C (en) 2015-07-17 2023-08-22 Cue Inc. Systems and methods for enhanced detection and quantification of analytes
WO2017015529A1 (en) 2015-07-22 2017-01-26 The University Of North Carolina At Chapel Hill Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis
EP3827795B1 (de) * 2016-07-14 2023-08-23 3M Innovative Properties Co. Vollmelder für medizinischen verband
CN110291396B (zh) * 2016-10-07 2021-02-26 刘新宇 用于自主免疫测定的微流体分析平台
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
GB201703233D0 (en) * 2017-02-28 2017-04-12 Ge Healthcare Bio Sciences Ab A modular bio-processing unit and a bio-processing system employing plural units
KR102013698B1 (ko) 2017-12-20 2019-08-26 주식회사 씨디젠 검정색 열가소성 수지 밸브 및 비접촉 온도 센서를 이용한 랩온어 디스크 장치
CN108855260B (zh) * 2018-06-16 2021-04-02 南京大学 一种石蜡微阀成型及其封装方法
US10738903B2 (en) * 2018-08-29 2020-08-11 International Business Machines Corporation Microfluidic relief valve

Family Cites Families (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1616419A (en) * 1925-04-03 1927-02-01 Everlasting Valve Co Automatic shut-off device for gas in case of fire
US1773401A (en) * 1927-10-20 1930-08-19 Luther D Lovekin Fusible-plug water release
US3528449A (en) * 1968-02-27 1970-09-15 Trw Inc Fluid flow control apparatus
US4139005A (en) * 1977-09-01 1979-02-13 Dickey Gilbert C Safety release pipe cap
US4673657A (en) 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
US4654127A (en) 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
US4612959A (en) * 1985-05-07 1986-09-23 Mobil Oil Corporation Valveless shut-off and transfer device
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5763262A (en) 1986-09-18 1998-06-09 Quidel Corporation Immunodiagnostic device
US4946562A (en) 1987-01-29 1990-08-07 Medtest Systems, Inc. Apparatus and methods for sensing fluid components
US5004583A (en) 1987-01-29 1991-04-02 Medtest Systems, Inc. Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid
US5001417A (en) 1987-06-01 1991-03-19 Abbott Laboratories Apparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes
GB8720470D0 (en) 1987-08-29 1987-10-07 Emi Plc Thorn Sensor arrangements
JPH01154460A (ja) * 1987-12-10 1989-06-16 Matsushita Electric Ind Co Ltd 電池用カドミウム極の製造法
US5503803A (en) 1988-03-28 1996-04-02 Conception Technologies, Inc. Miniaturized biological assembly
JPH0814337B2 (ja) * 1988-11-11 1996-02-14 株式会社日立製作所 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5053199A (en) 1989-02-21 1991-10-01 Boehringer Mannheim Corporation Electronically readable information carrier
FI86229C (fi) * 1989-04-10 1992-07-27 Niilo Kaartinen Foerfarande foer formning av ett uppvaermbart och nedkylbart element vid ett system behandlande smao vaetskemaengder samt ett medelst foerfarandet framstaellt element.
US4949742A (en) * 1989-04-26 1990-08-21 Spectra-Physics, Inc. Temperature operated gas valve
US5135872A (en) 1989-04-28 1992-08-04 Sangstat Medical Corporation Matrix controlled method of delayed fluid delivery for assays
US5061336A (en) 1989-05-01 1991-10-29 Soane Technologies, Inc. Gel casting method and apparatus
US5071531A (en) 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
AU635314B2 (en) 1989-09-08 1993-03-18 Terumo Kabushiki Kaisha Measuring apparatus
DE69004652T2 (de) 1989-09-29 1994-05-11 Glory Kogyo Kk Vorrichtung zum Bündeln von Papierblättern.
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US6054034A (en) 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5935401A (en) 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5208163A (en) 1990-08-06 1993-05-04 Miles Inc. Self-metering fluid analysis device
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
DE59105165D1 (de) 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
DE59104604D1 (de) 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
JPH05345900A (ja) 1991-07-08 1993-12-27 Fuji Oil Co Ltd 硬質油脂の製造法
DE4123348A1 (de) 1991-07-15 1993-01-21 Boehringer Mannheim Gmbh Elektrochemisches analysesystem
IT1249433B (it) 1991-08-06 1995-02-23 Pompeo Moscetta Procedimento per il dosaggio di analiti in campioni liquidi e relativaapparecchiatura.
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
EP1067134B1 (de) 1991-11-07 2004-07-28 Nanotronics, Inc. Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems
US5787032A (en) 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5559432A (en) 1992-02-27 1996-09-24 Logue; Delmar L. Joystick generating a polar coordinates signal utilizing a rotating magnetic field within a hollow toroid core
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5569364A (en) 1992-11-05 1996-10-29 Soane Biosciences, Inc. Separation media for electrophoresis
US5885432A (en) 1992-11-05 1999-03-23 Soane Biosciences Un-crosslinked polymeric media for electrophoresis
US5500187A (en) 1992-12-08 1996-03-19 Westinghouse Electric Corporation Disposable optical agglutination assay device and method for use
US5302348A (en) 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
US5339486A (en) 1993-03-10 1994-08-23 Persic Jr William V Golf ball cleaner
US5565171A (en) 1993-05-28 1996-10-15 Governors Of The University Of Alberta Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
EP0653631B1 (de) 1993-11-11 2003-05-14 Aclara BioSciences, Inc. Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
KR970702375A (ko) 1994-03-24 1997-05-13 알렉미안 Dna 멜토메터 및 이것의 사용방법(a dna meltometer and methods of use thereof)
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
JPH07332219A (ja) * 1994-06-02 1995-12-22 Zenichi Ogita 感温応答アクチュエータと、該アクチュエータにて作動する感温応答弁、及び感温応答スイッチ
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
CA2156226C (en) 1994-08-25 1999-02-23 Takayuki Taguchi Biological fluid analyzing device and method
US5627041A (en) 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
DE69533554T2 (de) 1994-11-10 2005-01-27 Orchid Biosciences, Inc. Flüssigkeitsverteilungssystem
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5731212A (en) 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
CA2223166A1 (en) 1995-06-06 1996-12-12 Paul L. Braun Method of producing micro-electrical conduits
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6057149A (en) 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
US5631337A (en) 1996-01-19 1997-05-20 Soane Bioscience Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5883211A (en) 1996-01-19 1999-03-16 Aclara Biosciences, Inc. Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5849598A (en) 1996-03-15 1998-12-15 Washington University Method for transferring micro quantities of liquid samples to discrete locations
WO1997036166A1 (en) 1996-03-25 1997-10-02 Diasys Corporation Apparatus and method for handling fluid samples of body materials
US5844238A (en) 1996-03-27 1998-12-01 David Sarnoff Research Center, Inc. Infrared imager using room temperature capacitance sensor
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6001307A (en) 1996-04-26 1999-12-14 Kyoto Daiichi Kagaku Co., Ltd. Device for analyzing a sample
US6083762A (en) 1996-05-31 2000-07-04 Packard Instruments Company Microvolume liquid handling system
US5939291A (en) 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US5912124A (en) 1996-06-14 1999-06-15 Sarnoff Corporation Padlock probe detection
CN1329729C (zh) 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
DE19749011A1 (de) * 1996-11-19 1998-05-20 Lang Volker Mikroventil
US5772966A (en) 1997-01-24 1998-06-30 Maracas; George N. Assay dispensing apparatus
US5964997A (en) 1997-03-21 1999-10-12 Sarnoff Corporation Balanced asymmetric electronic pulse patterns for operating electrode-based pumps
US5747666A (en) 1997-03-26 1998-05-05 Willis; John P. Point-of-care analyzer module
US5964995A (en) 1997-04-04 1999-10-12 Caliper Technologies Corp. Methods and systems for enhanced fluid transport
US5993750A (en) 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US5997708A (en) 1997-04-30 1999-12-07 Hewlett-Packard Company Multilayer integrated assembly having specialized intermediary substrate
US5980719A (en) 1997-05-13 1999-11-09 Sarnoff Corporation Electrohydrodynamic receptor
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US5900130A (en) 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5959291A (en) 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US5827481A (en) 1997-07-31 1998-10-27 Hewlett-Packard Company Cartridge system for effecting sample acquisition and introduction
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5919711A (en) 1997-08-07 1999-07-06 Careside, Inc. Analytical cartridge
US5916522A (en) 1997-08-07 1999-06-29 Careside, Inc. Electrochemical analytical cartridge
US5916776A (en) 1997-08-27 1999-06-29 Sarnoff Corporation Amplification method for a polynucleotide
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
JP2001515204A (ja) * 1997-09-02 2001-09-18 カリパー テクノロジーズ コーポレイション 電気流体制御および電気熱制御を有するマイクロ流体システム
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US5993611A (en) 1997-09-24 1999-11-30 Sarnoff Corporation Capacitive denaturation of nucleic acid
US6012902A (en) 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
US6084734A (en) * 1997-12-08 2000-07-04 Maxtor Corporation Data recovery using targeted ECC correction
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6375901B1 (en) * 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6261431B1 (en) * 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6306273B1 (en) 1999-04-13 2001-10-23 Aclara Biosciences, Inc. Methods and compositions for conducting processes in microfluidic devices
US6287254B1 (en) 1999-11-02 2001-09-11 W. Jean Dodds Animal health diagnosis
AU2001251340A1 (en) * 2000-04-06 2001-10-23 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
JP3548858B2 (ja) * 2001-01-22 2004-07-28 独立行政法人産業技術総合研究所 流量の制御方法及びそれに用いるマイクロバルブ

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WO2003012325A1 (en) 2003-02-13
JP4519462B2 (ja) 2010-08-04
US6575188B2 (en) 2003-06-10
EP1425528A1 (de) 2004-06-09
EP1425528A4 (de) 2005-07-20
JP2012149773A (ja) 2012-08-09
EP1425528B1 (de) 2011-10-26
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JP2004537695A (ja) 2004-12-16
JP5129286B2 (ja) 2013-01-30

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