ATE531447T1 - Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system - Google Patents

Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system

Info

Publication number: ATE531447T1
Authority: AT; Austria
Prior art keywords: aquate; phase system; microspheres; injectable hydrogel; hydrogel microspheres
Prior art date: 2003-01-17

Application number

AT03789852T

Other languages

English (en)

Inventor

Chih-Chang Chu

Xian-Zheng Zhang

Da-Qing Wu

Original Assignee

Cornell Res Foundation Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-17

Filing date

2003-12-04

Publication date

2011-11-15

2003-12-04 Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE531447T1 publication Critical patent/ATE531447T1/de

Links

239000000017 hydrogel Substances 0.000 title abstract 5
239000004005 microsphere Substances 0.000 title abstract 3
-1 poly(ethylene glycol) Polymers 0.000 abstract 3
239000002243 precursor Substances 0.000 abstract 3
229920002307 Dextran Polymers 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 2
239000000839 emulsion Substances 0.000 abstract 2
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
239000008346 aqueous phase Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
125000004386 diacrylate group Chemical group 0.000 abstract 1
QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 abstract 1
239000012071 phase Substances 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
230000000379 polymerizing effect Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Colloid Chemistry (AREA)
Polymerisation Methods In General (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT03789852T 2003-01-17 2003-12-04 Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system ATE531447T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US44064603P	2003-01-17	2003-01-17
PCT/US2003/037076 WO2004066704A2 (en)	2003-01-17	2003-12-04	Injectable hydrogel microspheres from aqueous two-phase system

Publications (1)

Publication Number	Publication Date
ATE531447T1 true ATE531447T1 (de)	2011-11-15

Family

ID=32825136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03789852T ATE531447T1 (de)	2003-01-17	2003-12-04	Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system

Country Status (8)

Country	Link
US (2)	US7776240B2 (de)
EP (1)	EP1631375B1 (de)
JP (1)	JP2006517523A (de)
CN (1)	CN100418619C (de)
AT (1)	ATE531447T1 (de)
AU (1)	AU2003294369B2 (de)
CA (1)	CA2513483C (de)
WO (1)	WO2004066704A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235592B2 (en)	2004-10-12	2007-06-26	Zimmer Gmbh	PVA hydrogel
US8262730B2 (en)	2005-12-07	2012-09-11	Zimmer, Inc.	Methods of bonding or modifying hydrogels using irradiation
US8017107B2 (en)	2005-12-22	2011-09-13	Zimmer, Inc.	Perfluorocyclobutane crosslinked hydrogels
US7731988B2 (en)	2007-08-03	2010-06-08	Zimmer, Inc.	Multi-polymer hydrogels
US8062739B2 (en)	2007-08-31	2011-11-22	Zimmer, Inc.	Hydrogels with gradient
US7947784B2 (en)	2007-11-16	2011-05-24	Zimmer, Inc.	Reactive compounding of hydrogels
US20110008404A1 (en) *	2007-12-19	2011-01-13	Georgia Tech Research Corporation	Modification Of Biomaterials With Microgel Films
US8034362B2 (en)	2008-01-04	2011-10-11	Zimmer, Inc.	Chemical composition of hydrogels for use as articulating surfaces
US10688026B2 (en)	2009-04-27	2020-06-23	Premier Dental Products Company	Buffered microencapsulated compositions and methods
US9814657B2 (en)	2009-04-27	2017-11-14	Premier Dental Products Company	Buffered microencapsulated compositions and methods
CA2769162C (en) *	2009-07-31	2017-12-05	Ascendis Pharma As	Biodegradable polyethylene glycol based water-insoluble hydrogels
EP2536819B1 (de)	2010-02-16	2024-12-18	The University of North Carolina at Chapel Hill	Array von mikrogeformten strukturen zum sammeln oder kultivieren von zellen
US20120231072A1 (en) *	2011-03-11	2012-09-13	Chemisches Institut Schaefer Ag	Thermo-responsive hydrogel compositions
CN102627779B (zh) *	2012-02-23	2014-12-10	宁波争光树脂有限公司	一种魔芋葡甘聚糖凝胶微球的制备方法
US10538864B2 (en)	2012-10-24	2020-01-21	Dsm Ip Assets, B.V.	Fibers comprising polyesteramide copolymers for drug delivery
AU2014321277B2 (en)	2013-09-19	2017-07-20	Terumo Corporation	Polymer particles
EP3046956B1 (de)	2013-09-19	2019-08-28	Microvention, Inc.	Polymerfilme
EP3065719A4 (de)	2013-11-08	2017-08-09	Terumo Corporation	Polymerpartikel
WO2016154592A1 (en)	2015-03-26	2016-09-29	Microvention, Inc.	Embiolic particles
US20160303281A1 (en)	2015-04-17	2016-10-20	Rochal Industries, Llc	Composition and kits for pseudoplastic microgel matrices
AU2016293784B2 (en)	2015-07-13	2021-11-11	Cosmed Pharmaceutical Co., Ltd.	Drug sustained-release carrier and method for producing same
ES2883235T3 (es) *	2015-09-09	2021-12-07	Eth Zuerich	Hidrogeles macroporosos inyectables
EP3205393A1 (de) *	2016-02-12	2017-08-16	Basf Se	Verfahren zur herstellung von mikrokapseln
US20170239183A1 (en) *	2016-02-23	2017-08-24	PixarBio Corporation	COMPOSITIONS COMPRISING NAv1.7 SELECTIVE INHIBITORS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME
EP3518983B1 (de)	2016-09-28	2024-04-24	Terumo Corporation	Polymerpartikel
CN106589264B (zh) *	2016-11-10	2019-01-08	江苏大学	一种丙烯酸基复合水凝胶的制备方法
AR111190A1 (es)	2017-03-22	2019-06-12	Genentech Inc	Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados
US12590188B2 (en)	2019-04-12	2026-03-31	The Regents Of The University Of Michigan	Tri-block copolymers and nano-fibrous gelling microspheres including the same
CA3160955A1 (en)	2019-11-12	2021-05-20	Dsm Ip Assets B.V.	Polyesteramide copolymers possessing high glass transition temperatures
CN111096924A (zh) *	2020-02-20	2020-05-05	山东大学	一种水包水防晒乳液及制备方法及应用
CN111304189A (zh) *	2020-02-28	2020-06-19	西南交通大学	一种基于双水相体系的载酶海藻酸钙微球强化级联酶促反应方法
US12605311B2 (en) *	2021-02-05	2026-04-21	Kao Corporation	Hydrogel structure
CN115212813B (zh) *	2022-07-19	2023-07-25	西南交通大学	一种全水相双层多孔凝胶微球及其制备方法和应用
CN115785479B (zh) *	2022-10-19	2024-08-23	山东省药学科学院	一种无油相乳液凝胶的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1196862A (en)	1983-06-01	1985-11-19	Connaught Laboratories Limited	Microencapsulation of living tissue and cells
US4492720A (en) *	1983-11-15	1985-01-08	Benjamin Mosier	Method of preparing microspheres for intravascular delivery
SE459005B (sv) *	1985-07-12	1989-05-29	Aake Rikard Lindahl	Saett att framstaella sfaeriska polymerpartiklar
US5529914A (en) *	1990-10-15	1996-06-25	The Board Of Regents The Univeristy Of Texas System	Gels for encapsulation of biological materials
JP3135340B2 (ja)	1992-02-25	2001-02-13	森有一	ドラッグキャリアー
DE4321205B4 (de) *	1993-06-25	2006-06-29	Basf Ag	Mikrokapseln, Verfahren zu ihrer Herstellung und ihre Verwendung
NZ269411A (en)	1993-07-12	2001-03-30	Avant Immunotherapeutics Inc	Hydrogel microencapsulated vaccines containing antigens
GB2281861B (en) *	1993-09-21	1997-08-20	Johnson & Johnson Medical	Bioabsorbable wound implant materials containing microspheres
DE4423131A1 (de) *	1994-07-01	1996-01-04	Bayer Ag	Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4
US5998588A (en)	1995-09-01	1999-12-07	University Of Washington	Interactive molecular conjugates
US6194531B1 (en) *	1996-06-05	2001-02-27	Nippon Shokubai Co., Ltd.	Method for production of cross-linked polymer
JP3832970B2 (ja)	1998-05-11	2006-10-11	独立行政法人科学技術振興機構	温度応答型生体内分解性高分子
EP1072617A1 (de)	1999-07-30	2001-01-31	Universiteit van Utrecht	Temperaturempfindliche Polymere
AU6526100A (en)	1999-08-06	2001-03-05	Board Of Regents, The University Of Texas System	Drug releasing biodegradable fiber implant
MXPA02011891A (es)	2000-06-02	2004-04-02	Eidgenoess Tech Hochschule	Reacciones de adicion conjugadas para la entrega controlada de compuestos farmaceuticamente activos.
CN1160388C (zh) *	2001-06-29	2004-08-04	清华大学	多孔温敏性聚(n-异丙基丙烯酰胺)水凝胶的制备方法
EP1411861B1 (de)	2001-06-29	2012-04-04	Medgraft Microtech, Inc.	Biologisch abbaubare injizierbare implantate und verwandte herstellungs- und verwendungsmethoden

2003
- 2003-12-04 AT AT03789852T patent/ATE531447T1/de active
- 2003-12-04 CA CA2513483A patent/CA2513483C/en not_active Expired - Fee Related
- 2003-12-04 JP JP2004567410A patent/JP2006517523A/ja active Pending
- 2003-12-04 WO PCT/US2003/037076 patent/WO2004066704A2/en not_active Ceased
- 2003-12-04 EP EP03789852A patent/EP1631375B1/de not_active Expired - Lifetime
- 2003-12-04 AU AU2003294369A patent/AU2003294369B2/en not_active Ceased
- 2003-12-04 CN CNB2003801089120A patent/CN100418619C/zh not_active Expired - Fee Related
- 2003-12-04 US US10/538,477 patent/US7776240B2/en not_active Expired - Fee Related
2010
- 2010-08-12 US US12/855,429 patent/US8323794B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1631375A4 (de)	2008-07-02
CA2513483A1 (en)	2004-08-12
CN100418619C (zh)	2008-09-17
CA2513483C (en)	2011-11-29
WO2004066704A3 (en)	2005-12-08
EP1631375A2 (de)	2006-03-08
US7776240B2 (en)	2010-08-17
JP2006517523A (ja)	2006-07-27
WO2004066704A2 (en)	2004-08-12
EP1631375B1 (de)	2011-11-02
US8323794B2 (en)	2012-12-04
AU2003294369B2 (en)	2008-08-14
US20100316717A1 (en)	2010-12-16
US20060073281A1 (en)	2006-04-06
AU2003294369A1 (en)	2004-08-23
CN1835792A (zh)	2006-09-20

Publication	Publication Date	Title
ATE531447T1 (de)	2011-11-15	Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system
EP1544406A3 (de)	2007-09-05	Kolloid oder- kolloidartige-Systemen für wässerige tonenthaltende Spülungen
EP2582191A3 (de)	2013-05-01	Mobiles Kommunikationsverfahren, mobiles Kommunikationssystem und Zugriffseinheit
ATE383392T1 (de)	2008-01-15	Polyelektrolyte enthaltende schäume aus emulsionen mit grosser innerer phase
GB0307834D0 (en)	2003-05-14	Composition
NL1026027A1 (nl)	2004-10-27	Cannabinoïdreceptorliganden en toepassingen daarvan.
DE60104238D1 (de)	2004-08-19	Komponente und katalysatoren für polymerisation von olefine
DE60200605D1 (de)	2004-07-15	Turbomolekularpumpe
ATE413812T1 (de)	2008-11-15	Hochlösliches sojaprotein von hohem molekulargewicht
DE50207312D1 (de)	2006-08-03	Kolbenpumpe
DE50204944D1 (de)	2005-12-22	Kolbenpumpe
DE60128000D1 (de)	2007-05-31	Fluidpumpe und hochdruckkraftstoffförderpumpe
SE9901123D0 (sv)	1999-03-26	Method for efficient synchronization in a communication system
ATE323695T1 (de)	2006-05-15	Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer
DK1579130T3 (da)	2013-06-10	Stempelpumpesystem
ATA16872001A (de)	2004-07-15	Ventillose pumpe
ATE356833T1 (de)	2007-04-15	Polymerisate und ihre synthese
PL376506A1 (en)	2005-12-27	Lactide and glycolide (co)polymerization catalytic system
ITMI20011813A0 (it)	2001-08-24	Complessi di cobalto utili nella polimerizzazione del 1,3-butadiene
ATE287894T1 (de)	2005-02-15	Metallverbindungen und ihre verwendung zur polymerisation von olefinen
EA200700995A1 (ru)	2007-10-26	Свойства в твёрдом состоянии полиэтилена, получаемого с помощью каталитической системы на основе тетрагидроинденилов
ITMI20032307A1 (it)	2005-05-27	Complessi di rutenio, loro preparazione ed uso come catalizzatori
Diaz	1985	FORESTRY LABOUR, NEO-LIBERALISM AND THE AUTHORITARIAN STATE: CHILE, 1973-1981.
ITRM20030007A0 (it)	2003-01-10	Dispositivo di sollevamento a pistone, in particolare per l'uso in impianti di ascensori oleodinamici.
DE60303928D1 (de)	2006-05-04	Übergangsmetallverbindungen, deren herstellung und verwendung in katalysatorsystemen für die polymerisation und copolymerisation von olefinen