ATE323695T1 - Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer - Google Patents

Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer

Info

Publication number
ATE323695T1
ATE323695T1 AT03765694T AT03765694T ATE323695T1 AT E323695 T1 ATE323695 T1 AT E323695T1 AT 03765694 T AT03765694 T AT 03765694T AT 03765694 T AT03765694 T AT 03765694T AT E323695 T1 ATE323695 T1 AT E323695T1
Authority
AT
Austria
Prior art keywords
proton pump
pump inhibitor
benzimidazole derivatives
inhibitor prodrugs
prodrugs
Prior art date
Application number
AT03765694T
Other languages
English (en)
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Original Assignee
Winston Pharmaceuticals Llc
Univ California
Us Gov Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Winston Pharmaceuticals Llc, Univ California, Us Gov Veterans Affairs filed Critical Winston Pharmaceuticals Llc
Application granted granted Critical
Publication of ATE323695T1 publication Critical patent/ATE323695T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
AT03765694T 2002-07-19 2003-07-15 Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer ATE323695T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19

Publications (1)

Publication Number Publication Date
ATE323695T1 true ATE323695T1 (de) 2006-05-15

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03765694T ATE323695T1 (de) 2002-07-19 2003-07-15 Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer

Country Status (22)

Country Link
US (3) US6897227B2 (de)
EP (1) EP1556371B1 (de)
JP (1) JP4463103B2 (de)
KR (2) KR100788778B1 (de)
AT (1) ATE323695T1 (de)
AU (1) AU2003259154B2 (de)
BR (1) BR0312802A (de)
CA (1) CA2492718C (de)
CO (1) CO5690576A2 (de)
DE (1) DE60304726T2 (de)
DK (1) DK1556371T3 (de)
ES (1) ES2263028T3 (de)
IL (1) IL166371A0 (de)
MX (1) MXPA05000657A (de)
NO (1) NO20050801L (de)
NZ (1) NZ538221A (de)
PL (1) PL375255A1 (de)
PT (1) PT1556371E (de)
RU (1) RU2292342C2 (de)
TW (1) TW200502231A (de)
WO (1) WO2004009583A2 (de)
ZA (1) ZA200501116B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AU2003254282A1 (en) * 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
JP2007521314A (ja) * 2003-07-15 2007-08-02 アラーガン、インコーポレイテッド プロトンポンプ阻害薬の異性体純粋なプロドラッグを製造するための方法
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
EP1715854A2 (de) * 2004-02-18 2006-11-02 Allergan, Inc. Prodrugs für die intravenöse verabreichung von protonenpumpen-hemmern
WO2005082337A2 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
WO2005089758A1 (en) * 2004-03-11 2005-09-29 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
EP1740571B1 (de) 2004-04-28 2009-07-29 Hetero Drugs Limited Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
AU2007248949B2 (en) * 2006-05-09 2010-04-08 Astrazeneca Ab Parenteral formulation comprising proton pump inhibitor sterilized in its final container by ionizing radiation
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
WO2008036201A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
WO2008036211A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
WO2009044976A1 (en) * 2007-10-05 2009-04-09 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
US8927559B2 (en) 2010-10-11 2015-01-06 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as CRTH2 antagonists
BR112013015397A2 (pt) 2010-12-23 2016-09-20 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
US9290453B2 (en) 2010-12-23 2016-03-22 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as CRTH2 receptor modulators
WO2016112254A1 (en) * 2015-01-09 2016-07-14 The Regents Of The University Of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
US4758597A (en) * 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) * 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
WO1991019712A1 (en) * 1990-06-20 1991-12-26 Aktiebolaget Astra Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
CA2192202A1 (en) * 1994-06-10 1995-12-21 Bernhard Kohl Substituted arylalkylthioalkylthiopyridines for use in the control of helicobacter bacteria
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
ES2192394T3 (es) * 1998-08-10 2003-10-01 Winston Pharmateuticals Llc Profarmacos de inhibidores de la bomba de protones.
CA2340214C (en) * 1998-08-12 2007-10-30 Triangle Pharmaceuticals, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) * 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
AU2001294228A1 (en) 2000-10-12 2002-04-22 Takeda Chemical Industries Ltd. Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
US20040102484A1 (en) 2004-05-27
RU2292342C2 (ru) 2007-01-27
PL375255A1 (en) 2005-11-28
IL166371A0 (en) 2006-01-16
EP1556371B1 (de) 2006-04-19
DK1556371T3 (da) 2006-08-21
AU2003259154B2 (en) 2006-12-07
NZ538221A (en) 2006-11-30
DE60304726D1 (de) 2006-05-24
CO5690576A2 (es) 2006-10-31
TW200502231A (en) 2005-01-16
EP1556371A2 (de) 2005-07-27
WO2004009583A2 (en) 2004-01-29
US20050143423A1 (en) 2005-06-30
KR100822981B1 (ko) 2008-04-16
US6897227B2 (en) 2005-05-24
CA2492718A1 (en) 2004-01-29
BR0312802A (pt) 2005-04-19
PT1556371E (pt) 2006-09-29
WO2004009583A3 (en) 2004-03-18
MXPA05000657A (es) 2005-08-19
DE60304726T2 (de) 2007-08-09
AU2003259154C1 (en) 2004-02-09
ZA200501116B (en) 2006-11-29
NO20050801L (no) 2005-02-15
KR20050047078A (ko) 2005-05-19
KR100788778B1 (ko) 2007-12-27
ES2263028T3 (es) 2006-12-01
AU2003259154A1 (en) 2004-02-09
JP2005536519A (ja) 2005-12-02
JP4463103B2 (ja) 2010-05-12
US20050182101A1 (en) 2005-08-18
RU2005105564A (ru) 2005-10-10
HK1079207A1 (en) 2006-03-31
CA2492718C (en) 2010-12-21
KR20070005029A (ko) 2007-01-09

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