ATE531711T1 - Für die behandlung von autoimmunerkrankungen und entzündlichen erkrankungen geeignete tetrahydrocyclopentaäbüindol-3- ylcarbonsäurederivate - Google Patents

Für die behandlung von autoimmunerkrankungen und entzündlichen erkrankungen geeignete tetrahydrocyclopentaäbüindol-3- ylcarbonsäurederivate

Info

Publication number: ATE531711T1
Authority: AT; Austria
Prior art keywords: diseases; treatment; acid derivatives; tetrahydrocyclopentaäbüindol; carbonic acid
Prior art date: 2007-12-18

Application number

AT08861137T

Other languages

English (en)

Inventor

Robert Jones

Daniel Buzard

Andrew Kawasaki

Luis Lopez

Jeanne Moody

Lars THORESEN

Brett Ullman

Original Assignee

Arena Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-18

Filing date

2008-12-15

Publication date

2011-11-15

2008-12-15 Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE531711T1 publication Critical patent/ATE531711T1/de

Links

208000023275 Autoimmune disease Diseases 0.000 title 1
208000037979 autoimmune inflammatory disease Diseases 0.000 title 1
150000004649 carbonic acid derivatives Chemical class 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
SPDCGFKWKYRIIU-UHFFFAOYSA-N 1-(1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid Chemical class N1C2=CC=CC=C2C2=C1C(C(=O)O)CC2C=1N=CON=1 SPDCGFKWKYRIIU-UHFFFAOYSA-N 0.000 abstract 1
208000002874 Acne Vulgaris Diseases 0.000 abstract 1
206010009900 Colitis ulcerative Diseases 0.000 abstract 1
208000011231 Crohn disease Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 abstract 1
101710155454 Sphingosine 1-phosphate receptor 1 Proteins 0.000 abstract 1
102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
206010052779 Transplant rejections Diseases 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
206010000496 acne Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Oncology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)

AT08861137T 2007-12-18 2008-12-15 Für die behandlung von autoimmunerkrankungen und entzündlichen erkrankungen geeignete tetrahydrocyclopentaäbüindol-3- ylcarbonsäurederivate ATE531711T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US807907P	2007-12-18	2007-12-18
PCT/US2008/013753 WO2009078983A1 (en)	2007-12-18	2008-12-15	Tetrahydrocyclopenta[b]indol-3-yl carboxylic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

Publications (1)

Publication Number	Publication Date
ATE531711T1 true ATE531711T1 (de)	2011-11-15

Family

ID=40383785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08861137T ATE531711T1 (de)	2007-12-18	2008-12-15	Für die behandlung von autoimmunerkrankungen und entzündlichen erkrankungen geeignete tetrahydrocyclopentaäbüindol-3- ylcarbonsäurederivate

Country Status (8)

Country	Link
US (1)	US20100273806A1 (de)
EP (1)	EP2222668B1 (de)
JP (1)	JP2011506600A (de)
CN (1)	CN101945862A (de)
AT (1)	ATE531711T1 (de)
AU (1)	AU2008338965A1 (de)
CA (1)	CA2707513A1 (de)
WO (1)	WO2009078983A1 (de)

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EP2252615A1 (de) *	2008-01-25	2010-11-24	Arena Pharmaceuticals, Inc.	Dihydro-1h-pyrrolo[1,2-a]indol-1-ylcarbonsäurederivate, die als s1p1-agonisten wirken
WO2009151621A1 (en) *	2008-06-13	2009-12-17	Arena Pharmaceuticals, Inc.	Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists
WO2009151626A1 (en) *	2008-06-13	2009-12-17	Arena Pharmaceuticals, Inc.	Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists
US8580841B2 (en) *	2008-07-23	2013-11-12	Arena Pharmaceuticals, Inc.	Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
HRP20160890T1 (hr)	2008-08-27	2016-09-23	Arena Pharmaceuticals, Inc.	Derivati supstituirane tricikličke kiseline kao agonisti s1p1-receptora korisni u liječenju autoimunih i upalnih poremećaja
JP5391372B2 (ja) *	2009-07-08	2014-01-15	公益財団法人名古屋産業科学研究所	芳香族アミン化合物の製造方法
US9216972B2 (en)	2009-10-29	2015-12-22	Bristol-Myers Squibb Company	Tricyclic heterocyclic compounds
EP2509938A1 (de) *	2009-12-10	2012-10-17	Novartis AG	Halogenierte fty720-derivate
JP5856980B2 (ja)	2010-01-27	2016-02-10	アリーナファーマシューティカルズ，インコーポレイテッド	（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス
CN105503882B (zh)	2010-03-03	2019-07-05	艾尼纳制药公司	制备s1p1受体调节剂及其晶体形式的方法
MA34910B1 (fr) *	2011-01-19	2014-02-01	Actelion Pharmaceuticals Ltd	Dérivés de 2-methoxy-pyridin-4-yl
CA2827039A1 (en) *	2011-02-14	2012-08-23	The Governors Of The University Of Alberta	Boronic acid catalysts and methods of use thereof for activation and transformation of carboxylic acids
CN103058870A (zh) *	2013-01-14	2013-04-24	中国药科大学	一种2-氧代环戊基乙酸乙酯的制备方法
PL3242666T3 (pl)	2015-01-06	2025-02-17	Arena Pharmaceuticals, Inc.	Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
BR112017027656B1 (pt)	2015-06-22	2023-12-05	Arena Pharmaceuticals, Inc.	Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
TWI757266B (zh) *	2016-01-29	2022-03-11	美商維它藥物有限責任公司	ＲＯＲ－γ調節劑
KR102482825B1 (ko)	2016-09-02	2022-12-29	브리스톨-마이어스 스큅 컴퍼니	치환된 트리시클릭 헤테로시클릭 화합물
MX2019009841A (es)	2017-02-16	2020-01-30	Arena Pharm Inc	Compuestos y metodos para el tratamiento de la colangitis biliar primaria.
MX2019009843A (es)	2017-02-16	2020-01-30	Arena Pharm Inc	Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales.
US11046646B2 (en)	2017-08-09	2021-06-29	Bristol-Myers Squibb Company	Alkylphenyl compounds
US11059784B2 (en)	2017-08-09	2021-07-13	Bristol-Myers Squibb Company	Oxime ether compounds
CA3102136A1 (en)	2018-06-06	2019-12-12	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the s1p1 receptor
CN112955431A (zh)	2018-09-06	2021-06-11	艾尼纳制药公司	可用于治疗自身免疫性病症和炎性病症的化合物
CN111518091B (zh) *	2020-04-22	2023-02-03	安徽医科大学	一种1，2，4-噁二唑并吡啶类化合物ahmu07及其作为抗菌药物的应用
CN112812052B (zh) *	2021-02-02	2023-12-01	成都阿奇生物医药科技有限公司	一种治疗溃疡性结肠炎的化合物及其制备方法和用途
CN115260173B (zh) *	2021-04-30	2024-08-30	厦门宝太生物科技股份有限公司	环戊烷并吲哚类支链酸衍生物及其制备方法和应用
CN116836157A (zh) *	2022-03-25	2023-10-03	星希尔生物科技(上海)有限公司	一种噁二唑衍生物及其制备方法和用途
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US8580841B2 (en) *	2008-07-23	2013-11-12	Arena Pharmaceuticals, Inc.	Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

2008
- 2008-12-15 EP EP08861137A patent/EP2222668B1/de active Active
- 2008-12-15 CA CA2707513A patent/CA2707513A1/en not_active Abandoned
- 2008-12-15 WO PCT/US2008/013753 patent/WO2009078983A1/en not_active Ceased
- 2008-12-15 CN CN2008801270087A patent/CN101945862A/zh active Pending
- 2008-12-15 AT AT08861137T patent/ATE531711T1/de active
- 2008-12-15 JP JP2010539452A patent/JP2011506600A/ja not_active Withdrawn
- 2008-12-15 AU AU2008338965A patent/AU2008338965A1/en not_active Abandoned
- 2008-12-15 US US12/808,872 patent/US20100273806A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2011506600A (ja)	2011-03-03
EP2222668B1 (de)	2011-11-02
EP2222668A1 (de)	2010-09-01
CN101945862A (zh)	2011-01-12
US20100273806A1 (en)	2010-10-28
CA2707513A1 (en)	2009-06-25
AU2008338965A1 (en)	2009-06-25
WO2009078983A1 (en)	2009-06-25

Publication	Publication Date	Title
ATE531711T1 (de)	2011-11-15	Für die behandlung von autoimmunerkrankungen und entzündlichen erkrankungen geeignete tetrahydrocyclopentaäbüindol-3- ylcarbonsäurederivate
MX354134B (es)	2018-02-14	Derivados de acido 1,2,3,4-tetrahidrociclopenta [b] indol-3-il) acetico sustituidos utiles en el tratamiento de enfermedades autoinmune e inflamatorias.
EP3416948B1 (de)	2024-07-24	Indazen aufweisende sulfonylharnstoffe als entzündungshemmstoffe
CY1117830T1 (el)	2017-05-17	Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων
MA32898B1 (fr)	2011-12-01	Modulateurs allosteriques positifs du recepteur m1 d'arylmethylbenzoquinazolinone
AU2003235259B2 (en)	2008-10-16	Benzimidazole derivatives
BRPI0406762A (pt)	2005-12-20	Derivados de n-(1-benzil-2-oxo-2-(1-piperazinil)etil)-1-piperidincarb oxamida e compostos relacionados como antagonistas de cgrp, para tratamento de dores de cabeça
MX2010003346A (es)	2010-04-09	Piperazino-dihidrotienopirimidinas sustituidas en heterociclo.
NO20083500L (no)	2008-09-02	1,4-disubstituerte 3-cyano-pyridonderivater og deres anvendelse som positiv-allosteriske modulatorer av mGluR2 receptorer
MA33450B1 (fr)	2012-07-03	Dérivés d'oxazine et leur utilisation en tant qu'inhibiteurs de bace pour le traitement de troubles neurologiques
WO2008117269A3 (en)	2008-12-31	Heterotri cyciii c compounds as serotonergic and/or dopaminergic agents and uses thereof
MX2012004848A (es)	2012-05-29	Compuestos heterociclicos triciclicos.
GEP20166483B (en)	2016-05-25	Phenyl-3-aza-bicyclo[3.1.0] hex-3-yl-methanones and the use thereof as medicament
NZ605431A (en)	2015-06-26	D2 antagonists, methods of synthesis and methods of use
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