ATE532793T1 - Verfahren zur herstellung von molekülen mit verminderter immunogenität - Google Patents

Verfahren zur herstellung von molekülen mit verminderter immunogenität

Info

Publication number
ATE532793T1
ATE532793T1 AT04809479T AT04809479T ATE532793T1 AT E532793 T1 ATE532793 T1 AT E532793T1 AT 04809479 T AT04809479 T AT 04809479T AT 04809479 T AT04809479 T AT 04809479T AT E532793 T1 ATE532793 T1 AT E532793T1
Authority
AT
Austria
Prior art keywords
protein
peptide
reduced immunogenicity
producing molecules
cross
Prior art date
Application number
AT04809479T
Other languages
English (en)
Inventor
Christopher Marshall
Original Assignee
Avatar Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avatar Biotechnologies Inc filed Critical Avatar Biotechnologies Inc
Application granted granted Critical
Publication of ATE532793T1 publication Critical patent/ATE532793T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT04809479T 2003-07-03 2004-07-06 Verfahren zur herstellung von molekülen mit verminderter immunogenität ATE532793T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48488003P 2003-07-03 2003-07-03
PCT/US2004/021859 WO2005051975A2 (en) 2003-07-03 2004-07-06 Methods for obtaining molecules with reduced immunogenicity

Publications (1)

Publication Number Publication Date
ATE532793T1 true ATE532793T1 (de) 2011-11-15

Family

ID=34632731

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04809479T ATE532793T1 (de) 2003-07-03 2004-07-06 Verfahren zur herstellung von molekülen mit verminderter immunogenität

Country Status (7)

Country Link
US (1) US20050054572A1 (de)
EP (1) EP1641813B1 (de)
JP (1) JP5009614B2 (de)
AT (1) ATE532793T1 (de)
AU (2) AU2004293371A1 (de)
CA (1) CA2530756C (de)
WO (1) WO2005051975A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2665568C (en) 2006-10-04 2018-01-09 Janssen Pharmaceutica, N.V. Preparation of inactivated artificial antigen presenting cells and their use in cell therapies
WO2012149365A2 (en) 2011-04-27 2012-11-01 Northwestern University Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies
US20130302366A1 (en) * 2012-05-09 2013-11-14 Christopher Marshall Conformationally Specific Viral Immunogens
US10125172B2 (en) 2013-07-25 2018-11-13 Calder Biosciences Inc. Conformationally stabilized RSV pre-fusion F proteins
EP3395826B1 (de) 2013-08-03 2020-10-14 Calder Biosciences Inc. Verfahren zur herstellung und verwendung von influenza virus hämagglutinin komplexen
CN110913954A (zh) 2017-03-03 2020-03-24 黑曜石疗法公司 免疫疗法的组合物和方法
CN110831961B (zh) 2017-03-03 2024-01-02 黑曜石疗法公司 用于免疫疗法的cd19组合物和方法
AU2018313000B2 (en) 2017-08-07 2025-07-03 Calder Biosciences Inc. Conformationally stabilized RSV pre-fusion F proteins
US20220403001A1 (en) 2018-06-12 2022-12-22 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
WO2020086742A1 (en) 2018-10-24 2020-04-30 Obsidian Therapeutics, Inc. Er tunable protein regulation
KR20210149251A (ko) 2019-03-08 2021-12-08 옵시디안 테라퓨틱스, 인크. 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
JP2022537670A (ja) 2019-06-12 2022-08-29 オブシディアン セラピューティクス， インコーポレイテッド Ｃａ２の組成物および調整可能な制御方法
WO2020252404A1 (en) 2019-06-12 2020-12-17 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
WO2021046451A1 (en) 2019-09-06 2021-03-11 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747654A (en) * 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
US6410022B1 (en) * 1995-05-01 2002-06-25 Avant Immunotherapeutics, Inc. Modulation of cholesteryl ester transfer protein (CETP) activity
WO1998052976A1 (en) * 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
WO2001029247A1 (en) * 1999-10-15 2001-04-26 Avatar Medical, Llc Stabilized proteins
US7094555B2 (en) * 2001-04-05 2006-08-22 Benaroya Research Institute At Virginia Mason Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment

Also Published As

Publication number Publication date
EP1641813A4 (de) 2006-08-30
JP2007537133A (ja) 2007-12-20
AU2011200649A1 (en) 2011-03-10
WO2005051975A3 (en) 2005-12-29
AU2004293371A1 (en) 2005-06-09
US20050054572A1 (en) 2005-03-10
EP1641813A2 (de) 2006-04-05
CA2530756A1 (en) 2005-06-09
EP1641813B1 (de) 2011-11-09
CA2530756C (en) 2012-10-16
JP5009614B2 (ja) 2012-08-22
WO2005051975A2 (en) 2005-06-09

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