ATE334998T1 - Verfahren zur herstellung cyclischer peptide - Google Patents

Verfahren zur herstellung cyclischer peptide

Info

Publication number
ATE334998T1
ATE334998T1 AT04759123T AT04759123T ATE334998T1 AT E334998 T1 ATE334998 T1 AT E334998T1 AT 04759123 T AT04759123 T AT 04759123T AT 04759123 T AT04759123 T AT 04759123T AT E334998 T1 ATE334998 T1 AT E334998T1
Authority
AT
Austria
Prior art keywords
cyclic peptides
producing cyclic
polypeptides
producing
peptides
Prior art date
Application number
AT04759123T
Other languages
English (en)
Inventor
Avi Tovi
Chaim Eidelman
Shimon Shushan
Shai Elster
Hagi Alon
Original Assignee
Novetide Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33299783&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE334998(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novetide Ltd filed Critical Novetide Ltd
Application granted granted Critical
Publication of ATE334998T1 publication Critical patent/ATE334998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04759123T 2003-04-07 2004-04-05 Verfahren zur herstellung cyclischer peptide ATE334998T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46122203P 2003-04-07 2003-04-07

Publications (1)

Publication Number Publication Date
ATE334998T1 true ATE334998T1 (de) 2006-08-15

Family

ID=33299783

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04759123T ATE334998T1 (de) 2003-04-07 2004-04-05 Verfahren zur herstellung cyclischer peptide

Country Status (9)

Country Link
US (3) US20040249121A1 (de)
EP (1) EP1511761B1 (de)
AT (1) ATE334998T1 (de)
DE (2) DE602004001727T2 (de)
DK (1) DK1511761T3 (de)
ES (1) ES2237356T3 (de)
PT (1) PT1511761E (de)
TW (1) TW200505939A (de)
WO (1) WO2004092202A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01063B (me) * 2004-04-08 2012-10-20 Millennium Pharm Inc Postupak za dobijanje eptifibatida i odgovarajućih intermedijernih jedinjenja
CA2560007A1 (en) * 2004-06-14 2005-12-22 Usv Limited Process for the preparation of peptides
US7897724B2 (en) * 2004-10-10 2011-03-01 Usv, Ltd. Solid phase Fmoc chemistry process to prepare peptides
ATE469912T1 (de) * 2004-10-04 2010-06-15 Novetide Ltd Gegenionenaustauschverfahren für peptide
EP1805203B1 (de) 2004-10-19 2010-01-13 Lonza Ag Peptid-cyclisierung auf harz
US8226949B2 (en) * 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
EP2057183A2 (de) * 2007-03-01 2009-05-13 Novetide Ltd. Peptide von hoher reinheit
CN101372505B (zh) * 2007-08-22 2011-03-30 深圳翰宇药业股份有限公司 一种制备醋酸去氨加压素的方法
WO2009150657A1 (en) * 2008-06-09 2009-12-17 Natco Pharma Limited Improved process for preparation of eptifibatide by fmoc solid phase synthesis
WO2010089757A2 (en) 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
WO2010119450A2 (en) 2009-04-06 2010-10-21 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
WO2011011342A1 (en) * 2009-07-20 2011-01-27 Mallinckrodt Inc. Synthesis of desmopressin
PL2464655T3 (pl) * 2009-08-11 2017-08-31 Biocon Limited Procesy chromatograficzne
EP2542571B1 (de) 2010-03-03 2016-05-25 The University of British Columbia Oligomer-spezifisches amyloid-beta-epitop und antikörper dazu
WO2011156686A2 (en) * 2010-06-11 2011-12-15 The Regents Of The University Of Colorado, A Body Corporate Method for synthesizing a cyclic multivalent peptide using a thiol-mediated reaction
RU2441018C1 (ru) * 2010-09-28 2012-01-27 Закрытое Акционерное Общество "Фарм-Синтез" Способ хроматографической очистки октреотида
US9388212B2 (en) 2013-02-21 2016-07-12 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
KR102159138B1 (ko) * 2013-02-21 2020-09-24 케미컬 앤드 바이오파마슈티컬 라보라토리즈 오브 파트라스 에스.에이. 측쇄 부착을 통한 고상 펩타이드 합성 방법
CN104761619A (zh) * 2015-01-06 2015-07-08 苏州天马医药集团天吉生物制药有限公司 醋酸去氨加压素的固相制备工艺
US10774120B2 (en) 2015-11-09 2020-09-15 The University Of British Columbia Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide
BR112020025831A2 (pt) * 2018-06-20 2021-03-23 Axcella Health Inc. métodos de fabricação de composições de aminoácidos
CN109942686B (zh) * 2019-05-06 2021-06-25 上海上药第一生化药业有限公司 一种加压素乙酰化杂质的精制方法
CN110016070B (zh) * 2019-05-06 2021-07-20 上海上药第一生化药业有限公司 一种加压素[+Gly]杂质的精制方法
CN112521482B (zh) * 2019-08-28 2023-09-12 深圳翰宇药业股份有限公司 一种固液结合合成奈西立肽的制备方法
CN114437233B (zh) * 2020-11-06 2025-06-24 湖北健翔生物制药有限公司 一种多肽二聚体的定向合成方法
CN115057913A (zh) * 2022-06-20 2022-09-16 遵义医科大学珠海校区 一种短杆菌肽s类似物gs-5的制备方法
WO2024112250A1 (en) * 2022-11-23 2024-05-30 Polypeptide Laboratories Holding (Ppl) Ab Method of preparing vasopressin
CN116023441A (zh) * 2022-12-29 2023-04-28 江苏诺泰澳赛诺生物制药股份有限公司 一种制备纯化去氨加压素亚砜杂质的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
CY1327A (en) * 1979-11-27 1986-06-27 Sandoz Ag Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
US5686570A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5500413A (en) * 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
AU4400997A (en) * 1997-09-18 1999-04-05 Hyundai Pharm. Ind. Co., Ltd. Process for the preparation of calcitonin
US5889146A (en) * 1997-11-26 1999-03-30 Institute Of Nuclear Energy Research Method for synthesis of bifunctional chelating agents-peptides
ES2144357B1 (es) * 1998-01-29 2000-12-16 Lipotec Sa Procedimiento para la obtencion del analogo de somatostatina octreotide.
WO2001005757A2 (en) * 1999-07-19 2001-01-25 Nycomed Imaging As Process for the deprotection of protected thiols

Also Published As

Publication number Publication date
TW200505939A (en) 2005-02-16
US20100137559A1 (en) 2010-06-03
PT1511761E (pt) 2006-11-30
DE602004001727T2 (de) 2007-08-02
US20100240865A1 (en) 2010-09-23
WO2004092202A1 (en) 2004-10-28
EP1511761B1 (de) 2006-08-02
DE04759123T1 (de) 2005-08-18
ES2237356T1 (es) 2005-08-01
DK1511761T3 (da) 2006-11-27
EP1511761A1 (de) 2005-03-09
US20040249121A1 (en) 2004-12-09
DE602004001727D1 (de) 2006-09-14
ES2237356T3 (es) 2007-04-01

Similar Documents

Publication Publication Date Title
DE602004001727D1 (de) Verfahren zur herstellung cyclischer peptide
DE602006011099D1 (de) Verfahren zur herstellung von peptidderivaten
MX361694B (es) Fragmentos de peptidos para inducir sintesis de proteinas de matriz extra-celular.
IL232501A0 (en) Stable analogs of medicinal peptides and polypeptides
WO2004019890A3 (en) In vivo production of cyclic peptides for inhibiting protein-protein interaction
ATE449167T1 (de) Verfahren zur herstellung von l-aminosäuren mit stämmen der familie enterobacteriaceae
WO2003031464A3 (en) Remodeling and glycoconjugation of peptides
ATE540055T1 (de) Zusammensetzungen und verfahren zur herstellung von glykosylierungsmutanten des menschlichen wachstumshormons
DE502006007198D1 (de) Verfahren zur herstellung von permanenten humanen zelllinien
DE50303749D1 (de) Verfahren zur herstellung von phthalocyaninpigmentzubereitungen
DE60320362D1 (de) Verfahren zur Herstellung von Dipeptiden
DE602005009856D1 (de) Verfahren zur reinigung von fsh
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
ATE430160T1 (de) Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
IL175021A0 (en) Chromatin insulator, its preparation and use in protein expression
ATE309353T1 (de) Verfahren zur herstellung von rekombinanten peptiden
DE10390418D2 (de) Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen
IL172729A0 (en) Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
DE60118359D1 (de) Humanische pellino-polypeptide
DE60300144D1 (de) Verfahren zur Herstellung von Al-Sinterlegierung
ATE332905T1 (de) Verfahren zur herstellung von acylphosphinoxiden
DE60309847D1 (de) Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga
IL173954A0 (en) Libraries of recombinant chimeric proteins and methods of generating the same
DE60332556D1 (de) Cytokine und cytokinrezeptoren mit reduzierter immunogenität
ATE533113T1 (de) Verfahren zur herstellung von immunogenen zusammensetzungen aus variablen peptidepitopen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties