ATE534634T1 - 2-phenyl-4-cyclopropyl-pyrimidinderivate - Google Patents

2-phenyl-4-cyclopropyl-pyrimidinderivate

Info

Publication number: ATE534634T1
Authority: AT; Austria
Prior art keywords: cyclopropyl; phenyl; pyrimidine derivatives; pyrimidine; derivatives
Prior art date: 2008-04-11

Application number

AT09730987T

Other languages

English (en)

Inventor

Eva Caroff

Emmanuel Meyer

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-11

Filing date

2009-04-09

Publication date

2011-12-15

2009-04-09 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE534634T1 publication Critical patent/ATE534634T1/de

Links

VVSVMCMSJARUID-UHFFFAOYSA-N 4-cyclopropyl-2-phenylpyrimidine Chemical class C1CC1C1=CC=NC(C=2C=CC=CC=2)=N1 VVSVMCMSJARUID-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT09730987T 2008-04-11 2009-04-09 2-phenyl-4-cyclopropyl-pyrimidinderivate ATE534634T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2008051389		2008-04-11
PCT/IB2009/051498 WO2009125365A1 (en)	2008-04-11	2009-04-09	2-phenyl-4-cyclopropyl-pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
ATE534634T1 true ATE534634T1 (de)	2011-12-15

Family

ID=40790423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT09730987T ATE534634T1 (de)	2008-04-11	2009-04-09	2-phenyl-4-cyclopropyl-pyrimidinderivate

Country Status (17)

Country	Link
US (1)	US8466156B2 (de)
EP (1)	EP2283011B1 (de)
JP (1)	JP5374578B2 (de)
KR (1)	KR101610417B1 (de)
CN (1)	CN101998953B (de)
AR (1)	AR071653A1 (de)
AT (1)	ATE534634T1 (de)
AU (1)	AU2009235123A1 (de)
CA (1)	CA2719569C (de)
ES (1)	ES2376820T3 (de)
IL (1)	IL208548A0 (de)
MA (1)	MA32277B1 (de)
MX (1)	MX2010010932A (de)
NZ (1)	NZ589169A (de)
TW (1)	TW200944516A (de)
WO (1)	WO2009125365A1 (de)
ZA (1)	ZA201008052B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200640877A (en)	2005-04-28	2006-12-01	Actelion Pharmaceuticals Ltd	Pyrimidine derivatives
AR063258A1 (es)	2006-10-13	2009-01-14	Actelion Pharmaceuticals Ltd	Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
AR063518A1 (es)	2006-10-25	2009-01-28	Actelion Pharmaceuticals Ltd	Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis
ES2388958T3 (es)	2007-11-29	2012-10-22	Actelion Pharmaceuticals Ltd.	Derivados de acido fosfonico y su uso como antagonista del receptor P2Y12
AR071652A1 (es)	2008-04-11	2010-07-07	Actelion Pharmaceuticals Ltd	Derivados 2- fenil-piridina substituidos
KR101694563B1 (ko)	2009-04-08	2017-01-09	액테리온 파마슈티칼 리미티드	Ａｄｐ 수용체 길항제로서 6-(3-아자-비시클로〔3.1.0〕헥스-3-일)-2-페닐-피리미딘
EP2421859B1 (de)	2009-04-22	2014-04-09	Actelion Pharmaceuticals Ltd.	Thiazolderivate und ihre verwendung als p2y12 rezeptor antagonisten
WO2013033178A1 (en)	2011-08-30	2013-03-07	University Of Utah Research Foundation	Methods and compositions for treating nephrogenic diabetes insipidus
HUE057772T2 (hu)	2016-09-22	2022-06-28	Idorsia Pharmaceuticals Ltd	Kristályos formák
US11179390B2 (en)	2017-03-15	2021-11-23	Idorsia Pharmaceuticals Ltd	Subcutaneous administration of a P2Y12 receptor antagonist

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2020437A1 (en)	1989-07-05	1991-01-06	Yoshihide Fuse	Cinnamamide derivative
JPH05303586A (ja)	1992-04-07	1993-11-16	Nec Corp	高精度連立一次方程式解析装置
DE60022508T2 (de)	1999-06-14	2006-06-08	Eli Lilly And Co., Indianapolis	Inhibitoren von serin proteasen
US6861424B2 (en)	2001-06-06	2005-03-01	Schering Aktiengesellschaft	Platelet adenosine diphosphate receptor antagonists
OA12970A (en)	2002-12-11	2006-10-13	Schering Ag	2-aminocarbonyl-quinoline compounds as platelet adenosine diphosphate receptor antagonists.
CA2521313A1 (en)	2003-04-09	2004-10-28	Wyeth	Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists
TW200640877A (en)	2005-04-28	2006-12-01	Actelion Pharmaceuticals Ltd	Pyrimidine derivatives
WO2007046075A1 (en)	2005-10-21	2007-04-26	Actelion Pharmaceuticals Ltd	Piperazine derivatives as antimalarial agents
AR063258A1 (es)	2006-10-13	2009-01-14	Actelion Pharmaceuticals Ltd	Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
AR063518A1 (es)	2006-10-25	2009-01-28	Actelion Pharmaceuticals Ltd	Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis
KR20100015886A (ko)	2007-04-23	2010-02-12	사노피-아벤티스	Ｐ2ｙ12 길항제로서의 퀴놀린-카복스아미드 유도체
ES2388958T3 (es)	2007-11-29	2012-10-22	Actelion Pharmaceuticals Ltd.	Derivados de acido fosfonico y su uso como antagonista del receptor P2Y12
EP2238128B1 (de)	2007-12-26	2012-08-22	Sanofi	Heterocyclische pyrazolcarboxamide als p2y12-antagonisten
WO2009080227A2 (en)	2007-12-26	2009-07-02	Sanofi-Aventis	Pyrazole-carboxamide derivatives as p2y12 antagonists
AR071652A1 (es)	2008-04-11	2010-07-07	Actelion Pharmaceuticals Ltd	Derivados 2- fenil-piridina substituidos
KR101694563B1 (ko)	2009-04-08	2017-01-09	액테리온 파마슈티칼 리미티드	Ａｄｐ 수용체 길항제로서 6-(3-아자-비시클로〔3.1.0〕헥스-3-일)-2-페닐-피리미딘
EP2421859B1 (de)	2009-04-22	2014-04-09	Actelion Pharmaceuticals Ltd.	Thiazolderivate und ihre verwendung als p2y12 rezeptor antagonisten

2009
- 2009-04-08 AR ARP090101256A patent/AR071653A1/es unknown
- 2009-04-09 CA CA2719569A patent/CA2719569C/en active Active
- 2009-04-09 JP JP2011503537A patent/JP5374578B2/ja not_active Expired - Fee Related
- 2009-04-09 WO PCT/IB2009/051498 patent/WO2009125365A1/en not_active Ceased
- 2009-04-09 KR KR1020107024690A patent/KR101610417B1/ko not_active Expired - Fee Related
- 2009-04-09 EP EP09730987A patent/EP2283011B1/de active Active
- 2009-04-09 AU AU2009235123A patent/AU2009235123A1/en not_active Abandoned
- 2009-04-09 ES ES09730987T patent/ES2376820T3/es active Active
- 2009-04-09 NZ NZ589169A patent/NZ589169A/en not_active IP Right Cessation
- 2009-04-09 US US12/936,664 patent/US8466156B2/en not_active Expired - Fee Related
- 2009-04-09 CN CN200980112591.9A patent/CN101998953B/zh not_active Expired - Fee Related
- 2009-04-09 MX MX2010010932A patent/MX2010010932A/es unknown
- 2009-04-09 AT AT09730987T patent/ATE534634T1/de active
- 2009-04-10 TW TW098112082A patent/TW200944516A/zh unknown
2010
- 2010-10-07 IL IL208548A patent/IL208548A0/en unknown
- 2010-11-01 MA MA33296A patent/MA32277B1/fr unknown
- 2010-11-10 ZA ZA2010/08052A patent/ZA201008052B/en unknown

Also Published As

Publication number	Publication date
CN101998953B (zh)	2014-12-17
TW200944516A (en)	2009-11-01
AU2009235123A1 (en)	2009-10-15
IL208548A0 (en)	2010-12-30
AR071653A1 (es)	2010-07-07
MA32277B1 (fr)	2011-05-02
US8466156B2 (en)	2013-06-18
US20110028484A1 (en)	2011-02-03
EP2283011B1 (de)	2011-11-23
JP5374578B2 (ja)	2013-12-25
CA2719569C (en)	2016-06-07
KR20100132541A (ko)	2010-12-17
CA2719569A1 (en)	2009-10-15
ZA201008052B (en)	2012-04-25
JP2011516539A (ja)	2011-05-26
KR101610417B1 (ko)	2016-04-07
CN101998953A (zh)	2011-03-30
NZ589169A (en)	2012-06-29
WO2009125365A1 (en)	2009-10-15
EP2283011A1 (de)	2011-02-16
ES2376820T3 (es)	2012-03-20
MX2010010932A (es)	2010-11-05

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