BRPI0914649A2 - Piprazolo-quinazolinas - Google Patents

Piprazolo-quinazolinas

Info

Publication number
BRPI0914649A2
BRPI0914649A2 BRPI0914649-0A BRPI0914649A BRPI0914649A2 BR PI0914649 A2 BRPI0914649 A2 BR PI0914649A2 BR PI0914649 A BRPI0914649 A BR PI0914649A BR PI0914649 A2 BRPI0914649 A2 BR PI0914649A2
Authority
BR
Brazil
Prior art keywords
piprazole
quinazolines
Prior art date
Application number
BRPI0914649-0A
Other languages
English (en)
Inventor
Mariana Caldarelli
Helena Posteri
Mauro Angiolini
Riccardo Colombo
Teresa Disingrini
Stefano Nuvoloni
Matteo Salsa
Marco Silvagni
Original Assignee
Nerviano Medical Science S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40887152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0914649(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nerviano Medical Science S R L filed Critical Nerviano Medical Science S R L
Publication of BRPI0914649A2 publication Critical patent/BRPI0914649A2/pt
Publication of BRPI0914649B1 publication Critical patent/BRPI0914649B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0914649-0A 2008-06-26 2009-06-17 Pirazolo-quinazolinas BRPI0914649B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08159114.1 2008-06-26
EP08159114 2008-06-26
PCT/EP2009/057512 WO2009156315A1 (en) 2008-06-26 2009-06-17 Pyrazolo-quinazolines

Publications (2)

Publication Number Publication Date
BRPI0914649A2 true BRPI0914649A2 (pt) 2015-07-07
BRPI0914649B1 BRPI0914649B1 (pt) 2021-07-06

Family

ID=40887152

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914649-0A BRPI0914649B1 (pt) 2008-06-26 2009-06-17 Pirazolo-quinazolinas

Country Status (20)

Country Link
US (1) US8846701B2 (pt)
EP (1) EP2303891B1 (pt)
JP (1) JP5542133B2 (pt)
CN (1) CN102076689B (pt)
AR (2) AR072374A1 (pt)
AU (1) AU2009264431B2 (pt)
BR (1) BRPI0914649B1 (pt)
CA (1) CA2729436C (pt)
CL (1) CL2010001538A1 (pt)
CY (1) CY1117595T1 (pt)
DK (1) DK2303891T3 (pt)
EA (1) EA020703B9 (pt)
ES (1) ES2572360T3 (pt)
HR (1) HRP20160243T1 (pt)
HU (1) HUE027527T2 (pt)
MX (1) MX2010013843A (pt)
PL (1) PL2303891T3 (pt)
SI (1) SI2303891T1 (pt)
TW (1) TWI464172B (pt)
WO (1) WO2009156315A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5400791B2 (ja) * 2007-12-04 2014-01-29 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 置換ジヒドロプテリジン−６−オン誘導体、その製造方法及びキナーゼ阻害剤としてのその使用
US8772280B2 (en) 2009-03-27 2014-07-08 Nerviano Medical Sciences S.R.L. N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors
ES2539972T3 (es) 2010-07-30 2015-07-07 Nerviano Medical Sciences S.R.L. Isoxazolo-quinazolinas como moduladores de la actividad de proteina cinasa
UA113280C2 (xx) 2010-11-11 2017-01-10 АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
BR112013008527A2 (pt) * 2010-12-17 2016-07-12 Nerviano Medical Sciences Srl derivados de pirazolo-quinazolina substituídos como inibidores de cinase
ES2544609T3 (es) * 2010-12-17 2015-09-02 Bayer Intellectual Property Gmbh Imidazopirazinas 2-sustituidas para uso como inhibidores de Mps-1 y TTK en el tratamiento de trastornos hiper-proliferativos
HUE032643T2 (en) * 2011-01-21 2017-10-30 Basilea Pharmaceutica Ag Use of BUBR1 as a biomarker for response to furazanobenzimidazoles
US8916577B2 (en) * 2011-01-26 2014-12-23 Nerviano Medical Sciences S.R.L. Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
RU2591191C2 (ru) * 2011-01-26 2016-07-10 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Трициклические пирроло производные, способ их получения и их применение в качестве ингибиторов киназы
WO2012139930A1 (en) 2011-04-11 2012-10-18 Nerviano Medical Sciences S.R.L. Pyrazolyl-pyrimidine derivatives as kinase inhibitors
CN104379563B (zh) * 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
WO2014020041A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
CN103130810B (zh) * 2013-03-11 2015-02-25 河南师范大学 一种吡唑并[1,5-c]喹唑啉类化合物的合成方法
DK3129374T3 (en) * 2014-04-07 2019-04-08 Netherlands Translational Res Center B V (5,6-dihydro) pyrimido [4,5-e] INDOLIZINER
EP3283642B1 (en) 2015-04-17 2023-10-11 Netherlands Translational Research Center Holding B.V. Prognostic biomarkers for ttk inhibitor chemotherapy
UY37778A (es) * 2017-06-29 2019-01-31 Servier Lab NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN
AR112217A1 (es) * 2017-06-30 2019-10-02 Servier Lab Una combinación de un inhibidor de mps1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta
CN110997678B (zh) * 2017-07-11 2023-02-21 内尔维亚诺医疗科学公司 作为胆碱激酶抑制剂的吡唑并喹唑啉衍生物
JP7233743B2 (ja) * 2017-08-11 2023-03-07 晟科薬業（江蘇）有限公司 プロテインキナーゼ阻害剤としての１ｈ－ピラゾロ［４，３－ｈ］キナゾリン系化合物
JP2023519892A (ja) * 2020-03-27 2023-05-15 ランドス バイオファーマ インコーポレイテッド Ｐｌｘｄｃ２リガンド
WO2022111634A1 (zh) * 2020-11-26 2022-06-02 成都赛璟生物医药科技有限公司 杂芳基并喹唑啉类化合物作为蛋白激酶抑制剂
CN114685520B (zh) * 2020-12-25 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
CN116528871A (zh) * 2020-12-31 2023-08-01 恒元生物医药科技(苏州)有限公司 一种吡唑并喹唑啉类化合物、其制备方法及应用
AU2022408915B2 (en) * 2021-12-15 2026-05-14 Sillajen, Inc. Methods of treating neoplastic diseases
WO2025021587A1 (en) 2023-07-21 2025-01-30 Nerviano Medical Sciences S.R.L. Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof
EP4506015A1 (en) 2023-08-09 2025-02-12 Nerviano Medical Sciences S.r.l. Combination of a mps1 inhibitor and an antibody drug conjugate
CN119060058A (zh) * 2024-08-21 2024-12-03 武汉九州钰民医药科技有限公司 一种甲苯磺酸利特昔替尼的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5330698A (en) * 1996-12-23 1998-07-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
WO2003070706A1 (en) * 2002-02-19 2003-08-28 Pharmacia Corporation Tricyclic pyrazole derivatives for the treatment of inflammation
EA010904B1 (ru) * 2003-05-22 2008-12-30 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
HUE024105T2 (hu) * 2006-12-21 2016-02-29 Nerviano Medical Sciences Srl Szubsztituált pirazolo-kinazolin származékok, eljárás azok elõállítására és kináz inhibitorként történõ alkalmazásuk

Also Published As

Publication number Publication date
CN102076689B (zh) 2014-10-15
AU2009264431A1 (en) 2009-12-30
CA2729436C (en) 2016-08-09
EP2303891B1 (en) 2016-02-17
SI2303891T1 (sl) 2016-06-30
AR072374A1 (es) 2010-08-25
TW201004960A (en) 2010-02-01
EA020703B1 (ru) 2015-01-30
EP2303891A1 (en) 2011-04-06
AU2009264431A2 (en) 2011-02-17
CN102076689A (zh) 2011-05-25
HUE027527T2 (en) 2016-10-28
PL2303891T3 (pl) 2016-08-31
MX2010013843A (es) 2011-01-21
JP2011525516A (ja) 2011-09-22
CA2729436A1 (en) 2009-12-30
EA201170090A1 (ru) 2011-08-30
AR113818A2 (es) 2020-06-17
HK1154383A1 (en) 2012-04-20
HRP20160243T1 (hr) 2016-04-08
EA020703B9 (ru) 2015-12-30
AU2009264431B2 (en) 2013-11-07
US20110105542A1 (en) 2011-05-05
CY1117595T1 (el) 2017-04-26
ES2572360T3 (es) 2016-05-31
DK2303891T3 (en) 2016-05-30
WO2009156315A1 (en) 2009-12-30
US8846701B2 (en) 2014-09-30
CL2010001538A1 (es) 2012-02-03
BRPI0914649B1 (pt) 2021-07-06
JP5542133B2 (ja) 2014-07-09
TWI464172B (zh) 2014-12-11

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Legal Events

Date Code Title Description
B25C Requirement related to requested transfer of rights

Owner name: NERVIANO MEDICAL SCIENCE S.R.L. (IT)

B25A Requested transfer of rights approved

Owner name: LES LABORATOIRES SERVIER (FR)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/06/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B25A Requested transfer of rights approved

Owner name: NERVIANO MEDICAL SCIENCES S.R.L. (IT)