ATE534659T1 - Biosynthetische gencluster für lantibiotikum aus a. garbadinensis und a. liguriae - Google Patents

Biosynthetische gencluster für lantibiotikum aus a. garbadinensis und a. liguriae

Info

Publication number
ATE534659T1
ATE534659T1 AT07704921T AT07704921T ATE534659T1 AT E534659 T1 ATE534659 T1 AT E534659T1 AT 07704921 T AT07704921 T AT 07704921T AT 07704921 T AT07704921 T AT 07704921T AT E534659 T1 ATE534659 T1 AT E534659T1
Authority
AT
Austria
Prior art keywords
actagardine
biosynthetic gene
garbadinensis
liguriae
lantibiotics
Prior art date
Application number
AT07704921T
Other languages
English (en)
Inventor
Steven Boakes
Bargallo Jesus Cortes
Michael Dawson
Original Assignee
Novacta Biosystems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacta Biosystems Ltd filed Critical Novacta Biosystems Ltd
Application granted granted Critical
Publication of ATE534659T1 publication Critical patent/ATE534659T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/365Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/045Actinoplanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT07704921T 2006-01-17 2007-01-17 Biosynthetische gencluster für lantibiotikum aus a. garbadinensis und a. liguriae ATE534659T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0600928.6A GB0600928D0 (en) 2006-01-17 2006-01-17 Improvements relating to lantibiotics
PCT/GB2007/000138 WO2007083112A2 (en) 2006-01-17 2007-01-17 Lantibiotic biosynthetic gene clusters from a. garbadinensis and a. liguriae

Publications (1)

Publication Number Publication Date
ATE534659T1 true ATE534659T1 (de) 2011-12-15

Family

ID=35998187

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07704921T ATE534659T1 (de) 2006-01-17 2007-01-17 Biosynthetische gencluster für lantibiotikum aus a. garbadinensis und a. liguriae

Country Status (20)

Country Link
US (3) US7989416B2 (de)
EP (2) EP1979375B9 (de)
JP (1) JP5219837B2 (de)
KR (1) KR101573536B1 (de)
CN (1) CN101389641B (de)
AT (1) ATE534659T1 (de)
AU (1) AU2007206769B2 (de)
BR (1) BRPI0706525A2 (de)
CA (1) CA2637315A1 (de)
CY (1) CY1112559T1 (de)
DK (1) DK1979375T3 (de)
ES (1) ES2378090T3 (de)
GB (1) GB0600928D0 (de)
IL (1) IL192446A0 (de)
MX (1) MX2008009047A (de)
NZ (1) NZ569486A (de)
PL (1) PL1979375T3 (de)
PT (1) PT1979375E (de)
SI (1) SI1979375T1 (de)
WO (1) WO2007083112A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714030D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
CA2749278A1 (en) * 2009-01-14 2010-07-22 Novacta Biosystems Limited Deoxyactagardine derivatives
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
CN102388060B (zh) * 2009-02-04 2014-09-10 诺瓦克塔生物系统有限公司 阿肽加定衍生物
CA2789164A1 (en) 2010-02-02 2011-08-11 Novacta Biosystems Limited Lantibiotic salts
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
EA201291461A1 (ru) 2010-07-14 2013-08-30 Новакта Биосистемс Лимитед Состав, содержащий лантибиотик типа b
GB201013508D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013507D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
GB201013509D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
EP2925342A4 (de) * 2012-11-30 2016-07-06 Naicons Srl Neue lantibiotische derivate und verfahren zu deren herstellung
CN103483433B (zh) * 2013-09-10 2015-05-27 中国科学院微生物研究所 一种新型高效的羊毛硫细菌素cerecidin及其应用
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途
CN113777306A (zh) * 2020-06-09 2021-12-10 首都医科大学附属北京世纪坛医院 尿液果糖二磷酸醛缩酶b及其多肽片段在烧伤中的应用
CN115637247B (zh) * 2021-07-20 2026-02-24 中国科学院微生物研究所 生物氧化脱硫的盐单胞菌工程菌株及其全细胞催化脱硫方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
GB8507528D0 (en) 1985-03-22 1985-05-01 Lepetit Spa Basis monocarboxyamide derivatives
US5304540A (en) 1988-06-22 1994-04-19 Applied Microbiology, Inc. Pharmaceutical bacteriocin compositions and methods for using the same
IN167138B (de) 1988-08-17 1990-09-01 Hoechst India
GB8926639D0 (en) 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
IT1260505B (it) 1992-06-01 1996-04-09 Poli Ind Chimica Spa Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon
IL107887A (en) 1992-12-08 2003-07-06 Ambi Inc Stabilized lanthionine containing bacteriocin compositions
US5512269A (en) 1993-06-09 1996-04-30 Burroughs Wellcome, Co. Method of treating retained pulmonary secretions
EP0700998B1 (de) 1994-09-12 2003-11-26 Aventis Pharma Deutschland GmbH Rekombinantes Mersacidin und Verfahren zu seiner Herstellung
NZ311535A (en) 1995-06-23 2001-05-25 Ambi Inc A method for the control of antibiotic-resistant gram positive bacteria and treatment of infection
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US5958873A (en) 1997-06-09 1999-09-28 University Of Cincinnati Oral formulation for treatment of bacteria-induced diseases of the colon
US5985823A (en) 1997-06-09 1999-11-16 Ambi Inc. Method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon
DE19745583A1 (de) * 1997-10-15 1999-04-22 Hoechst Marion Roussel De Gmbh Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben
US6569830B1 (en) 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
KR100786927B1 (ko) 2000-06-28 2007-12-17 스미스클라인비이참피이엘시이 습식 분쇄방법
GB0110432D0 (en) * 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
WO2002103010A1 (en) 2001-06-14 2002-12-27 Plant Bioscience Limited Methods and materials for targeted gene disruption in actinomycete bacteria
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
AU2003275129A1 (en) 2002-10-10 2004-05-04 Molichem Medicines, Inc. Nucleic acids encoding duramycin
US7351687B2 (en) 2003-07-18 2008-04-01 Vicuron Pharmaceuticals, Inc. Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
ES2281808T3 (es) 2003-07-18 2007-10-01 Vicuron Pharmaceuticals, Inc. Antibiotico 107891, sus factores a1 y a2, composiciones y sales farmaceuticamente aceptables y uso del mismo.
WO2005079508A2 (en) * 2004-02-17 2005-09-01 Cancervax Corporation Method and composition for angiogenesis inhibition
GB0406870D0 (en) 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
WO2007036706A1 (en) 2005-09-27 2007-04-05 Novacta Biosystems Limited Variants of the lantibiotic mersacidin and their use
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
CN101595133B (zh) 2006-10-27 2012-11-14 比利时胶囊公司 羟丙基甲基纤维素硬胶囊及制备方法
CA2690267A1 (en) 2007-06-12 2008-12-18 The University Of British Columbia Small cationic antimicrobial peptides
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
KR20110086582A (ko) 2008-11-24 2011-07-28 센티넬라 파마세티컬즈, 인크. 항균활성이 강화된 란티바이오틱 카르복시아미드 유도체
CA2749278A1 (en) 2009-01-14 2010-07-22 Novacta Biosystems Limited Deoxyactagardine derivatives
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
CN102388060B (zh) 2009-02-04 2014-09-10 诺瓦克塔生物系统有限公司 阿肽加定衍生物
EP2216937A1 (de) 2009-02-10 2010-08-11 Alcatel Lucent Alarmbenachrichtigung zwischen dem Gerät auf Kundengelände und einem ferngesteuerten Verwaltungsserver

Also Published As

Publication number Publication date
GB0600928D0 (en) 2006-02-22
CA2637315A1 (en) 2007-07-26
KR101573536B1 (ko) 2015-12-11
DK1979375T3 (da) 2012-03-19
SI1979375T1 (sl) 2012-03-30
PT1979375E (pt) 2012-03-06
US8465947B2 (en) 2013-06-18
US20110306091A1 (en) 2011-12-15
EP1979375B9 (de) 2012-05-09
US7989416B2 (en) 2011-08-02
JP2009523777A (ja) 2009-06-25
BRPI0706525A2 (pt) 2011-03-29
EP1979375A2 (de) 2008-10-15
US20100048459A1 (en) 2010-02-25
NZ569486A (en) 2011-07-29
IL192446A0 (en) 2008-12-29
ES2378090T3 (es) 2012-04-04
AU2007206769B2 (en) 2013-06-20
MX2008009047A (es) 2008-12-18
CN101389641A (zh) 2009-03-18
EP1979375B1 (de) 2011-11-23
JP5219837B2 (ja) 2013-06-26
USRE45003E1 (en) 2014-07-08
WO2007083112A2 (en) 2007-07-26
AU2007206769A1 (en) 2007-07-26
EP2189472A1 (de) 2010-05-26
WO2007083112A3 (en) 2008-05-08
PL1979375T3 (pl) 2012-04-30
CY1112559T1 (el) 2016-02-10
CN101389641B (zh) 2013-06-05
KR20080086517A (ko) 2008-09-25

Similar Documents

Publication Publication Date Title
ATE534659T1 (de) Biosynthetische gencluster für lantibiotikum aus a. garbadinensis und a. liguriae
WO2010075983A8 (en) Process for the production of bivalirudin
ATE554096T1 (de) Verfahren zum erhöhen der resistenz gegen sojabohnenrost in transgenen pflanzen
ATE453670T1 (de) Acrylierte hyaluronsäure
EP2041274A4 (de) Herstellung eines kurzkettigen flüchtigen kohlenwasserstoffes anhand gentechnisch manipulierter mikroalgen, cyanobakterien oder bakterien
CR9866A (es) Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos
ATE451409T1 (de) Aminosäurefunktionelle siloxane, herstellungsverfahren und anwendungen
SMT201700529T1 (it) Metodi per un'aumentata produzione di proteine
ZA200701500B (en) Process for the production of low sulfur, low olefin gasoline
WO2008146745A1 (ja) 新規なリゾホスファチジン酸アシル基転移酵素遺伝子
DE602007013181D1 (de) Spannungspufferungsgehäuse für ein halbleiterbauelement
ZA200710943B (en) Autoactivated resistance protein
PL2333076T3 (pl) Żywność o niskiej zawartości akrylamidu
MY150589A (en) Thioetherification processes for the removal of mercaptans from gas streams
PT1962578E (pt) Plantas de melão resistentes a closterovirus
MY187548A (en) Leaf-specific chlorophyll a/b binding protein promoter
EP1989306A4 (de) Pflanzliche eizellentranskriptionskontrollsequenzen
DK1948689T3 (da) Højaktivitetsvækstfaktormutanter
PL1797022T3 (pl) Sposób oczyszczania znakowanych radioaktywnie produktów przy użyciu odczynników zmiatających zawieszonych na stałym nośniku
ATE402610T1 (de) Legenest für geflügel
WO2009054511A1 (ja) 新規なatp:クエン酸リアーゼ遺伝子
WO2007144492A3 (fr) Peptides a activite anti-proliferative
ATE509017T1 (de) Antibiotikum und verfahren zur herstellung
EP1888599A4 (de) Verfahren zur kontinuierlichen herstellung von polyhedralen oligomeren olefin-silsesquioxan-käfigen
PL1945760T3 (pl) Czynnik białkowy zwiększający produktywność, nowe linie komórek i ich zastosowania