CR9866A - Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos - Google Patents

Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos

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Publication number
CR9866A
CR9866A CR9866A CR9866A CR9866A CR 9866 A CR9866 A CR 9866A CR 9866 A CR9866 A CR 9866A CR 9866 A CR9866 A CR 9866A CR 9866 A CR9866 A CR 9866A
Authority
CR
Costa Rica
Prior art keywords
novedosos
bicicloalquilo
psychotic
aza
derived
Prior art date
Application number
CR9866A
Other languages
English (en)
Inventor
Dominik Feuerbach
Mathias Frederiksen
Martin Marzi
Bernard Lucien Roy
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR9866A publication Critical patent/CR9866A/es

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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
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Abstract

La presente invencion proporciona un compuesto de la formual (I), en donde X, R, Y, D, A, y B, son como se definen en la presente. Estos compuestos son adecuados como agonistas de nic-alfa 7, y como tales, para el tratamiento de trastornos psicoticos o neurodegenerativos.
CR9866A 2005-10-21 2008-04-04 Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos CR9866A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0521508.2A GB0521508D0 (en) 2005-10-21 2005-10-21 Organic compounds

Publications (1)

Publication Number Publication Date
CR9866A true CR9866A (es) 2008-06-09

Family

ID=35458483

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9866A CR9866A (es) 2005-10-21 2008-04-04 Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos

Country Status (23)

Country Link
US (1) US8173667B2 (es)
EP (1) EP1940832B1 (es)
JP (1) JP4838313B2 (es)
KR (1) KR101026330B1 (es)
CN (1) CN101268071A (es)
AT (1) ATE536354T1 (es)
AU (1) AU2006303453B2 (es)
BR (1) BRPI0617508A2 (es)
CA (1) CA2622356A1 (es)
CR (1) CR9866A (es)
EC (1) ECSP088369A (es)
ES (1) ES2376890T3 (es)
GB (1) GB0521508D0 (es)
IL (1) IL190394A0 (es)
MA (1) MA29870B1 (es)
MY (1) MY143250A (es)
NO (1) NO20082266L (es)
NZ (1) NZ567081A (es)
RU (1) RU2008119692A (es)
TN (1) TNSN08174A1 (es)
UA (1) UA95257C2 (es)
WO (1) WO2007045478A1 (es)
ZA (1) ZA200802725B (es)

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GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US20120157464A1 (en) 2009-07-23 2012-06-21 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
MX2013008704A (es) * 2011-01-27 2013-08-21 Novartis Ag Uso de activadores del receptor de acetil-colina nicotinico alfa-7.
MX2013010698A (es) 2011-03-18 2014-02-17 Novartis Ag Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
CA2852268C (en) 2011-10-20 2020-08-25 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
CA2894384C (en) 2012-12-11 2018-03-06 Novartis Ag Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
KR101879921B1 (ko) * 2013-01-15 2018-07-18 노파르티스 아게 기면증의 치료를 위한 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
ES2865736T3 (es) * 2013-01-15 2021-10-15 Novartis Ag Uso de agonistas del receptor de acetilcolina nicotínico alfa 7
JP6338223B2 (ja) 2013-01-15 2018-06-06 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アゴニストの使用
EP3233087B1 (en) 2014-12-16 2019-10-02 Axovant Sciences GmbH Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
JP2018516973A (ja) 2015-06-10 2018-06-28 フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物
WO2017027600A1 (en) * 2015-08-12 2017-02-16 Forum Pharmaceuticals, Inc. GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
US11299481B2 (en) 2017-10-20 2022-04-12 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
EP3703680B1 (en) 2017-10-31 2024-05-15 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
JP7352294B2 (ja) * 2018-02-02 2023-09-28 ヴァンダービルト ユニバーシティー ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3

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EP1940832B1 (en) 2011-12-07
BRPI0617508A2 (pt) 2011-07-26
AU2006303453A1 (en) 2007-04-26
CN101268071A (zh) 2008-09-17
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NZ567081A (en) 2011-05-27
UA95257C2 (ru) 2011-07-25
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IL190394A0 (en) 2008-11-03
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MY143250A (en) 2011-04-15
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