ATE534662T1 - Methode zur identifizierung einer nukeinsäure kodierend für eine hemopexin-ähnliche struktur mit spezifischer bindung zu einem vorgegebenen molekul - Google Patents

Methode zur identifizierung einer nukeinsäure kodierend für eine hemopexin-ähnliche struktur mit spezifischer bindung zu einem vorgegebenen molekul

Info

Publication number
ATE534662T1
ATE534662T1 AT06700410T AT06700410T ATE534662T1 AT E534662 T1 ATE534662 T1 AT E534662T1 AT 06700410 T AT06700410 T AT 06700410T AT 06700410 T AT06700410 T AT 06700410T AT E534662 T1 ATE534662 T1 AT E534662T1
Authority
AT
Austria
Prior art keywords
specific binding
nucein
hemopexin
identifying
acid encoding
Prior art date
Application number
AT06700410T
Other languages
English (en)
Inventor
Martin Lanzendoerfer
Michael Schraeml
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE534662T1 publication Critical patent/ATE534662T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • C12N9/6491Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT06700410T 2005-01-03 2006-01-02 Methode zur identifizierung einer nukeinsäure kodierend für eine hemopexin-ähnliche struktur mit spezifischer bindung zu einem vorgegebenen molekul ATE534662T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05000013 2005-01-03
PCT/EP2006/000004 WO2006072563A2 (en) 2005-01-03 2006-01-02 Hemopexin-like structure as polypeptide-scaffold

Publications (1)

Publication Number Publication Date
ATE534662T1 true ATE534662T1 (de) 2011-12-15

Family

ID=34933192

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06700410T ATE534662T1 (de) 2005-01-03 2006-01-02 Methode zur identifizierung einer nukeinsäure kodierend für eine hemopexin-ähnliche struktur mit spezifischer bindung zu einem vorgegebenen molekul

Country Status (9)

Country Link
US (1) US20090054252A1 (de)
EP (2) EP1836223B1 (de)
JP (2) JP2008526186A (de)
CN (1) CN101098887B (de)
AT (1) ATE534662T1 (de)
CA (1) CA2589060A1 (de)
ES (1) ES2376586T3 (de)
SG (1) SG171481A1 (de)
WO (1) WO2006072563A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1930342B1 (de) * 2006-12-04 2012-01-25 Institut Pasteur Als Gerüst verwendeter OB-Fold zur Entwicklung neuer spezifischer Bindemittel
AU2013200275B2 (en) * 2006-12-04 2014-08-14 Centre National De La Recherche Scientifique OB-fold used as scaffold for engineering new specific binders
WO2012048291A2 (en) 2010-10-08 2012-04-12 Proteapex Therapeutics Llc Compositions and methods for inhibition of mmp:mmp-substrate interactions
RU2482856C2 (ru) 2011-08-05 2013-05-27 Общество С Ограниченной Ответственностью "Оксигон" Комплексное соединение 2-хлорпропионата цинка и 2-хлорпропионовой кислоты, фармацевтическая композиция для лечения заболеваний кожи, способ ее получения и способ лечения поражений кожи, ногтей и видимых слизистых
EP2922862B1 (de) 2012-11-22 2019-01-02 Factor Therapeutics Limited Komplexformierungsmodulierende wirkstoffe und verwendungen davon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725838A4 (de) * 1993-10-26 1997-02-26 United Biomedical Inc Strukturierte synthetische antigenbanken als diagnostika, impfstoffe und therapeutische mittel
AU738782B2 (en) * 1996-05-31 2001-09-27 Scripps Research Institute, The Methods and compositions useful for inhibition of alphavbeta5 mediated angiogenesis
WO2000023564A2 (en) * 1998-10-16 2000-04-27 Xencor, Inc. Protein design automation for protein libraries
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
JP2003521933A (ja) * 2000-02-10 2003-07-22 ゼンコー タンパク質ライブラリーに関するタンパク質設計オートメーション
ATE472609T1 (de) * 2001-04-26 2010-07-15 Amgen Mountain View Inc Kombinatorische bibliotheken von monomerdomänen
CA2456950A1 (en) * 2001-08-10 2003-02-20 Xencor Protein design automation for protein libraries

Also Published As

Publication number Publication date
EP2261243A2 (de) 2010-12-15
EP2261243A3 (de) 2011-08-10
JP2012143235A (ja) 2012-08-02
US20090054252A1 (en) 2009-02-26
JP2008526186A (ja) 2008-07-24
CN101098887B (zh) 2011-05-04
WO2006072563A2 (en) 2006-07-13
EP1836223A2 (de) 2007-09-26
CN101098887A (zh) 2008-01-02
EP1836223B1 (de) 2011-11-23
ES2376586T3 (es) 2012-03-15
CA2589060A1 (en) 2006-07-13
SG171481A1 (en) 2011-06-29
WO2006072563A3 (en) 2006-08-31

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