ATE534728T1 - Nestinexprimierende haarfollikelstammzellen - Google Patents

Nestinexprimierende haarfollikelstammzellen

Info

Publication number
ATE534728T1
ATE534728T1 AT02773519T AT02773519T ATE534728T1 AT E534728 T1 ATE534728 T1 AT E534728T1 AT 02773519 T AT02773519 T AT 02773519T AT 02773519 T AT02773519 T AT 02773519T AT E534728 T1 ATE534728 T1 AT E534728T1
Authority
AT
Austria
Prior art keywords
stem cells
hair follicle
nestin
follicle stem
implanted
Prior art date
Application number
AT02773519T
Other languages
English (en)
Inventor
Lingna Li
Meng Yang
Original Assignee
Anticancer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anticancer Inc filed Critical Anticancer Inc
Application granted granted Critical
Publication of ATE534728T1 publication Critical patent/ATE534728T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C12N5/0628—Hair stem cells; Hair progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
    • C12N2506/092—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells from hair cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
AT02773519T 2001-09-20 2002-09-20 Nestinexprimierende haarfollikelstammzellen ATE534728T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32396301P 2001-09-20 2001-09-20
PCT/US2002/030027 WO2003024406A2 (en) 2001-09-20 2002-09-20 Nestin-expressing hair follicle stem cells

Publications (1)

Publication Number Publication Date
ATE534728T1 true ATE534728T1 (de) 2011-12-15

Family

ID=23261470

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02773519T ATE534728T1 (de) 2001-09-20 2002-09-20 Nestinexprimierende haarfollikelstammzellen

Country Status (9)

Country Link
US (2) US7666675B2 (de)
EP (2) EP2287290B1 (de)
JP (4) JP3978179B2 (de)
KR (3) KR101568055B1 (de)
CN (2) CN101407785B (de)
AT (1) ATE534728T1 (de)
AU (1) AU2002336742B2 (de)
CA (1) CA2460985C (de)
WO (1) WO2003024406A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666675B2 (en) * 2001-09-20 2010-02-23 Anticancer, Inc. Nestin-expressing hair follicle stem cells
DE10224982A1 (de) * 2002-06-05 2003-12-24 Rolf Hoffmann Mesenchymale Stammzellen des Haarfollikels und deren Verwendung
US8778308B2 (en) 2003-10-28 2014-07-15 Yasuyuki Amoh Angiogensis models using nestin-expressing stem cells to image nascent blood vessels
EP2329833A1 (de) * 2004-01-27 2011-06-08 The Hospital for Sick Children Research Institute Verfahren zur Herstellung und Verwendung von aus der Haut abgeleiteten Stammzellen
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
KR100668371B1 (ko) * 2004-12-30 2007-01-12 한훈 제대혈 유래 줄기세포를 이용한 대머리 치료
WO2006110806A2 (en) * 2005-04-12 2006-10-19 The Trustees Of The University Of Pennsylvania Multipotent adult stem cells
GB0509748D0 (en) * 2005-05-13 2005-06-22 Univ Glasgow Materials and methods relating to cell based therapies
US8206980B2 (en) * 2005-09-30 2012-06-26 Phoenixbio Co., Ltd. Method for cultivation of hair follicular dermal sheath cells
WO2007062386A2 (en) * 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
TW200803877A (en) * 2005-11-22 2008-01-16 Aderans Res Inst Inc Hair grafts derived from plucked hair
US20070253931A1 (en) * 2006-01-12 2007-11-01 Osiris Therapeutics, Inc. Use of mesenchymal stem cells for treating genetic diseases and disorders
US20080286249A1 (en) * 2006-01-12 2008-11-20 Varney Timothy R Use of mesenchymal stem cells for treating genetic diseases and disorders
US20070258956A1 (en) * 2006-05-02 2007-11-08 Biomet Manufacturing Corp. Methods and apparatus for promoting hair growth using adipose cell based therapies
KR100825864B1 (ko) * 2006-09-21 2008-04-28 부산대학교 산학협력단 피부 유래 줄기세포를 함유하는 신경질환 치료용세포치료제
CA2689484A1 (en) 2007-06-06 2008-12-11 The Hospital For Sick Children Skin-derived precursor cells and uses thereof
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US20110158961A1 (en) * 2008-05-09 2011-06-30 The University Court Of The University Of Glasgow Materials and methods relating to cell based therapies
US8748177B2 (en) 2008-09-30 2014-06-10 The Hospital For Sick Children Compositions for proliferation of cells and related methods
BRPI1011999A2 (pt) * 2009-06-05 2017-06-27 Skinrephair Ltd "uso de células-tronco de bainhas radiculares do cabelo e células precursoras de queratinócitos para a regeneração de pele envelhecida"
WO2011144901A1 (en) * 2010-05-20 2011-11-24 The University Of Newcastle Upon Tyne Expansion and directed differentiation of epidermal neural crest stem cells
CN101914495A (zh) * 2010-07-22 2010-12-15 吉林大学 用于体外大量扩增毛囊干细胞的培养方法
WO2012132265A1 (ja) 2011-03-25 2012-10-04 パナソニック株式会社 生体音処理装置および生体音処理方法
CN103146644B (zh) * 2013-02-27 2014-09-24 青岛农业大学 一种小鼠毛囊干细胞体外向原始生殖细胞分化的技术方法
CA3080691C (en) * 2017-11-10 2022-11-15 Regenesis Science Co., Ltd. Method for producing cultured cell, and method for producing therapeutic agent for spinal cord injury disease
SG11202011395RA (en) * 2018-06-22 2020-12-30 Skin2Neuron Pty Ltd Expansion and differentiation of neuronal precursor cells
US20210338568A1 (en) * 2018-08-31 2021-11-04 Shiseido Company, Ltd. Cosmetic method
JP2024503534A (ja) * 2021-01-22 2024-01-25 スキンツーニューロン ピーティーワイ エルティーディー ニューロン前駆体を製造する方法
CN118086207B (zh) * 2024-03-28 2024-11-29 海南一龄医疗产业发展有限公司 一种毛囊干细胞诱导分化为神经干细胞的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556783A (en) * 1991-03-27 1996-09-17 Trustees Of Univ. Of Penna Methods of culturing and modulating the growth of hair follicular stem cells
JP2000510582A (ja) 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
DE10056465A1 (de) * 2000-11-14 2002-07-18 Rosemarie Daig Zellkonstrukte erhältlich aus mesenchymalen Stammzellen und davon ableitbaren Zellen und ihre Verwendung
US7666675B2 (en) * 2001-09-20 2010-02-23 Anticancer, Inc. Nestin-expressing hair follicle stem cells

Also Published As

Publication number Publication date
EP1435787B1 (de) 2011-11-23
JP2009039125A (ja) 2009-02-26
JP2005502377A (ja) 2005-01-27
JP3978179B2 (ja) 2007-09-19
WO2003024406A2 (en) 2003-03-27
US20100159589A1 (en) 2010-06-24
EP2287290B1 (de) 2016-05-11
US8481318B2 (en) 2013-07-09
KR101568055B1 (ko) 2015-11-10
KR100973424B1 (ko) 2010-08-03
CA2460985A1 (en) 2003-03-27
KR20040070332A (ko) 2004-08-07
CN100420739C (zh) 2008-09-24
US7666675B2 (en) 2010-02-23
WO2003024406A3 (en) 2003-12-04
CA2460985C (en) 2016-01-05
JP2011067216A (ja) 2011-04-07
EP2287290A2 (de) 2011-02-23
KR20120112887A (ko) 2012-10-11
JP2007267739A (ja) 2007-10-18
AU2002336742B2 (en) 2008-01-03
KR101204188B1 (ko) 2012-11-23
KR20100040334A (ko) 2010-04-19
EP2287290A3 (de) 2011-06-01
US20030077823A1 (en) 2003-04-24
EP1435787A2 (de) 2004-07-14
EP1435787A4 (de) 2004-12-01
CN1589103A (zh) 2005-03-02
CN101407785A (zh) 2009-04-15
JP4810557B2 (ja) 2011-11-09
CN101407785B (zh) 2015-02-11

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