DK0948255T3 - Forbedret chondrogen differentiering af humane mesenkymale stamceller - Google Patents
Forbedret chondrogen differentiering af humane mesenkymale stamcellerInfo
- Publication number
- DK0948255T3 DK0948255T3 DK97952253T DK97952253T DK0948255T3 DK 0948255 T3 DK0948255 T3 DK 0948255T3 DK 97952253 T DK97952253 T DK 97952253T DK 97952253 T DK97952253 T DK 97952253T DK 0948255 T3 DK0948255 T3 DK 0948255T3
- Authority
- DK
- Denmark
- Prior art keywords
- stem cells
- mesenchymal stem
- human mesenchymal
- chondrogenic differentiation
- enhanced
- Prior art date
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 title abstract 2
- 230000009816 chondrogenic differentiation Effects 0.000 title 1
- 238000000338 in vitro Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 230000022159 cartilage development Effects 0.000 abstract 1
- 210000001612 chondrocyte Anatomy 0.000 abstract 1
- 230000002648 chondrogenic effect Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 235000021309 simple sugar Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/10—Mineral substrates
- C12N2533/14—Ceramic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3527496P | 1996-12-06 | 1996-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0948255T3 true DK0948255T3 (da) | 2006-03-06 |
Family
ID=21881662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97952253T DK0948255T3 (da) | 1996-12-06 | 1997-12-05 | Forbedret chondrogen differentiering af humane mesenkymale stamceller |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0948255B1 (da) |
| JP (1) | JP4531135B2 (da) |
| AT (1) | ATE306811T1 (da) |
| AU (1) | AU742638B2 (da) |
| CA (1) | CA2274122C (da) |
| DE (1) | DE69734395T2 (da) |
| DK (1) | DK0948255T3 (da) |
| ES (1) | ES2251746T3 (da) |
| WO (1) | WO1998032333A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69714035T2 (de) | 1997-08-14 | 2003-03-06 | Sulzer Innotec Ag, Winterthur | Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren |
| DE19842802A1 (de) * | 1998-09-18 | 2000-03-23 | Christoph Geissmaier | Kultursystem zur optimierten Anregung des Wachstums und der Differenzierung von Knorpelzellen und/oder von Knochenzellen, Verfahren zur Herstellung des Kultursystems sowie Produkt unter Verwendung des Kultursystems |
| US6582960B1 (en) | 1998-09-18 | 2003-06-24 | Massachusetts Institute Of Technology | Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering |
| IL142914A0 (en) * | 1998-11-09 | 2002-04-21 | Consorzio Per La Gestione Del | Serum free medium for chondrocyte-like cells |
| US6761887B1 (en) * | 1998-11-16 | 2004-07-13 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
| WO2000029552A1 (en) * | 1998-11-16 | 2000-05-25 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
| US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| DE10100305B4 (de) * | 2001-01-05 | 2007-10-25 | Cytonet Gmbh & Co. Kg | Knorpelzellmarker, Verfahren sowie Verwendungen desselben |
| WO2002067978A1 (en) * | 2001-02-23 | 2002-09-06 | Wyeth | Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp |
| US20040138285A1 (en) * | 2001-04-27 | 2004-07-15 | Makoto Okazaki | Chondrogenesis promoters |
| US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US7595043B2 (en) | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
| US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
| US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
| CA2469370C (en) | 2001-12-07 | 2014-07-08 | Macropore Biosurgery, Inc. | Adipose-derived cell processing unit |
| WO2005056072A1 (ja) * | 2003-12-11 | 2005-06-23 | Japan Science And Technology Agency | 擬微小重力環境下での骨髄細胞を用いた３次元軟骨組織構築方法 |
| CN101014699B (zh) * | 2004-08-24 | 2010-05-26 | 富士软件株式会社 | 去分化型软骨细胞向软骨细胞的再分化用培养基 |
| US7531355B2 (en) | 2005-07-29 | 2009-05-12 | The Regents Of The University Of California | Methods and compositions for smooth muscle reconstruction |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| JP5663841B2 (ja) * | 2009-02-23 | 2015-02-04 | 富士レビオ株式会社 | 骨細胞への分化誘導培地及び方法 |
| EP2424463B1 (en) | 2009-05-01 | 2016-12-28 | Bimini Technologies LLC | Systems, methods and compositions for optimizing tissue and cell enriched grafts |
| US8574614B2 (en) * | 2010-02-04 | 2013-11-05 | Hwa-Chang Liu | Surgical grafts for repairing chondral defects |
| CA2917674A1 (en) | 2012-08-10 | 2014-02-13 | The Trustees Of Columbia University In The City Of New York | Injectable brown adipose microtissues for treatment and prevention of obesity and diabetes |
| KR20150014369A (ko) | 2013-07-24 | 2015-02-06 | 주식회사 엠씨티티바이오 | 구슬형 연골세포 치료제의 제조방법 |
| ES3067580T3 (en) | 2013-12-06 | 2026-05-22 | Boehringer Ingelheim Veterinary Medicine Belgium Nv | Method and composition for inducing chondrogenesis or tenogenesis in mesenchymal stem cells |
| JP6864335B2 (ja) * | 2016-08-24 | 2021-04-28 | 国立大学法人 東京大学 | 軟骨細胞の製造方法 |
| CN114058570A (zh) * | 2021-11-29 | 2022-02-18 | 广东普罗凯融生物医药科技有限公司 | 一种用于诱导牙髓干细胞向软骨细胞分化的培养基及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| AU669850B2 (en) * | 1991-06-18 | 1996-06-27 | Osiris Therapeutics, Inc. | Monoclonal antibodies specific for marrow-derived mesenchymal cells |
| US5770209A (en) * | 1991-08-30 | 1998-06-23 | University Of South Florida | Acceleration of wound healing using connective tissue growth factor |
| US5466572A (en) * | 1992-09-03 | 1995-11-14 | Systemix, Inc. | High speed flow cytometric separation of viable cells |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5908782A (en) * | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| CA2237890C (en) * | 1995-11-16 | 2011-03-29 | Case Western Reserve University | In vitro chondrogenic induction of human mesenchymal stem cells |
-
1997
- 1997-12-05 CA CA002274122A patent/CA2274122C/en not_active Expired - Fee Related
- 1997-12-05 AU AU55911/98A patent/AU742638B2/en not_active Ceased
- 1997-12-05 DE DE69734395T patent/DE69734395T2/de not_active Expired - Lifetime
- 1997-12-05 ES ES97952253T patent/ES2251746T3/es not_active Expired - Lifetime
- 1997-12-05 DK DK97952253T patent/DK0948255T3/da active
- 1997-12-05 AT AT97952253T patent/ATE306811T1/de active
- 1997-12-05 JP JP52812098A patent/JP4531135B2/ja not_active Expired - Lifetime
- 1997-12-05 EP EP97952253A patent/EP0948255B1/en not_active Expired - Lifetime
- 1997-12-05 WO PCT/US1997/022022 patent/WO1998032333A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU742638B2 (en) | 2002-01-10 |
| EP0948255A4 (en) | 2002-10-23 |
| EP0948255B1 (en) | 2005-10-19 |
| CA2274122A1 (en) | 1998-07-30 |
| DE69734395T2 (de) | 2006-07-27 |
| ATE306811T1 (de) | 2005-11-15 |
| EP0948255A1 (en) | 1999-10-13 |
| ES2251746T3 (es) | 2006-05-01 |
| CA2274122C (en) | 2004-02-17 |
| JP2001512304A (ja) | 2001-08-21 |
| JP4531135B2 (ja) | 2010-08-25 |
| AU5591198A (en) | 1998-08-18 |
| WO1998032333A1 (en) | 1998-07-30 |
| DE69734395D1 (de) | 2006-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0868505T3 (da) | Chondrogen in vitro induktion af humane mesenchymstamceller | |
| DE69734395D1 (de) | Verbesserte chondrogene differenzierung von menschlichen mesenchym-stammzellen | |
| ATE357508T1 (de) | Zellinien-gerichtete induktion der menschlichen mesenchymalen stammzelldifferenzierung | |
| DE69328776D1 (de) | Rekonstruiertes knorpelgewebe | |
| BG101132A (en) | Pyridoanilated thienyl and furanyl oxazolidinons | |
| BR9612258B1 (pt) | inibidores de enzima conversora de interleucina-1beta, bem como composição farmacêutica. | |
| NO985204D0 (no) | Forbedring av implantasjonsfrekvensen etter in vitro fertilisering | |
| IL147803A0 (en) | 28-epirapalogs | |
| ES2110386T3 (es) | Conjugados de interferon. | |
| EP0953040A4 (en) | REGENERATION OF THE SKIN USING MESENCHYMAL STEM CELLS | |
| DE69729302D1 (de) | Illudin analoge verwendet als antitumormittel | |
| ES2194237T3 (es) | Preparaciones cosmeticas. | |
| WO2000066731A3 (en) | Recombinant laminin 5 | |
| ZA9710114B (en) | Method for the expression of genes. | |
| EP1331264A4 (en) | PROCESS FOR CULTURING HUMAN CHONDROCYTES | |
| FI963547A0 (fi) | Apparat foer behandling av haor, i synnerhet foer torkning av haor och/eller utformning av frisyr | |
| ZA988637B (en) | Methods for regulating trkA expression. | |
| IT221361Z2 (it) | Accenditore per fluorescenti. | |
| ZA967037B (en) | Composition for an artificial track. | |
| DE69826029D1 (de) | Acetyl-coa-carboxylase von candida albicans | |
| DK0827505T3 (da) | Udvalgte opløselige estere af hydroxylholdige indolocarbazoler | |
| DK0925064T3 (da) | 5-Androsten-3-beta,17-alpha-diol som inhibitor for tumorvækst | |
| GR3031236T3 (en) | Process for the preparation of pilocarpine. | |
| MX9709783A (es) | Inmortalizacion y desinmortalizacion de celulas. | |
| ZA9710343B (en) | Utilization of an egg-based preparation as an antidepressant. |