ATE535615T1 - Chemisch modifizierte nukleinsäuren und methode zur kopplung von nukleinsäuren an einen festen träger - Google Patents

Chemisch modifizierte nukleinsäuren und methode zur kopplung von nukleinsäuren an einen festen träger

Info

Publication number
ATE535615T1
ATE535615T1 AT99920342T AT99920342T ATE535615T1 AT E535615 T1 ATE535615 T1 AT E535615T1 AT 99920342 T AT99920342 T AT 99920342T AT 99920342 T AT99920342 T AT 99920342T AT E535615 T1 ATE535615 T1 AT E535615T1
Authority
AT
Austria
Prior art keywords
nucleic acids
chemically modified
solid support
coupling
modified nucleic
Prior art date
Application number
AT99920342T
Other languages
English (en)
Inventor
Allan Bradley
Wei Cai
Original Assignee
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Application granted granted Critical
Publication of ATE535615T1 publication Critical patent/ATE535615T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/197—Modifications characterised by incorporating a spacer/coupling moiety
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT99920342T 1998-05-04 1999-05-04 Chemisch modifizierte nukleinsäuren und methode zur kopplung von nukleinsäuren an einen festen träger ATE535615T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/071,876 US6048695A (en) 1998-05-04 1998-05-04 Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
PCT/US1999/009810 WO1999057323A1 (en) 1998-05-04 1999-05-04 Chemically modified nucleic acids and methods for coupling nucleic acids to solid support

Publications (1)

Publication Number Publication Date
ATE535615T1 true ATE535615T1 (de) 2011-12-15

Family

ID=22104163

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99920342T ATE535615T1 (de) 1998-05-04 1999-05-04 Chemisch modifizierte nukleinsäuren und methode zur kopplung von nukleinsäuren an einen festen träger

Country Status (8)

Country Link
US (3) US6048695A (de)
EP (1) EP1075544B1 (de)
JP (1) JP4477774B2 (de)
AT (1) ATE535615T1 (de)
AU (1) AU770695B2 (de)
CA (1) CA2326684C (de)
DE (1) DE99920342T1 (de)
WO (1) WO1999057323A1 (de)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426183B1 (en) * 1995-12-21 2002-07-30 Kenneth L. Beattie Oligonucleotide microarrays: direct covalent attachment to glass
US7078224B1 (en) 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
AU2001263094B2 (en) * 1998-05-04 2008-07-10 Baylor College Of Medicine Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2000157272A (ja) * 1998-12-01 2000-06-13 Hitachi Software Eng Co Ltd バイオチップ及びその製造方法
DE19957827C2 (de) * 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
JP2001149060A (ja) * 1999-11-29 2001-06-05 Nisshinbo Ind Inc 核酸固定化基板
SE9904506D0 (sv) * 1999-12-09 1999-12-09 Karolinska Innovations Ab Method for immobilisation
EP1110967A1 (de) * 1999-12-21 2001-06-27 LION Bioscience AG Ein Biomolekül und ein Organosilan enthaltende Verbindung
EP1244812A1 (de) * 1999-12-21 2002-10-02 LION Bioscience AG Verzweigte verbindungen zur verwendung in reaktionen zum nachweis und zur analyse von nukleinsäuren
EP1111069A1 (de) * 1999-12-22 2001-06-27 BioChip Technologies GmbH Modifizierte Nukleinsäuren und deren Verwendung
CA2397091A1 (en) * 2000-01-11 2001-07-19 Markus Schweitzer Biomolecules having multiple attachment moieties for binding to a substrate surface
FR2804129B1 (fr) * 2000-01-20 2002-10-18 Centre Nat Rech Scient Procedes de synthese et d'immobilisation d'acides nucleiques sur un support solide silanise
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
KR20020097181A (ko) 2000-02-22 2002-12-31 제노스펙트라 인코포레이티드 마이크로어레이 제작 기술 및 장치
US6953551B2 (en) * 2000-02-22 2005-10-11 Genospectra, Inc. Microarray fabrication techniques and apparatus
JP3502803B2 (ja) * 2000-03-06 2004-03-02 日立ソフトウエアエンジニアリング株式会社 マイクロアレイ、マイクロアレイ作製方法及びマイクロアレイにおけるピン間スポット量誤差補正方法
US20020081597A1 (en) * 2000-03-31 2002-06-27 Genentech, Inc. Compositions and methods for detecting and quantifying gene expression
KR100352171B1 (ko) * 2000-04-14 2002-09-12 (주) 제노텍 올리고뉴클레오타이드를 지지체에 고정시키는 방법 및 그방법에 의하여 제조되는 올리고뉴클레오타이드 어레이
US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
US6890483B2 (en) * 2000-07-05 2005-05-10 Cuno Incorporated Non-luminescent substrate
BR0106969A (pt) * 2000-07-05 2004-07-13 Cuno Inc Método de fabricação de um substrato multicelular e substrato multicelular
US20020076727A1 (en) * 2000-08-03 2002-06-20 Cardone Michael H. Microarrays of functional biomolecules and uses therefor
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
KR100379720B1 (ko) * 2000-10-14 2003-04-11 주식회사 마크로젠 덴드리머 단일층 지지체 및 그의 제조방법
EP1334113A4 (de) * 2000-10-20 2007-08-08 Expression Diagnostics Inc Erstellen von leukozytenexpressionsprofilen
US6861214B1 (en) 2000-10-23 2005-03-01 Beckman Coulter, Inc. Immobilization of biopolymers to aminated substrates by direct adsorption
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
US20020146684A1 (en) * 2001-04-09 2002-10-10 Meldal Morten Peter One dimensional unichemo protection (UCP) in organic synthesis
WO2002090923A2 (en) * 2001-05-03 2002-11-14 Sigma-Genosys, Ltd. Methods for assembling protein microarrays
JP2005500023A (ja) * 2001-05-10 2005-01-06 ベイラー　カレッジ　オブ　メディスン 生体分子のアレイ型ゲノム核酸解析を行うための組成物および方法
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
FR2826957B1 (fr) * 2001-07-09 2005-09-30 Centre Nat Rech Scient Procede de fonctionnalisation de supports solides, supports solides fonctionnalises et leurs utilisations
EP1417337B1 (de) * 2001-07-11 2009-03-04 Baylor College of Medicine Verfahren und vorrichtungen auf grundlage einer neuen form eines nukleinsäureduplex auf einer oberfläche
US10272409B2 (en) * 2001-07-11 2019-04-30 Michael E. Hogan Methods and devices based upon a novel form of nucleic acid duplex on a surface
DE10139283A1 (de) * 2001-08-09 2003-03-13 Epigenomics Ag Verfahren und Nukleinsäuren zur Analyse von Colon-Krebs
US20030087309A1 (en) * 2001-08-27 2003-05-08 Shiping Chen Desktop drug screening system
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US9671396B2 (en) * 2001-09-05 2017-06-06 Joon Won Park Solid substrate comprising array of dendrons and methods for using the same
JP2005525786A (ja) * 2001-09-27 2005-09-02 スペクトラル ジェノミクス、インク． アレイを用いた遺伝子モザイクの検出方法
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
EP1451318A4 (de) * 2001-10-12 2007-06-27 Perkinelmer Las Inc Zusammenstellungen von nukleinsäuren und arrays und verfahren zu ihrer verwendung
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
WO2003048727A2 (en) * 2001-12-03 2003-06-12 Invitrogen Corporation Identification of rearrangements in nucleic acid molecules
EP1486561B1 (de) * 2001-12-26 2013-12-04 Canon Kabushiki Kaisha Sondenmedium
KR100450191B1 (ko) * 2001-12-28 2004-10-02 삼성에스디아이 주식회사 생체물질 고정용 기판 및 이의 제조방법
WO2003076903A2 (en) * 2002-03-08 2003-09-18 Spectral Genomics, Inc. Articles of manufacture and methods for making hydrophobic derivatized arrays
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
PT1497418E (pt) 2002-04-19 2013-01-25 Dsm Ip Assets Bv Fosfolípases, ácidos nucleicos que as codificam e métodos para as preparar e utilizar
US7217512B2 (en) 2002-05-09 2007-05-15 Corning Incorporated Reagent and method for attaching target molecules to a surface
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US7129046B2 (en) * 2002-10-21 2006-10-31 Agilent Technologies, Inc. Linking to chemical array assemblies with metal layers
US7195908B2 (en) 2002-10-31 2007-03-27 Corning Incorporated Supports treated with triamine for immobilizing biomolecules
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
JP2007524374A (ja) * 2003-02-28 2007-08-30 プレキシコン，インコーポレーテッド Ｐｙｋ２結晶構造および使用
EP3508578A1 (de) 2003-03-06 2019-07-10 BASF Enzymes, LLC Amylasen, nukleinsäuren zur codierung davon und verfahren zur herstellung und verwendung davon
EP2853593B1 (de) 2003-03-07 2017-10-04 DSM IP Assets B.V. Hydrolasen, Nucleinsäuren zur Codierung davon sowie Verfahren zur Herstellung und Verwendung davon
DK2341136T3 (en) 2003-04-04 2016-09-12 Basf Enzymes Llc Pectate lyases, nucleic acids encoding them, and methods of making and using them
US20060263813A1 (en) * 2005-05-11 2006-11-23 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
FR2854696A1 (fr) * 2003-05-06 2004-11-12 Commissariat Energie Atomique Support de biopuce utilisant des couches minces de materiau sol gel et procede de realisation
BRPI0412279A (pt) 2003-07-02 2006-09-19 Diversa Corp glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
CA2535526C (en) 2003-08-11 2015-09-29 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
WO2005028624A2 (en) * 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US7279280B2 (en) * 2003-09-25 2007-10-09 Mgp Biotech, Inc. Apparatus and method for detecting genetic mutations and single nucleotide polymorphisms
EP1675682B1 (de) * 2003-10-24 2017-07-19 Aushon Biosystems, Inc. Vorrichtung und verfahren zur dosierung von flüssigen, halbfesten und festen proben
WO2005044086A2 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
JP4202391B2 (ja) * 2004-03-17 2008-12-24 パナソニック株式会社 バイオチップの製造方法、プローブ溶液、および、バイオチップ
JP2008503446A (ja) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド Ｐｄｅ４ｂ阻害剤及びその使用
US8911942B2 (en) * 2004-05-20 2014-12-16 Quest Diagnostics Investments Incorporated Single label comparative hybridization
ES2461857T3 (es) 2004-06-16 2014-05-21 Dsm Ip Assets B.V. Composiciones y métodos para la decoloración enzimática de clorofila
JP2008503473A (ja) * 2004-06-17 2008-02-07 プレキシコン，インコーポレーテッド Ｃ−ｋｉｔ活性を調節する化合物
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
EP1786813A2 (de) * 2004-09-03 2007-05-23 Plexxikon, Inc. Bizyklische heteroaryl-pde4b-inhibitoren
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
WO2006053972A2 (fr) * 2004-11-16 2006-05-26 Commissariat A L'energie Atomique Agents de silanisation a groupement saccharidique terminal et leurs utilisations, notamment pour la fonctionnalisation de supports solides
WO2006060742A2 (en) * 2004-12-02 2006-06-08 Oncotech, Inc. Reagents and methods for predicting drug resistance
US20060147943A1 (en) * 2004-12-30 2006-07-06 Lewis Mark A Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof
WO2006081353A2 (en) * 2005-01-27 2006-08-03 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
EP2886658A1 (de) 2005-03-10 2015-06-24 BASF Enzymes LLC Lyaseenzyme, Nukleinsäuren zur Codierung davon und Verfahren zur Herstellung und Verwendung davon
NZ594810A (en) 2005-03-15 2012-12-21 Verenium Corp Cellulases, nucleic acids encoding them and methods for making and using them
WO2006102497A2 (en) * 2005-03-22 2006-09-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
CA2608733A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
DK2395004T3 (en) * 2005-06-22 2016-03-21 Plexxikon Inc Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
CA2613094A1 (en) * 2005-07-01 2007-01-11 Promega Corporation Network of buoyant particles for biomolecule purification
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
WO2007075894A2 (en) 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Comparative genomic hybridization on encoded multiplex particles
US7932037B2 (en) 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
US20100009373A1 (en) * 2005-12-23 2010-01-14 Perkinelmer Health Sciences, Inc. Methods and compositions relating to multiplex genomic gain and loss assays
US20090104613A1 (en) * 2005-12-23 2009-04-23 Perkinelmer Las, Inc. Methods and compositions relating to multiplexed genomic gain and loss assays
EP2216403A3 (de) 2006-02-02 2010-11-24 Verenium Corporation Esterasen und dazugehörige Nukleinsäuren und Verfahren
NZ595501A (en) 2006-02-10 2013-05-31 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
TR201809912T4 (tr) 2006-02-14 2018-07-23 Bp Corp North America Inc Ksilanazlar, bunları kodlayan nükleik asitler ve bunları yapmak ve kullanmak için yöntemler.
EP2112227B1 (de) 2006-03-07 2013-05-15 Cargill, Incorporated Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung
EA029538B1 (ru) 2006-03-07 2018-04-30 Басф Энзаймс Ллк Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
CA2648580A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
DK2069389T3 (en) 2006-08-04 2015-01-12 Bp Corp North America Inc Glucanases, nucleic acids encoding them, and processes for their preparation and use
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
CA2663001A1 (en) 2006-09-21 2008-03-27 Verenium Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
HUE029140T2 (hu) 2006-09-21 2017-02-28 Basf Enzymes Llc Fitázok, ezeket kódoló nukleinsavak, valamint eljárások az elõállításukra és alkalmazásuk
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
US8148067B2 (en) * 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008080015A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
BRPI0719449A2 (pt) 2006-12-21 2017-06-20 Syngenta Participations Ag molécula de ácido nucléico isolada, sintética ou recombinante, polipeptídeo isolado, planta ou parte de planta, eículo de clonagem que compreende um ácido nucléico, cassete de expressão que compreende uma molécula de ácido nucléico e método para hidrolisar um polissacarídeo, oligossacarídeo ou amido
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
NZ578309A (en) 2007-01-30 2012-06-29 Verenium Corp Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
MX347887B (es) 2007-04-27 2017-05-16 The Regents Of The Univ Of California At San Diego Sensores de co2 de planta, acidos nucleicos que los codifican y metodos para hacerlos y usarlos.
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
CN110577945A (zh) 2007-10-03 2019-12-17 维莱尼姆公司 木聚糖酶、编码它们的核酸以及其制备和应用方法
EP2238242B9 (de) 2008-01-03 2015-06-10 BASF Enzymes LLC Transferasen und oxidoreduktasen, dafür kodierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
WO2010025340A2 (en) 2008-08-29 2010-03-04 Centocor Ortho Biotech Inc. Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel
DE102008053270A1 (de) * 2008-10-27 2010-05-12 Medizinische Hochschule Hannover Vorrichtung und Verfahren zur Analyse von Zellen
WO2010054195A2 (en) 2008-11-07 2010-05-14 Centocor Ortho Biotech Inc. Markers and methods for assessing and treating lupus patients susceptible to photoprovocation
US20100260739A1 (en) * 2009-03-09 2010-10-14 Bioatla, Llc Mirac Proteins
HUE027598T2 (en) * 2009-04-03 2016-10-28 Hoffmann La Roche Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
CN106011159A (zh) 2009-05-21 2016-10-12 巴斯夫酶有限责任公司 肌醇六磷酸酶、编码它们的核酸及制备和使用它们的方法
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011028533A2 (en) * 2009-08-24 2011-03-10 Perkinelmer Health Sciences, Inc. Methods for detecting dna methylation using encoded particles
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
CN102630250A (zh) * 2009-09-25 2012-08-08 基因诊断测试公司 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
WO2011048495A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
WO2011048499A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
EP2491141A2 (de) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Differenzierung zwischen brca2-tumoren und sporadischen tumoren mittels array-basierter vergleichender genomhybridisierung
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
NL2004275C2 (en) * 2010-02-22 2011-08-23 Univ Leiden Raman spectrometry.
US20140018251A1 (en) 2010-09-20 2014-01-16 Stichting Het Nederlands Kanker Instituut Methods for Predicting Response to Anti-Cancer Therapy in Cancer Patients
BR112013008347A2 (pt) 2010-10-06 2016-06-14 Bp Corp North America Inc polipeptídeos de variantes cbh i
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2709622A4 (de) 2011-05-17 2015-03-04 Plexxikon Inc Kinasemodulation und indikationen dafür
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
WO2013095941A1 (en) 2011-12-19 2013-06-27 Valley Health System Methods and kits for detecting subjects at risk of having cancer
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP3339861B8 (de) 2012-06-15 2023-11-01 Genesis Theranostix Korlatolt Felelossegu Tarsasag Biomarkertest zur vorhersage oder früherkennung von präeklampsie
EP3182126A3 (de) 2012-06-15 2017-08-02 Wayne State University Biomarkertest zur vorhersage oder früherkennung von präeklampsie und/oder hellp-syndrom
ES2765573T3 (es) 2012-08-13 2020-06-09 Univ Rockefeller Tratamiento y diagnóstico de melanoma
JP6109951B2 (ja) 2012-10-31 2017-04-05 ザ ロックフェラー ユニバーシティー 結腸癌の処置および診断
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
CN106795557A (zh) 2014-06-02 2017-05-31 瓦利保健系统公司 用于肺癌诊断的方法和系统
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
ES3034398T3 (en) 2014-08-28 2025-08-18 Bioatla Inc Conditionally active chimeric antigen receptors for modified t-cells
EP3189152A4 (de) 2014-09-03 2018-04-04 BioAtla LLC Entdeckung und herstellung von bedingt aktiven biologischen proteinen in denselben wirten zur herstellung eukaryontischer zellen
CA2977687C (en) 2015-02-24 2024-02-13 Hwai Wen Chang Conditionally active proteins
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
FR3038734A1 (fr) * 2015-07-10 2017-01-13 Centre Nat De La Rech Scient (Cnrs) Nouveaux materiaux optiques fonctionnalises
WO2017019804A2 (en) 2015-07-28 2017-02-02 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN108368110A (zh) 2015-12-07 2018-08-03 普莱希科公司 用于激酶调节的化合物和方法以及其适应症
TWI851939B (zh) 2016-05-13 2024-08-11 美商拜奧亞特拉公司 抗-ror2抗體、抗體片段、其免疫結合物及其用途
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
AU2017395023B2 (en) 2016-12-23 2022-04-07 Plexxikon Inc. Compounds and methods for CDK8 modulation and indications therefor
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
WO2019136560A1 (en) 2018-01-09 2019-07-18 Mcmaster University Fluorosilinated liquid-infused surfaces with embedded biomolecules, methods of making and uses thereof
EP3594290A1 (de) 2018-07-13 2020-01-15 Haelixa GmbH Markierte artikel und verifizierungsverfahren
EP3660172A1 (de) 2018-11-28 2020-06-03 Bioscreening and Diagnostics LLC Verfahren zur diagnose von traumatischen hirnverletzungen
EP4073025B1 (de) 2019-12-13 2024-03-27 Inspirna, Inc. Metallsalze und verwendungen davon
EP4368613A1 (de) 2022-11-08 2024-05-15 aeChem Life Technologies Sàrl Phthalimidin-dicyanomethanid-derivate
WO2025212475A2 (en) 2024-04-03 2025-10-09 Mars, Incorporated Compositions and methods to detect infectious organisms

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231910A (en) * 1979-02-08 1980-11-04 Dow Corning Corporation Primer composition
CA1130228A (en) * 1980-05-21 1982-08-24 Chiang-Chang Liao Support matrix for amino-containing biologically active substances
CA1253129A (en) * 1984-02-09 1989-04-25 Thomas R. Jones Porous inorganic materials
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4637687A (en) * 1984-06-14 1987-01-20 General Electric Company Cascaded, dual cell transflective liquid crystal display
US4818681A (en) * 1985-02-22 1989-04-04 Molecular Diagnostics, Inc. Fast and specific immobilization of nucleic acids to solid supports
US5641630A (en) * 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
US4806631A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on solvolyzed nylon supports
US5190864A (en) * 1986-04-15 1993-03-02 Northeastern University Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
US4937188A (en) * 1986-04-15 1990-06-26 Northeastern University Enzyme activity amplification method for increasing assay sensitivity
US4713116A (en) * 1987-01-02 1987-12-15 Ralston Purina Company Protein modified with a silanation reagent as an adhesive binder and process of producing
EP0318236B1 (de) * 1987-11-27 1993-04-14 Ecc International Limited Poröse anorganische Materialien
GB8803413D0 (en) * 1988-02-15 1988-03-16 Ecc Int Ltd Biological support
US5024933A (en) * 1988-05-10 1991-06-18 Enzo Biochem, Inc. Method and kit for sample adherence to test substrate
US5071909A (en) * 1989-07-26 1991-12-10 Millipore Corporation Immobilization of proteins and peptides on insoluble supports
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5215882A (en) * 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
ATE167523T1 (de) * 1990-05-11 1998-07-15 Microprobe Corp Teststreifen zum eintauchen für nukleinsäure- hybridisierungsassays und verfahren zur kovalenten immobilisierung von oligonucleotiden
DE4018778A1 (de) * 1990-06-12 1991-12-19 Braun Melsungen Ag Adsorptionsmaterial zur selektiven entfernung von ldl- oder/und vldl
IL102486A (en) * 1991-10-04 1997-11-20 Orgenics Ltd Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US6015880A (en) * 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5554744A (en) * 1994-09-23 1996-09-10 Hybridon, Inc. Method for loading solid supports for nucleic acid synthesis
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5807756A (en) * 1995-01-10 1998-09-15 At Point Bio Ceramic assembly for use in biological assays
US5601982A (en) * 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US5959098A (en) * 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5630932A (en) * 1995-09-06 1997-05-20 Molecular Imaging Corporation Tip etching system and method for etching platinum-containing wire
US5658802A (en) * 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
US5851769A (en) * 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
US6156502A (en) * 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
US6426183B1 (en) * 1995-12-21 2002-07-30 Kenneth L. Beattie Oligonucleotide microarrays: direct covalent attachment to glass
US5567294A (en) * 1996-01-30 1996-10-22 Board Of Governors, University Of Alberta Multiple capillary biochemical analyzer with barrier member
AU734704B2 (en) * 1996-05-30 2001-06-21 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules

Also Published As

Publication number Publication date
DE99920342T1 (de) 2005-01-20
EP1075544A4 (de) 2005-03-09
US6858713B1 (en) 2005-02-22
EP1075544A1 (de) 2001-02-14
EP1075544B1 (de) 2011-11-30
JP4477774B2 (ja) 2010-06-09
WO1999057323A1 (en) 1999-11-11
US6048695A (en) 2000-04-11
US20050064494A1 (en) 2005-03-24
CA2326684A1 (en) 1999-11-11
JP2002513814A (ja) 2002-05-14
AU3786199A (en) 1999-11-23
AU770695B2 (en) 2004-02-26
CA2326684C (en) 2006-03-14

Similar Documents

Publication Publication Date Title
CA2326684A1 (en) Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
ATE397092T1 (de) Methode zur direkten sequenzierung von nukleinsäuren
ATE400030T1 (de) Methode zur identifizierung von t-zellepitopen und deren anwendung zur herstellung von molekülen mit reduzierter immunogenität
EP0777750A4 (de) Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren
ATE294229T1 (de) Verfahren zur trocknung von kompetenten zellen
NO20042159L (no) Cellokulturprosess
DK1053355T3 (da) PNA- og DNA-konjugater og metoder til fremstilling heraf
ATE414162T1 (de) Verfahren und materialien zur herstellung von glucosamin
DE50113396D1 (de) System zur gezielten Deformation von optischen Elementen
IL126566A0 (en) Small molecule mimetics of erythropoietin
DE60234425D1 (de) Verfahren zur optimaliserung von verkerhrsinformationsinhalt
DK1100880T3 (da) Urat oxidase
DE60330841D1 (de) Überexpression von extremozymgenen in pseudomonas und nahe verwandte bakterien
DE60045451D1 (de) Vorrichtung zur Herstellung von Mikroarrays
DE69637579D1 (de) Methode zur Amplifizierung von Nukleinsäure und entsprechende Regenzien dafür
ATE417605T1 (de) Proteine die cross-beta-struktur enthaltendes amyloid binden, sowie verfahren zur modulation der cross-beta-struktur, ihrer bildung und der damit zusammenhängenden toxizität
DE69914061D1 (de) Reaktiv distillierungsverfahren zur herstellung von xylolen
DE60320201D1 (de) Verfahren zur Herstellung von optischen Polyimid-Wellenleitern.
ATE402198T1 (de) Verfahren zur immobilisierung biologischer moleküle an feste oberflächen
IS7154A (is) Bv8 kjarnsýrur og fjölpeptíð með mítósu-valdandi verkun
DE69707473D1 (de) Tresteruntertaucheinrichtung zur Weinherstellung
DE69732857D1 (de) Nukleinsaeuren und proteine der katze fc-epsilon rezeptor alpha-kette und deren verwendungen
DE60008926D1 (de) Verfahren zur Weinstabilisierung
ATE324178T1 (de) Verfahren zur herstellung eines arrays zur detektion von komponenten aus einer biologischen probe
DE60005440D1 (de) Anordnung zur Herstellung von Matrixen von Proben