ATE536412T1 - Verfahren zur herstellung von sclareol - Google Patents
Verfahren zur herstellung von sclareolInfo
- Publication number
- ATE536412T1 ATE536412T1 AT09710375T AT09710375T ATE536412T1 AT E536412 T1 ATE536412 T1 AT E536412T1 AT 09710375 T AT09710375 T AT 09710375T AT 09710375 T AT09710375 T AT 09710375T AT E536412 T1 ATE536412 T1 AT E536412T1
- Authority
- AT
- Austria
- Prior art keywords
- sclareol
- nucleic acid
- present
- polypeptide
- provides
- Prior art date
Links
- XVULBTBTFGYVRC-HHUCQEJWSA-N sclareol Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CC[C@](O)(C)C=C)[C@](C)(O)CC[C@H]21 XVULBTBTFGYVRC-HHUCQEJWSA-N 0.000 title abstract 6
- XVULBTBTFGYVRC-UHFFFAOYSA-N Episclareol Natural products CC1(C)CCCC2(C)C(CCC(O)(C)C=C)C(C)(O)CCC21 XVULBTBTFGYVRC-UHFFFAOYSA-N 0.000 title abstract 3
- LAEIZWJAQRGPDA-UHFFFAOYSA-N Manoyloxid Natural products CC1(C)CCCC2(C)C3CC=C(C)OC3(C)CCC21 LAEIZWJAQRGPDA-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 244000182022 Salvia sclarea Species 0.000 abstract 1
- 235000002911 Salvia sclarea Nutrition 0.000 abstract 1
- 108030004291 Sclareol synthases Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000001691 salvia sclarea Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/07—Diphosphoric monoester hydrolases (3.1.7)
- C12Y301/07004—Sclareol cyclase (3.1.7.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08101655 | 2008-02-15 | ||
| PCT/EP2009/051620 WO2009101126A1 (en) | 2008-02-15 | 2009-02-12 | Method for producing sclareol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE536412T1 true ATE536412T1 (de) | 2011-12-15 |
Family
ID=40578786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09710375T ATE536412T1 (de) | 2008-02-15 | 2009-02-12 | Verfahren zur herstellung von sclareol |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8586328B2 (de) |
| EP (1) | EP2245161B1 (de) |
| CN (2) | CN104846020B (de) |
| AT (1) | ATE536412T1 (de) |
| WO (1) | WO2009101126A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009095366A1 (en) | 2008-01-29 | 2009-08-06 | Firmenich Sa | Method for producing sclareol |
| CN103282492A (zh) | 2010-10-29 | 2013-09-04 | 奥利里克斯股份有限公司 | 修饰的瓦伦烯合酶多肽、编码核酸分子及其用途 |
| EP2783004B1 (de) | 2011-11-21 | 2019-08-07 | The University of British Columbia | Diterpensynthasen und verfahren zur herstellung diterpenoiden |
| US9550815B2 (en) | 2012-01-23 | 2017-01-24 | University Of British Columbia | ABC terpenoid transporters and methods of using the same |
| CN103387944A (zh) * | 2012-05-09 | 2013-11-13 | 中国科学院大连化学物理研究所 | 高产香紫苏醇菌株的构建方法 |
| EP2880159A1 (de) | 2012-07-30 | 2015-06-10 | Allylix, Inc. | Für nukleinsäuremoleküle codierende sclareol- und labdendioldiphosphatsynthasepolypeptide und ihre verwendung |
| WO2014206412A1 (en) | 2013-06-28 | 2014-12-31 | Københavns Universitet | Heterologous production of patchoulol, beta-santalene, and sclareol in moss cells |
| EP2886647A1 (de) * | 2013-12-20 | 2015-06-24 | Technical University of Denmark | Polypeptide mit Diterpensynthaseaktivität |
| WO2015091943A1 (en) * | 2013-12-20 | 2015-06-25 | Technical Unversity Of Denmark | Stereo-specific synthesis of (13r)-manoyl oxide |
| WO2015113569A1 (en) | 2014-01-31 | 2015-08-06 | University Of Copenhagen | Biosynthesis of forskolin and related compounds |
| US10208326B2 (en) | 2014-11-13 | 2019-02-19 | Evolva Sa | Methods and materials for biosynthesis of manoyl oxide |
| US10131922B2 (en) | 2015-03-10 | 2018-11-20 | Indian Institute Of Science Education And Research | Increase production of isoprenoids in saccharomyces cerevisiae by carotenoid optimization and screening |
| US10752922B2 (en) * | 2016-12-22 | 2020-08-25 | Firmenich Sa | Production of manool |
| MX2024000376A (es) | 2021-07-06 | 2024-02-08 | Isobionics B V | Elaboracion recombinante de alcoholes terpenoides c-20. |
| CN116262929B (zh) * | 2021-12-15 | 2025-03-21 | 中国科学院大连化学物理研究所 | 一种工程菌的构建方法及其应用 |
| WO2026041452A2 (en) | 2024-08-19 | 2026-02-26 | Firmenich Sa | Method for production of terpene compounds |
| CN120924519B (zh) * | 2025-07-21 | 2026-04-28 | 河北维达康生物科技股份有限公司 | 一种香紫苏醇合酶突变体、重组基因工程菌株及其应用 |
| CN121065228A (zh) * | 2025-07-22 | 2025-12-05 | 上海锐康生物技术研发有限公司 | 一种高产香紫苏醇重组菌株及其构建方法和用途 |
| CN121450629B (zh) * | 2026-01-06 | 2026-04-07 | 四川盈嘉合生科技有限公司 | 香紫苏醇合酶及生产香紫苏醇的酵母工程菌 |
| CN121450628B (zh) * | 2026-01-06 | 2026-04-07 | 四川盈嘉合生科技有限公司 | 焦磷酸赖百当烯二醇酯合酶及生产香紫苏醇的酵母工程菌 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2546271T3 (es) * | 2006-02-24 | 2015-09-22 | Kao Corporation | Microorganismo y procedimiento para producir decahidro-2-hidroxi-2,5,5,8a-tetrametilnaftalenetanol y/o esclareólido (decahidro-3a,6,6,9a-tetrametilnafto[2,1-b]furan-2(1H)-ona) usando el mismo |
| FR2903703B1 (fr) | 2006-07-13 | 2012-09-28 | Librophyt | Genes codant pour la cis-labda-12,14-dien-8 alpha-ol (cis-abienol)synthase et la syn-copalyl-8-ol diphosphate synthase et leurs utilisations |
| WO2009095366A1 (en) | 2008-01-29 | 2009-08-06 | Firmenich Sa | Method for producing sclareol |
| CN103282492A (zh) * | 2010-10-29 | 2013-09-04 | 奥利里克斯股份有限公司 | 修饰的瓦伦烯合酶多肽、编码核酸分子及其用途 |
-
2009
- 2009-02-12 US US12/867,861 patent/US8586328B2/en active Active
- 2009-02-12 EP EP09710375A patent/EP2245161B1/de active Active
- 2009-02-12 CN CN201510132253.9A patent/CN104846020B/zh active Active
- 2009-02-12 WO PCT/EP2009/051620 patent/WO2009101126A1/en not_active Ceased
- 2009-02-12 CN CN200980104742.6A patent/CN101939430B/zh active Active
- 2009-02-12 AT AT09710375T patent/ATE536412T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009101126A1 (en) | 2009-08-20 |
| CN104846020B (zh) | 2021-12-21 |
| BRPI0906468A2 (pt) | 2019-07-02 |
| US20110041218A1 (en) | 2011-02-17 |
| CN101939430B (zh) | 2015-05-13 |
| EP2245161A1 (de) | 2010-11-03 |
| CN101939430A (zh) | 2011-01-05 |
| WO2009101126A9 (en) | 2010-08-26 |
| CN104846020A (zh) | 2015-08-19 |
| US8586328B2 (en) | 2013-11-19 |
| EP2245161B1 (de) | 2011-12-07 |
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