ATE536865T1 - Sublinguale brausetablette aus progesteron zusammen mit cyclodextrin - Google Patents
Sublinguale brausetablette aus progesteron zusammen mit cyclodextrinInfo
- Publication number
- ATE536865T1 ATE536865T1 AT08805213T AT08805213T ATE536865T1 AT E536865 T1 ATE536865 T1 AT E536865T1 AT 08805213 T AT08805213 T AT 08805213T AT 08805213 T AT08805213 T AT 08805213T AT E536865 T1 ATE536865 T1 AT E536865T1
- Authority
- AT
- Austria
- Prior art keywords
- sublingual
- cyclodextrin
- effervescent tablet
- progesterone
- tablet made
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 6
- 229960003387 progesterone Drugs 0.000 title abstract 3
- 239000000186 progesterone Substances 0.000 title abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 title 1
- 239000007938 effervescent tablet Substances 0.000 title 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nanotechnology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Reproductive Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001971A ITMI20071971A1 (it) | 2007-10-10 | 2007-10-10 | Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione |
| PCT/EP2008/063595 WO2009047321A2 (en) | 2007-10-10 | 2008-10-10 | A sublingual effervescent tablet of progesterone associated with cyclodextrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE536865T1 true ATE536865T1 (de) | 2011-12-15 |
Family
ID=40313810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08805213T ATE536865T1 (de) | 2007-10-10 | 2008-10-10 | Sublinguale brausetablette aus progesteron zusammen mit cyclodextrin |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9066858B2 (de) |
| EP (1) | EP2217219B1 (de) |
| JP (1) | JP2011500534A (de) |
| KR (1) | KR20100077159A (de) |
| CN (1) | CN101854923B (de) |
| AT (1) | ATE536865T1 (de) |
| CA (1) | CA2701857C (de) |
| DK (1) | DK2217219T3 (de) |
| ES (1) | ES2378917T3 (de) |
| IT (1) | ITMI20071971A1 (de) |
| PL (1) | PL2217219T3 (de) |
| PT (1) | PT2217219E (de) |
| WO (1) | WO2009047321A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102317294B (zh) | 2009-08-18 | 2015-04-01 | 株式会社Lg化学 | 化合物、含有该化合物的催化剂组合物和使用该组合物制备基于环烯烃的聚合物的方法 |
| US20110312928A1 (en) * | 2010-06-18 | 2011-12-22 | Lipocine Inc. | Progesterone Containing Oral Dosage Forms and Related Methods |
| US9675551B2 (en) * | 2011-10-25 | 2017-06-13 | Expermed S.A. | Sublingual pharmaceutical composition containing an antihistamine agent and method for the preparation thereof |
| ITMI20122027A1 (it) | 2012-11-28 | 2014-05-29 | Altergon Sa | Soluzioni acquose orali di ormoni steroidei e hp¿cd con biodisponibilità ottimizzata |
| CN103877048A (zh) * | 2014-03-26 | 2014-06-25 | 邵娜 | 一种黄体酮口腔崩解片及其制备方法 |
| ITUB20161027A1 (it) | 2016-02-24 | 2017-08-24 | Altergon Sa | Preparazioni farmaceutiche oromucosali ad elevata biodisponibilita’ a base di ciclodestrina e sucralosio |
| NO20171457A1 (no) * | 2016-12-20 | 2018-06-21 | X Ing As | Effervesent sugetablett |
| WO2018117855A1 (en) * | 2016-12-20 | 2018-06-28 | X-Ing As | Effervescent lozenge |
| US20230225994A1 (en) * | 2017-09-06 | 2023-07-20 | pHase Pharmaceuticals LLC | Sublingual epinephrine formulations and methods of use |
| IL272957B2 (en) * | 2017-09-06 | 2024-04-01 | pHase Pharmaceuticals LLC | Sublingual epinephrine tablets |
| CN109381424A (zh) * | 2018-11-21 | 2019-02-26 | 南京泽恒医药技术开发有限公司 | 稳定的黄体酮水溶注射剂及其制备方法 |
| CN118141823A (zh) * | 2022-12-07 | 2024-06-07 | 杭州同惠医药科技有限公司 | 一种黄体酮药物组合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419074A (en) * | 1972-06-09 | 1975-12-24 | Ici Ltd | Process for manufacturing substituted thiophene compounds |
| US4596795A (en) * | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| DE69306595T2 (de) * | 1992-11-23 | 1997-04-03 | Pfizer | Regioselektive synthese von 4-chlor-2-thiophencarbonsäure |
| US6323227B1 (en) * | 1996-01-02 | 2001-11-27 | Aventis Pharmaceuticals Products Inc. | Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
| GB0028575D0 (en) * | 2000-11-23 | 2001-01-10 | Elan Corp Plc | Oral pharmaceutical compositions containing cyclodextrins |
| DE10061876A1 (de) * | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| CA2466375A1 (en) * | 2001-11-08 | 2003-05-15 | Pharmacia & Upjohn Company | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease |
| WO2004002977A1 (en) * | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company Llc | Inhibitors of hcv ns5b polymerase |
| CN102078310B (zh) * | 2003-12-31 | 2013-01-23 | 奇马实验室公司 | 大体线性的泡腾口服芬太尼剂型和施用方法 |
-
2007
- 2007-10-10 IT IT001971A patent/ITMI20071971A1/it unknown
-
2008
- 2008-10-10 PT PT08805213T patent/PT2217219E/pt unknown
- 2008-10-10 KR KR1020107007573A patent/KR20100077159A/ko not_active Withdrawn
- 2008-10-10 AT AT08805213T patent/ATE536865T1/de active
- 2008-10-10 DK DK08805213.9T patent/DK2217219T3/da active
- 2008-10-10 JP JP2010528409A patent/JP2011500534A/ja active Pending
- 2008-10-10 US US12/734,078 patent/US9066858B2/en active Active
- 2008-10-10 WO PCT/EP2008/063595 patent/WO2009047321A2/en not_active Ceased
- 2008-10-10 CN CN2008801120605A patent/CN101854923B/zh active Active
- 2008-10-10 PL PL08805213T patent/PL2217219T3/pl unknown
- 2008-10-10 CA CA2701857A patent/CA2701857C/en active Active
- 2008-10-10 EP EP08805213A patent/EP2217219B1/de active Active
- 2008-10-10 ES ES08805213T patent/ES2378917T3/es active Active
-
2015
- 2015-05-27 US US14/722,320 patent/US20150265631A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009047321A2 (en) | 2009-04-16 |
| PL2217219T3 (pl) | 2012-05-31 |
| US20150265631A1 (en) | 2015-09-24 |
| CA2701857A1 (en) | 2009-04-16 |
| DK2217219T3 (da) | 2012-03-12 |
| PT2217219E (pt) | 2012-03-29 |
| ES2378917T3 (es) | 2012-04-19 |
| WO2009047321A3 (en) | 2009-07-09 |
| EP2217219A2 (de) | 2010-08-18 |
| US9066858B2 (en) | 2015-06-30 |
| US20100240631A1 (en) | 2010-09-23 |
| JP2011500534A (ja) | 2011-01-06 |
| CN101854923B (zh) | 2012-04-18 |
| CN101854923A (zh) | 2010-10-06 |
| ITMI20071971A1 (it) | 2009-04-11 |
| EP2217219B1 (de) | 2011-12-14 |
| KR20100077159A (ko) | 2010-07-07 |
| CA2701857C (en) | 2015-03-24 |
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