ATE537178T1 - Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten - Google Patents
Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheitenInfo
- Publication number
- ATE537178T1 ATE537178T1 AT09742523T AT09742523T ATE537178T1 AT E537178 T1 ATE537178 T1 AT E537178T1 AT 09742523 T AT09742523 T AT 09742523T AT 09742523 T AT09742523 T AT 09742523T AT E537178 T1 ATE537178 T1 AT E537178T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidines
- spiro
- treatment
- neurodegenerative diseases
- new class
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5042308P | 2008-05-05 | 2008-05-05 | |
| PCT/IB2009/051815 WO2009136350A1 (en) | 2008-05-05 | 2009-05-04 | Novel class of spiro piperidines for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE537178T1 true ATE537178T1 (de) | 2011-12-15 |
Family
ID=40902870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09742523T ATE537178T1 (de) | 2008-05-05 | 2009-05-04 | Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20110046160A1 (de) |
| EP (1) | EP2300484B1 (de) |
| JP (1) | JP2011519913A (de) |
| KR (1) | KR20110000749A (de) |
| CN (1) | CN102083841A (de) |
| AP (1) | AP2010005456A0 (de) |
| AT (1) | ATE537178T1 (de) |
| AU (1) | AU2009245322B2 (de) |
| BR (1) | BRPI0912433A2 (de) |
| CA (1) | CA2721786A1 (de) |
| CO (1) | CO6321280A2 (de) |
| CR (1) | CR11759A (de) |
| DO (1) | DOP2010000317A (de) |
| EA (1) | EA201001566A1 (de) |
| EC (1) | ECSP10010597A (de) |
| ES (1) | ES2375913T3 (de) |
| IL (1) | IL208793A0 (de) |
| MA (1) | MA32290B1 (de) |
| MX (1) | MX2010012066A (de) |
| NZ (1) | NZ588589A (de) |
| SV (1) | SV2010003725A (de) |
| WO (1) | WO2009136350A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| EP2556076A2 (de) * | 2010-04-09 | 2013-02-13 | Pfizer Inc. | Neue sultamverbindungen |
| EP2694489B1 (de) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6-oxacyclus-fusionierte thiadiazindioxidverbindungen als bace-hemmer sowie zusammensetzungen daraus und ihre verwendung |
| EP2694521B1 (de) | 2011-04-07 | 2015-11-25 | Merck Sharp & Dohme Corp. | Pyrrolidin-kondensierte thiadiazindioxidverbindungen als bace-hemmer, zusammensetzungen daraus und ihre verwendung |
| CN103874496A (zh) | 2011-08-22 | 2014-06-18 | 默沙东公司 | 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 |
| US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1720873B1 (de) * | 2004-01-08 | 2011-02-23 | F. Hoffmann-La Roche AG | Diazaspiropiperidinderivate |
| JP2006044497A (ja) * | 2004-08-05 | 2006-02-16 | Toyota Motor Corp | 車輪情報処理装置 |
| US8114887B2 (en) * | 2004-10-13 | 2012-02-14 | Merck, Sharp & Dohme Corp. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP2009502786A (ja) * | 2005-07-18 | 2009-01-29 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病を治療するためのスピロピペリジンβ−セクレターゼ阻害剤 |
| US20100298342A1 (en) * | 2006-09-07 | 2010-11-25 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease |
| CA2673888A1 (en) * | 2007-01-04 | 2008-07-17 | Merck And Co., Inc. | Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
-
2009
- 2009-05-04 JP JP2011508035A patent/JP2011519913A/ja not_active Withdrawn
- 2009-05-04 WO PCT/IB2009/051815 patent/WO2009136350A1/en not_active Ceased
- 2009-05-04 BR BRPI0912433A patent/BRPI0912433A2/pt not_active Application Discontinuation
- 2009-05-04 AP AP2010005456A patent/AP2010005456A0/xx unknown
- 2009-05-04 US US12/990,739 patent/US20110046160A1/en not_active Abandoned
- 2009-05-04 AU AU2009245322A patent/AU2009245322B2/en not_active Ceased
- 2009-05-04 EA EA201001566A patent/EA201001566A1/ru unknown
- 2009-05-04 ES ES09742523T patent/ES2375913T3/es active Active
- 2009-05-04 CN CN2009801261947A patent/CN102083841A/zh active Pending
- 2009-05-04 EP EP09742523A patent/EP2300484B1/de active Active
- 2009-05-04 KR KR1020107024794A patent/KR20110000749A/ko not_active Ceased
- 2009-05-04 MX MX2010012066A patent/MX2010012066A/es not_active Application Discontinuation
- 2009-05-04 AT AT09742523T patent/ATE537178T1/de active
- 2009-05-04 CA CA2721786A patent/CA2721786A1/en not_active Abandoned
- 2009-05-04 NZ NZ588589A patent/NZ588589A/en not_active IP Right Cessation
-
2010
- 2010-10-18 IL IL208793A patent/IL208793A0/en unknown
- 2010-10-21 DO DO2010000317A patent/DOP2010000317A/es unknown
- 2010-10-26 CR CR11759A patent/CR11759A/es not_active Application Discontinuation
- 2010-11-05 MA MA33328A patent/MA32290B1/fr unknown
- 2010-11-05 SV SV2010003725A patent/SV2010003725A/es not_active Application Discontinuation
- 2010-11-09 EC EC2010010597A patent/ECSP10010597A/es unknown
- 2010-11-11 CO CO10141834A patent/CO6321280A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2010000317A (es) | 2010-11-15 |
| US20110046160A1 (en) | 2011-02-24 |
| WO2009136350A1 (en) | 2009-11-12 |
| CN102083841A (zh) | 2011-06-01 |
| IL208793A0 (en) | 2010-12-30 |
| AU2009245322B2 (en) | 2011-07-14 |
| ES2375913T3 (es) | 2012-03-07 |
| BRPI0912433A2 (pt) | 2015-12-22 |
| EA201001566A1 (ru) | 2011-04-29 |
| SV2010003725A (es) | 2011-07-05 |
| MX2010012066A (es) | 2010-12-06 |
| JP2011519913A (ja) | 2011-07-14 |
| EP2300484B1 (de) | 2011-12-14 |
| NZ588589A (en) | 2012-07-27 |
| AU2009245322A1 (en) | 2009-11-12 |
| CR11759A (es) | 2010-11-22 |
| KR20110000749A (ko) | 2011-01-05 |
| MA32290B1 (fr) | 2011-05-02 |
| AP2010005456A0 (en) | 2010-12-31 |
| CA2721786A1 (en) | 2009-11-12 |
| EP2300484A1 (de) | 2011-03-30 |
| ECSP10010597A (es) | 2010-12-30 |
| CO6321280A2 (es) | 2011-09-20 |
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