ATE537269T1 - Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen - Google Patents

Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen

Info

Publication number
ATE537269T1
ATE537269T1 AT05857432T AT05857432T ATE537269T1 AT E537269 T1 ATE537269 T1 AT E537269T1 AT 05857432 T AT05857432 T AT 05857432T AT 05857432 T AT05857432 T AT 05857432T AT E537269 T1 ATE537269 T1 AT E537269T1
Authority
AT
Austria
Prior art keywords
coa
isoprenoid
hmg
present
invention further
Prior art date
Application number
AT05857432T
Other languages
English (en)
Inventor
Jay Keasling
Jack Newman
Douglas Pitera
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36793476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE537269(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE537269T1 publication Critical patent/ATE537269T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT05857432T 2004-05-21 2005-05-20 Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen ATE537269T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57349204P 2004-05-21 2004-05-21
PCT/US2005/017874 WO2006085899A2 (en) 2004-05-21 2005-05-20 Method for enhancing production of isoprenoid compounds

Publications (1)

Publication Number Publication Date
ATE537269T1 true ATE537269T1 (de) 2011-12-15

Family

ID=36793476

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05857432T ATE537269T1 (de) 2004-05-21 2005-05-20 Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen

Country Status (11)

Country Link
US (2) US7183089B2 (de)
EP (2) EP2365090A1 (de)
JP (1) JP4926061B2 (de)
CN (1) CN101023181A (de)
AT (1) ATE537269T1 (de)
AU (1) AU2005327292B2 (de)
BR (1) BRPI0510115B1 (de)
CA (1) CA2567547C (de)
ES (1) ES2379368T3 (de)
MX (1) MXPA06013502A (de)
WO (1) WO2006085899A2 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69732101T2 (de) * 1996-04-17 2005-12-22 Köster, Hubert, Dr., Cambridge Kombinatorische schutzgruppestrategie für multifunktionelle molekule
US20050287596A9 (en) * 1998-06-26 2005-12-29 Braisted Andrew C Novel ligands and libraries of ligands
EP2281890A1 (de) 2000-07-31 2011-02-09 Danisco US Inc. Manipulation der in der Mevalonsäure- und Isoprenoid-Biosynthese verantwortlichen Gene zur Herstellung von geänderten Merkmalen in transgenen Organismen
US7172886B2 (en) * 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
AU2003224674A1 (en) * 2002-03-11 2003-09-29 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
SG153699A1 (en) * 2003-01-16 2009-07-29 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
EP3467096B1 (de) 2005-06-07 2022-01-12 DSM Nutritional Products AG Eukaryotische mikroorganismen zur herstellung von lipiden und antioxidantien
US8097438B2 (en) * 2005-10-07 2012-01-17 The Regents Of The University Of California Nucleic acids encoding modified cytochrome P450 enzymes and methods of use thereof
US8114645B2 (en) * 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
EP2021486B9 (de) * 2006-05-26 2022-04-20 Amyris, Inc. System zur Herstellung von bio-organischen Verbindungen
ES2572833T3 (es) * 2006-08-01 2016-06-02 Dsm Nutritional Products Ag Proceso de producción de aceite microbiano que contiene ácidos grasos poliinsaturados
WO2008039499A2 (en) * 2006-09-26 2008-04-03 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
US8234641B2 (en) * 2006-10-17 2012-07-31 Managelq, Inc. Compliance-based adaptations in managed virtual systems
WO2008094546A2 (en) * 2007-01-31 2008-08-07 The Regents Of The University Of California Genetically modified host cells for increased p450 activity levels and methods of use thereof
WO2009006386A2 (en) 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing isoprenyl alkanoates
US8067632B2 (en) * 2007-07-26 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Process to produce prostratin and structural or functional analogs thereof
WO2009064910A2 (en) * 2007-11-13 2009-05-22 Synthetic Genomics, Inc. Dimethyloctane as an advanced biofuel
JP6049982B2 (ja) * 2007-12-13 2016-12-21 ダニスコ・ユーエス・インク イソプレンを産出する組成物及び方法
EP2247746A4 (de) * 2008-01-31 2012-08-01 Amyris Inc Verfahren zur überwachung von stoffwechselwegen
CN102066551B (zh) * 2008-03-27 2013-10-09 基因组股份公司 用于产生己二酸和其他化合物的微生物
US20090253174A1 (en) * 2008-04-08 2009-10-08 Zach Serber Expression of Heterologous Sequences
JP2011518564A (ja) 2008-04-23 2011-06-30 ダニスコ・ユーエス・インク 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
EP3483265B1 (de) * 2008-05-16 2021-07-21 Genomatica, Inc. Verfahren und zusammensetzungen zur herstellung von fettalkoholen und fettaldehyden
AU2009248852B9 (en) * 2008-05-23 2015-08-13 Cibus Europe B.V. Production of squalene using yeast
SG167485A1 (en) * 2008-06-30 2011-01-28 Danisco Us Inc Polymers of isoprene from renewable resources
EP3406722A1 (de) 2008-07-02 2018-11-28 Danisco US Inc. Zusammensetzungen und verfahren zur herstellung von c5-freiem isopren unter entkoppelungsbedingungen und/oder sicheren betriebsbereichen
US20100184178A1 (en) * 2008-09-15 2010-07-22 Zachary Quinn Beck Increased isoprene production using mevalonate kinase and isoprene synthase
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
JP2012506715A (ja) 2008-10-28 2012-03-22 エルエス9・インコーポレイテッド 脂肪アルコールを生産するための方法および組成物
CA2759700A1 (en) 2009-04-23 2010-10-28 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
CN107058145A (zh) * 2009-11-23 2017-08-18 纽塞利斯公司 使用酵母产生角鲨烯的方法和组合物
MY185668A (en) 2010-06-02 2021-05-28 Evolva Inc Recombinant production of steviol glycosides
BR112013010551A8 (pt) 2010-10-27 2018-07-03 Danisco Us Inc variantes de isopreno sintase para produção aprimorada de isopreno
KR101815063B1 (ko) 2011-08-08 2018-01-05 에볼바 에스아 사프란 화합물의 재조합 생성을 위한 방법 및 물질
KR102114493B1 (ko) 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
US8415136B1 (en) * 2011-11-09 2013-04-09 Amyris, Inc. Production of acetyl-coenzyme a derived isoprenoids
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
JP5827601B2 (ja) * 2012-07-04 2015-12-02 住友ゴム工業株式会社 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
CN103087972B (zh) 2013-02-01 2014-11-05 中国科学院天津工业生物技术研究所 生产萜类化合物的重组微生物及构建方法
CN105051195B (zh) 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
US9873880B2 (en) 2013-03-13 2018-01-23 Dsm Nutritional Products Ag Engineering microorganisms
JP6282813B2 (ja) * 2013-07-16 2018-02-21 住友ゴム工業株式会社 ヒドロキシメチルグルタリルCoAレダクターゼの発現をbZIP型転写因子により調整する方法、bZIP型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
CN103602626B (zh) * 2013-10-12 2016-02-10 中国科学院青岛生物能源与过程研究所 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌
EP3179869A1 (de) 2014-08-11 2017-06-21 Evolva SA Erzeugung von steviolglycosiden in rekombinanten wirten
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー.Evolva Sa. 組み換え宿主におけるステビオールグリコシドの生産
EP3250686A1 (de) 2015-01-30 2017-12-06 Evolva SA Erzeugung von steviolglycosiden in rekombinanten wirten
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
MY198001A (en) 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CN106367508B (zh) * 2016-09-13 2019-10-29 东北农业大学 一种用于鉴定杂合型类异戊二烯化合物产生菌的简并引物与应用
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2019055325A2 (en) * 2017-09-12 2019-03-21 Biocapital Holdings, Llc BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES
WO2019090286A2 (en) * 2017-11-06 2019-05-09 The Regents Of The University Of California Production of valerenic acid in fungal cells
CN111699247A (zh) 2017-12-07 2020-09-22 齐默尔根公司 通过发酵产生(6e)-8-羟基香叶醇的经改造的生物合成途径
BR112020012704A8 (pt) 2017-12-21 2022-03-03 Zymergen Inc Nepetalactol oxidorredutases, nepetalactol sintases, e micróbios capazes de produzir nepetalactona
CN109777815B (zh) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN117165502A (zh) * 2022-05-26 2023-12-05 牛津大学(苏州)科技有限公司 一种合成萜类化合物的共培养系统和方法
NL2032683B1 (en) * 2022-07-18 2024-01-26 Sestina Bio Llc Bioproduction of isoprenoids
US20260071241A1 (en) * 2022-11-14 2026-03-12 Agency For Science, Technology And Research Biosynthesis of isoprenoid
CN116925991B (zh) * 2023-07-28 2024-08-09 天津大学 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用
CN120041291A (zh) * 2023-11-24 2025-05-27 牛津大学(苏州)科技有限公司 用于合成目标化合物的共培养系统和方法
WO2025217176A1 (en) * 2024-04-08 2025-10-16 Board Of Trustees Of Michigan State University Genetically engineered bacteria as a chassis host for high yield terpenoid production

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
KR100551104B1 (ko) 1994-12-09 2006-02-09 임페리얼 컬리지 이노베이션스 리미티드 유전자의 동정
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス,インコーポレイティド 核酸分析法
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
US6033861A (en) 1997-11-19 2000-03-07 Incyte Genetics, Inc. Methods for obtaining nucleic acid containing a mutation
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
MX276941B (es) 1998-07-06 2010-06-28 Dcv Inc Haciendo Negocios Como Metodo para producir vitamina.
CN1308623A (zh) * 1998-07-06 2001-08-15 伊斯曼化学公司 生产维生素e的方法
AR022383A1 (es) 1998-09-18 2002-09-04 Univ Kentucky Res Found Sintasas
US6645747B1 (en) 1999-09-21 2003-11-11 E. I. Du Pont De Nemours And Company Cis-prenyltransferases from plants
GB9925453D0 (en) * 1999-10-27 1999-12-29 Univ Bristol Increasing isoprenoid biosynthesis
EP2281890A1 (de) 2000-07-31 2011-02-09 Danisco US Inc. Manipulation der in der Mevalonsäure- und Isoprenoid-Biosynthese verantwortlichen Gene zur Herstellung von geänderten Merkmalen in transgenen Organismen
CA2422730A1 (en) 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
US20040063182A1 (en) 2000-12-28 2004-04-01 Chikara Ohto Process for producing prenyl alcohol
JP3838033B2 (ja) 2000-12-28 2006-10-25 トヨタ自動車株式会社 プレニルアルコールの製造方法
US7238514B2 (en) 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
GB0105924D0 (en) 2001-03-09 2001-04-25 Microscience Ltd Promoter
AU2002316966B2 (en) * 2001-06-06 2007-05-17 Dsm Ip Assets B.V. Improved isoprenoid production
US20040110259A1 (en) 2001-08-03 2004-06-10 Baugh Mariah R Drug metabolizing enzymes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7927794B2 (en) * 2003-09-29 2011-04-19 The Regents Of The University Of California Methods for identifying a biosynthetic pathway gene product

Also Published As

Publication number Publication date
CA2567547A1 (en) 2006-08-17
AU2005327292B2 (en) 2010-11-04
JP4926061B2 (ja) 2012-05-09
US7670825B2 (en) 2010-03-02
WO2006085899A2 (en) 2006-08-17
US7183089B2 (en) 2007-02-27
WO2006085899A3 (en) 2007-05-18
US20060079476A1 (en) 2006-04-13
CA2567547C (en) 2012-10-23
AU2005327292A1 (en) 2006-08-17
US20090004724A1 (en) 2009-01-01
EP2365090A1 (de) 2011-09-14
JP2008500063A (ja) 2008-01-10
BRPI0510115B1 (pt) 2022-09-27
MXPA06013502A (es) 2007-03-01
BRPI0510115A (pt) 2007-09-25
CN101023181A (zh) 2007-08-22
EP1765418A4 (de) 2008-07-02
EP1765418B1 (de) 2011-12-14
ES2379368T3 (es) 2012-04-25
EP1765418A2 (de) 2007-03-28

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