ATE537438T1 - Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge - Google Patents

Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge

Info

Publication number
ATE537438T1
ATE537438T1 AT03738941T AT03738941T ATE537438T1 AT E537438 T1 ATE537438 T1 AT E537438T1 AT 03738941 T AT03738941 T AT 03738941T AT 03738941 T AT03738941 T AT 03738941T AT E537438 T1 ATE537438 T1 AT E537438T1
Authority
AT
Austria
Prior art keywords
excitation wavelength
detectors
samples
detectable markers
signals based
Prior art date
Application number
AT03738941T
Other languages
English (en)
Inventor
Howard King
Steven Boege
Eugene Young
Mark Oldman
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE537438T1 publication Critical patent/ATE537438T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0627—Use of several LED's for spectral resolution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0628—Organic LED [OLED]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Lasers (AREA)
AT03738941T 2002-05-17 2003-05-19 Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge ATE537438T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38167102P 2002-05-17 2002-05-17
US40915202P 2002-09-09 2002-09-09
US45073403P 2003-02-28 2003-02-28
PCT/US2003/015941 WO2003098278A2 (en) 2002-05-17 2003-05-19 Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength

Publications (1)

Publication Number Publication Date
ATE537438T1 true ATE537438T1 (de) 2011-12-15

Family

ID=29554253

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03738941T ATE537438T1 (de) 2002-05-17 2003-05-19 Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge

Country Status (7)

Country Link
US (3) US10768110B2 (de)
EP (5) EP3312594B1 (de)
JP (1) JP2005526253A (de)
AT (1) ATE537438T1 (de)
AU (1) AU2003245302A1 (de)
ES (1) ES2543587T3 (de)
WO (1) WO2003098278A2 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119345B2 (en) 2003-02-28 2006-10-10 Applera Corporation Excitation and emission filter
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
JP2005526253A (ja) 2002-05-17 2005-09-02 アプレラ コーポレイション 励起波長による複数の蛍光シグナルを分化するための装置および方法
KR100580639B1 (ko) 2003-12-30 2006-05-16 삼성전자주식회사 미세유체 검출을 위한 형광검출기
JP3840546B2 (ja) * 2004-02-13 2006-11-01 大学共同利用機関法人 高エネルギー加速器研究機構 微小物体の観察装置
US8128871B2 (en) 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US20050221504A1 (en) * 2004-04-01 2005-10-06 Petruno Patrick T Optoelectronic rapid diagnostic test system
CN101080627B (zh) * 2004-12-17 2010-06-23 皇家飞利浦电子股份有限公司 多点检查装置
US7315376B2 (en) * 2005-01-07 2008-01-01 Advanced Molecular Systems, Llc Fluorescence detection system
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US20060241351A1 (en) * 2005-04-08 2006-10-26 Rosemount Analytical Inc. Integrated optical device for luminescence sensing
US9891217B2 (en) 2005-04-22 2018-02-13 Alverix, Inc. Assay test strips with multiple labels and reading same
EP1886145A2 (de) * 2005-05-03 2008-02-13 Applera Corporation Fluoreszenznachweissystem und farbstoffsatz zur verwendung damit
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
GB0610432D0 (en) * 2006-05-26 2006-07-05 B G Res Ltd Performance issues in use of vessels for biological applications
EP1962084A1 (de) 2007-02-21 2008-08-27 Roche Diagnostics GmbH Gerät zur Emission und Detektion von Lichtstrahlen
JP5282088B2 (ja) 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド 処理実行に使用する機器および容器
AU2009240461A1 (en) 2008-04-24 2009-10-29 3M Innovative Properties Company Analysis of nucleic acid amplification curves using wavelet transformation
WO2010121643A1 (en) * 2009-04-20 2010-10-28 Agilent Technologies, Inc. Identifying calibration markers in multiple detection channels
US9481906B2 (en) 2011-02-04 2016-11-01 Universal Bio Research Co., Ltd. Automatic light measurement device with a movable mount for coupling with multiple reaction containers
AU2012222178B2 (en) 2011-02-24 2014-12-18 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
DE102011016138A1 (de) * 2011-03-30 2012-10-04 Karl Storz Gmbh & Co. Kg Vorrichtung zur Fluoreszenzdiagnose
ES2929040T3 (es) 2011-10-28 2022-11-24 Aeneas Gmbh & Co Kg Dispositivo y procedimiento para detectar sustancias presentes en muestras biológicas o químicas
EP2605001A1 (de) * 2011-12-15 2013-06-19 Hain Lifescience GmbH Vorrichtung und Verfahren zur optischen Messung der Fluoreszenz von Nukleinsäuren in Testproben und Verwendung der Vorrichtung und des Verfahrens
US20130265795A1 (en) * 2012-01-16 2013-10-10 Scott A. Chalmers High-lifetime broadband light source for low-power applications
EP2883040A1 (de) * 2012-08-09 2015-06-17 Life Technologies Corporation Beleuchtungssysteme
BR112015013166A2 (pt) * 2012-12-05 2017-07-11 Genepoc Inc dispositivo de interrogação óptica
JP6082273B2 (ja) * 2013-02-25 2017-02-15 日本板硝子株式会社 蛍光検出装置
CZ304793B6 (cs) * 2013-12-03 2014-10-22 Technická univerzita v Liberci Způsob únavového testování fotochromního, fluorescenčního nebo fosforescenčního barviva/barviv, nebo směsi alespoň dvou z nich, a zařízení k jeho provádění
DE102014115564A1 (de) * 2014-10-27 2016-04-28 Christian-Albrechts-Universität Zu Kiel Mobile photometrische Messvorrichtung und Verfahren zur mobilen photometrischen Messung von Mikrotitierplatten
JP6494269B2 (ja) * 2014-12-17 2019-04-03 ルネサスエレクトロニクス株式会社 磁気計測装置
EP3719481B1 (de) * 2015-02-06 2023-03-29 Life Technologies Corporation Ein optisches instrument für die biologische analyse
US20160265032A1 (en) * 2015-03-11 2016-09-15 Hexna Corp. Portable dna analysis machine
KR101838640B1 (ko) * 2015-06-17 2018-03-14 (주)동국이노텍 마이크로플레이트 기반 세포 대사 측정 실험 장치
US9810631B2 (en) * 2015-07-25 2017-11-07 Stem Arts Projects, Llc Wavelength scanning apparatus and method of use thereof
US9568429B1 (en) * 2015-07-25 2017-02-14 Stem Arts Projects, Llc Wavelength scanning apparatus and method of use thereof
FR3051251B1 (fr) * 2016-05-10 2018-06-15 Commissariat A L'energie Atomique Et Aux Energies Alternatives Systeme d'observation d'une plaque a puits
US10473591B2 (en) * 2017-05-01 2019-11-12 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample
CN107287116A (zh) * 2017-07-04 2017-10-24 王效芬 一种384孔辅助加样器
CN107515209A (zh) * 2017-10-02 2017-12-26 西南石油大学 一种多功能荧光样品发光测试台
US20210293707A1 (en) * 2018-08-02 2021-09-23 The Charles Stark Draper Laboratory, Inc. Fluorescence Lifetime Well Array Reader and Actuator
US11378444B2 (en) * 2020-08-05 2022-07-05 Visera Technologies Company Limited Biosensor and bio detection system
US11703445B2 (en) * 2021-05-28 2023-07-18 Visera Technologies Company Limited Biosensor with grating array
CN118202229A (zh) 2021-10-20 2024-06-14 生物辐射实验室股份有限公司 荧光检测系统
WO2023069651A1 (en) * 2021-10-20 2023-04-27 Bio-Rad Laboratories, Inc. Fluorescence detection system
US12203857B2 (en) * 2022-03-15 2025-01-21 Kla Corporation Multi-element super resolution optical inspection system
CN114989972A (zh) * 2022-05-26 2022-09-02 北京市眼科研究所 用于细胞光损伤测量的装置及其用途
WO2025117843A1 (en) * 2023-11-29 2025-06-05 Abbott Diagnostics Scarborough, Inc. Device, system and method for detecting fluorescence

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973129A (en) * 1975-01-10 1976-08-03 Bell Telephone Laboratories, Incorporated Fluorimetric apparatus and method for analysis of body fluid
US3963351A (en) * 1975-04-14 1976-06-15 Britton Chance Multi-channel optical time-sharing apparatus having a rotating filter wheel with position-encoding means
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4356429A (en) 1980-07-17 1982-10-26 Eastman Kodak Company Organic electroluminescent cell
JPS57186169A (en) 1981-05-12 1982-11-16 Olympus Optical Co Ltd Detector for particle coagulation pattern
US4626684A (en) * 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
DE3329257A1 (de) * 1983-08-12 1985-02-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Fluorometer
FR2566543B1 (fr) * 1984-06-20 1988-02-26 Commissariat Energie Atomique Dispositif optique a rendement de collection eleve et cytofluorimetre en faisant application
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5656493A (en) * 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5073029A (en) * 1990-02-16 1991-12-17 Eqm Research, Inc. Multisource device for photometric analysis and associated chromogens
EP0443700A3 (en) * 1990-02-21 1991-10-16 Mitsubishi Jukogyo Kabushiki Kaisha Method for counting living cells of microbes and apparatus therefor
US5169601A (en) * 1990-04-27 1992-12-08 Suzuki Motor Corporation Immunological agglutination detecting apparatus with separately controlled supplementary light sources
US5215883A (en) * 1990-07-09 1993-06-01 The Research Foundation Electrophoretic mobility of fluorophore labeled particles in gels by fluorophore movement after photobleaching
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US6352672B1 (en) * 1991-01-28 2002-03-05 Cis Bio International Apparatus for measuring the luminescence emitted in a luminescent assay
DE4102767A1 (de) * 1991-01-31 1992-08-06 Metallgesellschaft Ag Verfahren zur qualitativen analyse von kunststoffteilchen
US5243540A (en) * 1991-04-03 1993-09-07 The United States Of America As Represented By The Secretary Of The Army Computer-driven amino acid indexer for peptide synthesis
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5315375A (en) * 1992-02-11 1994-05-24 Acrogen, Inc. Sensitive light detection system
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5383023A (en) * 1993-03-01 1995-01-17 Walleczek; Jan Method and apparatus for performing dual-beam dual-wavelength fluorescence spectrophotometric evaluation of a biological specimen
US5371016A (en) * 1993-04-26 1994-12-06 Becton, Dickinson And Company Detecting biological activities in culture vials
EP0622762B1 (de) * 1993-04-27 1998-07-01 The Furukawa Electric Co., Ltd. Vorrichtung zum Nachweis von Fluoreszenz
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5919712A (en) * 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5397709A (en) * 1993-08-27 1995-03-14 Becton Dickinson And Company System for detecting bacterial growth in a plurality of culture vials
CA2129787A1 (en) 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
JPH07120393A (ja) 1993-10-13 1995-05-12 Nippon Tectron Co Ltd 蛍光検出法
JPH07120392A (ja) 1993-10-28 1995-05-12 Shimadzu Corp 塩基配列決定装置
US6309601B1 (en) * 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
CA2159830C (en) * 1994-04-29 2001-07-03 Applied Biosystems, Llc System for real time detection of nucleic acid amplification products
US5766889A (en) * 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
WO1996018205A1 (en) * 1994-12-08 1996-06-13 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
JPH07174701A (ja) 1994-12-28 1995-07-14 Shimadzu Corp 塩基配列決定装置
US5554450A (en) 1995-03-08 1996-09-10 Eastman Kodak Company Organic electroluminescent devices with high thermal stability
US5567947A (en) * 1995-06-01 1996-10-22 Aerodyne Research, Inc. Spectral line discriminator for passive detection of fluorescence
US6411835B1 (en) * 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
US5593788A (en) 1996-04-25 1997-01-14 Eastman Kodak Company Organic electroluminescent devices with high operational stability
US5926271A (en) * 1995-12-20 1999-07-20 Zeta Technology Laser-induced fluorescence detector having a capillary detection cell and method for identifying trace compounds implemented by the same device
US5759781A (en) * 1995-12-22 1998-06-02 Yale University Multiparametric fluorescence in situ hybridization
US5792610A (en) * 1996-05-01 1998-08-11 Biorad Laboratories, Inc. Method for conducting multiparametric fluorescence in situ hybridization
EP0879297A4 (de) 1995-12-22 2003-04-16 Biorad Lab Inc Verfahren und gerät zur durchführung von fluoreszenz in situ hybridisierung unter messung einer vielzahl von parametern
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
AT403745B (de) 1996-02-29 1998-05-25 Avl Verbrennungskraft Messtech Messanordnung mit einem für anregungs- und messstrahlung transparentem trägerelement
US6287871B1 (en) * 1996-03-19 2001-09-11 University Of Utah Research Foundation System for determining analyte concentration
KR100443223B1 (ko) * 1996-03-28 2004-09-18 미쯔비시 레이온 가부시끼가이샤 굴절율분포형광섬유및그의제조방법
JPH09281078A (ja) 1996-04-09 1997-10-31 Hitachi Electron Eng Co Ltd Ｄｎａ塩基配列決定装置
JP2000512744A (ja) * 1996-05-16 2000-09-26 アフィメトリックス，インコーポレイテッド 標識材料を検出するシステムおよび方法
PT2298931E (pt) 1996-06-04 2013-11-11 Univ Utah Res Found Aparelho para executar uma pcr e monitorização fluorescente contínua da reacção de pcr
US5736333A (en) * 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
JP3400650B2 (ja) * 1996-06-28 2003-04-28 株式会社日立製作所 電気泳動分離検出方法及び装置
US5699157A (en) * 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6312611B1 (en) 1996-07-31 2001-11-06 The F.B. Leopold Co., Inc. Apparatus for distributing gas and liquid during concurrent gas/liquid backwash in filter underdrain flumes
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
JP4663824B2 (ja) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド 多重化分子分析装置および方法
US6084667A (en) * 1997-03-12 2000-07-04 Nz Applied Technologies System and method for molecular sample measurement
BR9809154B1 (pt) * 1997-05-23 2012-09-04 aparelho e sistema de teste microbiológico diagnóstico.
DE19725050C2 (de) 1997-06-13 1999-06-24 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung
US6365024B1 (en) * 1997-06-30 2002-04-02 Spectrumedix Corporation Motorized positioning apparatus having coaxial carrousels
US5943129A (en) * 1997-08-07 1999-08-24 Cambridge Research & Instrumentation Inc. Fluorescence imaging system
GB9717021D0 (en) * 1997-08-12 1997-10-15 Kalibrant Limited A detector
US6043506A (en) * 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
US6597450B1 (en) * 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
JPH1195120A (ja) * 1997-09-19 1999-04-09 Olympus Optical Co Ltd 顕微鏡の観察方法
WO2001004608A1 (en) 1999-07-07 2001-01-18 Ljl Biosystems, Inc. Light detection device
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6399936B1 (en) 1997-12-01 2002-06-04 New Dimension Research Instrument, Inc. Optical confocal device having a common light directing means
US6121603A (en) * 1997-12-01 2000-09-19 Hang; Zhijiang Optical confocal device having a common light directing means
JPH11218690A (ja) * 1998-02-04 1999-08-10 Olympus Optical Co Ltd 落射蛍光照明光学系を備えた顕微鏡
US6929953B1 (en) * 1998-03-07 2005-08-16 Robert A. Levine Apparatus for analyzing biologic fluids
US6388788B1 (en) * 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
EP1064353B1 (de) * 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
ATE425448T1 (de) * 1998-05-16 2009-03-15 Applera Corp Optisches gerät insbesondere zur überwachung von dns-polymerasekettenreaktionen
US6010756A (en) 1998-05-19 2000-01-04 Lockheed Martin Corporation Rugate filter and method of making same
ATE255727T1 (de) * 1998-07-17 2003-12-15 Vertex Pharma San Diego Llc Detektor und siebvorrichtung für ionenkanäle
CA2341359A1 (en) * 1998-08-21 2000-03-02 Ian Walton Novel optical architectures for microvolume laser-scanning cytometers
DE19940750A1 (de) 1998-08-28 2000-06-21 Febit Ferrarius Biotech Gmbh Träger für Analytbestimmungsverfahren und Verfahren zur Herstellung des Trägers
US6326144B1 (en) 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6426513B1 (en) 1998-09-18 2002-07-30 Massachusetts Institute Of Technology Water-soluble thiol-capped nanocrystals
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
EP1115888B1 (de) 1998-09-24 2008-03-12 Indiana University Research and Technology Corporation Wasserlösliche lumineszente quantum-dots sowie deren biokonjugate
US6455861B1 (en) * 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
US7115365B2 (en) * 1998-12-07 2006-10-03 Olympus Optical Co., Ltd. Method of analyzing a target nucleic acid
EP1151139A2 (de) * 1999-01-25 2001-11-07 UT-Battelle, LLC Mehrzweck- und multispektral-biosensorgeräte, sowie verfahren zu deren verwendung
US6355934B1 (en) * 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
US6274323B1 (en) 1999-05-07 2001-08-14 Quantum Dot Corporation Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label
US6645777B1 (en) * 1999-11-05 2003-11-11 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantation Tapered tubular optical waveguide probe for magnetic focusing immunosensors
EP2264439A3 (de) 1999-11-12 2011-01-19 E.I. Du Pont De Nemours And Company Fluorometer mit Lichtquelle mit geringer Wärmeerzeugung
US6331438B1 (en) 1999-11-24 2001-12-18 Iowa State University Research Foundation, Inc. Optical sensors and multisensor arrays containing thin film electroluminescent devices
EP1269159A4 (de) 2000-02-25 2005-01-26 Cambridge Res & Instrmnt Inc Momentan-doppelband-fluoreszenzdetektionssysteme
AU2001249237A1 (en) 2000-03-16 2001-09-24 Spectrumedix Corporation Multi-wavelength array reader for biological assay
AU2001250287B2 (en) * 2000-04-11 2005-06-23 Chemometec A/S Method and apparatus for detecting fluorescence of a sample
US6783934B1 (en) * 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
AU6152301A (en) 2000-05-12 2001-11-26 Caliper Techn Corp Detection of nucleic acid hybridization by fluorescence polarization
US6795189B2 (en) * 2000-06-15 2004-09-21 Packard Instrument Company Universal microplate analyzer
US6558624B1 (en) * 2000-07-25 2003-05-06 General Electric Company Method and analytical system for rapid screening of combinatorial libraries
US6789040B2 (en) * 2000-08-22 2004-09-07 Affymetrix, Inc. System, method, and computer software product for specifying a scanning area of a substrate
US6930314B2 (en) * 2000-10-27 2005-08-16 Molecular Devices Corporation Light detection device
US6650411B2 (en) * 2001-04-26 2003-11-18 Affymetrix, Inc. System, method, and product for pixel clocking in scanning of biological materials
US6529275B2 (en) 2001-06-22 2003-03-04 Biocal Technology, Inc. Optical detection in bio-separation device using a widened detection zone
US6709857B2 (en) 2001-06-26 2004-03-23 Becton, Dickinson And Company System and method for optically monitoring the concentration of a gas in a sample vial using photothermal spectroscopy to detect sample growth
US6995841B2 (en) * 2001-08-28 2006-02-07 Rice University Pulsed-multiline excitation for color-blind fluorescence detection
US20030047881A1 (en) 2001-09-13 2003-03-13 Worm Steven Lee Sealing system and pressure chamber assembly including the same
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US20030160182A1 (en) * 2002-02-25 2003-08-28 Emerge Interactive, Inc. Apparatus and method for detecting fecal and ingesta contamination using a hand held illumination and imaging device
JP2005526253A (ja) 2002-05-17 2005-09-02 アプレラ コーポレイション 励起波長による複数の蛍光シグナルを分化するための装置および方法
US6987259B2 (en) * 2002-05-30 2006-01-17 Dmetrix, Inc. Imaging system with an integrated source and detector array
US20030230728A1 (en) * 2002-06-13 2003-12-18 Zhengshan Dai Multiwavelength transilluminator for absorbance and fluorescence detection using light emitting diodes

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EP2775291B1 (de) 2016-01-13
EP1506390A4 (de) 2009-12-02
EP3035037A1 (de) 2016-06-22
US8809040B2 (en) 2014-08-19
EP3312594A1 (de) 2018-04-25
EP2444793B1 (de) 2014-05-07
AU2003245302A1 (en) 2003-12-02
EP3035037B1 (de) 2017-09-13
WO2003098278A3 (en) 2004-02-12
US20120087832A1 (en) 2012-04-12
EP1506390A2 (de) 2005-02-16
US10768110B2 (en) 2020-09-08
WO2003098278A2 (en) 2003-11-27
JP2005526253A (ja) 2005-09-02
AU2003245302A8 (en) 2003-12-02
US20150293024A1 (en) 2015-10-15
EP2775291A1 (de) 2014-09-10
EP2444793A1 (de) 2012-04-25
EP3312594B1 (de) 2019-07-24
US9719925B2 (en) 2017-08-01
ES2543587T3 (es) 2015-08-20
EP1506390B1 (de) 2011-12-14
US20100216143A1 (en) 2010-08-26

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