ATE538105T1 - Substituierte tetrazolverbindungen und ihre verwendung - Google Patents
Substituierte tetrazolverbindungen und ihre verwendungInfo
- Publication number
- ATE538105T1 ATE538105T1 AT08837110T AT08837110T ATE538105T1 AT E538105 T1 ATE538105 T1 AT E538105T1 AT 08837110 T AT08837110 T AT 08837110T AT 08837110 T AT08837110 T AT 08837110T AT E538105 T1 ATE538105 T1 AT E538105T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- tetrazole compounds
- compounds
- substituted tetrazole
- methods
- Prior art date
Links
- -1 TETRAZOLE COMPOUNDS Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97960107P | 2007-10-12 | 2007-10-12 | |
| PCT/US2008/079755 WO2009049305A2 (en) | 2007-10-12 | 2008-10-14 | 5- (2-hydroxyphenyl) tetrazoles as hsp90 inhibitors against cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538105T1 true ATE538105T1 (de) | 2012-01-15 |
Family
ID=40473811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08837110T ATE538105T1 (de) | 2007-10-12 | 2008-10-14 | Substituierte tetrazolverbindungen und ihre verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7932279B2 (de) |
| EP (1) | EP2217580B1 (de) |
| JP (1) | JP4792128B2 (de) |
| CN (1) | CN101821247A (de) |
| AT (1) | ATE538105T1 (de) |
| CA (1) | CA2700893A1 (de) |
| WO (1) | WO2009049305A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| CN104583185A (zh) | 2012-08-31 | 2015-04-29 | 株式会社Api | 联芳基化合物的制造方法 |
| IN2015DN02241A (de) | 2012-09-26 | 2015-08-21 | Api Corp | |
| CN107709314A (zh) | 2015-06-11 | 2018-02-16 | 巴斯利尔药物国际股份公司 | 外排泵抑制剂及其治疗性用途 |
| CN105418527A (zh) * | 2015-12-28 | 2016-03-23 | 青岛友诚高新技术有限公司 | 一种具有抗乳腺导管癌活性的化合物及其制备方法、用途 |
| EP3909577A1 (de) * | 2020-05-13 | 2021-11-17 | Fundación Profesor Novoa Santos | Ubiquitin-ligase-inhibitoren zur behandlung von krebs |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1486057A (en) | 1975-06-09 | 1977-09-14 | Ici Ltd | Hydroxyphenyl tetrazoles and their use in the extraction of metals |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| US6975843B2 (en) | 2000-12-21 | 2005-12-13 | Telefonaktiebolaget L M Ericsson (Publ) | Method and an arrangement relating to telecommunications systems |
| US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| US7074824B2 (en) | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| WO2003030937A1 (en) * | 2001-10-05 | 2003-04-17 | Ono Pharmaceutical Co., Ltd. | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists |
| GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
| SI1611112T1 (sl) | 2003-02-11 | 2012-12-31 | Vernalis (R&D) Limited | Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov |
| CA2526285A1 (en) | 2003-05-15 | 2004-12-23 | Arqule, Inc. | Inhibitors of p38 and methods of using the same |
| GB0315111D0 (en) * | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| JP2007509968A (ja) * | 2003-10-28 | 2007-04-19 | ファルマシア・コーポレーション | 新形成を治療または予防するためのｈｓｐ９０阻害剤およびホスホジエステラーゼ阻害剤を含む組み合わせ |
| JPWO2005063222A1 (ja) * | 2003-12-26 | 2007-07-19 | 協和醗酵工業株式会社 | Ｈｓｐ９０ファミリー蛋白質阻害剤 |
| FR2865736B1 (fr) | 2004-02-02 | 2006-07-14 | Synt Em | Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese |
| JP2005225787A (ja) | 2004-02-12 | 2005-08-25 | Nippon Kayaku Co Ltd | Ｈｓｐ９０阻害剤 |
| WO2006011052A1 (en) | 2004-07-23 | 2006-02-02 | Pharmacia & Upjohn Company Llc | Method for the racemization of 2-trifluoro-2h-chromene-3-carboxylic acids |
| PE20060572A1 (es) | 2004-07-27 | 2006-06-27 | Novartis Ag | Compuestos de benzoimidazolona como inhibidores de hsp90 |
| DE102004039280A1 (de) | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| EP2258704A1 (de) | 2004-10-19 | 2010-12-08 | ArQule, Inc. | Synthese aus Imidazooxazol- und Imidazothiazol-hemmern der P38-map-kinase |
| EP1817295B1 (de) * | 2004-11-18 | 2012-11-07 | Synta Pharmaceuticals Corp. | Hsp90-aktivität modulierende triazolverbindungen |
| DE102005007304A1 (de) | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
| JP2006306755A (ja) | 2005-04-27 | 2006-11-09 | Nippon Kayaku Co Ltd | 新規なピラゾール誘導体とそれを有効成分とするｈｓｐ９０阻害剤 |
| JP2008540395A (ja) | 2005-05-03 | 2008-11-20 | ファイザー・インク | アミドレソルシノール化合物 |
| US7608635B2 (en) * | 2005-08-12 | 2009-10-27 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| WO2007021877A1 (en) * | 2005-08-18 | 2007-02-22 | Synta Pharmaceuticals Corp. | Imidazole compounds that modulate hsp90 activity |
| JP5118039B2 (ja) | 2005-08-18 | 2013-01-16 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０活性を調節するトリアゾール化合物 |
| WO2007123892A2 (en) | 2006-04-17 | 2007-11-01 | Arqule Inc. | Raf inhibitors and their uses |
-
2008
- 2008-10-14 CN CN200880111766A patent/CN101821247A/zh active Pending
- 2008-10-14 US US12/251,093 patent/US7932279B2/en active Active
- 2008-10-14 CA CA2700893A patent/CA2700893A1/en not_active Abandoned
- 2008-10-14 JP JP2010529145A patent/JP4792128B2/ja not_active Expired - Fee Related
- 2008-10-14 WO PCT/US2008/079755 patent/WO2009049305A2/en not_active Ceased
- 2008-10-14 EP EP08837110A patent/EP2217580B1/de not_active Not-in-force
- 2008-10-14 AT AT08837110T patent/ATE538105T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| US7932279B2 (en) | 2011-04-26 |
| JP4792128B2 (ja) | 2011-10-12 |
| CA2700893A1 (en) | 2009-04-16 |
| EP2217580B1 (de) | 2011-12-21 |
| US20090130117A1 (en) | 2009-05-21 |
| CN101821247A (zh) | 2010-09-01 |
| WO2009049305A2 (en) | 2009-04-16 |
| JP2011500603A (ja) | 2011-01-06 |
| WO2009049305A3 (en) | 2009-07-02 |
| EP2217580A2 (de) | 2010-08-18 |
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