ATE522531T1 - Indolylpyrrolidine zur behandlung von krebs - Google Patents

Indolylpyrrolidine zur behandlung von krebs

Info

Publication number
ATE522531T1
ATE522531T1 AT08771523T AT08771523T ATE522531T1 AT E522531 T1 ATE522531 T1 AT E522531T1 AT 08771523 T AT08771523 T AT 08771523T AT 08771523 T AT08771523 T AT 08771523T AT E522531 T1 ATE522531 T1 AT E522531T1
Authority
AT
Austria
Prior art keywords
present
cancer
pyrrolidine
indolylpyrrolidine
treatment
Prior art date
Application number
AT08771523T
Other languages
English (en)
Inventor
Neil Westlund
Jason Hill
Mark Ashwell
Nivedita Namdev
Jianqiang Wang
Syed Ali
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Application granted granted Critical
Publication of ATE522531T1 publication Critical patent/ATE522531T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08771523T 2007-06-22 2008-06-19 Indolylpyrrolidine zur behandlung von krebs ATE522531T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94582007P 2007-06-22 2007-06-22
PCT/US2008/067566 WO2009002807A2 (en) 2007-06-22 2008-06-19 Indolyl pyrrolidines for the treatment of cancer

Publications (1)

Publication Number Publication Date
ATE522531T1 true ATE522531T1 (de) 2011-09-15

Family

ID=39767054

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08771523T ATE522531T1 (de) 2007-06-22 2008-06-19 Indolylpyrrolidine zur behandlung von krebs

Country Status (8)

Country Link
US (1) US8513292B2 (de)
EP (2) EP2392574B1 (de)
JP (2) JP5490688B2 (de)
CN (1) CN101801969B (de)
AT (1) ATE522531T1 (de)
CA (2) CA2912546A1 (de)
TW (1) TWI421251B (de)
WO (1) WO2009002807A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2690799C (en) * 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
KR101669707B1 (ko) * 2009-12-23 2016-10-27 아르퀼 인코포레이티드 정제된 피롤로퀴놀리닐-피롤리딘-2,5-디온 조성물 및 이의 제조 방법 및 사용 방법
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
EP2655372B8 (de) * 2010-12-23 2016-09-07 ArQule, Inc. Pyrrolochinolinyl-pyrrolidin-2,5-dion-zusammensetzungen und verfahren zu ihrer herstellung und verwendung
US9216998B2 (en) 2012-02-15 2015-12-22 Janssen Pharmaceutica Nv Tricyclic indole derivatives useful endothelial lipase inhibitors
CN103626762B (zh) * 2012-08-24 2015-07-29 上海医药工业研究院 苯并吡啶氮杂卓类化合物及其应用
CN113845961B (zh) * 2021-10-11 2022-08-12 山东三品新能源有限公司 一种齿轮用润滑油组合物及其制备方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US36736A (en) * 1862-10-21 Improvement in curry-combs
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
USRE36736E (en) 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
MC2096A1 (fr) 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL94274A0 (en) 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
AU3761393A (en) 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
DK0817627T3 (da) 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
WO1995030682A1 (en) 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides
KR20000064764A (ko) 1996-03-20 2000-11-06 피터지.스트링거 인돌릴말레이미드의제조방법
PE91698A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
JP2000516632A (ja) 1996-08-23 2000-12-12 イーライ・リリー・アンド・カンパニー ビスインドリルマレイミド類の合成
SE9603283D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
WO1998016528A1 (en) 1996-10-11 1998-04-23 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
AU4929999A (en) 1998-07-30 2000-02-21 Japan Tobacco Inc. Disubstituted maleimide compounds and medicinal utilization thereof
AU2327700A (en) 1999-02-09 2000-08-29 Rei Asakai Pyrrole derivatives and cell death inhibitors
DE60010934T2 (de) 1999-12-16 2005-05-19 Eli Lilly And Co., Indianapolis Medikamente geeignet zur Behandlung von proliferativen Erkrankungen
US6867198B2 (en) * 1999-12-16 2005-03-15 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
EP1275646A4 (de) 2000-03-30 2003-05-28 Sagami Chem Res Indolylpyrrol-derivate und zelltod-inhibitoren
CA2408747C (en) 2000-05-11 2011-04-05 Consejo Superior Investigaciones Cientificas Heterocyclic inhibitors of glycogen synthase kinase gsk-3
AU7785401A (en) 2000-06-29 2002-01-14 Long Island Jewish Res Inst Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof
WO2003066808A2 (en) 2002-01-23 2003-08-14 Texas Tech University Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells
CA2477967C (en) 2002-03-05 2010-08-10 Eli Lilly And Company Purine derivatives as kinase inhibitors
EP1620573A4 (de) 2003-04-15 2006-12-20 Avalon Pharmaceuticals Bestimmung von mit krebs in verbindung gebrachten genen und therapeutischen zielen unter verwendung molekularer zytogenetischer verfahren
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
EP2093570A1 (de) 2003-06-06 2009-08-26 Genentech, Inc. Modulierung der Interaktion zwischen HGF-beta-Kette und c-Met
CA2539190A1 (en) 2003-07-07 2005-01-27 George F. Vande Woude Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor
WO2005058965A1 (en) 2003-12-11 2005-06-30 Genentech, Inc. Methods and compositions for inhibiting c-met dimerization and activation
DK1846406T5 (da) * 2005-02-09 2011-10-31 Arqule Inc Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
ES2440953T3 (es) 2005-03-31 2014-01-31 The General Hospital Corporation Modulación de la actividad de HGF/HGFR para tratar un linfedema
CA2690799C (en) * 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer

Also Published As

Publication number Publication date
CN101801969A (zh) 2010-08-11
JP5792239B2 (ja) 2015-10-07
WO2009002807A2 (en) 2008-12-31
US8513292B2 (en) 2013-08-20
CN101801969B (zh) 2014-10-29
TW200918530A (en) 2009-05-01
CA2690782A1 (en) 2008-12-31
CA2690782C (en) 2016-02-02
EP2173748B1 (de) 2011-08-31
EP2173748A2 (de) 2010-04-14
US20100183603A1 (en) 2010-07-22
WO2009002807A3 (en) 2009-07-30
JP5490688B2 (ja) 2014-05-14
JP2010530884A (ja) 2010-09-16
TWI421251B (zh) 2014-01-01
EP2392574B1 (de) 2013-12-18
EP2392574A1 (de) 2011-12-07
CA2912546A1 (en) 2008-12-31
JP2013241458A (ja) 2013-12-05

Similar Documents

Publication Publication Date Title
DE602006017965D1 (de) Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs
UA107783C2 (en) Isoindoline compounds for use in treating cancer
EA201100119A1 (ru) Химические соединения 251
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
MX2011006959A (es) Compuestos substituidos de 5,6-dihidro-6-fenilbenzo [f] isoquinolina-2-amina.
EA201170670A1 (ru) Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета
EA200700501A1 (ru) Композиция (варианты) и способ для лечения гиперпролиферативных процессов, способ лечения рака (варианты) и способ получения твёрдой дисперсии вещества
EA201001639A1 (ru) Композиции и способы их получения и применения
EA200870415A1 (ru) Хиназолины для ингибирования pdk 1
EA200971026A1 (ru) Новые макроциклические ингибиторы репликации вируса гепатита с
EA200971041A1 (ru) Новые пептидные ингибиторы репликации вируса гепатита с
EA201290919A1 (ru) Индазольные соединения и их применение
MX2009013815A (es) Compuestos de quinazolinona y metodos de uso para los mismos.
EA200901212A1 (ru) 3-имидазолилиндолы, предназначенные для лечения пролиферативных заболеваний
MY157124A (en) Substituted imidazopyridinyl-aminopyridine compounds
PH12012501337A1 (en) Substituted pyrrolo-aminopyrimidine compounds
EA201071045A1 (ru) Соединения оксадиазоантрацена для лечения диабета
EA201001865A1 (ru) Противовоспалительные агенты
UA108369C2 (uk) Піролопіримідини як інгібітори cdk4/6
ATE395905T1 (de) Pharmazeutische zusammensetzungen in form fester dispersionen zur behandlung von krebs
EA201001094A1 (ru) Производные индазола
WO2009026446A3 (en) Hdac inhibitors
EP2515904A4 (de) Gereinigte pyrrolochinolinyl-pyrrolidin-2,5-dion-zusammensetzungen und verfahren zu ihrer herstellung und verwendung
EA201791321A1 (ru) Составы ингибитора lfa-1
ATE522500T1 (de) Amidderivate als ionenkanalliganden sowie pharmazeutische zusammensetzungen und verwendungsverfahren dafür

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties