ATE539061T1 - 2-ä(3s)-ä3-ä(2e)-(7-chlorchinolin-2- yl)ethenylüphenylü-3- halogenpropylübenzoesäuremethylester - Google Patents
2-ä(3s)-ä3-ä(2e)-(7-chlorchinolin-2- yl)ethenylüphenylü-3- halogenpropylübenzoesäuremethylesterInfo
- Publication number
- ATE539061T1 ATE539061T1 AT04770671T AT04770671T ATE539061T1 AT E539061 T1 ATE539061 T1 AT E539061T1 AT 04770671 T AT04770671 T AT 04770671T AT 04770671 T AT04770671 T AT 04770671T AT E539061 T1 ATE539061 T1 AT E539061T1
- Authority
- AT
- Austria
- Prior art keywords
- chloroquinolin
- ethenyl
- phenyl
- methyl
- halopropylbenzoic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000004702 methyl esters Chemical class 0.000 title 1
- -1 7-chloro quinolin-2-yl Chemical group 0.000 abstract 3
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 3
- KPCSDMZEMDMWKQ-SPNSGGJLSA-N methyl 2-[(3s)-3-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1CC[C@H](O)C1=CC=CC(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)=C1 KPCSDMZEMDMWKQ-SPNSGGJLSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- KJZUERNXOFYKNT-UHFFFAOYSA-M lithium methane sulfuryl dichloride bromide Chemical compound [Br-].[Li+].S(=O)(=O)(Cl)Cl.C KJZUERNXOFYKNT-UHFFFAOYSA-M 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- GVQPSSGWDYNZQT-UHFFFAOYSA-M sodium;chloro(trimethyl)silane;iodide Chemical compound [Na+].[I-].C[Si](C)(C)Cl GVQPSSGWDYNZQT-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2004/000211 WO2006008750A2 (en) | 2004-07-19 | 2004-07-19 | Methyl 2-[(3s)-[3-[(2e)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539061T1 true ATE539061T1 (de) | 2012-01-15 |
Family
ID=35785611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04770671T ATE539061T1 (de) | 2004-07-19 | 2004-07-19 | 2-ä(3s)-ä3-ä(2e)-(7-chlorchinolin-2- yl)ethenylüphenylü-3- halogenpropylübenzoesäuremethylester |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7858793B2 (de) |
| EP (1) | EP1812393B1 (de) |
| AT (1) | ATE539061T1 (de) |
| WO (1) | WO2006008750A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007004237A2 (en) * | 2005-07-05 | 2007-01-11 | Matrix Laboratories Ltd | A process for the preparation of montelukast |
| EP2069307A4 (de) * | 2006-08-04 | 2010-03-03 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen daraus |
| KR20090080038A (ko) * | 2006-09-15 | 2009-07-23 | 씨아이피엘에이 엘티디. | 몬테루카스트의 제조방법 및 그의 중간체 |
| CN102442948B (zh) * | 2011-11-01 | 2013-10-16 | 上海璎黎科技有限公司 | 孟鲁司特钠中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565473A (en) | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| DK0480717T3 (da) | 1990-10-12 | 1999-02-08 | Merck Frosst Canada Inc | Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister |
| TW448160B (en) | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
-
2004
- 2004-07-19 AT AT04770671T patent/ATE539061T1/de active
- 2004-07-19 WO PCT/IN2004/000211 patent/WO2006008750A2/en not_active Ceased
- 2004-07-19 US US11/791,048 patent/US7858793B2/en not_active Expired - Fee Related
- 2004-07-19 EP EP04770671A patent/EP1812393B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20080275243A1 (en) | 2008-11-06 |
| EP1812393A2 (de) | 2007-08-01 |
| US7858793B2 (en) | 2010-12-28 |
| WO2006008750A2 (en) | 2006-01-26 |
| WO2006008750A3 (en) | 2006-12-21 |
| EP1812393B1 (de) | 2011-12-28 |
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