ATE539741T1 - Sphingolipide bei der behandlung und prävention von hepatischer steatose - Google Patents
Sphingolipide bei der behandlung und prävention von hepatischer steatoseInfo
- Publication number
- ATE539741T1 ATE539741T1 AT05813546T AT05813546T ATE539741T1 AT E539741 T1 ATE539741 T1 AT E539741T1 AT 05813546 T AT05813546 T AT 05813546T AT 05813546 T AT05813546 T AT 05813546T AT E539741 T1 ATE539741 T1 AT E539741T1
- Authority
- AT
- Austria
- Prior art keywords
- prevention
- treatment
- sphingolipids
- hepatic steatosis
- sphingolipid
- Prior art date
Links
- 150000003408 sphingolipids Chemical class 0.000 title abstract 4
- 230000002265 prevention Effects 0.000 title abstract 3
- 206010019708 Hepatic steatosis Diseases 0.000 title abstract 2
- 206010019851 Hepatotoxicity Diseases 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 231100000334 hepatotoxic Toxicity 0.000 abstract 2
- 230000003082 hepatotoxic effect Effects 0.000 abstract 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 1
- HOMYIYLRRDTKAA-UHFFFAOYSA-N 2-hydroxy-N-[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide Chemical compound CCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=CCCCCCCCCC)COC1OC(CO)C(O)C(O)C1O HOMYIYLRRDTKAA-UHFFFAOYSA-N 0.000 abstract 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 abstract 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 abstract 1
- 206010019668 Hepatic fibrosis Diseases 0.000 abstract 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 abstract 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 abstract 1
- 229940033329 phytosphingosine Drugs 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- OTKJDMGTUTTYMP-ZWKOTPCHSA-N sphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ZWKOTPCHSA-N 0.000 abstract 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 1
- 230000007863 steatosis Effects 0.000 abstract 1
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078265A EP1661562A1 (de) | 2004-11-30 | 2004-11-30 | Verwendung von Sphingolipiden zur Behandlung und Vorbeugung von Steatose |
| EP05075856 | 2005-04-12 | ||
| EP05077029 | 2005-09-06 | ||
| PCT/NL2005/000813 WO2006059897A1 (en) | 2004-11-30 | 2005-11-25 | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539741T1 true ATE539741T1 (de) | 2012-01-15 |
Family
ID=35744899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05813546T ATE539741T1 (de) | 2004-11-30 | 2005-11-25 | Sphingolipide bei der behandlung und prävention von hepatischer steatose |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7906488B2 (de) |
| EP (1) | EP1830829B1 (de) |
| JP (1) | JP2008521888A (de) |
| AT (1) | ATE539741T1 (de) |
| AU (1) | AU2005310341A1 (de) |
| WO (1) | WO2006059897A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10227290B2 (en) | 2012-02-07 | 2019-03-12 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| US10329315B2 (en) | 2012-10-12 | 2019-06-25 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| WO2015085121A1 (en) * | 2013-12-05 | 2015-06-11 | University Of Miami | Compositions and methods for reducing intraocular pressure |
| DE102018217334A1 (de) | 2018-10-10 | 2020-04-16 | Harbins Ruhr Bioscience, Inc. | Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel |
| WO2022015348A1 (en) | 2020-07-16 | 2022-01-20 | Harbins Ruhr Bioscience, Inc. | Sphingoid compounds for use in prophylaxis and/or therapy of coronaviridae infection |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492259A1 (fr) | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
| JPS61152632A (ja) | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
| JPS6344842A (ja) | 1986-08-12 | 1988-02-25 | Kao Corp | 油中水中油型乳化油脂組成物 |
| IT1235162B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisosfingolipidi |
| US5190876A (en) * | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
| CA2007507C (en) | 1989-02-03 | 1998-05-19 | Yasuyuki Igarashi | Sphingosine and n-methyl-sphingosine as inhibitor of cell growth |
| EP0543922A4 (en) * | 1990-08-13 | 1993-07-28 | Duke University | Methods for inducing cell differentiation using ceramides |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| FR2674748B1 (fr) | 1991-04-03 | 1995-01-13 | Oreal | Utilisation de sphingolipides dans la preparation d'une composition cosmetique ou dermopharmaceutique protegeant la peau et les cheveux contre les effets nocifs de la pollution atmospherique. |
| US5232837A (en) * | 1991-08-05 | 1993-08-03 | Emory University | Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination |
| US5374616A (en) * | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
| US6190894B1 (en) * | 1993-03-19 | 2001-02-20 | The Regents Of The University Of California | Method and compositions for disrupting the epithelial barrier function |
| US5478860A (en) * | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
| US5830853A (en) * | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6773719B2 (en) * | 1994-03-04 | 2004-08-10 | Esperion Luv Development, Inc. | Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias |
| US20020182250A1 (en) * | 1995-09-06 | 2002-12-05 | Goro Hori | Lipid metabolism improving agent |
| US5714478A (en) | 1995-09-29 | 1998-02-03 | Spiegel; Sarah | Sphingosylphosphorylcholine as a wound-healing agent |
| DE19602108A1 (de) | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen |
| WO1997030174A1 (en) * | 1996-02-20 | 1997-08-21 | Sloan-Kettering Institute For Cancer Research | Combinations of pkc inhibitors and therapeutic agents for treating cancers |
| CN1222293C (zh) | 1997-04-10 | 2005-10-12 | 麒麟麦酒株式会社 | 含有α-糖基神经酰胺的NKT细胞活化剂 |
| US6800661B1 (en) * | 1997-04-15 | 2004-10-05 | Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| US5989803A (en) * | 1997-09-05 | 1999-11-23 | The Trustees Of Columbia University In The City Of New York | Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase |
| US6610835B1 (en) * | 1998-02-12 | 2003-08-26 | Emory University | Sphingolipid derivatives and their methods of use |
| JP3581010B2 (ja) | 1998-03-18 | 2004-10-27 | 雪印乳業株式会社 | 脂質の消化吸収機能改善剤 |
| CA2329124A1 (en) | 1998-05-26 | 1999-12-02 | Office Of The Dean Of Research And Graduate Education | Sphingosine kinase, cloning, expression and methods of use |
| WO2000050574A1 (en) | 1999-02-24 | 2000-08-31 | Johns Hopkins University | Compositions and methods for modulating serum cholesterol |
| JP3544493B2 (ja) | 1999-06-10 | 2004-07-21 | 雪印乳業株式会社 | 乳幼児用栄養組成物 |
| KR100341793B1 (ko) | 1999-07-02 | 2002-06-24 | 권 영 근 | 스핑고신 1-포스페이트를 유효성분으로 포함하는 혈관신생 촉진제 |
| WO2001003739A1 (fr) * | 1999-07-12 | 2001-01-18 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate |
| JP2001213858A (ja) | 1999-11-24 | 2001-08-07 | Sagami Chem Res Center | スフィンゴシン誘導体 |
| JP2001158735A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 歯周病の予防及び改善剤 |
| JP2001158736A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 骨関節疾患の予防及び改善剤 |
| WO2001060807A1 (en) | 2000-02-18 | 2001-08-23 | Merck & Co. Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| EP1268414A1 (de) | 2000-03-28 | 2003-01-02 | The Liposome Company, Inc. | Ceramid-derivate und verwendungsmethode |
| JP2002068998A (ja) * | 2000-08-29 | 2002-03-08 | Meiji Milk Prod Co Ltd | 経腸栄養および静脈栄養に伴う脂肪肝発生予防組成物 |
| AU2001212597A1 (en) | 2000-10-27 | 2002-05-06 | N.V. Marc Boone | Method for obtaining products enriched in phospho- and sphingolipids |
| US6949247B2 (en) * | 2000-12-28 | 2005-09-27 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Stable skin care compositions containing a retinoid and a retinoid booster system |
| FR2820037B1 (fr) | 2001-01-29 | 2005-12-09 | Dermaconcept Jmc | Composition dermatologique a usage veterinaire comprenant une base sphingoide |
| JP2002226394A (ja) | 2001-02-01 | 2002-08-14 | Meiji Milk Prod Co Ltd | 脂質代謝改善組成物 |
| ATE554779T1 (de) | 2001-06-18 | 2012-05-15 | Neptune Technologies & Bioressources Inc | Krill zur prävention und/oder behandlung von herz-kreislauf-erkrankungen |
| US8030348B2 (en) * | 2001-07-27 | 2011-10-04 | Neptune Technologies & Bioressources, Inc. | Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications |
| EP1291340B1 (de) | 2001-09-05 | 2006-03-15 | Charmzone Co., Ltd | Phytosphingosinderivate mit Antitumorwirkung |
| US20030109044A1 (en) * | 2001-10-16 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Methods of using 279, a human G protein-coupled protein receptor |
| JP4035759B2 (ja) | 2001-11-06 | 2008-01-23 | 独立行政法人産業技術総合研究所 | アミノアルコールリン酸化合物、製造方法、及びその利用方法 |
| DE10217555A1 (de) | 2002-04-19 | 2004-02-19 | Degussa Bioactives Deutschland Gmbh | Physiologisch verträgliche, Phospholipid-haltige, stabile und harte Matrix |
| JP2006507223A (ja) | 2002-05-17 | 2006-03-02 | エスペリオン セラピューティクス,インコーポレイテッド | 脂質代謝異常疾患の治療方法 |
| AU2002349521A1 (en) | 2002-08-14 | 2004-03-03 | Tae-Yoon Kim | A composition comprising phytospingosine derivatives for apoptosis induction |
| WO2004064820A2 (en) * | 2003-01-20 | 2004-08-05 | Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno | Use of sphingolipids for reducing plasma cholesterol and triacylglycerol levels |
| NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| GB0301395D0 (en) | 2003-01-21 | 2003-02-19 | Univ Aston | Inflammatory disorder treatment |
| US9717754B2 (en) * | 2003-02-27 | 2017-08-01 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
| WO2005032462A2 (en) * | 2003-02-27 | 2005-04-14 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
| US20040171522A1 (en) | 2003-02-27 | 2004-09-02 | Yaron Ilan | Regulation of immune responses by manipulation of intermediary metabolite levels |
| EP1617808A4 (de) | 2003-04-25 | 2011-11-02 | Penn State Res Found | Verfahren und system für die systemische abgabe von wachstumshemmenden von lipiden stammenden bioaktiven verbindungen |
-
2005
- 2005-11-25 AT AT05813546T patent/ATE539741T1/de active
- 2005-11-25 AU AU2005310341A patent/AU2005310341A1/en not_active Abandoned
- 2005-11-25 JP JP2007544288A patent/JP2008521888A/ja active Pending
- 2005-11-25 US US11/791,876 patent/US7906488B2/en not_active Expired - Fee Related
- 2005-11-25 WO PCT/NL2005/000813 patent/WO2006059897A1/en not_active Ceased
- 2005-11-25 EP EP05813546A patent/EP1830829B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006059897A1 (en) | 2006-06-08 |
| EP1830829B1 (de) | 2012-01-04 |
| JP2008521888A (ja) | 2008-06-26 |
| EP1830829A1 (de) | 2007-09-12 |
| US7906488B2 (en) | 2011-03-15 |
| AU2005310341A1 (en) | 2006-06-08 |
| US20080182902A1 (en) | 2008-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ630589A (en) | Methods of treating alzheimer’s disease and pharmaceutical compositions thereof | |
| CY1115484T1 (el) | Ενωσεις, συνθεσεις και μεθοδοι για την θεραπεια αμυλοειδικων ασθενειων και συνουκλεϊνοπαθειων, οπως νοσος alzheimer, διαβητης τυπου 2 και νοσος parkinson | |
| TW200736223A (en) | N-(pyridin-2-yl)-sulfonamide derivatives | |
| EP2065040A3 (de) | Von Sphingolipiden abgeleitete pharmazeutische Zusammensetzungen | |
| NZ707640A (en) | Treatment or prevention of cardiovascular events via the administration of a colchicine derivative | |
| JP2010522698A5 (de) | ||
| CA2792467A1 (en) | Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases | |
| RU2018111327A (ru) | Способ ингибирования всасывания и/или повышения выведения липидов с использованием d-псикозы | |
| MY148844A (en) | Fumarate salt of (alpha s, beta r)-6- bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol | |
| AR060974A1 (es) | Compuesto de 4-piridinona, su uso para la preparacion de un medicamento, composicion farmaceutica que lo comprende, proceso para su preparacion y proceso para la preparacion de un compuesto intermediario de utilidad en el anterior | |
| NO20080936L (no) | Transdermale medikamentleveringsinnretninger inneholdende O-desmetylvenlafaksin (ODV) eller salter derav | |
| BRPI0414347A (pt) | associação compreendendo um ligando de alfa-2-delta e um ssri e/ou snri para tratamento de depressão e distúrbios da ansiedade | |
| PH12015500653B1 (en) | Combination drug comprising gemigliptin and metformin, and method for the preparation thereof | |
| IL179012A (en) | A drug containing cetirizine for the treatment of nasal inflammation, a process for its preparation and use | |
| EP2746254A3 (de) | Oxadiazolderivat mit Wirkung auf Sphingosin-1-phosphat (s1p) | |
| ATE539741T1 (de) | Sphingolipide bei der behandlung und prävention von hepatischer steatose | |
| MY168531A (en) | Medicament form for release of active ingredients | |
| WO2011065867A3 (en) | Liposomes containing oligopeptide fragments of myelin basic protein, a pharmaceutical composition and a method for treatment of multiple sclerosis | |
| NZ589618A (en) | PAEDIATRIC COMPOSITIONS COMPRISING 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol FOR TREATING MULTIPLE SCLEROSIS | |
| GB2446341A (en) | Method and system for transdermal drug delivery | |
| JP2006516278A5 (de) | ||
| WO2018093237A3 (ko) | 포름산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 비만 또는 비만으로 야기된 대사증후군의 예방 또는 치료용 조성물 | |
| PH12013500980A1 (en) | Complex formulation comprising lercanidipine hydrochloride and valsartan and method for the preparation thereof | |
| BRPI0715740A8 (pt) | Agente redutor de triglicerídeos séricos | |
| MX2007009985A (es) | Diastereoisomeros de 4-hidroxiisoleucina y usos de los mismos. |