JO3813B1 - أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية - Google Patents

أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية

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Publication number
JO3813B1
JO3813B1 JOP/2015/0150A JOP20150150A JO3813B1 JO 3813 B1 JO3813 B1 JO 3813B1 JO P20150150 A JOP20150150 A JO P20150150A JO 3813 B1 JO3813 B1 JO 3813B1
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JO
Jordan
Prior art keywords
disease
conjugate
fatty acid
diabetes
alcoholic
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JOP/2015/0150A
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English (en)
Inventor
Richardson Usera Aimee
Marshall Bruce Alexandra
Yamada Ken
Clare Kirman Louise
Duttaroy Alokesh
Ibebunjo Chikwendu
Weninger Barnes David
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Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of JO3813B1 publication Critical patent/JO3813B1/ar

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Abstract

يوفر الاختراع متقارن يشتمل على جزئ حيوي مرتبط بحمض دهني من خلال رابط حيث يكون للحمض الدهني الصيغ التالية A1، A2 أو A3: A1 A2 أو A3 1) حيث تكون R1, R2, R3, R4, Ak, n, m وp معرفة هنا. يتعلق الاختراع أيضاً بطريقة لتصنيع متقارن الاختراع مثل متقارن GDF15، واستخداماته العلاجية مثل علاج أو الوقاية من اضطرابات أو أمراض أيضية، النوع الثاني من داء السكري، السمنة، التهاب البنكرياس، عسر شحميات الدم، مرض الكبد الدهني الكحولي وغير الكحولي/التهاب الكبد الدهني وغيرها من أمراض الكبد التقدمية، مقاومة الأنسولين، فرط الانسولينية، الحساسية المفرطة تجاه الجلوكوز، ارتفاع السكر في الدم، المتلازمة الأيضية، ارتفاع ضغط الدم، أمراض القلب والأوعية الدموية، تصلب الشرايين، أمراض الشرايين الطرفية، السكتة الدماغية، هبوط القلب، مرض القلب التاجي، مضاعفات السكري (تتضمن لكنها لا تقتصر على مرض الكلى المزمن)، اعتلال الأعصاب، خزل المعدة واضطرابات أيضية أخرى. يوفر الاختراع الحالي كذلك توليفة من عوامل نشطة صيدلية وتركيبة صيدلية.
JOP/2015/0150A 2014-06-23 2015-06-21 أحماض دهنية جديدة واستخدامها بالاقتران مع جزيئات حيوية JO3813B1 (ar)

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US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23

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Families Citing this family (70)

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Publication number Priority date Publication date Assignee Title
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
JP5977814B2 (ja) 2011-04-08 2016-08-24 アムジエン・インコーポレーテツド 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を治療または改善する方法
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