ATE540042T1 - Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren - Google Patents

Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren

Info

Publication number
ATE540042T1
ATE540042T1 AT09761399T AT09761399T ATE540042T1 AT E540042 T1 ATE540042 T1 AT E540042T1 AT 09761399 T AT09761399 T AT 09761399T AT 09761399 T AT09761399 T AT 09761399T AT E540042 T1 ATE540042 T1 AT E540042T1
Authority
AT
Austria
Prior art keywords
met
indazolyl
annated
mediators
dihydropyridine derivatives
Prior art date
Application number
AT09761399T
Other languages
English (en)
Inventor
Martin Michels
Markus Follmann
Alexandros Vakalopoulos
Katja Zimmermann
Nicole Teusch
Karen Engel
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of ATE540042T1 publication Critical patent/ATE540042T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT09761399T 2008-06-09 2009-05-29 Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren ATE540042T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08010423 2008-06-09
PCT/EP2009/003837 WO2009149836A1 (en) 2008-06-09 2009-05-29 Annellated 4- (indazolyl) -1,4-dihydropyridine derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE540042T1 true ATE540042T1 (de) 2012-01-15

Family

ID=40933643

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09761399T ATE540042T1 (de) 2008-06-09 2009-05-29 Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren

Country Status (7)

Country Link
US (1) US8642595B2 (de)
EP (1) EP2300482B1 (de)
JP (1) JP5480891B2 (de)
AT (1) ATE540042T1 (de)
CA (1) CA2727199C (de)
ES (1) ES2377809T3 (de)
WO (1) WO2009149836A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102639537B (zh) * 2009-07-10 2015-07-22 拜耳知识产权有限责任公司 吲唑基取代的二氢异*唑并吡啶及其使用方法
DE102009056886A1 (de) * 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose
CA2819373A1 (en) 2010-12-09 2012-06-14 Amgen Inc. Bicyclic compounds as pim inhibitors
JP2014510105A (ja) 2011-03-22 2014-04-24 アムジエン・インコーポレーテツド Ｐｉｍ阻害剤としてのアゾール化合物
KR102730905B1 (ko) * 2022-05-03 2024-11-15 충북대학교 산학협력단 신규한 n-히드록시프로펜아미드 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653313B2 (en) * 2000-08-10 2003-11-25 Warner-Lambert Company Llc 1,4-dihydropyridine compounds as bradykinin antagonists
GB2392910A (en) * 2002-09-10 2004-03-17 Bayer Ag 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors
EP1546113B1 (de) * 2002-09-10 2013-05-01 Bayer Intellectual Property GmbH Pyrimidinonderivate als therapeutische mittel gegen aktute und chronische entzündliche, ischämische und verändernde prozesse
ES2428503T3 (es) * 2004-02-26 2013-11-08 Bayer Intellectual Property Gmbh 1,4-Diaril-dihidropirimidin-2-onas y su uso como inhibidores de elastasa de neutrófilos humanos
JP4825194B2 (ja) * 2004-02-26 2011-11-30 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト １，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用
WO2007103308A2 (en) * 2006-03-07 2007-09-13 Array Biopharma Inc. Heterobicyclic pyrazole compounds and methods of use
AU2007240496A1 (en) * 2006-04-19 2007-11-01 Novartis Ag Indazole compounds and methods for inhibition of CDC7
EA200900779A1 (ru) * 2006-12-14 2010-02-26 Байер Шеринг Фарма Акциенгезельшафт Производные дигидропиридина, полезные как ингибиторы протеинкиназы

Also Published As

Publication number Publication date
CA2727199C (en) 2016-11-22
CA2727199A1 (en) 2009-12-17
US8642595B2 (en) 2014-02-04
US20110172221A1 (en) 2011-07-14
JP2011524348A (ja) 2011-09-01
EP2300482A1 (de) 2011-03-30
WO2009149836A1 (en) 2009-12-17
ES2377809T3 (es) 2012-04-02
EP2300482B1 (de) 2012-01-04
JP5480891B2 (ja) 2014-04-23

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