NO20083568L - Hydantoinforbindelser for behandling av inflammatoriske forstyrrelser - Google Patents

Hydantoinforbindelser for behandling av inflammatoriske forstyrrelser

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Publication number
NO20083568L
NO20083568L NO20083568A NO20083568A NO20083568L NO 20083568 L NO20083568 L NO 20083568L NO 20083568 A NO20083568 A NO 20083568A NO 20083568 A NO20083568 A NO 20083568A NO 20083568 L NO20083568 L NO 20083568L
Authority
NO
Norway
Prior art keywords
treatment
inflammatory disorders
hydantoin compounds
compounds
hydantoin
Prior art date
Application number
NO20083568A
Other languages
English (en)
Inventor
Bandarpalle B Shankar
Joseph A Kozlowski
Ling Tong
Guowel Zhou
Neng-Yang Shih
Wensheng Yu
Michael K C Wong
Seong Heon Kim
M Arshad Siddiqui
Brian J Lavey
De-Yi Yang
Kristin E Rosner
Chaoyang Dai
Janeta Popovici-Muller
Vinay Girijavallabhan
Dansu Li
Razia Rizvi
Aneta M Micula
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38038495&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083568(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20083568L publication Critical patent/NO20083568L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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Abstract

Denne oppfinnelsen vedrører forbindelser med formel (I) eller farmasøytisk akseptabelt salt, solvat eller isomer derav, som kan være anvendbare til behandlingen av sykdommer eller tilstander mediert av MMP-er, ADAM-er, TACE, aggrekanase, TNF-a eller kombinasjoner derav.
NO20083568A 2006-01-17 2008-08-15 Hydantoinforbindelser for behandling av inflammatoriske forstyrrelser NO20083568L (no)

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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7488745B2 (en) * 2004-07-16 2009-02-10 Schering Corporation Compounds for the treatment of inflammatory disorders
ATE478864T1 (de) 2004-07-16 2010-09-15 Schering Corp Hydantoinderivate zur behandlung von entzündlichen erkrankungen
US7504424B2 (en) 2004-07-16 2009-03-17 Schering Corporation Compounds for the treatment of inflammatory disorders
PL1848435T3 (pl) * 2005-01-25 2016-08-31 Synta Pharmaceuticals Corp Związki przeciwko zapaleniom i zastosowania związane z odpornością
US7902352B2 (en) 2005-05-06 2011-03-08 Medtronic, Inc. Isolated nucleic acid duplex for reducing huntington gene expression
US7879997B2 (en) * 2005-08-12 2011-02-01 Schering Corporation Compounds for the treatment of inflammatory disorders
AR059036A1 (es) * 2006-01-17 2008-03-12 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
US20090175852A1 (en) 2006-06-06 2009-07-09 Schering Corporation Imidazopyrazines as protein kinase inhibitors
EP2057127B1 (en) 2006-08-31 2012-01-11 Schering Corporation Hydantoin derivatives useful as antibacterial agents
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
CN101186611B (zh) * 2006-11-15 2011-05-18 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉-2-酮衍生物及其制备和应用
EP2346857B1 (en) 2008-09-24 2019-11-27 Merck Sharp & Dohme Corp. Compounds for the treatment of inflammatory disorders
TW201024304A (en) 2008-09-24 2010-07-01 Schering Corp Compounds for the treatment of inflammatory disorders
US8569336B2 (en) 2008-11-10 2013-10-29 Ling Tong Compounds for the treatment of inflammatory disorders
EP2356111A1 (en) * 2008-11-10 2011-08-17 Schering Corporation Compounds for the treatment of inflammatory disorders
DK2597084T3 (en) 2010-07-08 2016-08-15 Kaken Pharma Co Ltd N-HYDROXYFORMAMIDE DERIVATIVE AND MEDICINAL CONTAINING SAME
EP2705024B1 (en) * 2011-05-03 2015-12-16 Merck Sharp & Dohme Corp. Alkyne benzotriazole derivatives
PT2789607T (pt) * 2011-12-09 2018-03-22 Kaken Pharma Co Ltd Derivado de piridona e medicamento contendo o mesmo
AR092971A1 (es) * 2012-10-26 2015-05-06 Lilly Co Eli Inhibidores de agrecanasa
CN105531270B (zh) 2013-06-07 2017-09-05 科研制药株式会社 (+)－5－(3，4－二氟苯基)－5－[(3－甲基－2－氧吡啶－1(2h)－基)甲基]咪唑烷－2，4－二酮及含有该化合物的药物
CN104803861B (zh) * 2014-01-27 2017-05-24 上海博邦医药科技有限公司 一种合成盐酸他喷他多的方法
EP3102576B8 (en) 2014-02-03 2019-06-19 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma
PT3207043T (pt) 2014-10-14 2019-03-25 Vitae Pharmaceuticals Llc Inibidores de di-hidropirrolopiridina de ror-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
SG11201708622UA (en) 2015-02-02 2017-11-29 Forma Therapeutics Inc 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
JP6754360B2 (ja) * 2015-07-09 2020-09-09 田辺三菱製薬株式会社 新規イミド誘導体およびその医薬としての用途
CN105153048B (zh) * 2015-07-31 2017-10-24 苏州大学 一种2,4‑喹唑啉二酮类化合物的制备方法
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
US11008340B2 (en) 2015-11-20 2021-05-18 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
CA3029109A1 (en) 2016-06-29 2018-01-04 Orion Corporation Benzodioxane derivatives and their pharmaceutical use
US10710980B2 (en) * 2016-07-20 2020-07-14 Novartis Ag Aminopyridine derivatives and their use as selective ALK-2 inhibitors
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CN107382679A (zh) * 2017-07-12 2017-11-24 安徽省诚联医药科技有限公司 达格列净中间体的制备方法
CN107311962A (zh) * 2017-07-12 2017-11-03 安徽省诚联医药科技有限公司 依帕列净中间体的制备方法
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
JP2020528904A (ja) 2017-07-24 2020-10-01 ヴァイティー ファーマシューティカルズ，エルエルシー ＲＯＲγの阻害剤
CN107573311A (zh) * 2017-08-09 2018-01-12 江苏工程职业技术学院 一种达格列净的合成方法
CN107556309B (zh) * 2017-09-11 2020-12-01 浙江永宁药业股份有限公司 多取代四氢萘啶类化合物的药物用途及其制备方法
MX2020013785A (es) 2018-07-03 2021-03-25 Jiangsu Hengrui Medicine Co Derivado de la pirido-pirimidina, metodo de preparacion del mismo y uso medico del mismo.
AU2020321955A1 (en) 2019-07-30 2022-03-17 Eikonizo Therapapeutics, Inc. HDAC6 inhibitors and uses thereof
CN115038443A (zh) 2019-11-22 2022-09-09 因西特公司 包含alk2抑制剂和jak2抑制剂的组合疗法
WO2021204185A1 (zh) * 2020-04-10 2021-10-14 深圳信立泰药业股份有限公司 一种苯并[d]氮杂卓类衍生物蛋白聚糖酶2抑制剂及其制备方法和医药用途
CN113754635B (zh) * 2020-06-02 2024-06-21 成都康弘药业集团股份有限公司 稠环类化合物及其制备方法和用途
JP2023530316A (ja) 2020-06-16 2023-07-14 インサイト・コーポレイション 貧血の治療のためのａｌｋ２阻害剤
KR102952279B1 (ko) * 2021-02-05 2026-04-14 시노허브 파마슈티컬 씨오., 엘티디 플라스민 억제제, 이의 제조 방법 및 이의 용도
IL316201A (en) 2022-04-08 2024-12-01 Eikonizo Therapeutics Inc Oxadiazole HDAC6 inhibitors and their uses
TW202521544A (zh) * 2023-08-16 2025-06-01 美商雷瑟拉股份有限公司 TNFα活性調節劑及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228869B1 (en) 1996-10-16 2001-05-08 American Cyanamid Company Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
DK1210326T3 (da) 1999-08-18 2004-06-21 Warner Lambert Co Hydroxamsyreforbindelser, der er nyttige som matrixmetalloproteinaseinhibitorer
JP2003528097A (ja) 2000-03-17 2003-09-24 ブリストル−マイヤーズ スクイブ ファーマ カンパニー マトリックスメタロプロテアーゼおよびＴＮＦ−α阻害剤としてのβ−アミノ酸誘導体
JP2004527511A (ja) 2001-03-15 2004-09-09 アストラゼネカ・アクチエボラーグ メタロプロテイナーゼ阻害剤
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
US6890915B2 (en) 2001-05-25 2005-05-10 Bristol-Myers Squibb Pharma Company Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
AU2002357312A1 (en) 2001-12-20 2003-07-09 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-alpha converting enzyme (tace) and/or matrix metalloproteinases
WO2003053940A1 (en) 2001-12-20 2003-07-03 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
WO2004012663A2 (en) 2002-08-01 2004-02-12 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
GB0221250D0 (en) 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
GB0221246D0 (en) 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
AU2003282920A1 (en) * 2002-10-04 2004-05-04 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
ATE443044T1 (de) 2002-12-19 2009-10-15 Vertex Pharma Tace inhibitoren
ATE478864T1 (de) * 2004-07-16 2010-09-15 Schering Corp Hydantoinderivate zur behandlung von entzündlichen erkrankungen
US7504424B2 (en) 2004-07-16 2009-03-17 Schering Corporation Compounds for the treatment of inflammatory disorders
US7488745B2 (en) 2004-07-16 2009-02-10 Schering Corporation Compounds for the treatment of inflammatory disorders
AR059036A1 (es) 2006-01-17 2008-03-12 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
EP2057127B1 (en) 2006-08-31 2012-01-11 Schering Corporation Hydantoin derivatives useful as antibacterial agents

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CA2637196A1 (en) 2007-07-26
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KR20080085222A (ko) 2008-09-23
EP1973900A1 (en) 2008-10-01
WO2007084455A1 (en) 2007-07-26
BRPI0706599A2 (pt) 2011-03-29
CN101410390A (zh) 2009-04-15
EP1973901B1 (en) 2014-12-17
PE20071241A1 (es) 2008-01-14
JP2009523796A (ja) 2009-06-25
US7683088B2 (en) 2010-03-23
US7524842B2 (en) 2009-04-28
CA2637198A1 (en) 2007-07-26
CN101405286A (zh) 2009-04-08
ECSP088626A (es) 2008-08-29
US8178553B2 (en) 2012-05-15
AR059037A1 (es) 2008-03-12
WO2007084451A1 (en) 2007-07-26
AU2007207711A1 (en) 2007-07-26
KR20080085221A (ko) 2008-09-23
US20070265299A1 (en) 2007-11-15
BRPI0706598A2 (pt) 2011-04-05
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IL192691A0 (en) 2009-02-11
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JP2009523797A (ja) 2009-06-25
US20070197564A1 (en) 2007-08-23
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ECSP088625A (es) 2008-08-29
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US20090156586A1 (en) 2009-06-18
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