ATE540054T1 - Antimikrobielle theta defensine und verfahren zu deren verwendung - Google Patents

Antimikrobielle theta defensine und verfahren zu deren verwendung

Info

Publication number: ATE540054T1
Authority: AT; Austria
Prior art keywords: cys; xaa1; arg; xaa5; xaa4
Prior art date: 1999-05-10

Application number

AT00930577T

Other languages

English (en)

Inventor

Michael Selsted

Yi-Quan Tang

Jun Yuan

Andre Ouellette

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-10

Filing date

2000-05-10

Publication date

2012-01-15

2000-05-10 Application filed by Univ California filed Critical Univ California

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE540054T1 publication Critical patent/ATE540054T1/de

Links

108010034266 theta-defensin Proteins 0.000 title abstract 7
230000000845 anti-microbial effect Effects 0.000 title abstract 2
ZKIAWZPHVZQYMG-QYJCGYSGSA-N θ-defensin Chemical compound O=C([C@@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(=O)N1)=O)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)[C@@H](C)CC)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CSSC1 ZKIAWZPHVZQYMG-QYJCGYSGSA-N 0.000 abstract 6
125000003275 alpha amino acid group Chemical group 0.000 abstract 2
101100505161 Caenorhabditis elegans mel-32 gene Proteins 0.000 abstract 1
108010069514 Cyclic Peptides Proteins 0.000 abstract 1
102000001189 Cyclic Peptides Human genes 0.000 abstract 1
101100330292 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-12 gene Proteins 0.000 abstract 1
101100386050 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-14 gene Proteins 0.000 abstract 1
101100386053 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-3 gene Proteins 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT00930577T 1999-05-10 2000-05-10 Antimikrobielle theta defensine und verfahren zu deren verwendung ATE540054T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/309,487 US6335318B1 (en)	1999-05-10	1999-05-10	Antimicrobial theta defensins and methods of using same
PCT/US2000/012842 WO2000068265A1 (en)	1999-05-10	2000-05-10	Antimicrobial theta defensins and methods of using same

Publications (1)

Publication Number	Publication Date
ATE540054T1 true ATE540054T1 (de)	2012-01-15

Family

ID=23198440

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00930577T ATE540054T1 (de)	1999-05-10	2000-05-10	Antimikrobielle theta defensine und verfahren zu deren verwendung

Country Status (6)

Country	Link
US (5)	US6335318B1 (de)
EP (1)	EP1187850B1 (de)
AT (1)	ATE540054T1 (de)
AU (1)	AU4837300A (de)
CA (1)	CA2372821C (de)
WO (1)	WO2000068265A1 (de)

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DE10201862A1 (de) *	2002-01-18	2003-08-07	Deutsches Krebsforsch	Konjugat zur Behandlung prokaryontischer Infektionen
WO2003070176A2 (en) *	2002-02-19	2003-08-28	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Modified defensins and their use
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FR2839514A1 (fr) *	2002-05-07	2003-11-14	Centre Nat Rech Scient	Nouveaux peptides cycliques, leur utilisation comme agents anti-microbiens
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DE10226216A1 (de) *	2002-06-13	2003-12-24	Bayer Ag	Behandlung von schweren Infektionen und septischem Schock
JP4026491B2 (ja) *	2002-12-13	2007-12-26	ソニー株式会社	画像信号処理装置、画像信号処理方法、並びにプログラムおよび媒体
SE0203700D0 (sv) *	2002-12-16	2002-12-16	Bohlin Lars	On-Growth Inhibiting Compounds
NZ540506A (en) *	2002-12-19	2008-09-26	Yitzchak Hillman	Disease treatment via antimicrobial peptide inhibitors
US20040219612A1 (en) *	2003-05-02	2004-11-04	Beckman Coulter, Inc.	Methods for detecting intracellular defensins in various leukocyte subpopulations
US20050244916A1 (en) *	2004-03-22	2005-11-03	Michael Yeaman	Methods for predicting protein activity based on identification of multidimensional signatures
US7232939B2 (en)	2004-05-28	2007-06-19	E.I. Du Pont De Nemours And Company	Nucleic acid molecules encoding cyclotide polypeptides and methods of use
US20080255052A1 (en) *	2004-12-23	2008-10-16	The Regents Of The University Of California	Immunologic regulation by theta defensins
WO2006084463A1 (en) *	2005-02-08	2006-08-17	Novozymes A/S	Systemic treatment of infections with defensins
RU2403260C2 (ru) *	2005-03-18	2010-11-10	Новозимс Эдениум Байотек А/С	Полипептиды, обладающие противомикробным действием, и кодирующие их полинуклеотиды
US7534762B2 (en) *	2005-03-18	2009-05-19	Novozymes A/S	Polypeptides having antimicrobial activity and polynucleotides encoding same
EP1863836B1 (de) *	2005-03-18	2012-07-11	Novozymes Adenium Biotech A/S	Polypeptide mit antimikrobieller aktivität und dafür kodierende polynukleotide
US8202835B2 (en) *	2005-06-17	2012-06-19	Yitzchak Hillman	Disease treatment via antimicrobial peptides or their inhibitors
US9044438B2 (en)	2005-06-17	2015-06-02	Yitzchak Hillman	Disease treatment via antimicrobial peptides or their inhibitors
WO2007009978A1 (en) *	2005-07-15	2007-01-25	Novozymes A/S	Polypeptides having antimicrobial activity and polynucleotides encoding same
ES2658834T3 (es) *	2006-02-21	2018-03-12	System Spa	Decoración con material en polvo
JP2009535027A (ja)	2006-04-27	2009-10-01	シンガポールヘルスサービシーズピーティーイーリミテッド	抗菌ペプチド
CN102409003B (zh) *	2010-09-26	2013-05-15	中国农业科学院饲料研究所	多拷贝高效表达重组菌丝霉素的毕赤酵母
US10967031B2 (en)	2010-12-28	2021-04-06	Kamedis Ltd.	Synergistic herbal compositions with prebiotic properties for treatment of skin infections, allergies and inflammation
KR101947126B1 (ko)	2010-12-28	2019-02-13	카메디스 리미티드	감염의 치료 및 예방을 위한 식물 추출물
BR112013030874B8 (pt)	2011-06-02	2021-09-14	Univ California	Uso de uma theta-defensina ou análogo da mesma para tratar uma condição inflamatória crônica
KR20220042129A (ko) *	2019-06-26	2022-04-04	마이클 이. 셀스테드	신규한 세타 디펜신 유사체(novel theta defensin analogs)
EP4172178A4 (de)	2020-06-26	2024-07-31	The University Of Southern California	Zusammensetzungen und verfahren zur behandlung von pilzinfektionen
CN115433263B (zh) *	2021-06-02	2025-03-14	中国科学院动物研究所	人类口腔放线菌来源的防御素、及其编码基因和用途
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1999
- 1999-05-10 US US09/309,487 patent/US6335318B1/en not_active Expired - Lifetime
2000
- 2000-05-10 EP EP00930577A patent/EP1187850B1/de not_active Expired - Lifetime
- 2000-05-10 CA CA2372821A patent/CA2372821C/en not_active Expired - Lifetime
- 2000-05-10 US US10/009,317 patent/US7399823B1/en not_active Expired - Lifetime
- 2000-05-10 WO PCT/US2000/012842 patent/WO2000068265A1/en not_active Ceased
- 2000-05-10 AU AU48373/00A patent/AU4837300A/en not_active Abandoned
- 2000-05-10 AT AT00930577T patent/ATE540054T1/de active
2001
- 2001-09-26 US US09/967,808 patent/US6514727B1/en not_active Expired - Lifetime
2002
- 2002-12-05 US US10/313,994 patent/US6890537B2/en not_active Expired - Lifetime
2005
- 2005-05-10 US US11/126,468 patent/US20050261193A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2000068265A1 (en)	2000-11-16
CA2372821C (en)	2014-07-08
US20050261193A1 (en)	2005-11-24
EP1187850B1 (de)	2012-01-04
US7399823B1 (en)	2008-07-15
US6890537B2 (en)	2005-05-10
CA2372821A1 (en)	2000-11-16
US6335318B1 (en)	2002-01-01
US20030162718A1 (en)	2003-08-28
US6514727B1 (en)	2003-02-04
AU4837300A (en)	2000-11-21
EP1187850A1 (de)	2002-03-20

Publication	Publication Date	Title
ATE540054T1 (de)	2012-01-15	Antimikrobielle theta defensine und verfahren zu deren verwendung
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