ATE331735T1 - Verfahren zur monomerisierung von humanen serumalbumin-polymeren - Google Patents

Verfahren zur monomerisierung von humanen serumalbumin-polymeren

Info

Publication number
ATE331735T1
ATE331735T1 AT01978881T AT01978881T ATE331735T1 AT E331735 T1 ATE331735 T1 AT E331735T1 AT 01978881 T AT01978881 T AT 01978881T AT 01978881 T AT01978881 T AT 01978881T AT E331735 T1 ATE331735 T1 AT E331735T1
Authority
AT
Austria
Prior art keywords
human serum
serum albumin
multimer
uncorrected
monomers
Prior art date
Application number
AT01978881T
Other languages
English (en)
Inventor
Toshinobu Nouchi
Kikuchi-Shi
Hiroshi Mizokami
Yoshitaka Tajima
Hiroyuki Yokote
Satoshi Adachi
Yoshinobu Miyatsu
Tetsuro Tanabe
Yoshitaka Ushio
Shinichi Shibata
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2000324027A external-priority patent/JP4798830B2/ja
Priority claimed from JP2000324028A external-priority patent/JP4798831B2/ja
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of ATE331735T1 publication Critical patent/ATE331735T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01978881T 2000-10-24 2001-10-24 Verfahren zur monomerisierung von humanen serumalbumin-polymeren ATE331735T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000324027A JP4798830B2 (ja) 2000-10-24 2000-10-24 ヒト血清アルブミン多量体の単量体化方法
JP2000324028A JP4798831B2 (ja) 2000-10-24 2000-10-24 ヒト血清アルブミンのミスホールディングを抑制する方法

Publications (1)

Publication Number Publication Date
ATE331735T1 true ATE331735T1 (de) 2006-07-15

Family

ID=26602656

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01978881T ATE331735T1 (de) 2000-10-24 2001-10-24 Verfahren zur monomerisierung von humanen serumalbumin-polymeren

Country Status (11)

Country Link
US (1) US20030027991A1 (de)
EP (1) EP1329460B1 (de)
KR (1) KR100827750B1 (de)
CN (2) CN1275981C (de)
AT (1) ATE331735T1 (de)
AU (1) AU783571B2 (de)
CA (1) CA2395587C (de)
DE (1) DE60121196T2 (de)
DK (1) DK1329460T3 (de)
ES (1) ES2261487T3 (de)
WO (1) WO2002034785A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866890B1 (fr) * 2004-02-27 2008-04-04 Lab Francais Du Fractionnement Procede de purification d'albumine comprenant une etape de nanofiltration, solution et composition a usage therapeutique la contenant
JP2005245269A (ja) * 2004-03-03 2005-09-15 Nipro Corp 血清アルブミン多量体を含む遺伝子組換え型蛋白質
WO2011106086A1 (en) * 2010-02-25 2011-09-01 Albert Einstein College Of Medicine Of Yeshiva University Pegylated albumin polymers and uses thereof
CN102241767B (zh) * 2011-06-22 2013-07-10 河南省医药科学研究院 一种牛血清白蛋白提取方法
KR101595151B1 (ko) * 2012-01-31 2016-02-18 이화여자대학교 산학협력단 일산화질소에 의해 형성되는 알부민 다량체 및 알부민 구조변형체
EP3429345B1 (de) 2016-10-04 2019-09-11 Albumedix Ltd. Verwendungen von rekombinantem, von hefe abgeleitetem serumalbumin
CN112823278B (zh) * 2018-08-27 2024-06-28 香港科技大学 一种在生物液体中检测人血清白蛋白的方法
CN109111498B (zh) * 2018-09-12 2025-07-04 山东省妇幼保健院 一种减少蛋白在protein L凝胶层析中形成多聚体的方法
US20230000774A1 (en) 2019-12-04 2023-01-05 Albumedix Limited Methods and compositions produced thereby

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169829A (en) * 1972-07-05 1979-10-02 Institut Merieux Process for the preparation of purified albumin and albumin obtained by said process
US4705848A (en) * 1986-06-02 1987-11-10 International Minerals & Chemical Corp. Isolation of bioactive, monomeric growth hormone
IL88326A (en) * 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
JPH0671434B2 (ja) * 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
DE69434126T3 (de) * 1993-12-17 2009-07-09 Mitsubishi Pharma Corp. Verfahren zum Entfärben von menschlichemn Serum-Albumin
JP4798833B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 加熱処理工程を含むヒト血清アルブミンの製造方法
JP4798832B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法

Also Published As

Publication number Publication date
WO2002034785A1 (fr) 2002-05-02
EP1329460A1 (de) 2003-07-23
EP1329460B1 (de) 2006-06-28
AU783571B2 (en) 2005-11-10
DK1329460T3 (da) 2006-07-31
CA2395587C (en) 2012-09-18
US20030027991A1 (en) 2003-02-06
AU1093402A (en) 2002-05-06
DE60121196D1 (de) 2006-08-10
KR20020065607A (ko) 2002-08-13
ES2261487T3 (es) 2006-11-16
DE60121196T2 (de) 2007-07-12
KR100827750B1 (ko) 2008-05-07
EP1329460A4 (de) 2004-08-11
CA2395587A1 (en) 2002-05-02
CN1651462A (zh) 2005-08-10
CN1406247A (zh) 2003-03-26
CN1275981C (zh) 2006-09-20

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