ATE540953T1 - Bizyklische imidazol- oder thiadiazol- heterozyklen als selektive androgen-rezeptor- modulatoren - Google Patents

Bizyklische imidazol- oder thiadiazol- heterozyklen als selektive androgen-rezeptor- modulatoren

Info

Publication number
ATE540953T1
ATE540953T1 AT07756561T AT07756561T ATE540953T1 AT E540953 T1 ATE540953 T1 AT E540953T1 AT 07756561 T AT07756561 T AT 07756561T AT 07756561 T AT07756561 T AT 07756561T AT E540953 T1 ATE540953 T1 AT E540953T1
Authority
AT
Austria
Prior art keywords
androgen receptor
bizyclic
imidazole
receptor modulators
selective androgen
Prior art date
Application number
AT07756561T
Other languages
English (en)
Inventor
Zhihua Sui
Xuqing Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE540953T1 publication Critical patent/ATE540953T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07756561T 2006-02-10 2007-02-01 Bizyklische imidazol- oder thiadiazol- heterozyklen als selektive androgen-rezeptor- modulatoren ATE540953T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77216806P 2006-02-10 2006-02-10
PCT/US2007/061438 WO2007095423A1 (en) 2006-02-10 2007-02-01 Bicyclic imidazole or thiadiazole heterocycles useful as selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
ATE540953T1 true ATE540953T1 (de) 2012-01-15

Family

ID=38102669

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07756561T ATE540953T1 (de) 2006-02-10 2007-02-01 Bizyklische imidazol- oder thiadiazol- heterozyklen als selektive androgen-rezeptor- modulatoren

Country Status (9)

Country Link
US (2) US7626036B2 (de)
EP (1) EP1991549B1 (de)
JP (1) JP5171649B2 (de)
CN (1) CN101415710B (de)
AT (1) ATE540953T1 (de)
AU (1) AU2007215004B2 (de)
CA (1) CA2642205C (de)
ES (1) ES2377667T3 (de)
WO (1) WO2007095423A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092371A1 (en) 2009-02-10 2010-08-19 Astrazeneca Ab Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543057A (en) 1978-09-22 1980-03-26 Mitsubishi Chem Ind Ltd Perhydropyrroloimidazole derivative and bactericidal agent for agri- and forticulture containing the same
WO2002000653A2 (en) * 2000-06-28 2002-01-03 Bristol-Myers Squibb Company Fused cyclic compounds as modulators of nuclear hormone receptor function
WO2003011824A1 (en) * 2001-07-31 2003-02-13 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
US7820702B2 (en) * 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
WO2006013887A1 (ja) * 2004-08-03 2006-02-09 Chugai Seiyaku Kabushiki Kaisha 新規イミダゾリジン誘導体

Also Published As

Publication number Publication date
US20100160330A1 (en) 2010-06-24
CA2642205C (en) 2015-01-27
AU2007215004A1 (en) 2007-08-23
JP2009526078A (ja) 2009-07-16
US20070197521A1 (en) 2007-08-23
CN101415710B (zh) 2013-08-21
EP1991549B1 (de) 2012-01-11
CA2642205A1 (en) 2007-08-23
ES2377667T3 (es) 2012-03-29
WO2007095423A1 (en) 2007-08-23
AU2007215004B2 (en) 2012-03-01
CN101415710A (zh) 2009-04-22
US7626036B2 (en) 2009-12-01
US8097730B2 (en) 2012-01-17
EP1991549A1 (de) 2008-11-19
JP5171649B2 (ja) 2013-03-27

Similar Documents

Publication Publication Date Title
TW200621725A (en) Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
UA94639C2 (ru) Трициклические соединения и их применение как модуляторов глюкокортикоидного рецептора
MX2009010984A (es) Moduladores de heterociclo cinasa de anillo fusionado.
DE602008002733D1 (de) Verbindungen und zusammensetzungen als modulatoren der gpr119-aktivität
UA94441C2 (ru) 2-замещенные бензимидазолы как селективные модуляторы рецептора андрогена (sarms)
PL1979355T3 (pl) Pochodne spiro imidazoli jako modulatory PPAR
MA32508B1 (fr) Composes organiques
TW200621235A (en) Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms)
ATE517106T1 (de) Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren
TW200608960A (en) 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
EA200602242A1 (ru) 3-аминоциклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
TW200606146A (en) Novel indole derivatives as selective androgen receptor modulators (SARMS)
MX2013012652A (es) Derivados de n-[(1h-pirazol-1-il)aril]-1h-indol o 1h-indazol-3-carboxamida, su preparacion y su uso como antagonistas p2y12.
ATE453660T1 (de) 17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren
TW200624424A (en) Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
MX2009008286A (es) Compuestos triciclicos y su uso como moduladores del receptor de glucocorticosteroides.
TW200734323A (en) 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
TW200604171A (en) Novel indole derivatives as selective androgen receptor modulators (SARMs)
ATE473741T1 (de) Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren
EA201290534A1 (ru) Бициклические тиазолы в качестве аллостерических модуляторов mglur5 рецепторов
UA119446C2 (uk) 1,2,4-ТРИАЗОЛО[4,3-а]ПІРИДИНОВІ СПОЛУКИ ТА ЇХ ЗАСТОСУВАННЯ ЯК ПОЗИТИВНИХ АЛОСТЕРИЧНИХ МОДУЛЯТОРІВ РЕЦЕПТОРІВ MGLUR2
TW200604170A (en) Novel indole derivatives as selective androgen receptor modulators (SARMs)
ATE370133T1 (de) Thiazolinderivate als selektive androgenrezeptormodulatoren (sarms)
MX2010003373A (es) Moduladores de receptores muscarinicos.
ATE485286T1 (de) Tetracyclische steroidderivate als progesteron- rezeptormodulatoren