ATE541580T1 - Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor - Google Patents

Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor

Info

Publication number
ATE541580T1
ATE541580T1 AT04817014T AT04817014T ATE541580T1 AT E541580 T1 ATE541580 T1 AT E541580T1 AT 04817014 T AT04817014 T AT 04817014T AT 04817014 T AT04817014 T AT 04817014T AT E541580 T1 ATE541580 T1 AT E541580T1
Authority
AT
Austria
Prior art keywords
self
growth factor
assembling peptide
peptide amphiphiles
relevant methods
Prior art date
Application number
AT04817014T
Other languages
English (en)
Inventor
Samuel Stupp
Jack Donners
Gabriel Silva
Heather Behanna
Shawn Anthony
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern filed Critical Univ Northwestern
Application granted granted Critical
Publication of ATE541580T1 publication Critical patent/ATE541580T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Surgery (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04817014T 2003-12-05 2004-12-06 Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor ATE541580T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52750403P 2003-12-05 2003-12-05
PCT/US2004/040550 WO2005056039A1 (en) 2003-12-05 2004-12-06 Self-assembling peptide amphiphiles and related methods for growth factor delivery

Publications (1)

Publication Number Publication Date
ATE541580T1 true ATE541580T1 (de) 2012-02-15

Family

ID=34676751

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04817014T ATE541580T1 (de) 2003-12-05 2004-12-06 Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor

Country Status (12)

Country Link
US (3) US7544661B2 (de)
EP (2) EP2314305A3 (de)
JP (2) JP4851939B2 (de)
KR (1) KR20070004560A (de)
CN (2) CN1905892A (de)
AT (1) ATE541580T1 (de)
AU (2) AU2004296181A1 (de)
CA (1) CA2549164A1 (de)
ES (1) ES2380340T3 (de)
MX (1) MXPA06006388A (de)
NZ (1) NZ547671A (de)
WO (1) WO2005056039A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003054146A2 (en) 2001-11-14 2003-07-03 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) * 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) * 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
MXPA05008483A (es) 2003-02-11 2006-03-10 Univ Northwestern Metodos y materiales para revestimientos de superficie nanocristalinos y union de nanofibras de anfililos peptidicos sobre las mismas.
ATE541580T1 (de) 2003-12-05 2012-02-15 Univ Northwestern Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
WO2005056576A2 (en) * 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
US7923109B2 (en) 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
CN101150954A (zh) * 2005-01-21 2008-03-26 西北大学 包封细胞的方法和组合物
CA2598251A1 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
US9162005B2 (en) 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
JP4766528B2 (ja) * 2005-06-27 2011-09-07 株式会社メニコン 自己組織化ペプチドおよびそれより得られるゲル
CN100475836C (zh) * 2005-12-09 2009-04-08 中国人民解放军军事医学科学院野战输血研究所 间充质干细胞亲和肽的筛选与用途
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
AU2007219714A1 (en) * 2006-02-28 2007-09-07 Regenertech Pty Limited Tissue regeneration II
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods
AU2009237414A1 (en) * 2008-04-14 2009-10-22 Adocia Osteogenic composition including a complex growth factor/amphiphilic polymer, a soluble cation salt, and an organic substrate
WO2009127939A1 (fr) * 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un facteur de croissance un sel soluble de cation et un support organique
JP5763535B2 (ja) 2008-06-24 2015-08-12 バイオアクティブ サージカル インコーポレイテッド 幹細胞または他の生理活性材料が組み込まれた外科手術用縫合糸
US8889168B2 (en) 2008-08-07 2014-11-18 Bioactive Surgical Inc. Stem cell capture and immobilization coatings for medical devices and implants
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
US8883967B2 (en) * 2009-03-27 2014-11-11 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
AU2010236584A1 (en) * 2009-04-13 2011-11-10 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
WO2011002258A2 (ko) * 2009-07-02 2011-01-06 한양대학교 산학협력단 아르기닌 기제 양친성 펩티드 마이셀
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
US9067084B2 (en) * 2010-03-31 2015-06-30 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US8940858B2 (en) * 2010-05-17 2015-01-27 Northwestern University Fibrous microcapsules and methods of assembly and use thereof
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
KR20130137164A (ko) * 2010-09-01 2013-12-16 더 리전트 오브 더 유니버시티 오브 캘리포니아 지방생성 및 근섬유모세포 분화 제어 작용제에 대한 세포 배양 스크리닝
EP2618821A4 (de) 2010-09-24 2014-08-13 Brigham & Womens Hospital Nanostrukturierte gele zur kontrollierten freisetzung verkapselter mittel
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
WO2012149515A2 (en) * 2011-04-29 2012-11-01 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
EP2922869B1 (de) 2012-11-25 2017-09-27 The Regents of The University of California Peptide zur stimulierung der subkutanen adipogenese
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
KR102391734B1 (ko) * 2013-03-15 2022-04-29 인3바이오 리미티드 자기조립형 합성 단백질
CN105658252A (zh) 2013-08-22 2016-06-08 阿奇生物外科有限公司 用于控制流体移动的可植入网状物
WO2015048747A1 (en) 2013-09-30 2015-04-02 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
CN106414477A (zh) * 2013-11-30 2017-02-15 新加坡科技研究局 自组装为纳米纤维水凝胶的新超短疏水性肽及其用途
US10844102B2 (en) 2014-05-28 2020-11-24 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
US20160159869A1 (en) 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
DE102015000363A1 (de) 2015-01-20 2016-07-21 Emc Microcollections Gmbh Neue modular funktionalisierbare Peptid-Hydrogele
US10792327B2 (en) * 2015-04-14 2020-10-06 Northwestern University Supramolecular gylcosaminoglycans
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
US11517648B2 (en) 2015-10-14 2022-12-06 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
US11021516B2 (en) 2016-09-09 2021-06-01 Research Foundation Of The City University Of New York Self-assembling peptide polymer
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2018075885A1 (en) 2016-10-21 2018-04-26 Northwestern University Anti-microbial supramolecular structures
US10818377B2 (en) 2016-11-16 2020-10-27 University Of Washington Computational design of self-assembling cyclic protein homo-oligomers
CN106749522B (zh) * 2016-11-23 2023-11-14 华东理工大学 一种含有聚组氨酸的抗癌多肽及其制备与应用
WO2018101826A1 (en) 2016-11-30 2018-06-07 Universiteit Twente Functionalization of biopolymers with growth factor-binding peptides
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
US10584146B2 (en) 2016-12-07 2020-03-10 Uchicago Argonne, Llc Heme peptide materials for anti-inflammatory regenerative nanobiomedicine
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
JP7211974B2 (ja) 2017-05-08 2023-01-24 アリヴィオ セラピューティクス, インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
US12122811B2 (en) 2018-04-06 2024-10-22 Northwestern University BDNF mimetic peptide amphiphiles
WO2019200298A1 (en) 2018-04-13 2019-10-17 Northwestern University Nanomolecules for the treatment of inflammatory bowel diseases
EP3863602A1 (de) 2018-10-11 2021-08-18 Alivio Therapeutics, Inc. Nicht injizierbare hydrogelformulierungen zur intelligenten freisetzung
WO2020154631A1 (en) 2019-01-24 2020-07-30 Northwestern University Dynamics within supramolecular 1kvav matrices enhance functional maturation of human ipscs-der1ved neurons and regeneration
US12214076B2 (en) 2019-02-18 2025-02-04 Northwestern University Drug delivery vehicles for atherosclerosis nanomedicine
WO2020236978A1 (en) * 2019-05-20 2020-11-26 Convalesce Inc. Hydrogels, methods of making, and methods of use
CN110283231B (zh) * 2019-06-03 2021-04-27 中南民族大学 一种基于两亲性寡肽自组装新型溶致液晶的制备和应用
US11964000B2 (en) 2020-04-10 2024-04-23 Northwestern University Cancer treatment methods using nanofiber stabilized growth factors
US12247063B2 (en) 2020-07-13 2025-03-11 Northwestern University Cell surface modification by coating with peptide amphiphiles (PAs)
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
US12116461B2 (en) 2020-08-21 2024-10-15 Northwestern University Host-guest interactions for pa superstructure formation
WO2022099123A1 (en) * 2020-11-06 2022-05-12 The Medical College Of Wisconsin, Inc. Peptide inhibitors of human mitochondrial fission protein 1 and methods of use
WO2022182737A2 (en) * 2021-02-23 2022-09-01 Northwestern University Dynamic bioactive scaffolds and therapeutic uses thereof after cns injury
US12570709B2 (en) 2021-07-29 2026-03-10 Northwestern University Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (TGF-ß1) mimetic epitope
CA3229054A1 (en) * 2021-08-09 2023-02-16 Gel4Med, Inc. Self-assembling amphiphilic peptide hydrogels for treatment of nerve injury
WO2024064661A2 (en) * 2022-09-20 2024-03-28 The Curators Of The University Of Missouri Amino acid-modified lipids for rna delivery
CN117986325B (zh) * 2024-01-25 2024-12-13 中国人民解放军军事科学院军事医学研究院 一种多肽单体分子mbp、多肽共组装纳米粒及其应用

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5110604A (en) 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (ja) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol 短繊維型螺旋状分子会合体の長さ制御方法
DE4026978A1 (de) 1990-08-25 1992-02-27 Bayer Ag Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung
SG47470A1 (en) 1991-04-25 1998-04-17 Univ Brown Res Found Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
EP0842209B1 (de) 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (fr) 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
SE9504347D0 (sv) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
JP3862760B2 (ja) 1996-06-12 2006-12-27 トレスパファン、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング 低い薄膜干渉を示す透明なバリヤコーティング
US6085206A (en) 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
ATE244579T1 (de) 1997-01-22 2003-07-15 Univ Texas Verfahren und zusammensetzungen des gewebefaktors zur koagulation und behandlung von tumoren
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2307954C (en) 1997-04-03 2010-07-13 California Institute Of Technology Enzyme-medicated modification of fibrin for tissue engineering
US6181909B1 (en) 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
US6391297B1 (en) 1997-12-02 2002-05-21 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (sv) 1998-03-30 2003-04-15 Viranative Ab Näringsmedium innehållande metionin samt användning av detta
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
DE69936212T2 (de) 1998-09-04 2008-01-24 Scios Inc., Sunnyvale Hydrogelzusammensetzungen mit kontrollierter Freigabe für die Verabreichung von Wachstumsfaktoren
US6207218B1 (en) 1998-09-15 2001-03-27 Isotis B.V. Method for coating medical implants
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
CA2359318C (en) 1999-02-01 2009-06-30 Universitat Zurich Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
CA2361612A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
WO2000052145A2 (en) 1999-03-02 2000-09-08 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
WO2000064481A1 (en) 1999-04-22 2000-11-02 Eidgenössische Technische Hochschule (ETH) Controlled release of growth factors from heparin containing matrices
US20090087878A9 (en) 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
EP1196426A4 (de) 1999-06-30 2003-09-03 Advanced Cell Tech Inc Zytoplasmatischer transfer zur de-differenzierung von gefässzellen
US6444723B1 (en) 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
ES2304359T3 (es) * 1999-12-28 2008-10-16 The Regents Of The University Of Michigan Procedimiento de formacion ex vivo de hueso de mamiferos y usos del mismo.
WO2001055321A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US20030077808A1 (en) * 2000-01-31 2003-04-24 Rosen Craig A. Nucleic acids, proteins, and antibodies
JP2003521351A (ja) 2000-02-04 2003-07-15 イソティス エヌ.ブイ. 蛋白質性コーティング
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
CA2406823A1 (en) 2000-04-28 2001-11-08 Lawrence John Penkler Amphiphilic macrocyclic derivatives and their analogues
US20020046018A1 (en) 2000-05-11 2002-04-18 Daniel Marcu Discourse parsing and summarization
EP1315840A4 (de) * 2000-09-08 2005-11-02 Univ Texas Biopanning und schnelle analyse von selektiven interaktiven liganden
EP1355965B1 (de) 2000-10-19 2012-09-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) Verfahren zur herstellung von blockcopolymeren für multifunktionelle selbstorganisierende systeme
DE60033576T2 (de) * 2000-11-06 2007-10-31 Thrasos, Inc., Waltham Methoden zum screening knochenmorphogenetishemimetika
JP2004524559A (ja) 2001-01-23 2004-08-12 エデュケーショナル テスティング サービス 論文の自動分析方法
EP1367961B1 (de) 2001-02-06 2008-12-31 Massachusetts Institute Of Technology Peptidgerüstverkapselung von gewebszellen und verwendungen davon
US7449180B2 (en) 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
US7179784B2 (en) 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
AU2002361601A1 (en) 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
WO2003054146A2 (en) 2001-11-14 2003-07-03 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) * 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
US6890654B2 (en) 2002-04-18 2005-05-10 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長cDNAおよびその利用
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
US20040155517A1 (en) 2002-07-23 2004-08-12 Stupp Samuel I. Self-assembled hybrid compositions and methods of making, using and ordering the same
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
AU2003304280A1 (en) 2002-11-12 2005-01-21 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
MXPA05008483A (es) 2003-02-11 2006-03-10 Univ Northwestern Metodos y materiales para revestimientos de superficie nanocristalinos y union de nanofibras de anfililos peptidicos sobre las mismas.
CN100364672C (zh) 2003-02-11 2008-01-30 西北大学 纳米晶体表面涂层和肽亲水脂分子纳米纤维向其上附着的方法和材料
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
WO2004091370A2 (en) 2003-04-10 2004-10-28 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
WO2005056576A2 (en) 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
ATE541580T1 (de) 2003-12-05 2012-02-15 Univ Northwestern Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
KR20070007837A (ko) 2004-03-23 2007-01-16 라이프라인 뉴트러세티컬스 코포레이션 포유류에서 염증과 산화적 스트레스 완화를 위한 조성물 및방법
CN101150954A (zh) 2005-01-21 2008-03-26 西北大学 包封细胞的方法和组合物
US20060188555A1 (en) 2005-01-21 2006-08-24 Micheal Cormier Therapeutic peptide formulations with improved stability
CA2598251A1 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
WO2007022287A2 (en) 2005-08-15 2007-02-22 Vegenics Limited Modified vegf and pdgf with improved angiogenic properties
CN1915438A (zh) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
WO2008101104A2 (en) * 2007-02-14 2008-08-21 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods
AU2010236584A1 (en) * 2009-04-13 2011-11-10 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use

Also Published As

Publication number Publication date
KR20070004560A (ko) 2007-01-09
JP2007513174A (ja) 2007-05-24
CN102225964A (zh) 2011-10-26
EP2314305A3 (de) 2011-08-10
EP1696945A1 (de) 2006-09-06
MXPA06006388A (es) 2006-09-04
US7544661B2 (en) 2009-06-09
AU2004296181A1 (en) 2005-06-23
CA2549164A1 (en) 2005-06-23
US20050209145A1 (en) 2005-09-22
CN1905892A (zh) 2007-01-31
WO2005056039A1 (en) 2005-06-23
US8138140B2 (en) 2012-03-20
AU2011201593A1 (en) 2011-04-28
EP2314305A2 (de) 2011-04-27
JP4851939B2 (ja) 2012-01-11
JP2012006951A (ja) 2012-01-12
US20090269847A1 (en) 2009-10-29
EP1696945A4 (de) 2007-03-21
US20120264912A1 (en) 2012-10-18
ES2380340T3 (es) 2012-05-10
EP1696945B1 (de) 2012-01-18
US8580923B2 (en) 2013-11-12
NZ547671A (en) 2009-10-30

Similar Documents

Publication Publication Date Title
EP2314305A3 (de) Selbst anordnende Peptid-Amphiphile und relevante Verfahren für die Abgabe von Wachstumsfaktoren
SG153865A1 (en) Metastin derivatives and use thereof
EA200601313A1 (ru) Варианты участка f
CY1111225T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c
DE60230456D1 (de) Faktor-viii-polypeptide auf hohem expressionsnivea und verwendungsverfahren
EP1990059A3 (de) Verfahren zur Behandlung von Krebs
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
DE60223058D1 (de) Zusammensetzungen und verfahren zur behandlung von diabetes
NO20073914L (no) Biologisk aktive peptider
ATE506370T1 (de) Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
EP1666413A4 (de) Tantalcarbid, verfahren zur herstellung von tantalcarbid, tantalcarbiddraht und tantalcarbidelektrode
HUP0402327A2 (hu) Inzulinszerű növekedési faktort kötő 5-ös fehérje expressziójának antiszensz módosítása
ATE543833T1 (de) Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen
IL173929A (en) Kahlalid F analogs and their pharmacy preparations
ATE328000T1 (de) Phospholipidester von clofarabin
DE602004028239D1 (de) Protease, für die protease codierende dna und verfahren zur herstellung der protease
WO2003093300A3 (en) Anti-microbial peptides and compositions
ATE505538T1 (de) Dna-vektoren
DE60120187D1 (de) Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
EP1392340A4 (de) Zytotoxische peptide und darauf basierende peptidomimetika und verfahren zur verwendung davon
ATE529437T1 (de) Verfahren zur sauerstoff-regulierten produktion von recombinanter staphylokinase