ATE541582T1 - Stabilisierte pharmazeutische glp-1 peptid zusammensetzungen - Google Patents
Stabilisierte pharmazeutische glp-1 peptid zusammensetzungenInfo
- Publication number
- ATE541582T1 ATE541582T1 AT04735870T AT04735870T ATE541582T1 AT E541582 T1 ATE541582 T1 AT E541582T1 AT 04735870 T AT04735870 T AT 04735870T AT 04735870 T AT04735870 T AT 04735870T AT E541582 T1 ATE541582 T1 AT E541582T1
- Authority
- AT
- Austria
- Prior art keywords
- glp
- peptide compositions
- stabilized pharmaceutical
- peptide
- pharmaceutical
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 title 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 title 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 108010088406 Glucagon-Like Peptides Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300819 | 2003-06-03 | ||
| US47627903P | 2003-06-05 | 2003-06-05 | |
| DKPA200400075 | 2004-01-19 | ||
| US53852504P | 2004-01-22 | 2004-01-22 | |
| PCT/DK2004/000380 WO2004105781A2 (en) | 2003-06-03 | 2004-06-03 | Stabilized pharmaceutical peptide compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE541582T1 true ATE541582T1 (de) | 2012-02-15 |
Family
ID=36645905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04735870T ATE541582T1 (de) | 2003-06-03 | 2004-06-03 | Stabilisierte pharmazeutische glp-1 peptid zusammensetzungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7632806B2 (de) |
| EP (1) | EP2292254A3 (de) |
| JP (1) | JP4936884B2 (de) |
| KR (1) | KR101308912B1 (de) |
| CN (1) | CN102940879B (de) |
| AT (1) | ATE541582T1 (de) |
| BR (1) | BRPI0410972C1 (de) |
| ES (1) | ES2380437T3 (de) |
Families Citing this family (51)
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| WO2003072143A1 (en) * | 2002-02-27 | 2003-09-04 | Pharmain, Ltd. | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
| US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| EP1633391B1 (de) * | 2003-06-03 | 2011-10-19 | Novo Nordisk A/S | Stabilisierte pharmazeutische peptid zusammensetzungen |
| WO2005112977A2 (en) * | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| MX2008014870A (es) | 2006-05-30 | 2009-02-12 | Intarcia Therapeutics Inc | Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas. |
| EP2049081B1 (de) | 2006-08-09 | 2012-11-14 | Intarcia Therapeutics, Inc. | Osmotische freisetzungssysteme und kolbenanordnungen |
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| KR100746658B1 (ko) | 2007-04-23 | 2007-08-06 | 성균관대학교산학협력단 | 소수성 담즙산이 접합된 엑센딘-4 유도체, 이의 제조방법및 이를 포함하는 약학 조성물 |
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| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| JP2011516541A (ja) * | 2008-04-07 | 2011-05-26 | ナショナル インスティテュート オブ イミュノロジー | 糖尿病および他の慢性疾患の治療に有用な組成物 |
| SMT201700583T1 (it) | 2009-09-28 | 2018-01-11 | Intarcia Therapeutics Inc | Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario |
| BR112012012945A2 (pt) | 2009-11-25 | 2020-12-29 | Arisgen Sa | Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo |
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| EP2895506A1 (de) | 2012-09-17 | 2015-07-22 | Imperial Innovations Limited | Peptidanaloga von glucagon und glp1 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| HK1211232A1 (en) | 2012-12-21 | 2016-05-20 | Sanofi | Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists |
| SMT201700401T1 (it) * | 2013-06-28 | 2017-09-07 | Amgen Inc | Formulazione liquida stabile di amg 416 (velcalcetide) |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080152A1 (de) | 2013-12-13 | 2016-10-19 | Sanofi | Nicht-acylierte exendin-4-peptidanaloga |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| EP3160491A4 (de) * | 2014-06-25 | 2018-01-17 | GlaxoSmithKline LLC | Pharmazeutische zusammensetzungen |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
| KR102568413B1 (ko) | 2017-06-15 | 2023-08-21 | 한국전자통신연구원 | 이온 빔 치료장치 |
| HRP20240485T1 (hr) * | 2017-08-24 | 2024-07-05 | Novo Nordisk A/S | Pripravci glp-1 i njihova upotreba |
| CN110551203B (zh) * | 2019-09-25 | 2023-02-10 | 成都奥达生物科技有限公司 | 一种艾塞那肽类似物 |
| PE20230819A1 (es) | 2020-02-18 | 2023-05-19 | Novo Nordisk As | Composiciones y usos de glp-1 |
| EP4142695B1 (de) * | 2020-04-29 | 2025-11-05 | Novo Nordisk A/S | Feste zusammensetzungen mit einem glp-1-agonisten und histidin |
| EP4281039A2 (de) | 2021-01-25 | 2023-11-29 | Mylan Ireland Limited | Pharmazeutische glp-peptid-zusammensetzungen und verfahren zu ihrer herstellung |
| CN118307645A (zh) * | 2021-05-28 | 2024-07-09 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
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| EP1351984A2 (de) * | 2000-12-13 | 2003-10-15 | Eli Lilly And Company | Amidiertes glucagonähnliches peptid-1 |
| US20020151467A1 (en) * | 2000-12-21 | 2002-10-17 | Leung Frank K. | Methods and compositions for oral insulin delivery |
| GB2371227A (en) | 2001-01-10 | 2002-07-24 | Grandis Biotech Gmbh | Crystallisation - resistant aqueous growth hormone formulations |
| ATE396202T1 (de) * | 2001-02-16 | 2008-06-15 | Conjuchem Biotechnologies Inc | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen |
| US6573237B2 (en) * | 2001-03-16 | 2003-06-03 | Eli Lilly And Company | Protein formulations |
| AU2002316811A1 (en) * | 2001-06-28 | 2003-03-03 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
| CN1335182A (zh) | 2001-08-08 | 2002-02-13 | 华中科技大学 | 胰岛素口腔喷剂及其制备工艺 |
| CA2458371A1 (en) | 2001-08-23 | 2003-03-06 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
| CA2452044A1 (en) * | 2001-08-28 | 2003-03-13 | Eli Lilly And Company | Pre-mixes of glp-1 and basal insulin |
| WO2003035099A1 (en) | 2001-10-19 | 2003-05-01 | Eli Lilly And Company | Biphasic mixtures of glp-1 and insulin |
| JP2005526084A (ja) | 2002-03-15 | 2005-09-02 | ナットイムネ・アクティーゼルスカブ | マンノース結合レクチンを含む医薬組成物 |
| WO2003084563A1 (en) * | 2002-04-04 | 2003-10-16 | Novo Nordisk A/S | Glp-1 agonist and cardiovascular complications |
| DE60321473D1 (de) | 2002-09-25 | 2008-07-17 | Novo Nordisk As | Aufreinigungsverfahren, das eine mikrofiltration bei erhöhten temperaturen beinhaltet |
| US7273921B2 (en) * | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
| WO2004089985A1 (en) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Stable pharmaceutical compositions |
| EP1631308B1 (de) | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Neue verfahren und zusammensetzungen für die verbesserte transmukosale abgabe von peptiden und proteinen |
| CA2527743A1 (en) | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
| US20060287221A1 (en) * | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
| EP1684793B1 (de) | 2003-11-13 | 2011-09-21 | Novo Nordisk A/S | Pharmazeutische zusammensetzung umfassend eine insulinotrope glp-1(7-37) analoge, asp(b28)-insulin, und eine oberflächenaktive verbindung |
| WO2006025882A2 (en) | 2004-08-25 | 2006-03-09 | The Uab Research Foundation | Absorption enhancers for drug administration |
-
2004
- 2004-06-03 AT AT04735870T patent/ATE541582T1/de active
- 2004-06-03 CN CN201210497503.5A patent/CN102940879B/zh not_active Expired - Lifetime
- 2004-06-03 EP EP10178212A patent/EP2292254A3/de not_active Withdrawn
- 2004-06-03 ES ES04735870T patent/ES2380437T3/es not_active Expired - Lifetime
- 2004-06-03 KR KR1020127027174A patent/KR101308912B1/ko not_active Expired - Lifetime
- 2004-06-03 BR BRPI0410972A patent/BRPI0410972C1/pt active IP Right Grant
- 2004-06-03 JP JP2006508132A patent/JP4936884B2/ja not_active Expired - Lifetime
-
2005
- 2005-11-30 US US11/290,634 patent/US7632806B2/en not_active Expired - Lifetime
-
2009
- 2009-11-05 US US12/612,888 patent/US8614181B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR101308912B1 (ko) | 2013-09-23 |
| BRPI0410972A (pt) | 2006-07-04 |
| US8614181B2 (en) | 2013-12-24 |
| EP2292254A2 (de) | 2011-03-09 |
| JP4936884B2 (ja) | 2012-05-23 |
| BRPI0410972B1 (pt) | 2018-01-30 |
| ES2380437T3 (es) | 2012-05-11 |
| US7632806B2 (en) | 2009-12-15 |
| CN102940879B (zh) | 2017-06-06 |
| BRPI0410972B8 (pt) | 2018-12-04 |
| KR20120130264A (ko) | 2012-11-29 |
| BRPI0410972C1 (pt) | 2021-05-25 |
| US20100056451A1 (en) | 2010-03-04 |
| CN102940879A (zh) | 2013-02-27 |
| EP2292254A3 (de) | 2011-12-14 |
| US20060178304A1 (en) | 2006-08-10 |
| JP2008500262A (ja) | 2008-01-10 |
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