ATE541590T1 - Modifizierte antikörper-fragmente - Google Patents

Modifizierte antikörper-fragmente

Info

Publication number
ATE541590T1
ATE541590T1 AT04743216T AT04743216T ATE541590T1 AT E541590 T1 ATE541590 T1 AT E541590T1 AT 04743216 T AT04743216 T AT 04743216T AT 04743216 T AT04743216 T AT 04743216T AT E541590 T1 ATE541590 T1 AT E541590T1
Authority
AT
Austria
Prior art keywords
sub
antibody fragments
modified antibody
fragment
interchain cysteine
Prior art date
Application number
AT04743216T
Other languages
English (en)
Inventor
David Paul Humphreys
Sam Philip Heywood
Bruce Carrington
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Application granted granted Critical
Publication of ATE541590T1 publication Critical patent/ATE541590T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Jellies, Jams, And Syrups (AREA)
AT04743216T 2003-07-01 2004-07-01 Modifizierte antikörper-fragmente ATE541590T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0315450.7A GB0315450D0 (en) 2003-07-01 2003-07-01 Biological products
PCT/GB2004/002870 WO2005003170A2 (en) 2003-07-01 2004-07-01 Modified antibody fragments

Publications (1)

Publication Number Publication Date
ATE541590T1 true ATE541590T1 (de) 2012-02-15

Family

ID=27676491

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04743216T ATE541590T1 (de) 2003-07-01 2004-07-01 Modifizierte antikörper-fragmente

Country Status (8)

Country Link
US (1) US20070059301A1 (de)
EP (1) EP1644044B1 (de)
JP (1) JP2007535472A (de)
AT (1) ATE541590T1 (de)
AU (1) AU2004253746A1 (de)
CA (1) CA2527003A1 (de)
GB (1) GB0315450D0 (de)
WO (1) WO2005003170A2 (de)

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EP1644044A2 (de) 2006-04-12
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