ATE542135T1 - Testverfahren für kandidatenverbindungen auf anfälligkeit für biliäre ausscheidung - Google Patents

Testverfahren für kandidatenverbindungen auf anfälligkeit für biliäre ausscheidung

Info

Publication number
ATE542135T1
ATE542135T1 AT09166034T AT09166034T ATE542135T1 AT E542135 T1 ATE542135 T1 AT E542135T1 AT 09166034 T AT09166034 T AT 09166034T AT 09166034 T AT09166034 T AT 09166034T AT E542135 T1 ATE542135 T1 AT E542135T1
Authority
AT
Austria
Prior art keywords
biliary excretion
suspension
test methods
candidate compound
culture
Prior art date
Application number
AT09166034T
Other languages
English (en)
Inventor
Edward L Lecluyse
Xingrong Liu
Kim L R Brouwer
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22416897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE542135(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE542135T1 publication Critical patent/ATE542135T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Processing Of Solid Wastes (AREA)
AT09166034T 1999-03-17 2000-03-17 Testverfahren für kandidatenverbindungen auf anfälligkeit für biliäre ausscheidung ATE542135T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12481099P 1999-03-17 1999-03-17

Publications (1)

Publication Number Publication Date
ATE542135T1 true ATE542135T1 (de) 2012-02-15

Family

ID=22416897

Family Applications (3)

Application Number Title Priority Date Filing Date
AT00919459T ATE323283T1 (de) 1999-03-17 2000-03-17 Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion
AT09166034T ATE542135T1 (de) 1999-03-17 2000-03-17 Testverfahren für kandidatenverbindungen auf anfälligkeit für biliäre ausscheidung
AT06002377T ATE437360T1 (de) 1999-03-17 2000-03-17 Screening-verfahren für kandidatenverbindungen auf empfänglichkeit für gallenexkretion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00919459T ATE323283T1 (de) 1999-03-17 2000-03-17 Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06002377T ATE437360T1 (de) 1999-03-17 2000-03-17 Screening-verfahren für kandidatenverbindungen auf empfänglichkeit für gallenexkretion

Country Status (15)

Country Link
US (4) US6780580B2 (de)
EP (4) EP2293063A1 (de)
JP (2) JP4451570B2 (de)
KR (1) KR20020011370A (de)
AT (3) ATE323283T1 (de)
AU (3) AU782352B2 (de)
BR (1) BR0009073A (de)
CA (1) CA2365398C (de)
DE (2) DE60027279T2 (de)
DK (2) DK1659403T3 (de)
ES (2) ES2263464T3 (de)
IL (1) IL145176A0 (de)
MX (1) MXPA01009213A (de)
NZ (1) NZ513773A (de)
WO (1) WO2000055355A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601494B2 (en) 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
ATE323283T1 (de) * 1999-03-17 2006-04-15 Univ North Carolina Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion
US20050059150A1 (en) * 2003-09-17 2005-03-17 Becton, Dickinson And Company Environments that maintain function of primary liver cells
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
ES2569881T3 (es) * 2005-06-08 2016-05-12 The University Of North Carolina At Chapel Hill Procedimientos para facilitar la supervivencia de células neuronales usando miméticos de neurotrofina BDNF peptídicos y no peptídicos
WO2007146203A1 (en) * 2006-06-08 2007-12-21 The University Of North Carolina At Chapel Hill Pulsing of bile compartments in sandwich-cultured hepatocytes
US20090238899A1 (en) * 2008-03-24 2009-09-24 Bajpai Mangala P Method for rapid identification of pharmacologically active chemical entities associated with the efficacy of ethnobotanical substances
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
WO2013086070A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
CN105189449A (zh) 2013-03-15 2015-12-23 特罗菲克斯制药股份有限公司 非肽bdnf神经营养蛋白模拟物
CN105209427B (zh) 2013-03-15 2018-05-25 特罗菲克斯制药股份有限公司 非肽bdnf神经营养蛋白模拟物
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
WO2014200816A1 (en) 2013-06-14 2014-12-18 Biotranex, Llc Method for measuring bile salt export transport and/or formation activity
JP6087264B2 (ja) * 2013-11-29 2017-03-01 株式会社日立ハイテクノロジーズ 成分分析装置、薬効分析装置、及び分析方法
JP6644786B2 (ja) 2014-08-22 2020-02-12 ビオプレディク アンテルナシオナルＢｉｏｐｒｅｄｉｃ Ｉｎｔｅｒｎａｔｉｏｎａｌ 毛細胆管活性の機械的改変およびＲｈｏキナーゼミオシンＩＩ経路およびジャンクションの透過性の調節、その検出方法およびその誘導体の使用
JP2017527283A (ja) * 2014-09-02 2017-09-21 ヒューレル コーポレーション ｉｎ ｖｉｔｒｏ胆汁中排泄アッセイ
MA41048A (fr) 2014-10-07 2017-08-15 Qualyst Transp Solutions Llc Utilité d'une protéine dans la prédiction d'effets in vivo
US20180120298A1 (en) * 2015-03-27 2018-05-03 National Agriculture and Food Reserach Organization Hepatocyte culture device capable of enhancing accumulation and excretion of hepatic metabolite in and into bile canaliculus-like structure, and method for evaluating candidate compound sensitive to excretion into bile or blood and hepatic metabolite of said candidate compound using said hepatocyte culture device
JP6758026B2 (ja) 2015-04-17 2020-09-23 株式会社日立ハイテク 成分分析装置、薬剤成分分析装置、成分分析方法及び薬剤成分分析方法
JP6282362B2 (ja) * 2017-01-31 2018-02-21 株式会社日立ハイテクノロジーズ 成分分析装置、薬効分析装置、及び分析方法
JP6582070B2 (ja) * 2018-01-22 2019-09-25 株式会社日立ハイテクノロジーズ 分析方法
JP2023020221A (ja) * 2021-07-30 2023-02-09 ウシオ電機株式会社 薬剤評価方法
JP2025181719A (ja) 2024-05-31 2025-12-11 国立大学法人東京科学大学 毛細胆管作製用培地およびそれを用いた毛細胆管の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602026A (en) * 1988-10-14 1997-02-11 The General Hospital Corporation Culturing liver cells between two supports
US5504086A (en) 1989-10-17 1996-04-02 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering trifluorobenzodiazepines, propoxyphene, and nefazodone
EP0673433A1 (de) * 1992-11-25 1995-09-27 Merck & Co. Inc. Lebermodell
ATE190065T1 (de) 1994-05-12 2000-03-15 Balazs Sarkadi Stoffe zur aufhebung von arzneimittelresistenzen
WO1996001426A1 (en) * 1994-07-01 1996-01-18 W.R. Grace & Co.-Conn. Hepatocyte test kit
ATE323283T1 (de) 1999-03-17 2006-04-15 Univ North Carolina Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion
US7601494B2 (en) * 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
EP1574574A4 (de) 2002-11-15 2005-12-14 Univ Keio Exon 1-beta des gens für pdgf-rezeptor-alpha und verwendung davon

Also Published As

Publication number Publication date
EP2112511B1 (de) 2012-01-18
US20040219513A1 (en) 2004-11-04
AU782352B2 (en) 2005-07-21
ES2263464T3 (es) 2006-12-16
EP2112511A1 (de) 2009-10-28
MXPA01009213A (es) 2002-10-11
US20030044883A1 (en) 2003-03-06
AU2008264187B2 (en) 2011-07-07
IL145176A0 (en) 2002-06-30
DE60027279D1 (de) 2006-05-24
EP1659403A2 (de) 2006-05-24
WO2000055355A3 (en) 2000-12-14
DK1659403T3 (da) 2009-11-23
DE60042618D1 (de) 2009-09-03
AU2008264187A1 (en) 2009-01-29
ATE323283T1 (de) 2006-04-15
CA2365398A1 (en) 2000-09-21
JP2009273467A (ja) 2009-11-26
DK1163517T3 (da) 2006-08-21
ES2331743T3 (es) 2010-01-14
AU2005225094A1 (en) 2005-11-17
JP2003502016A (ja) 2003-01-21
US20100173333A1 (en) 2010-07-08
AU4014500A (en) 2000-10-04
EP2293063A1 (de) 2011-03-09
US7604934B2 (en) 2009-10-20
DE60027279T2 (de) 2007-03-29
EP1659403B1 (de) 2009-07-22
AU2005225094B2 (en) 2009-01-15
JP4451570B2 (ja) 2010-04-14
US20040214226A1 (en) 2004-10-28
EP1659403A3 (de) 2006-07-05
CA2365398C (en) 2013-01-08
EP1163517A2 (de) 2001-12-19
US6780580B2 (en) 2004-08-24
WO2000055355A2 (en) 2000-09-21
ATE437360T1 (de) 2009-08-15
US7682781B2 (en) 2010-03-23
NZ513773A (en) 2004-06-25
BR0009073A (pt) 2002-10-22
EP1163517B1 (de) 2006-04-12
KR20020011370A (ko) 2002-02-08

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