ATE542794T1 - Pyrrolderivat oder salz davon - Google Patents
Pyrrolderivat oder salz davonInfo
- Publication number
- ATE542794T1 ATE542794T1 AT07714469T AT07714469T ATE542794T1 AT E542794 T1 ATE542794 T1 AT E542794T1 AT 07714469 T AT07714469 T AT 07714469T AT 07714469 T AT07714469 T AT 07714469T AT E542794 T1 ATE542794 T1 AT E542794T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- treatment
- compound
- pyrrole derivative
- ibs
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 4
- 102000006969 5-HT2B Serotonin Receptor Human genes 0.000 abstract 3
- 108010072584 5-HT2B Serotonin Receptor Proteins 0.000 abstract 3
- 108091005436 5-HT7 receptors Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- -1 guanidinocarbonyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006041830 | 2006-02-20 | ||
| PCT/JP2007/052943 WO2007097276A1 (ja) | 2006-02-20 | 2007-02-19 | ピロール誘導体またはその塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE542794T1 true ATE542794T1 (de) | 2012-02-15 |
Family
ID=38437316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07714469T ATE542794T1 (de) | 2006-02-20 | 2007-02-19 | Pyrrolderivat oder salz davon |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8222274B2 (de) |
| EP (1) | EP1988075B1 (de) |
| JP (1) | JP5157893B2 (de) |
| KR (1) | KR20080105092A (de) |
| CN (1) | CN101384549B (de) |
| AT (1) | ATE542794T1 (de) |
| CA (1) | CA2642619A1 (de) |
| ES (1) | ES2379734T3 (de) |
| MX (1) | MX2008010644A (de) |
| WO (1) | WO2007097276A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006085510A1 (ja) * | 2005-02-08 | 2006-08-17 | Astellas Pharma Inc. | 過敏性腸症候群の治療薬 |
| CA2617473A1 (en) * | 2005-08-08 | 2007-02-15 | Astellas Pharma Inc. | Acylguanidine derivative or salt thereof |
| EP2185506A1 (de) * | 2007-08-22 | 2010-05-19 | Allergan, Inc. | Pyrrolverbindungen mit agonistischer oder antagonistischer biologischer wirkung am sphingosin-1-phosphatrezeptor |
| MX2011005221A (es) * | 2008-11-21 | 2011-08-03 | Raqualia Pharma Inc | Nuevo derivado de la pirazol-3-carboxamida que tiene actividad de antagonista del receptor de 5-ht2b. |
| KR20140041442A (ko) * | 2011-02-03 | 2014-04-04 | 루핀 리미티드 | 알파 7 ｎａｃｈｒ의 조절자로 사용된 피롤 유도체 |
| EP2800745B1 (de) | 2011-12-02 | 2020-02-12 | Phenex Pharmaceuticals AG | Pyrrolocarboxamid-verbindungen als modulatoren von mit orphan-nuklearrezeptor rar zusammenhängender orphan-rezeptor-gamma-aktivität (rory-nr1f3-aktivität) und zur behandlung chronischer entzündungs- und autoimmunerkrankungen |
| US10344002B2 (en) | 2016-09-26 | 2019-07-09 | Nusirt Sciences, Inc. | Compositions and methods for treating metabolic disorders |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3410857A (en) * | 1964-10-12 | 1968-11-12 | Endo Lab | 2-amino ethyl pyrrol-3-yl ketones |
| US3391157A (en) * | 1965-04-23 | 1968-07-02 | Endo Lab | 2, 4, 5-triloweralkyl-pyrrol-3-yl-hydroxymethyl ketones and ethers and carbamates thereof |
| US3407199A (en) * | 1966-01-18 | 1968-10-22 | Endo Lab | Tertiaryamino ethyl or propyl pyrrol-2-yl ketones |
| US3551571A (en) * | 1967-05-19 | 1970-12-29 | Endo Lab | Methods for reducing pain,reducing fever and alleviating inflammatory syndromes with heteroaromatic pyrrol-3-yl ketones |
| PL170837B1 (pl) * | 1991-10-18 | 1997-01-31 | Monsanto Co | S rod ek g r zybobó j c zy PL PL PL PL PL PL |
| CA2121391A1 (en) | 1993-04-28 | 1994-10-29 | Atsuyuki Kojima | Indoloylguanidine derivatives |
| EP0639573A1 (de) | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| AU679635B2 (en) | 1994-03-11 | 1997-07-03 | Eli Lilly And Company | Method for treating 5HT-2B receptor related conditions |
| US5663178A (en) * | 1995-02-06 | 1997-09-02 | Eli Lilly And Company | Tetrahydro-beta carbolines |
| JP3295277B2 (ja) | 1994-06-01 | 2002-06-24 | 呉羽化学工業株式会社 | 抗腎疾患剤及びベンズイミダゾール誘導体 |
| TW440563B (en) | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| GB9612884D0 (en) | 1996-06-20 | 1996-08-21 | Smithkline Beecham Plc | Novel compounds |
| JP4196419B2 (ja) | 1997-11-05 | 2008-12-17 | ソニー株式会社 | データ送受信システム、データ受信装置及びデータ送受信方法 |
| WO2000069437A1 (en) * | 1999-05-18 | 2000-11-23 | Synaptic Pharmaceutical Corporation | Use of agonists or antagonists of the 5-ht7 receptor to treat disorders of the bladder |
| US6534535B1 (en) * | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6444477B1 (en) | 2000-11-28 | 2002-09-03 | Pharmagene Laboratories Limited | Assay method for detecting 5-HT2B antagonists |
| ITRM20010356A1 (it) | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
| AU2002359376B2 (en) * | 2001-11-08 | 2008-01-10 | Elan Pharmaceuticals, Inc. | N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| JP4316232B2 (ja) | 2001-12-28 | 2009-08-19 | 武田薬品工業株式会社 | アンドロゲン受容体拮抗剤 |
| AU2002367424A1 (en) | 2001-12-28 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Androgen receptor antagonists |
| FR2842524B1 (fr) * | 2002-07-16 | 2005-04-22 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments |
| EP1541172A1 (de) | 2002-08-09 | 2005-06-15 | Ajinomoto Co., Inc. | Mittel zur behandlung von darmerkrankungen und viszeralen schmerzen |
| GB0230088D0 (en) * | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| CN101012193A (zh) | 2003-01-02 | 2007-08-08 | 霍夫曼-拉罗奇有限公司 | 新cb 1受体反激动剂 |
| JP2005162657A (ja) | 2003-12-02 | 2005-06-23 | Takeda Chem Ind Ltd | カンナビノイド受容体調節剤 |
| BRPI0506139A (pt) | 2004-02-20 | 2006-10-24 | Astellas Pharma Inc | derivados fluoreno |
| JPWO2005079845A1 (ja) | 2004-02-20 | 2007-08-02 | アステラス製薬株式会社 | 片頭痛予防薬 |
| ES2324720T3 (es) | 2004-05-10 | 2009-08-13 | F. Hoffmann-La Roche Ag | Pirrol o imidazol amidas para tratar la obesidad. |
| WO2006085510A1 (ja) | 2005-02-08 | 2006-08-17 | Astellas Pharma Inc. | 過敏性腸症候群の治療薬 |
| CA2617473A1 (en) | 2005-08-08 | 2007-02-15 | Astellas Pharma Inc. | Acylguanidine derivative or salt thereof |
| MX2008002014A (es) * | 2005-08-15 | 2008-03-27 | Hoffmann La Roche | Derivados de piperidina y piperazina como antagonistas de p2x3. |
| EP1984355A2 (de) * | 2006-02-16 | 2008-10-29 | Takeda Pharmaceutical Company Limited | Cyclische aminverbindung und deren verwendung zur prophylaxe oder behandlung von bluthochdruck |
| WO2007097197A1 (ja) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | アミド誘導体またはその塩 |
-
2007
- 2007-02-19 EP EP07714469A patent/EP1988075B1/de not_active Not-in-force
- 2007-02-19 ES ES07714469T patent/ES2379734T3/es active Active
- 2007-02-19 KR KR1020087022898A patent/KR20080105092A/ko not_active Withdrawn
- 2007-02-19 CA CA002642619A patent/CA2642619A1/en not_active Abandoned
- 2007-02-19 CN CN2007800059535A patent/CN101384549B/zh not_active Expired - Fee Related
- 2007-02-19 AT AT07714469T patent/ATE542794T1/de active
- 2007-02-19 MX MX2008010644A patent/MX2008010644A/es not_active Application Discontinuation
- 2007-02-19 US US12/278,609 patent/US8222274B2/en not_active Expired - Fee Related
- 2007-02-19 JP JP2008501700A patent/JP5157893B2/ja not_active Expired - Fee Related
- 2007-02-19 WO PCT/JP2007/052943 patent/WO2007097276A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN101384549B (zh) | 2011-04-13 |
| EP1988075A4 (de) | 2010-03-03 |
| JPWO2007097276A1 (ja) | 2009-07-16 |
| JP5157893B2 (ja) | 2013-03-06 |
| CN101384549A (zh) | 2009-03-11 |
| MX2008010644A (es) | 2008-10-28 |
| ES2379734T3 (es) | 2012-05-03 |
| US8222274B2 (en) | 2012-07-17 |
| US20090036421A1 (en) | 2009-02-05 |
| KR20080105092A (ko) | 2008-12-03 |
| EP1988075A1 (de) | 2008-11-05 |
| WO2007097276A1 (ja) | 2007-08-30 |
| EP1988075B1 (de) | 2012-01-25 |
| CA2642619A1 (en) | 2007-08-30 |
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