ATE542802T1 - Hiv-inhibierende 5-substituierte pyrimidine - Google Patents

Hiv-inhibierende 5-substituierte pyrimidine

Info

Publication number
ATE542802T1
ATE542802T1 AT05789686T AT05789686T ATE542802T1 AT E542802 T1 ATE542802 T1 AT E542802T1 AT 05789686 T AT05789686 T AT 05789686T AT 05789686 T AT05789686 T AT 05789686T AT E542802 T1 ATE542802 T1 AT E542802T1
Authority
AT
Austria
Prior art keywords
hiv
inhibiting
substituted pyrimidines
pyrimidines
substituted
Prior art date
Application number
AT05789686T
Other languages
English (en)
Inventor
Jerome Guillemont
Jan Heeres
Paulus Joannes Lewi
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34929637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE542802(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE542802T1 publication Critical patent/ATE542802T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05789686T 2004-09-30 2005-09-29 Hiv-inhibierende 5-substituierte pyrimidine ATE542802T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04104805 2004-09-30
PCT/EP2005/054932 WO2006035069A1 (en) 2004-09-30 2005-09-29 Hiv inhibiting 5-substituted pyrimidines

Publications (1)

Publication Number Publication Date
ATE542802T1 true ATE542802T1 (de) 2012-02-15

Family

ID=34929637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05789686T ATE542802T1 (de) 2004-09-30 2005-09-29 Hiv-inhibierende 5-substituierte pyrimidine

Country Status (17)

Country Link
US (1) US8946248B2 (de)
EP (1) EP1797047B1 (de)
JP (1) JP5046943B2 (de)
KR (1) KR20070057837A (de)
CN (1) CN101027288B (de)
AR (1) AR051315A1 (de)
AT (1) ATE542802T1 (de)
AU (1) AU2005288866B2 (de)
BR (1) BRPI0516748B8 (de)
CA (1) CA2575472C (de)
ES (1) ES2380631T3 (de)
IL (1) IL181056A (de)
MX (1) MX2007003796A (de)
RU (1) RU2410379C2 (de)
TW (1) TW200626561A (de)
WO (1) WO2006035069A1 (de)
ZA (1) ZA200702656B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5046943B2 (ja) 2004-09-30 2012-10-10 テイボテク・フアーマシユーチカルズ Ｈｉｖ阻害性５−置換ピリミジン
WO2006035067A2 (en) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-heterocyclyl pyrimidines
ES2533258T3 (es) * 2005-02-18 2015-04-08 Janssen Sciences Ireland Uc Derivados de óxido de 2-(4-cianofenilamino)pirimidina que inhiben el VIH
CN101405283B (zh) * 2006-03-30 2014-06-18 泰博特克药品有限公司 Hiv抑制性5-酰氨基取代的嘧啶类化合物
AU2007341227C1 (en) * 2006-12-29 2013-08-29 Janssen Sciences Ireland Uc HIV inhibiting 6-substituted pyrimidines
AU2007341228B2 (en) * 2006-12-29 2013-04-18 Janssen Sciences Ireland Uc HIV inhibiting 5,6-substituted pyrimidines
US9139534B2 (en) 2011-04-22 2015-09-22 Signal Pharmaceuticals, Llc Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
EP2872492B1 (de) * 2012-07-12 2018-01-31 Hetero Research Foundation Verfahren zur herstellung von rilpivirin über ein neues zwischenprodukt
ES2648226T3 (es) * 2012-11-08 2017-12-29 Bristol-Myers Squibb Company Compuestos de pirimidina sustituidos con alquilamida útiles en la modulación de IL-12, IL-23 y/o IFN
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US9513297B2 (en) 2014-12-16 2016-12-06 Signal Pharmaceuticals, Llc Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
CN107108524A (zh) 2014-12-16 2017-08-29 西格诺药品有限公司 2‑(叔丁基氨基)‑4‑((1r,3r,4r)‑3‑羟基‑4‑甲基环己基氨基)‑嘧啶‑5‑甲酰胺的配制物
EP3250557B1 (de) 2015-01-29 2024-11-20 Signal Pharmaceuticals, LLC Isotopologe von 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidin-5-carboxamid
CN107922287B (zh) 2015-07-24 2021-04-09 细胞基因公司 合成(1r,2r,5r)-5-氨基-2-甲基环己醇盐酸盐的方法和其中可用的中间体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) * 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
EP0310550B1 (de) * 1987-09-28 1993-05-26 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
BR9611562A (pt) 1995-11-23 1999-03-02 Janssen Pharmaceutica Nv Misturas sólidas de ciclodextrinas preparadas via extrusão sob fusão
NO311614B1 (no) 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
EP0945447A1 (de) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen
EA002973B1 (ru) 1998-03-27 2002-12-26 Янссен Фармацевтика Н.В. Производные пиримидина в качестве ингибиторов репликации вируса иммунодефицита человека
SK287270B6 (sk) 1998-11-10 2010-05-07 Janssen Pharmaceutica N. V. Derivát pyrimidínu
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
AU783981C (en) * 2000-05-08 2007-05-03 Janssen Pharmaceutica N.V. HIV replication inhibitors
US6989385B2 (en) * 2000-12-21 2006-01-24 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
EA009871B1 (ru) 2002-11-15 2008-04-28 Тиботек Фармасьютикалз Лтд. Замещённые индолпиридиниевые соединения в качестве противоинфекционного средства
US7504396B2 (en) * 2003-06-24 2009-03-17 Amgen Inc. Substituted heterocyclic compounds and methods of use
WO2006035067A2 (en) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-heterocyclyl pyrimidines
ES2371924T3 (es) * 2004-09-30 2012-01-11 Tibotec Pharmaceuticals Pirimidinas 5-carbo o heterociclo- sustituidas que inhiben el hiv.
JP5046943B2 (ja) 2004-09-30 2012-10-10 テイボテク・フアーマシユーチカルズ Ｈｉｖ阻害性５−置換ピリミジン
CN101405283B (zh) 2006-03-30 2014-06-18 泰博特克药品有限公司 Hiv抑制性5-酰氨基取代的嘧啶类化合物
AU2007341227C1 (en) * 2006-12-29 2013-08-29 Janssen Sciences Ireland Uc HIV inhibiting 6-substituted pyrimidines
AU2007341228B2 (en) * 2006-12-29 2013-04-18 Janssen Sciences Ireland Uc HIV inhibiting 5,6-substituted pyrimidines

Also Published As

Publication number Publication date
US20080262007A1 (en) 2008-10-23
AU2005288866B2 (en) 2012-07-26
IL181056A (en) 2014-02-27
CN101027288A (zh) 2007-08-29
EP1797047A1 (de) 2007-06-20
CA2575472A1 (en) 2006-04-06
ZA200702656B (en) 2008-08-27
IL181056A0 (en) 2007-07-04
ES2380631T3 (es) 2012-05-17
BRPI0516748A (pt) 2008-09-23
AR051315A1 (es) 2007-01-03
WO2006035069A1 (en) 2006-04-06
EP1797047B1 (de) 2012-01-25
CA2575472C (en) 2013-07-30
RU2007116172A (ru) 2008-11-10
AU2005288866A1 (en) 2006-04-06
KR20070057837A (ko) 2007-06-07
RU2410379C2 (ru) 2011-01-27
BRPI0516748B1 (pt) 2019-11-19
CN101027288B (zh) 2013-04-17
US8946248B2 (en) 2015-02-03
MX2007003796A (es) 2007-04-25
JP5046943B2 (ja) 2012-10-10
BRPI0516748B8 (pt) 2021-05-25
JP2008514681A (ja) 2008-05-08
TW200626561A (en) 2006-08-01

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