ATE520672T1 - Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine - Google Patents
Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidineInfo
- Publication number
- ATE520672T1 ATE520672T1 AT05803358T AT05803358T ATE520672T1 AT E520672 T1 ATE520672 T1 AT E520672T1 AT 05803358 T AT05803358 T AT 05803358T AT 05803358 T AT05803358 T AT 05803358T AT E520672 T1 ATE520672 T1 AT E520672T1
- Authority
- AT
- Austria
- Prior art keywords
- carbo
- hiv
- inhibiting
- substituted pyrimidines
- heterocyclic substituted
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104814 | 2004-09-30 | ||
| PCT/EP2005/054931 WO2006035068A2 (en) | 2004-09-30 | 2005-09-29 | Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520672T1 true ATE520672T1 (de) | 2011-09-15 |
Family
ID=34929640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05803358T ATE520672T1 (de) | 2004-09-30 | 2005-09-29 | Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7531548B2 (de) |
| EP (1) | EP1797048B1 (de) |
| JP (1) | JP5162245B2 (de) |
| KR (1) | KR20070057798A (de) |
| CN (1) | CN101031550B (de) |
| AR (1) | AR050970A1 (de) |
| AT (1) | ATE520672T1 (de) |
| AU (1) | AU2005288865B2 (de) |
| BR (1) | BRPI0515935B8 (de) |
| CA (1) | CA2573976C (de) |
| ES (1) | ES2371924T3 (de) |
| IL (1) | IL180760A (de) |
| MX (1) | MX2007003798A (de) |
| RU (1) | RU2403244C2 (de) |
| TW (1) | TW200626560A (de) |
| WO (1) | WO2006035068A2 (de) |
| ZA (1) | ZA200702655B (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4886511B2 (ja) | 2003-07-30 | 2012-02-29 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法 |
| ES2380631T3 (es) * | 2004-09-30 | 2012-05-17 | Tibotec Pharmaceuticals | Pirimidinas sustituidas en posición 5 inhibidoras de VIH |
| BRPI0516746A (pt) * | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
| AU2006254840B2 (en) | 2005-06-08 | 2012-08-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| ES2465666T3 (es) | 2006-03-30 | 2014-06-06 | Janssen R&D Ireland | Pirimidinas 5-amido-sustituidas inhibidoras del HIV |
| HRP20100696T1 (hr) * | 2006-03-30 | 2011-01-31 | Tibotec Pharmaceuticals | Hiv inhibirajuci 5-(hidroksimetilen i aminometilen) supstituirani pirimidini |
| AU2007332654B2 (en) | 2006-12-13 | 2013-06-20 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
| ES2523863T3 (es) * | 2006-12-29 | 2014-12-02 | Janssen R&D Ireland | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
| BRPI0720858B8 (pt) * | 2006-12-29 | 2021-05-25 | Janssen R & D Ireland | pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
| US7834024B2 (en) | 2007-03-26 | 2010-11-16 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| SG10201510696RA (en) | 2008-06-27 | 2016-01-28 | Celgene Avilomics Res Inc | Heteroaryl compounds and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| AR074209A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina utiles para el tratamiento del cancer |
| TWI491605B (zh) | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| JP5918693B2 (ja) | 2009-05-05 | 2016-05-18 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | Ｅｇｆｒ阻害剤及び疾患の治療方法 |
| MY160734A (en) | 2010-08-10 | 2017-03-15 | Celgene Avilomics Res Inc | Besylate salt of a btk inhibitor |
| NZ710636A (en) | 2010-11-01 | 2017-02-24 | Celgene Avilomics Res Inc | Heterocyclic compounds and uses thereof |
| WO2012061303A1 (en) | 2010-11-01 | 2012-05-10 | Avila Therapeutics, Inc. | Heteroaryl compounds and uses thereof |
| WO2012064706A1 (en) | 2010-11-10 | 2012-05-18 | Avila Therapeutics, Inc. | Mutant-selective egfr inhibitors and uses thereof |
| CA2853498A1 (en) | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Methods of treating a bruton's tyrosine kinase disease or disorder |
| SMT201800571T1 (it) | 2012-03-15 | 2019-01-11 | Celgene Car Llc | Sali di un inibitore di chinasi del recettore del fattore di crescita dell’epidermide |
| BR112014022789B1 (pt) | 2012-03-15 | 2022-04-19 | Celgene Car Llc | Formas sólidas de um inibidor de quinase de receptor do fator de crescimento epidérmico, composição farmacêutica e usos do mesmo |
| US9126950B2 (en) | 2012-12-21 | 2015-09-08 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US9561228B2 (en) | 2013-02-08 | 2017-02-07 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US10005760B2 (en) | 2014-08-13 | 2018-06-26 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
| AU2021224460A1 (en) | 2020-02-19 | 2022-12-15 | Pharmasyntez, Joint Stock Company | Pyrimidine-based bicycles as antiviral agents for the treatment and prevention of HIV infection |
| US12577240B2 (en) | 2020-07-11 | 2026-03-17 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| KR102939283B1 (ko) * | 2022-05-03 | 2026-03-13 | 한국화학연구원 | 5-클로로-2,4-다이아미노피리미딘을 포함하는 키나아제 억제 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| WO2024103400A1 (zh) * | 2022-11-18 | 2024-05-23 | 水木未来(北京)科技有限公司 | 作为gpr75激活剂的多环化合物、包含其的药物组合物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| BRPI9909191B8 (pt) * | 1998-03-27 | 2021-07-06 | Janssen Pharmaceutica Nv | derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende |
| NZ506679A (en) * | 1998-03-27 | 2002-11-26 | Janssen Pharmaceutica Nv | HIV inhibiting pyrimidine derivatives |
| EP0945447A1 (de) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| SK287269B6 (sk) | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| JP5230050B2 (ja) * | 2000-05-08 | 2013-07-10 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ複製阻害剤 |
| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| EA200500721A1 (ru) * | 2002-11-28 | 2005-12-29 | Шеринг Акциенгезельшафт | Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств |
-
2005
- 2005-09-29 KR KR1020077003634A patent/KR20070057798A/ko not_active Ceased
- 2005-09-29 CA CA2573976A patent/CA2573976C/en not_active Expired - Fee Related
- 2005-09-29 MX MX2007003798A patent/MX2007003798A/es active IP Right Grant
- 2005-09-29 RU RU2007116161/04A patent/RU2403244C2/ru active
- 2005-09-29 EP EP05803358A patent/EP1797048B1/de not_active Expired - Lifetime
- 2005-09-29 US US11/576,068 patent/US7531548B2/en not_active Expired - Lifetime
- 2005-09-29 WO PCT/EP2005/054931 patent/WO2006035068A2/en not_active Ceased
- 2005-09-29 CN CN200580033118.3A patent/CN101031550B/zh not_active Expired - Fee Related
- 2005-09-29 TW TW094134106A patent/TW200626560A/zh unknown
- 2005-09-29 ES ES05803358T patent/ES2371924T3/es active Active
- 2005-09-29 AU AU2005288865A patent/AU2005288865B2/en not_active Ceased
- 2005-09-29 AT AT05803358T patent/ATE520672T1/de not_active IP Right Cessation
- 2005-09-29 JP JP2007534027A patent/JP5162245B2/ja not_active Expired - Fee Related
- 2005-09-29 BR BRPI0515935A patent/BRPI0515935B8/pt not_active IP Right Cessation
- 2005-09-30 AR ARP050104154A patent/AR050970A1/es not_active Application Discontinuation
-
2007
- 2007-01-17 IL IL180760A patent/IL180760A/en active IP Right Grant
- 2007-03-29 ZA ZA200702655A patent/ZA200702655B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008514680A (ja) | 2008-05-08 |
| EP1797048A2 (de) | 2007-06-20 |
| BRPI0515935B8 (pt) | 2021-05-25 |
| ES2371924T3 (es) | 2012-01-11 |
| AU2005288865B2 (en) | 2012-07-19 |
| EP1797048B1 (de) | 2011-08-17 |
| JP5162245B2 (ja) | 2013-03-13 |
| AR050970A1 (es) | 2006-12-06 |
| BRPI0515935A (pt) | 2008-08-12 |
| WO2006035068A3 (en) | 2006-08-31 |
| US20070208022A1 (en) | 2007-09-06 |
| MX2007003798A (es) | 2007-04-23 |
| IL180760A (en) | 2013-02-28 |
| CN101031550B (zh) | 2015-05-27 |
| CA2573976C (en) | 2014-04-29 |
| RU2007116161A (ru) | 2008-11-10 |
| CN101031550A (zh) | 2007-09-05 |
| AU2005288865A1 (en) | 2006-04-06 |
| CA2573976A1 (en) | 2006-04-06 |
| US7531548B2 (en) | 2009-05-12 |
| IL180760A0 (en) | 2007-06-03 |
| BRPI0515935B1 (pt) | 2019-11-19 |
| WO2006035068A2 (en) | 2006-04-06 |
| ZA200702655B (en) | 2008-09-25 |
| TW200626560A (en) | 2006-08-01 |
| RU2403244C2 (ru) | 2010-11-10 |
| KR20070057798A (ko) | 2007-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |