ATE543080T1 - System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie - Google Patents

System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie

Info

Publication number
ATE543080T1
ATE543080T1 AT01957072T AT01957072T ATE543080T1 AT E543080 T1 ATE543080 T1 AT E543080T1 AT 01957072 T AT01957072 T AT 01957072T AT 01957072 T AT01957072 T AT 01957072T AT E543080 T1 ATE543080 T1 AT E543080T1
Authority
AT
Austria
Prior art keywords
pump
stoke
epi
raman scattering
stokes raman
Prior art date
Application number
AT01957072T
Other languages
English (en)
Inventor
Xiaoliang Xie
Andreas Volkmer
Ji-Xin Cheng
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE543080T1 publication Critical patent/ATE543080T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT01957072T 2000-07-13 2001-06-20 System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie ATE543080T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21809100P 2000-07-13 2000-07-13
PCT/US2001/019678 WO2002006778A1 (en) 2000-07-13 2001-06-20 System and method for epi-detected coherent anti-stokes raman scattering microscopy

Publications (1)

Publication Number Publication Date
ATE543080T1 true ATE543080T1 (de) 2012-02-15

Family

ID=22813707

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01957072T ATE543080T1 (de) 2000-07-13 2001-06-20 System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie

Country Status (4)

Country Link
US (1) US6809814B2 (de)
EP (1) EP1311813B9 (de)
AT (1) ATE543080T1 (de)
WO (1) WO2002006778A1 (de)

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US7414729B2 (en) * 2005-10-13 2008-08-19 President And Fellows Of Harvard College System and method for coherent anti-Stokes Raman scattering endoscopy
US7352458B2 (en) * 2005-10-26 2008-04-01 President And Fellows Of Harvard College System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses
WO2008052221A2 (en) * 2006-10-27 2008-05-02 Aretais, Inc. Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
EP2074661A4 (de) * 2006-10-27 2012-03-07 Aretais Inc Verwendung von quantensystemidentifikations- und quantensteuertechniken für medizinische diagnose und therapeutische zwecke
US7480045B2 (en) * 2006-10-31 2009-01-20 Academia Sinica Controlling pulses in optical microscopy
DE102006056429B3 (de) 2006-11-28 2008-02-14 Leica Microsystems Cms Gmbh Lasermikroskop mit räumlich trennendem Strahlteiler
US7869051B2 (en) * 2007-01-19 2011-01-11 Stc. Unm System and method for ratiometric non-linear coherent imaging
DE102007021378A1 (de) * 2007-05-04 2008-11-06 Ape Angewandte Physik Und Elektronik Gmbh Verfahren und optische Anordnung zum Erzeugen eines nicht-linearen optischen Signals an einem durch ein Anregungsfeld angeregten Material sowie Verwendung des Verfahrens und der optischen Anordnung
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WO2009149733A1 (en) * 2008-06-13 2009-12-17 Embl Heidelberg Next generation flow cytometer sorter
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WO2010071682A2 (en) 2008-12-20 2010-06-24 Purdue Research Foundation A multimodal platform for nonlinear optical microscopy and microspectroscopy
US9285575B2 (en) * 2009-01-26 2016-03-15 President And Fellows Of Harvard College Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping
US8264694B2 (en) * 2009-03-16 2012-09-11 Ut-Battelle, Llc Quantitative phase-contrast and excitation-emission systems
US8248614B2 (en) * 2009-03-16 2012-08-21 Ut-Battelle, Llc Quantitative phase-imaging systems
US8675201B2 (en) * 2009-06-05 2014-03-18 The Penn State Research Foundation Coherent anti-Stokes Raman holography
FR2955663B1 (fr) 2010-01-22 2014-09-12 Ct Nat De La Rech C N R S Methode pour la detection d'un signal optique non lineaire resonant et dispositif pour la mise en oeuvre de ladite methode
WO2011162787A1 (en) 2010-06-22 2011-12-29 President And Fellows Of Harvard College Systems and methods providing efficient detection of back-scattered illumination in modulation transfer microscopy or micro-spectroscopy
GB201013321D0 (en) 2010-08-06 2010-09-22 King S College London Method and apparatus for non-resonant background reduction in Coherent anti-strokes Raman Scattering (CARS) spectroscopy
US20130267855A1 (en) * 2011-10-28 2013-10-10 Kazuo Tsubota Comprehensive measuring method of biological materials and treatment method using broadly tunable laser
US9634454B1 (en) 2012-01-17 2017-04-25 President And Fellows Of Harvard College Laser illumination systems and methods for dual-excitation wavelength non-linear optical microscopy and micro-spectroscopy systems
US8792156B1 (en) 2012-01-17 2014-07-29 President And Fellows Of Harvard College Laser illumination systems and methods for dual-excitation wavelength non-linear optical microscopy and micro-spectroscopy systems
FR3003949B1 (fr) * 2013-03-26 2015-05-01 Univ Aix Marseille Dispositif et methode de detection raman stimulee.
US9506858B2 (en) * 2013-05-09 2016-11-29 The Board Of Trustees Of The University Of Illinois Optical parametric amplification of weak signals for imaging biological tissue
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US9778193B2 (en) 2013-08-22 2017-10-03 Kinetic River Corp. Methods and apparatuses for label-free particle analysis
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
JP6804065B2 (ja) 2015-09-25 2020-12-23 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ コヒーレントラマンイメージング用生検装置
CN106990089B (zh) * 2017-04-01 2019-06-04 上海理工大学 同步降频的相干反斯托克斯拉曼散射成像系统及成像方法
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Also Published As

Publication number Publication date
WO2002006778A1 (en) 2002-01-24
US6809814B2 (en) 2004-10-26
EP1311813A4 (de) 2006-05-10
EP1311813B1 (de) 2012-01-25
EP1311813A1 (de) 2003-05-21
EP1311813B9 (de) 2012-05-02
US20030160955A1 (en) 2003-08-28

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