ATE543494T1 - Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildung - Google Patents
Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildungInfo
- Publication number
- ATE543494T1 ATE543494T1 AT08761406T AT08761406T ATE543494T1 AT E543494 T1 ATE543494 T1 AT E543494T1 AT 08761406 T AT08761406 T AT 08761406T AT 08761406 T AT08761406 T AT 08761406T AT E543494 T1 ATE543494 T1 AT E543494T1
- Authority
- AT
- Austria
- Prior art keywords
- griseofulvin
- analogs
- inhibiting
- treating cancer
- cluster formation
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical class COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07111335A EP2008652A1 (de) | 2007-06-28 | 2007-06-28 | Griseofulvinanaloge zur Behandlung von Krebs durch Hemmung von zentrosomalem Clustering |
| PCT/EP2008/058410 WO2009000937A1 (en) | 2007-06-28 | 2008-06-30 | Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543494T1 true ATE543494T1 (de) | 2012-02-15 |
Family
ID=38667076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08761406T ATE543494T1 (de) | 2007-06-28 | 2008-06-30 | Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110178170A1 (de) |
| EP (2) | EP2008652A1 (de) |
| AT (1) | ATE543494T1 (de) |
| DK (1) | DK2190426T3 (de) |
| ES (1) | ES2381057T3 (de) |
| WO (1) | WO2009000937A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2204367A1 (de) * | 2008-12-22 | 2010-07-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Griseofulvinanaloge zur Behandlung von Krebs durch Hemmung von zentrosomalem Clustering |
| WO2014020101A1 (fr) * | 2012-08-01 | 2014-02-06 | Pierre Fabre Medicament | Derives de griseofulvine |
| CN103058971B (zh) * | 2013-01-17 | 2014-08-06 | 福州大学 | 一种源于棘孢曲霉的苯醌螺环化合物及其应用 |
| CN104860909B (zh) * | 2015-04-09 | 2017-03-08 | 西北农林科技大学 | 灰黄霉素衍生物、灰黄霉素及其衍生物的抗菌活性应用 |
| RU2736208C2 (ru) | 2016-03-30 | 2020-11-12 | Дайити Санкио Компани, Лимитед | Гризеофульвиновое соединение |
| TWI811243B (zh) * | 2017-09-29 | 2023-08-11 | 日商第一三共股份有限公司 | 灰黃黴素化合物及醫藥用途 |
| KR102125005B1 (ko) * | 2017-10-27 | 2020-06-22 | 한양대학교 에리카산학협력단 | 53bp1의 신규한 용도 |
| CN108484552B (zh) * | 2018-06-15 | 2020-03-10 | 河南大学 | 一种多取代3-苯并呋喃酮螺环己烯衍生物及其制备方法 |
| CN108823110B (zh) * | 2018-07-26 | 2021-07-16 | 福州工微生物科技有限公司 | 一株产灰黄霉素的菌株及其应用 |
| CN112080438B (zh) * | 2020-10-15 | 2023-05-12 | 内蒙古格林特制药有限责任公司 | 一种灰黄霉素低产沫菌种及低产沫菌种的制备方法和应用 |
| CN116076510B (zh) * | 2022-05-30 | 2024-10-29 | 河南大学 | 多取代3-苯并呋喃酮螺环己烯衍生物作为杀菌剂在防治植物病菌中的应用 |
| CN116199657B (zh) * | 2023-02-20 | 2024-11-29 | 延安大学 | 灰黄霉素4位醚化衍生物及其应用 |
| CN117229246B (zh) * | 2023-05-23 | 2024-06-07 | 湖北天勤生物科技股份有限公司 | 具有抗炎活性的化合物及其制备方法和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK14298A3 (en) * | 1995-08-03 | 1998-09-09 | Procter & Gamble | Use of griseofulvin for inhibiting the growth of cancers |
-
2007
- 2007-06-28 EP EP07111335A patent/EP2008652A1/de not_active Withdrawn
-
2008
- 2008-06-30 DK DK08761406.1T patent/DK2190426T3/da active
- 2008-06-30 US US12/666,730 patent/US20110178170A1/en not_active Abandoned
- 2008-06-30 AT AT08761406T patent/ATE543494T1/de active
- 2008-06-30 WO PCT/EP2008/058410 patent/WO2009000937A1/en not_active Ceased
- 2008-06-30 ES ES08761406T patent/ES2381057T3/es active Active
- 2008-06-30 EP EP08761406A patent/EP2190426B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009000937A1 (en) | 2008-12-31 |
| EP2190426B1 (de) | 2012-02-01 |
| DK2190426T3 (da) | 2012-03-26 |
| EP2190426A1 (de) | 2010-06-02 |
| ES2381057T3 (es) | 2012-05-22 |
| US20110178170A1 (en) | 2011-07-21 |
| EP2008652A1 (de) | 2008-12-31 |
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