EA201190235A1 - Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 - Google Patents

Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750

Info

Publication number
EA201190235A1
EA201190235A1 EA201190235A EA201190235A EA201190235A1 EA 201190235 A1 EA201190235 A1 EA 201190235A1 EA 201190235 A EA201190235 A EA 201190235A EA 201190235 A EA201190235 A EA 201190235A EA 201190235 A1 EA201190235 A1 EA 201190235A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
cyclilcarboxamide
cyanoethylgethero
substituted
therapy
Prior art date
Application number
EA201190235A
Other languages
English (en)
Inventor
Ронан Форд
Антонио Мете
Эндрю Мэтер
Айан Милличип
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201190235A1 publication Critical patent/EA201190235A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем изобретении предложены соединения формулы (I)где у, m, n, R, Rи Q являются такими, как определено в описании, способ их получения, содержащие их фармацевтические композиции и их применение в терапии.
EA201190235A 2009-05-07 2010-05-05 Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 EA201190235A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17627909P 2009-05-07 2009-05-07
US18562909P 2009-06-10 2009-06-10
PCT/GB2010/050736 WO2010128324A1 (en) 2009-05-07 2010-05-05 Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750

Publications (1)

Publication Number Publication Date
EA201190235A1 true EA201190235A1 (ru) 2012-05-30

Family

ID=42271991

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190235A EA201190235A1 (ru) 2009-05-07 2010-05-05 Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750

Country Status (22)

Country Link
US (2) US8193239B2 (ru)
EP (1) EP2427445A1 (ru)
JP (1) JP2012526093A (ru)
KR (1) KR20120034639A (ru)
CN (1) CN102574830A (ru)
AR (1) AR076551A1 (ru)
AU (1) AU2010244218B2 (ru)
BR (1) BRPI1015540A2 (ru)
CA (1) CA2759581A1 (ru)
CL (1) CL2011002787A1 (ru)
CO (1) CO6450612A2 (ru)
CR (1) CR20110579A (ru)
CU (1) CU20110204A7 (ru)
EA (1) EA201190235A1 (ru)
EC (1) ECSP11011439A (ru)
IL (1) IL215615A0 (ru)
MX (1) MX2011011661A (ru)
SG (1) SG175090A1 (ru)
TW (1) TW201041889A (ru)
UY (1) UY32611A (ru)
WO (1) WO2010128324A1 (ru)
ZA (1) ZA201108962B (ru)

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DK3265452T3 (en) * 2015-03-05 2020-06-08 Neuprozyme Therapeutics ApS Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors
CN106478629A (zh) * 2015-08-24 2017-03-08 上海医药工业研究院 一种利格列汀的制备工艺
DK3423451T3 (da) 2016-03-01 2022-11-28 Propellon Therapeutics Inc Inhibitorer af wdr5-protein-proteinbinding
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WO2018022978A1 (en) * 2016-07-29 2018-02-01 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating bronchiectasis
FI3758708T3 (fi) 2018-03-01 2025-02-18 Astrazeneca Ab (2s)-{(1s)-1-syano-2-[4-(3-metyyli-2-okso-2,3-dihydro-1,3-bentsoksatsol-5-yyli)fenyyli]etyyli}-1,4-oksatsepaani-2-karboksamidia käsittäviä farmaseuttisia koostumuksia
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KR20210032439A (ko) * 2018-07-17 2021-03-24 인스메드 인코포레이티드 염증성 장 질환을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
KR20210032431A (ko) 2018-07-17 2021-03-24 인스메드 인코포레이티드 루푸스 신염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
WO2020050241A1 (ja) 2018-09-04 2020-03-12 中外製薬株式会社 ４環性化合物の製造方法
RS66302B1 (sr) * 2020-08-26 2025-01-31 Haisco Pharmaceuticals Pte Ltd Derivat nitrila koji deluje kao inhibitor dipeptidil peptidaze 1 i njegova upotreba
CA3199568A1 (en) * 2020-12-04 2022-06-09 Reistone Biopharma Company Limited Small molecule inhibitor of cathepsin c and medicinal use thereof
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Also Published As

Publication number Publication date
BRPI1015540A2 (pt) 2019-09-24
JP2012526093A (ja) 2012-10-25
US8193239B2 (en) 2012-06-05
WO2010128324A1 (en) 2010-11-11
SG175090A1 (en) 2011-11-28
CL2011002787A1 (es) 2012-06-22
CO6450612A2 (es) 2012-05-31
ZA201108962B (en) 2012-08-29
CR20110579A (es) 2012-01-09
CU20110204A7 (es) 2012-03-15
KR20120034639A (ko) 2012-04-12
US20120329775A1 (en) 2012-12-27
US20100286118A1 (en) 2010-11-11
EP2427445A1 (en) 2012-03-14
IL215615A0 (en) 2011-12-29
AU2010244218A1 (en) 2011-11-03
TW201041889A (en) 2010-12-01
AU2010244218B2 (en) 2012-07-19
CA2759581A1 (en) 2010-11-11
CN102574830A (zh) 2012-07-11
UY32611A (es) 2010-12-31
MX2011011661A (es) 2011-11-18
ECSP11011439A (es) 2011-12-30
AR076551A1 (es) 2011-06-22

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